{"key":"op_284_IL","page":{"url":"https://us-uk.bookimed.com/clinics/country=israel/procedure=targeted-therapy/","procedure":{"id":284,"slug":"targeted-therapy","name":"Targeted therapy","name_forms":{"plural":{"status":"missing","reason":"not_collected"},"genitive":{"status":"missing","reason":"not_collected"}},"type":"therapy","grammar_number":{"status":"missing","reason":"not_collected"},"parent_id":"oncology","family_attribute":{"status":"missing","reason":"not_collected"}},"country":{"id":1,"iso":"IL","name":"Israel"},"currency":"USD","data_date":"2026-10-24"},"pages":{"clinics_url":"https://us-uk.bookimed.com/clinics/country=israel/procedure=targeted-therapy/","cost_url":"https://us-uk.bookimed.com/clinics/country=israel/procedure=targeted-therapy/cost/","best_url":{"status":"missing","reason":"template not live"}},"price":{"from":6500,"to":12500,"avg":{"status":"missing","reason":"no_offers"},"us":{"from":9000,"to":20000},"uk":{"from":3800,"to":9500},"by_technique":{"status":"missing","reason":"not_collected"},"by_city":[{"city":"Jerusalem","from":9500},{"city":"Haifa","from":6800},{"city":"Tel Aviv","from":6000}],"per_unit":{"status":"missing","reason":"not_collected"},"factors":{"status":"missing","reason":"not_collected"},"tiers":{"status":"missing","reason":"no_offers"},"comparison":[{"country_iso":"UA","from":1800,"to":4800},{"country_iso":"FR","from":6500,"to":13000},{"country_iso":"GB","from":3800,"to":9500},{"country_iso":"US","from":9000,"to":20000},{"country_iso":"TR","from":3000,"to":6000},{"country_iso":"MX","from":3500,"to":8000},{"country_iso":"DE","from":3000,"to":50000},{"country_iso":"CA","from":9000,"to":24000},{"country_iso":"AE","from":6500,"to":14000},{"country_iso":"TH","from":1000,"to":9000},{"country_iso":"PL","from":2500,"to":6000},{"country_iso":"KR","from":6500,"to":12500},{"country_iso":"CZ","from":3500,"to":8000},{"country_iso":"AT","from":9000,"to":21000},{"country_iso":"ES","from":13600,"to":{"status":"missing","reason":"not_collected"}},{"country_iso":"IT","from":4500,"to":9000},{"country_iso":"CN","from":3500,"to":11000},{"country_iso":"AU","from":9000,"to":21000},{"country_iso":"IN","from":1000,"to":8500},{"country_iso":"MY","from":6500,"to":13500},{"country_iso":"VN","from":4500,"to":9500},{"country_iso":"BR","from":4500,"to":7000},{"country_iso":"EG","from":1000,"to":4800}],"base_country":"US","base_is_fallback":false},"savings":{"pct":28,"variant":"ranges_overlap"},"package":{"included":{"status":"missing","reason":"no_offers"},"excluded":{"status":"missing","reason":"no_offers"},"extra_charges":{"status":"missing","reason":"not_collected"}},"clinics":{"count":5,"items":[{"id":1,"name":"Sourasky Medical Center (Ichilov)","city":"Tel Aviv","rating":4.5,"reviews_count":172,"accreditations":["World's Best Smart Hospitals 2021 by Newsweek","World's Best Hospitals 2021 by Newsweek","World's Best Hospitals 2020 by Newsweek","Patient choice for Check-up","Fastest treatment organization","Joint Commission International","World's Best Specialized Hospitals 2022 by Newsweek","World's Best Smart Hospitals 2023 by Newsweek","World's Best Hospitals 2022 by Newsweek"],"rank":1,"has_procedure":true,"why_ranked":"Offers Lutetium-177 PSMA therapy, a targeted approach combining diagnostic PSMA PET/CT and therapy. High success rates and JCI accreditation ensure quality care.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":8,"name":"Assuta Medical Center","city":"Tel Aviv","rating":4.4,"reviews_count":13,"accreditations":["Joint Commission International"],"rank":2,"has_procedure":true,"why_ranked":"Uses MRI-guided linear accelerator for targeted radiotherapy that can shorten treatment duration and replace surgery in some cases. JCI-accredited, first in Israel.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":16,"name":"Hadassah Medical Center","city":"Jerusalem","rating":4.2,"reviews_count":13,"accreditations":["Nobel Peace Prize","World's Best Hospitals 2021 by Newsweek","World's Best Smart Hospitals 2021 by Newsweek","World's Best Smart Hospitals 2023 by Newsweek"],"rank":3,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":17,"name":"Rambam Medical Center","city":"Haifa","rating":5,"reviews_count":2,"accreditations":["Joint Commission International","World's Best Hospitals 2021 by Newsweek","World's Best Smart Hospitals 2023 by Newsweek"],"rank":4,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":235,"name":"Shaare Zedek Medical Center","city":"Jerusalem","rating":{"status":"missing","reason":"not_collected"},"reviews_count":{"status":"missing","reason":"not_collected"},"accreditations":{"status":"missing","reason":"not_collected"},"rank":5,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}}]},"doctors":{"count":22,"languages":{"status":"missing","reason":"not_collected"}},"cities":[{"id":3,"slug":"jerusalem","name":"Jerusalem","clinics_count":{"status":"missing","reason":"not_collected"},"price_from":9500,"profile":{"city_type":"Historic city in the Judaean Mountains","access":["Ben Gurion Airport (TLV), 45 km from Jerusalem"],"sources":["https://en.wikipedia.org/wiki/Jerusalem","https://en.wikipedia.org/wiki/Ben_Gurion_Airport"],"checked_at":"2026-11-03","status":"ok"}},{"id":8,"slug":"haifa","name":"Haifa","clinics_count":{"status":"missing","reason":"not_collected"},"price_from":6800,"profile":{"city_type":"Major Mediterranean seaport city","access":["Ben Gurion Airport (TLV), 100 km from Haifa"],"sources":["https://en.wikipedia.org/wiki/Haifa","https://dislocations2019.net.technion.ac.il/general-information-2/travel-and-transportation/"],"checked_at":"2026-11-03","status":"ok"}},{"id":2,"slug":"tel-aviv","name":"Tel Aviv","clinics_count":{"status":"missing","reason":"not_collected"},"price_from":6000,"profile":{"city_type":"Mediterranean coastal economic and tech hub","access":["Ben Gurion Airport (TLV), 20 km southeast of city"],"sources":["https://en.wikipedia.org/wiki/Tel_Aviv","https://en.wikipedia.org/wiki/Ben_Gurion_Airport"],"checked_at":"2026-11-03","status":"ok"}}],"offers":{"active":{"status":"missing","reason":"no_offers"},"active_with_related":{"status":"missing","reason":"no_offers"},"hospital_nights_median":{"status":"missing","reason":"no_offers"},"days_in_country_median":{"status":"missing","reason":"no_offers"},"top_offers":{"status":"missing","reason":"no_offers"},"packages":{"status":"missing","reason":"no_offers"},"related_packages":{"status":"missing","reason":"no_offers"},"other_packages":{"status":"missing","reason":"no_offers"}},"medical":{"indications":["Cancers with molecular targets: HER2, EGFR, ALK, BRAF, BCR-ABL","Hematologic malignancies and solid tumors with a matched targeted agent","Some non-cancer conditions with defined molecular targets"],"contraindications":["Known severe hypersensitivity to the specific agent or its components","Pregnancy and breastfeeding for many agents (agent-specific)","Severe uncontrolled liver, heart or lung dysfunction (relative, agent-dependent)","Clinically significant drug interactions with the specific agent (relative, agent-specific)"],"operation_hours":{"min":0.5,"max":3,"unit":"hours","qualifier":"Per infusion visit; first infusion is longest. Oral agents are taken at home."},"anesthesia":["none"],"sessions_or_stages":{"sessions":{"min":4,"max":13,"unit":"visits","qualifier":"Infusion-based schedule every 1-3 weeks until first imaging; oral agents need no infusion visits."},"stages":[{"code":"biomarker_confirmation","label":"Biomarker confirmation and baseline tests","after":{"min":0,"max":0,"unit":"days","qualifier":"Before first dose."}},{"code":"treatment_start","label":"First dose or infusion","after":{"min":0,"max":7,"unit":"days","qualifier":"Starts once testing is confirmed."}},{"code":"response_assessment","label":"First response imaging","after":{"min":56,"max":90,"unit":"days","qualifier":"After several cycles."}}],"qualifier":"Treatment continues until progression or intolerance; typical first-phase schedule shown."},"hospital_nights":{"value":{"min":0,"max":0,"unit":"nights","qualifier":"Typical oral or infusion-based cycles are given without overnight stay; inpatient stay is not usual for uncomplicated treatment."},"source":"parsed_details"},"treatment_conditions":["outpatient"],"rehabilitation_days":{"min":0,"max":3,"unit":"days","qualifier":"Ordinary activity resumes quickly; longer if infusion reactions or fatigue occur."},"fly_home_after_days":{"min":1,"max":3,"unit":"days","qualifier":"After first dose, oncology team usually wants early tolerance observed; depends on agent and infusion reactions."},"back_to_work_days":{"min":0,"max":3,"unit":"days","qualifier":"Most patients keep working; depends on agent side effects and infusion schedule."},"exercise_resume_weeks":{"min":0,"max":1,"unit":"weeks","qualifier":"Light activity usually continues; intensity limited by fatigue, rash, diarrhea or cardiac precautions."},"final_result_months":{"min":2,"max":6,"unit":"months","qualifier":"Response is judged by imaging after several cycles; depends on tumor type and agent."},"result_longevity":"Response lasts as long as the drug is effective, often months to several years. Acquired resistance eventually develops in many cancers.","main_risks":["Skin reactions such as rash and dryness","Diarrhea, nausea and other gastrointestinal effects","Liver enzyme elevation","Hypertension, cardiac effects or bleeding with certain agents","Infusion reactions with antibody-based agents","Blood count changes"],"complication_rate_pct":{"min":20,"max":50,"unit":"percent","qualifier":"Grade 3-4 adverse events during treatment; any-grade side effects are far more common, varying by agent."},"revision_rate_pct":{"status":"missing","reason":"not_collected"},"success":{"metric":"Objective tumor response rate at first imaging","value":60,"horizon":"2-3 months","source":{"status":"missing","reason":"not_collected"},"evidence_status":"limited"},"scars":"No incisions or scars; only minor puncture marks from IV cannulation.","pain":"Treatment itself is painless apart from IV cannulation. Side effects such as rash, mouth sores or joint aches are usually mild to moderate.","preparation":["Molecular target or biomarker confirmed by tissue or blood testing","Baseline blood tests and organ function assessment","Review of current medications and supplements with the oncology team","Baseline cardiac or other agent-specific assessment where required","Discussion of expected side effects and contraception where relevant"],"recovery_timeline":[{"phase":"Treatment day","description":"Oral dose started or infusion given with observation for reactions.","restrictions":["Report fever or breathing difficulty immediately","Follow agent-specific food and drug rules"]},{"phase":"First 2 weeks","description":"Early side effects such as rash, diarrhea or fatigue may appear and are managed with supportive care.","restrictions":["Avoid sun exposure","Avoid new supplements without approval"]},{"phase":"Ongoing cycles","description":"Treatment continues with periodic blood tests and imaging to assess response.","restrictions":["Contraception where relevant","Avoid grapefruit with some agents"]}],"follow_up_visits":[{"purpose":"assessment","requirement":"routine","after":{"min":7,"max":21,"unit":"days","qualifier":"Early tolerance check with blood tests and side-effect review."}},{"purpose":"result_review","requirement":"routine","after":{"min":56,"max":90,"unit":"days","qualifier":"First response imaging and blood markers; timing depends on agent and cancer type."}}],"sources":{"status":"missing","reason":"not_collected"},"clinic_checks":{"status":"ok","items":[{"id":"C1","text":"Check that your tumor has been tested for the drug's target. Why: the drug is chosen for a specific target found in the tumor","scope":"procedure","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet","host":"cancer.gov","quote":"Most of the time, your tumor will need to be tested to see if it contains targets for which there is a drug.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C2","text":"Check the qualifications of the medical team that will treat you","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Have you checked the qualifications of the medical team treating you?","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C3","text":"Make sure you are clear how your aftercare will be coordinated after treatment abroad","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Ensure you're clear about how your aftercare will be coordinated.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C4","text":"Check that the surgeon who consults with you is the same person who will carry out the procedure","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Check that the surgeon you consult with, will be the same person carrying out the procedure.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C5","text":"Expect two consultations with the treating surgeon before any surgery, which also gives you time to reconsider","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/conditions/cosmetic-procedures/cosmetic-surgery-abroad/","host":"nhs.uk","quote":"You should have 2 consultations with the surgeon treating you before any surgery.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"red_flags":{"status":"ok","items":[{"id":"F1","text":"Pressure to decide quickly, or cheap time-limited offers to book now","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Don’t be pressured into quick decisions either through forceful persuasion or cheap, time limited offers.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"F2","text":"The doctor you consult may not be the one who actually treats you","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Check that the surgeon you consult with, will be the same person carrying out the procedure.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"F3","text":"Adverts or information promising complete success for the treatment","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Any advert or information that guarantees complete success should raise concerns.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"warning_signs":{"status":"ok","items":[{"id":"W1","text":"Unusual bleeding or bruising during targeted therapy","urgency":"contact_clinic","general":false,"source":{"url":"https://www.cancer.gov/about-cancer/treatment/side-effects/bleeding-bruising","host":"cancer.gov","quote":"Some cancer treatments, such as chemotherapy and targeted therapy, can increase your risk of bleeding and bruising.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W2","text":"Diarrhea that lasts or becomes more severe","urgency":"contact_clinic","general":false,"source":{"url":"https://cancer.gov/about-cancer/treatment/side-effects/diarrhea","host":"cancer.gov","quote":"Ask the health care team about when you should call them if the diarrhea lasts or becomes more severe.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W3","text":"Fever higher than your care team expects","urgency":"contact_clinic","general":true,"source":{"url":"https://mdanderson.org/patients-family/diagnosis-treatment/emotional-physical-effects/targeted-therapy-side-effects.html","host":"mdanderson.org","quote":"A fever higher than what your care team told you to expect","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"take_home":{"status":"ok","items":[{"id":"T1","text":"Shows which follow-up tests are due and which doctors are responsible for care","document":"written aftercare plan","source":{"url":"https://www.cdc.gov/cancer/survivors/life-after-cancer/survivorship-care-plans.htm","host":"cdc.gov","quote":"Your plan should say when you need to get follow-up tests, and which doctors are responsible for your care.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":403}},{"id":"T2","text":"Gives the home doctor an up-to-date, clear picture of the treatment received","document":"end of treatment summary","source":{"url":"https://cht.nhs.uk/services/clinical-services/oncology/end-of-treatment-summary","host":"cht.nhs.uk","quote":"It also provides the GP with an up-to-date and clear understanding of the patient's treatment.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"T3","text":"Ask for copies of all prescriptions before you leave","document":"prescription copies","source":{"url":"https://travelhealthpro.org.uk/news/699/travelling-abroad-for-treatment","host":"travelhealthpro.org.uk","quote":"Remember to ask for copies of all your treatment records, including prescriptions, scans and x-rays before you leave.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1}},"parsed_details":{"procedure_type":"therapy","fields":{"anesthesia":["none"],"back_to_work_days":{"min":0,"max":3,"unit":"days","qualifier":"Most patients keep working; depends on agent side effects and infusion schedule."},"complication_rate_pct":{"min":20,"max":50,"unit":"percent","qualifier":"Grade 3-4 adverse events during treatment; any-grade side effects are far more common, varying by agent."},"contraindications":["Known severe hypersensitivity to the specific agent or its components","Pregnancy and breastfeeding for many agents (agent-specific)","Severe uncontrolled liver, heart or lung dysfunction (relative, agent-dependent)","Clinically significant drug interactions with the specific agent (relative, agent-specific)"],"days_in_clinic":{"min":0,"max":0,"unit":"nights","qualifier":"Typical oral or infusion-based cycles are given without overnight stay; inpatient stay is not usual for uncomplicated treatment."},"diagnostic_duration_minutes":null,"diagnostic_preparation":null,"diagnostic_referral_needed":null,"diagnostic_result_time_hours":null,"exercise_resume_weeks":{"min":0,"max":1,"unit":"weeks","qualifier":"Light activity usually continues; intensity limited by fatigue, rash, diarrhea or cardiac precautions."},"final_result_months":{"min":2,"max":6,"unit":"months","qualifier":"Response is judged by imaging after several cycles; depends on tumor type and agent."},"fly_home_after_days":{"min":1,"max":3,"unit":"days","qualifier":"After first dose, oncology team usually wants early tolerance observed; depends on agent and infusion reactions."},"follow_up_visits":[{"purpose":"assessment","after":{"min":7,"max":21,"unit":"days","qualifier":"Early tolerance check with blood tests and side-effect review."},"requirement":"routine"},{"purpose":"result_review","after":{"min":56,"max":90,"unit":"days","qualifier":"First response imaging and blood markers; timing depends on agent and cancer type."},"requirement":"routine"}],"indications":["Cancers with molecular targets: HER2, EGFR, ALK, BRAF, BCR-ABL","Hematologic malignancies and solid tumors with a matched targeted agent","Some non-cancer conditions with defined molecular targets"],"main_risks":["Skin reactions such as rash and dryness","Diarrhea, nausea and other gastrointestinal effects","Liver enzyme elevation","Hypertension, cardiac effects or bleeding with certain agents","Infusion reactions with antibody-based agents","Blood count changes"],"pain":"Treatment itself is painless apart from IV cannulation. Side effects such as rash, mouth sores or joint aches are usually mild to moderate.","preparation":["Molecular target or biomarker confirmed by tissue or blood testing","Baseline blood tests and organ function assessment","Review of current medications and supplements with the oncology team","Baseline cardiac or other agent-specific assessment where required","Discussion of expected side effects and contraception where relevant"],"recovery_timeline":[{"phase":"Treatment day","description":"Oral dose started or infusion given with observation for reactions.","restrictions":["Report fever or breathing difficulty immediately","Follow agent-specific food and drug rules"]},{"phase":"First 2 weeks","description":"Early side effects such as rash, diarrhea or fatigue may appear and are managed with supportive care.","restrictions":["Avoid sun exposure","Avoid new supplements without approval"]},{"phase":"Ongoing cycles","description":"Treatment continues with periodic blood tests and imaging to assess response.","restrictions":["Contraception where relevant","Avoid grapefruit with some agents"]}],"rehabilitation_days":{"min":0,"max":3,"unit":"days","qualifier":"Ordinary activity resumes quickly; longer if infusion reactions or fatigue occur."},"result_longevity":"Response lasts as long as the drug is effective, often months to several years. Acquired resistance eventually develops in many cancers.","revision_rate_pct":null,"scars":"No incisions or scars; only minor puncture marks from IV cannulation.","sessions_or_stages":{"sessions":{"min":4,"max":13,"unit":"visits","qualifier":"Infusion-based schedule every 1-3 weeks until first imaging; oral agents need no infusion visits."},"stages":[{"code":"biomarker_confirmation","label":"Biomarker confirmation and baseline tests","after":{"min":0,"max":0,"unit":"days","qualifier":"Before first dose."}},{"code":"treatment_start","label":"First dose or infusion","after":{"min":0,"max":7,"unit":"days","qualifier":"Starts once testing is confirmed."}},{"code":"response_assessment","label":"First response imaging","after":{"min":56,"max":90,"unit":"days","qualifier":"After several cycles."}}],"qualifier":"Treatment continues until progression or intolerance; typical first-phase schedule shown."},"success":{"metric":"Objective tumor response rate at first imaging","value":60,"unit":"percent","horizon":"2-3 months","population":"Adults with biomarker-matched advanced cancer receiving a matched targeted agent","evidence_status":"limited"},"techniques":[{"name":"Small-molecule inhibitors (oral, e.g. tyrosine kinase inhibitors)","suits_whom":"Patients whose tumor carries a matching targetable alteration","recovery":"No recovery period; usually taken continuously at home with periodic monitoring."},{"name":"Monoclonal antibodies (intravenous or subcutaneous)","suits_whom":"Patients with target-expressing tumors such as HER2-positive cancers","recovery":"Given at scheduled infusion visits; usually no recovery time beyond infusion-related effects."},{"name":"Antibody-drug conjugates","suits_whom":"Selected patients with target-expressing cancers and suitable prior treatment history","recovery":"Given at scheduled infusion visits with monitoring for agent-specific toxicity."}],"treatment_conditions":["outpatient"],"treatment_duration_hours":{"min":0.5,"max":3,"unit":"hours","qualifier":"Per infusion visit; first infusion is longest. Oral agents are taken at home."},"initial_assessment_documents":["Pathology report with tumor type and stage","Molecular or genomic testing report","Recent CT or PET-CT scans","Summary of previous cancer treatments","Recent blood test results","Oncologist's latest treatment notes (if available)"],"travel_trips":{"min":2,"max":3,"one_trip_possible":false,"qualifier":"Start visit with first dose and tolerance check, then response imaging at 2-3 months; routine monitoring at home."},"clinic_checks":{"status":"ok","items":[{"id":"C1","text":"Check that your tumor has been tested for the drug's target. Why: the drug is chosen for a specific target found in the tumor","scope":"procedure","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet","host":"cancer.gov","quote":"Most of the time, your tumor will need to be tested to see if it contains targets for which there is a drug.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C2","text":"Check the qualifications of the medical team that will treat you","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Have you checked the qualifications of the medical team treating you?","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C3","text":"Make sure you are clear how your aftercare will be coordinated after treatment abroad","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Ensure you're clear about how your aftercare will be coordinated.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C4","text":"Check that the surgeon who consults with you is the same person who will carry out the procedure","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Check that the surgeon you consult with, will be the same person carrying out the procedure.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C5","text":"Expect two consultations with the treating surgeon before any surgery, which also gives you time to reconsider","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/conditions/cosmetic-procedures/cosmetic-surgery-abroad/","host":"nhs.uk","quote":"You should have 2 consultations with the surgeon treating you before any surgery.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"red_flags":{"status":"ok","items":[{"id":"F1","text":"Pressure to decide quickly, or cheap time-limited offers to book now","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Don’t be pressured into quick decisions either through forceful persuasion or cheap, time limited offers.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"F2","text":"The doctor you consult may not be the one who actually treats you","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Check that the surgeon you consult with, will be the same person carrying out the procedure.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"F3","text":"Adverts or information promising complete success for the treatment","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Any advert or information that guarantees complete success should raise concerns.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"warning_signs":{"status":"ok","items":[{"id":"W1","text":"Unusual bleeding or bruising during targeted therapy","urgency":"contact_clinic","general":false,"source":{"url":"https://www.cancer.gov/about-cancer/treatment/side-effects/bleeding-bruising","host":"cancer.gov","quote":"Some cancer treatments, such as chemotherapy and targeted therapy, can increase your risk of bleeding and bruising.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W2","text":"Diarrhea that lasts or becomes more severe","urgency":"contact_clinic","general":false,"source":{"url":"https://cancer.gov/about-cancer/treatment/side-effects/diarrhea","host":"cancer.gov","quote":"Ask the health care team about when you should call them if the diarrhea lasts or becomes more severe.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"W3","text":"Fever higher than your care team expects","urgency":"contact_clinic","general":true,"source":{"url":"https://mdanderson.org/patients-family/diagnosis-treatment/emotional-physical-effects/targeted-therapy-side-effects.html","host":"mdanderson.org","quote":"A fever higher than what your care team told you to expect","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"take_home":{"status":"ok","items":[{"id":"T1","text":"Shows which follow-up tests are due and which doctors are responsible for care","document":"written aftercare plan","source":{"url":"https://www.cdc.gov/cancer/survivors/life-after-cancer/survivorship-care-plans.htm","host":"cdc.gov","quote":"Your plan should say when you need to get follow-up tests, and which doctors are responsible for your care.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":403}},{"id":"T2","text":"Gives the home doctor an up-to-date, clear picture of the treatment received","document":"end of treatment summary","source":{"url":"https://cht.nhs.uk/services/clinical-services/oncology/end-of-treatment-summary","host":"cht.nhs.uk","quote":"It also provides the GP with an up-to-date and clear understanding of the patient's treatment.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"T3","text":"Ask for copies of all prescriptions before you leave","document":"prescription copies","source":{"url":"https://travelhealthpro.org.uk/news/699/travelling-abroad-for-treatment","host":"travelhealthpro.org.uk","quote":"Remember to ask for copies of all your treatment records, including prescriptions, scans and x-rays before you leave.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"alternatives":{"status":"ok","items":[{"id":"A1","text":"You want a treatment that may slow or stop cancer growth","name":"Chemotherapy","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/chemotherapy","host":"cancer.gov","quote":"Chemotherapy can be used to cure cancer, lessen the chance it will return, or stop or slow its growth.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200},"operation_id":37},{"id":"A2","text":"You want treatment that helps your immune system fight the cancer","name":"Immunotherapy","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/immunotherapy","host":"cancer.gov","quote":"Immunotherapy is a type of cancer treatment that helps your immune system fight cancer.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200},"operation_id":283}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"technique_details":{"status":"ok","items":[{"id":"small-molecule-inhibitors","name":"Small-molecule inhibitors (oral, e.g. tyrosine kinase inhibitors)","how_it_works":{"text":"Small drugs enter cells and act on targets inside them","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet","host":"cancer.gov","quote":"Small-molecule drugs are small enough to enter cells easily, so they are used for targets that are inside cells.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"}},{"id":"monoclonal-antibodies","name":"Monoclonal antibodies (intravenous or subcutaneous)","how_it_works":{"text":"Antibodies attach to specific targets found on cancer cells","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet","host":"cancer.gov","quote":"These proteins are designed to attach to specific targets found on cancer cells.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"}},{"id":"antibody-drug-conjugates","name":"Antibody-drug conjugates","how_it_works":{"text":"Antibodies are linked to cell-killing substances that reach cancer cells","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet","host":"cancer.gov","quote":"Some monoclonal antibodies are combined with cell-killing substances such as toxins, chemotherapy drugs, or radiation.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1}}},"techniques":[{"id":"small-molecule-inhibitors","name":"Small-molecule inhibitors (oral, e.g. tyrosine kinase inhibitors)","how_it_works":{"id":"H1","text":"Small drugs enter cells and act on targets inside them","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet","host":"cancer.gov","quote":"Small-molecule drugs are small enough to enter cells easily, so they are used for targets that are inside cells.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"},"suits_whom":"Patients whose tumor carries a matching targetable alteration","price_from":{"status":"missing","reason":"not_collected"},"recovery":"No recovery period; usually taken continuously at home with periodic monitoring."},{"id":"monoclonal-antibodies","name":"Monoclonal antibodies (intravenous or subcutaneous)","how_it_works":{"id":"H1","text":"Antibodies attach to specific targets found on cancer cells","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet","host":"cancer.gov","quote":"These proteins are designed to attach to specific targets found on cancer cells.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"},"suits_whom":"Patients with target-expressing tumors such as HER2-positive cancers","price_from":{"status":"missing","reason":"not_collected"},"recovery":"Given at scheduled infusion visits; usually no recovery time beyond infusion-related effects."},{"id":"antibody-drug-conjugates","name":"Antibody-drug conjugates","how_it_works":{"id":"H1","text":"Antibodies are linked to cell-killing substances that reach cancer cells","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet","host":"cancer.gov","quote":"Some monoclonal antibodies are combined with cell-killing substances such as toxins, chemotherapy drugs, or radiation.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},"recovery_daily":{"status":"missing","reason":"no_official_source"},"suits_whom":"Selected patients with target-expressing cancers and suitable prior treatment history","price_from":{"status":"missing","reason":"not_collected"},"recovery":"Given at scheduled infusion visits with monitoring for agent-specific toxicity."}],"alternatives":{"status":"ok","items":[{"id":"A1","text":"You want a treatment that may slow or stop cancer growth","name":"Chemotherapy","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/chemotherapy","host":"cancer.gov","quote":"Chemotherapy can be used to cure cancer, lessen the chance it will return, or stop or slow its growth.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200},"operation_id":37},{"id":"A2","text":"You want treatment that helps your immune system fight the cancer","name":"Immunotherapy","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/immunotherapy","host":"cancer.gov","quote":"Immunotherapy is a type of cancer treatment that helps your immune system fight cancer.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200},"operation_id":283}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"diagnostic":{"status":"not_applicable"},"country":{"why":{"status":"missing","reason":"no_official_source","checked_at":"2026-11-11","next_check_at":"2027-02-09"},"travel":{"status":"ok","items":[{"id":"V1","item":"visa","audience":"uk","volatile":true,"text":"British citizens can visit Israel as tourists without a visa","source":{"url":"https://www.gov.uk/foreign-travel-advice/israel/entry-requirements","host":"gov.uk","quote":"You can visit Israel without a visa as a tourist.","tier":"official_travel","fetched_at":"2026-11-11","http_status":200}},{"id":"V2","item":"passport_validity","audience":"uk","volatile":true,"text":"To enter Israel, your passport must have an expiry date at least 90 days after the date you arrive","source":{"url":"https://www.gov.uk/foreign-travel-advice/israel/entry-requirements","host":"gov.uk","quote":"To enter Israel or Palestine, your passport must have an ‘expiry date’ at least 90 days after the date you arrive.","tier":"official_travel","fetched_at":"2026-11-11","http_status":200}},{"id":"V3","item":"arrival_form","audience":"uk","volatile":true,"text":"Visitors must get an Electronic Travel Authorisation (ETA) before arriving in Israel","source":{"url":"https://www.gov.uk/foreign-travel-advice/israel/entry-requirements","host":"gov.uk","quote":"As of 1 January 2025, to visit Israel you will need to get an Electronic Travel Authorisation (ETA) before you arrive.","tier":"official_travel","fetched_at":"2026-11-11","http_status":200}},{"id":"V4","item":"hospital_payment","audience":"all","volatile":false,"text":"Hospitals in Israel insist on payment and may take legal action to stop you leaving until bills are paid","source":{"url":"https://www.gov.uk/foreign-travel-advice/israel/health","host":"gov.uk","quote":"Hospitals will insist on payment and may take legal action to stop you leaving until bills are paid.","tier":"official_travel","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-11","next_check_at":"2026-12-11","version":1},"other_countries_with_page":["austria","azerbaijan","china","egypt","germany","india","italy","latvia","malaysia","poland","republic-of-korea","spain","switzerland","thailand","turkey","ukraine","united-states"]},"often_combined_with":{"status":"missing","reason":"not_collected"},"reviews":{"avg_rating":4.48,"count":200,"scope":"clinic","rating_scale":5,"pros":{"status":"missing","reason":"not_collected"},"cons":{"status":"missing","reason":"not_collected"}},"current":{"seo_text":"<p>Targeted therapy in Israel typically ranges from _op_284_price_from_ to _op_284_price_to_ depending on the protocol and cancer type. Patients save around _price_percent_discount_% compared to the US, where this procedure costs _price_compare_US_average_ on average. Major medical hubs include Tel Aviv, Jerusalem, and Haifa. Costs usually include the medication, oncologist consultations, genomic testing, and administration in specialized oncology day-care units.</p>\n\n<ul>\n<li><strong>Lutetium-177 therapy:</strong> _op_830_price_from_ to _op_830_price_to_ for advanced prostate or neuroendocrine tumors.</li>\n<li><strong>Monoclonal antibodies:</strong> Usually adds a premium for specific breast or lung cancer protocols.</li>\n<li><strong>Hospital tier:</strong> Private facilities in Tel Aviv often cost 10-20% more than public centers.</li>\n<li><strong>Small-molecule drugs:</strong> Pricing varies by monthly cycle and specific pharmaceutical manufacturer used.</li>\n</ul>\n\n<p><strong>Bookimed Expert Insight:</strong> Israeli oncology centers offer significant value by providing access to early-phase clinical trials. For instance, Sourasky Medical Center (Ichilov) implements the PSIFAS National Genomic Medicine Initiative. Patients can find breast cancer packages starting around $2,050 including KADCYLA protocols. Choosing JCI-accredited clinics like Assuta or Hadassah ensures international safety standards while maintaining lower costs than US private care.</p>","faq":[{"q":"What is Targeted Therapy and How Does It Work in Israel?","a":"<p>Targeted therapy in Israel uses molecular profiling and genetic testing to identify specific proteins or genes fueling cancer growth. Drugs like monoclonal antibodies or small-molecule inhibitors then block these signals, destroying malignant cells while preserving healthy tissue in JCI-accredited facilities.</p> <ul> <li><strong>Molecular profiling:</strong> Clinics use Foundation One CDx to map genetic mutations for precise drug selection.</li> <li><strong>Advanced delivery:</strong> Therapies include intravenous monoclonal antibodies and oral small-molecule inhibitors for systemic treatment.</li> <li><strong>Therapeutic range:</strong> Specialists treat HER2+ breast cancer and gastrointestinal tumors with 90% success rates.</li> <li><strong>Specialized techniques:</strong> Israeli centers offer niche options like CAR T-cell therapy and Lutetium-177 peptide receptor radionuclides.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Israeli oncology centers often integrate genomic profiling with specialized Tumor Boards to personalize treatment. Data shows centers like Sourasky Medical Center manage 40,000 cancer patients annually, often providing access to proprietary CAR-T therapies for multiple myeloma. This high volume allows doctors like Dr. Ofer Merimsky to refine drug combinations that are often restricted to clinical trials elsewhere.</p> <p><strong>Patient Consensus:</strong> Patients value how these treatments target cell weaknesses while sparing normal tissue. Many note that advanced options like TIL therapy are physically demanding but offer hope when traditional methods fail.</p>"},{"q":"What are the Side Effects of Targeted Therapy?","a":"<p>Targeted therapy causes side effects when proteins found on cancer cells are also present on healthy tissue. Common reactions involve the skin, digestive system, and liver. Most symptoms subside within 30 days of treatment completion, though specific agents require ongoing heart and eye monitoring.</p> <ul> <li><strong>Skin reactions:</strong> Acne-like rashes on the face and scalp often signal the medicine is working.</li> <li><strong>Gastrointestinal distress:</strong> Severe diarrhea is common with HER2 inhibitors, requiring immediate hydration and medical management.</li> <li><strong>Physical exhaustion:</strong> Fatigue is a universal symptom reported across lung, breast, and melanoma regimens.</li> <li><strong>Organ function:</strong> Doctors monitor liver enzymes and thyroid levels via regular blood tests and check-ups.</li> <li><strong>Sun sensitivity:</strong> Many targeted agents increase UV sensitivity, making rigorous sun protection a medical necessity.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> While standard targeted therapy in Israel ranges from _op_284_price_from_ to _op_284_price_to_, the specific side effect profile often dictates the facility choice. Centers like Sourasky Medical Center (Ichilov) treat over 40,000 cancer patients annually. This high volume means their teams are exceptionally experienced in managing complex infusion reactions and managing strict oral dosing schedules to reduce nausea.</p> <p><strong>Patient Consensus:</strong> Patients often report persistent chills and shaking during certain therapies. They emphasize that adhering to exact fasting windows before taking oral medication is critical for minimizing severe nausea.</p>"},{"q":"What Types of Cancer Can Be Treated with Targeted Therapy in Israel?","a":"<p>Israeli oncology centers use targeted therapy to treat breast, lung, prostate, and gastrointestinal cancers, alongside advanced blood malignancies. Precision oncology programs at facilities like Sourasky Medical Center utilize genomic profiling to identify molecular markers, enabling the use of checkpoint inhibitors, CAR T-cell therapy, and peptide receptor radionuclide therapy.</p> <ul> <li><strong>Solid tumors:</strong> Targeted agents treat HER2-positive breast cancer, NSCLC, and metastatic sarcomas.</li> <li><strong>Hematologic malignancies:</strong> CAR T-cell therapy treats refractory leukemia, lymphoma, and multiple myeloma.</li> <li><strong>Advanced modalities:</strong> Options include Lutetium-177 for prostate cancer and SIRT for liver tumors.</li> <li><strong>Molecular diagnostics:</strong> Clinics use Foundation One CDx to match patients with specific biological drugs.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> While many countries import CAR T-cell therapies from the US, Israeli centers like Sheba Medical Center utilize homegrown protocols. This internal development often increases treatment accessibility for complex blood cancers. Patients should ask about clinical trials for TIL therapy if traditional immunotherapy fails for advanced melanoma.</p> <p><strong>Patient Consensus:</strong> Success in Israel often depends on distinguishing between standard targeted drugs and experimental breakthroughs like Alpha DaRT for head and neck cancers. Many emphasize verifying if a treatment is a standard protocol or part of a clinical trial phase.</p>"},{"q":"Is Targeted Therapy a Better Option than Chemotherapy?","a":"<p>Targeted therapy is better for patients with tumors showing specific genetic markers, as it selectively attacks cancer cells while sparing healthy tissue. Chemotherapy remains superior for broad application against rapidly dividing cells in cancers lacking identifiable biomarkers like EGFR, ALK, or HER2.</p> <ul> <li><strong>Treatment mechanism:</strong> Targeted agents block specific molecules; chemotherapy destroys all fast-growing cells.</li> <li><strong>Selection criteria:</strong> Mandatory Foundation One CDx genetic testing identifies actionable mutations for therapy.</li> <li><strong>Side effects:</strong> Targeted treatments typically cause fewer systemic reactions, enhancing daily quality of life.</li> <li><strong>Clinical application:</strong> Doctors often combine both methods to maximize tumor reduction and long-term control.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Israeli oncology centers like Sourasky (Ichilov) leverage extensive clinical research to achieve 90% success rates. Specialists such as Dr. Ari Raphael utilize precise genomic-guided protocols that may double survival rates in matched pancreatic cancer cases compared to standard chemotherapy alone. This precision-first model depends on liquid biopsies to monitor tumor evolution and prevent treatment resistance.</p> <p><strong>Patient Consensus:</strong> Patients value how targeted therapy preserves their energy and appearance, though they emphasize that biomarker testing is the essential first step. Many found that personalized protocols provided a practical alternative when traditional chemotherapy was no longer effective.</p>"},{"q":"How Long Does Targeted Therapy Last?","a":"<p>Targeted therapy in Israel typically lasts between 9 and 18 months on average, though duration varies by cancer stage and medication response. While some patients maintain disease control for 4 or more years, treatment often continues as long as the therapy remains effective.</p> <ul> <li><strong>Success rates:</strong> Specialists at JCI-accredited facilities report oncology success rates reaching 90% in targeted cases.</li> <li><strong>Fixed protocols:</strong> Certain treatments, including Nerlynx or KADCYLA for breast cancer, follow specific 1-year protocols.</li> <li><strong>Resistance patterns:</strong> Approximately 80% of patients develop drug resistance, often occurring within 6 to 9 months.</li> <li><strong>Average costs:</strong> Targeted therapy in Israel ranges from _op_284_price_from_ to _op_284_price_to_ per cycle.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Israeli oncology centers like Sourasky (Ichilov) leverage Oxford-trained specialists and Joint Commission International (JCI) standards to optimize therapy duration. Data shows that early tumor shrinkage in the first few cycles is a strong predictor of long-term survival. With costs averaging _price_percent_discount_% lower than in the US, patients often access advanced genomic profiling like Foundation One CDx to identify resistance markers earlier.</p> <p><strong>Patient Consensus:</strong> Many patients emphasize monitoring early response metrics and testing for specific resistance markers like MET amplification. They often highlight the importance of navigating the emotional shift if resistance develops after the initial months of successful control.</p>"},{"q":"Why is Israel a top destination for neurosurgery?","a":"<p>Israel is a premier neurosurgery hub due to its fusion of high-density medical innovation and elite surgical expertise. Top facilities like Sheba Medical Center integrate AI-guided navigation and real-time intraoperative MRI. Specialized centers report 98% success rates for complex procedures including awake craniotomy and movement disorder treatments.</p> <ul> <li><strong>Advanced technology:</strong> Clinics utilize MRI-guided focused ultrasound (MRgFUS) and robotic systems for incisions.</li> <li><strong>Surgical expertise:</strong> Surgeons like Dr. Zvi Ram lead international associations with 25+ years experience.</li> <li><strong>Rapid access:</strong> International patients typically schedule complex brain or spine surgeries within 2–4 weeks.</li> <li><strong>Accredited care:</strong> Major centers like Sourasky (Ichilov) and Assuta hold JCI accreditation for safety.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Data shows a clear divide between public and private options in Israel. Private centers like Assuta Medical Center perform over 92,000 operations annually and allow patients to select their specific lead surgeon. This is a vital advantage for complex cases where a specific expert like Dr. Eli Ashkenazi is preferred for his 1,000+ spine surgery record.</p> <p><strong>Patient Consensus:</strong> Patients emphasize bringing original imaging on a USB for local review to streamline the surgical plan. They also note that private packages often include hotel coordination and airport transfers, making the logistics much smoother.</p>"},{"q":"What types of neurosurgical conditions are treated in Israel?","a":"<p>Israeli neurosurgeons treat a full spectrum of conditions ranging from brain and spinal tumors to complex functional disorders. Specialized centers utilize advanced technologies like Gamma Knife, deep brain stimulation, and intraoperative MRI to manage epilepsy, Parkinson disease, and cerebrovascular pathologies with high precision.</p> <ul> <li><strong>Oncological conditions:</strong> Treatment for gliomas, meningiomas, and pituitary tumors using skull base resection.</li> <li><strong>Functional disorders:</strong> Management of Parkinson disease and essential tremors via deep brain stimulation.</li> <li><strong>Spinal pathologies:</strong> Correction of scoliosis, herniated discs, and spinal tumors using robotic systems.</li> <li><strong>Cerebrovascular care:</strong> Surgical repair of brain aneurysms and arteriovenous malformations with endovascular interventions.</li> <li><strong>Pediatric neurosurgery:</strong> Specialized care for hydrocephalus and congenital anomalies at dedicated children centers.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Israeli hospitals often combine specialties to handle complex cases. At Sourasky Medical Center, neurosurgeons like Dr. Zvi Lidar bridge neurosurgery and orthopedics for spinal care. This multidisciplinary approach allows clinics to perform 34,000+ operations annually. Choosing a facility with this crossover expertise often leads to more comprehensive treatment plans for degenerative diseases.</p> <p><strong>Patient Consensus:</strong> Patients value the ability to access specialized treatments like fluorescence-guided surgery for tumors which are often unavailable elsewhere. Many note that the staff is fluent in English and provides clear communication through teleconsultations before traveling.</p>"},{"q":"Which hospitals in Israel are best known for neurosurgery?","a":"<p>Israel is home to world-renowned neurosurgery centers like Sourasky Medical Center, Sheba Medical Center, and Hadassah Medical Center. These facilities are globally ranked for treating complex brain tumors, spinal disorders, and movement diseases. They utilize advanced technologies like Gamma Knife, robotic systems, and intra-operative MRI.</p> <ul> <li><strong>Sourasky (Ichilov):</strong> Performs 2,500+ neurosurgical operations yearly with a 98% success rate in Tel Aviv.</li> <li><strong>Sheba Medical Center:</strong> Ranked among the world's top 10 hospitals. It treats 1.9 million patients annually.</li> <li><strong>Hadassah Medical Center:</strong> A Nobel Peace Prize nominee. It leads in pediatric neurosurgery and gene-based therapies.</li> <li><strong>Assuta Medical Center:</strong> Israel's largest private facility. It specializes in minimally invasive spine and brain surgeries.</li> <li><strong>Schneider Children's:</strong> The primary center for pediatric neurosurgery. It treats 275,000 children every year.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Our data shows that while most patients focus on Tel Aviv, Rambam Medical Center in Haifa offers unique expertise in neuro-trauma. It operates a specialized neuro-ICU and serves nearly 1 million patients annually. This makes it an essential choice for complex post-trauma brain surgeries that requires intensive recovery support.</p> <p><strong>Patient Consensus:</strong> Patients note it is important to start consultations early. They often highlight that the precision and follow-up care for complex brain tumors exceeded their expectations. One patient emphasized how quickly they could connect with top professors for second opinions during critical neurosurgical cases.</p>"},{"q":"Who are Israel’s leading neurosurgeons?","a":"<p>Israel's leading neurosurgeons include Prof. Zvi Ram, Prof. Shlomi Constantini, and Prof. Itzhak Fried at Sourasky Medical Center. These specialists hold leadership roles in the European Association of Neurosurgical Societies (EANS) and the World Society for Stereotactic and Functional Neurosurgery (WSSFN). They utilize advanced intraoperative mapping and robotic systems.</p> <ul> <li><strong>Prof. Zvi Ram:</strong> Expert in minimally invasive brain tumor surgery and gene-based oncology therapies.</li> <li><strong>Prof. Shlomi Constantini:</strong> Specializes in complex pediatric neuro-endoscopy and brain tumor microsurgery.</li> <li><strong>Prof. Itzhak Fried:</strong> Authority on epilepsy surgery, functional brain mapping, and deep brain stimulation.</li> <li><strong>Dr. Eli Ashkenazi:</strong> Leading spine surgeon at Assuta, specializing in the innovative TOPS system.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Data from Sourasky and Sheba indicates a strong correlation between high surgical volumes and patient safety. For example, Sourasky performs 34,000+ operations annually with a 90% oncology success rate. Patients seeking complex tumor removals should prioritize centers like these where surgeons perform hundreds of specific cases each year.</p> <p><strong>Patient Consensus:</strong> Patients emphasize the importance of finding a surgeon who specializes specifically in your condition rather than a generalist. Many note that high-volume centers provide better access to English-speaking staff and coordinated care for international visitors.</p>"},{"q":"What are the admission requirements for international neurosurgery patients?","a":"<p>International neurosurgery patients in Israel must provide comprehensive medical records including recent MRI or CT scans translated into English. Admission requires a clinical review by specialists to confirm treatment feasibility. Hospitals often mandate full advance payment or a significant deposit before confirming surgery dates or issuing visa support letters.</p> <ul> <li><strong>Medical documentation:</strong> Submit detailed English-translated reports and imaging for clinical review within 48 hours.</li> <li><strong>Financial clearance:</strong> Provide proof of funds for approximately _price_from_ to _price_to_ for treatment.</li> <li><strong>Visa support:</strong> Clinics like Sourasky Medical Center (Ichilov) issue official letters for medical B-2 visas.</li> <li><strong>Consultation phase:</strong> Initial assessment often occurs via online consultation with surgeons like Dr. Strauss Ido.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Data shows that top Israeli facilities like Sheba Medical Center and Hadassah Medical Center handle massive patient volumes, exceeding 1,000,000 people annually. This high demand means clinics prioritize complex or rare cases over routine procedures. Patients with unique or high-risk conditions often receive faster admission approval than those seeking standard treatments available elsewhere.</p> <p><strong>Patient Consensus:</strong> Patients note that having all imaging results ready in English is essential for quick scheduling. Many emphasize that while the medical care is excellent, coordinating around Shabbat closures is necessary to avoid unexpected diagnostic delays.</p>"},{"q":"How long will I need to stay in Israel for neurosurgery and follow-up?","a":"<p>A standard stay for neurosurgery in Israel ranges from 10 to 14 days for uncomplicated cases. Patients undergoing complex procedures like brain tumor removal or deep brain stimulation often require 4 to 6 weeks. This timeline covers pre-operative diagnostics, the surgical procedure, and essential post-operative monitoring.</p> <ul> <li><strong>Hospitalization duration:</strong> Minimally invasive procedures require 1–3 days. Regular craniotomies average 3–10 days.</li> <li><strong>Local recovery:</strong> Stay in Israel for 7–14 days post-discharge for mandatory follow-up checks.</li> <li><strong>Flight safety:</strong> Surgeons recommend waiting 4–6 weeks before flying to stabilize internal head pressure.</li> <li><strong>Follow-up schedule:</strong> In-person clinical reviews typically occur at days 3, 7, and 14 post-surgery.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Data from Sourasky Medical Center shows they treat over 400,000 patients annually with high success rates. Clinics with such high volumes, like Hadassah or Assuta, often have streamlined discharge protocols. This helps international patients transition to hotel-based recovery faster while maintaining access to top specialists.</p> <p><strong>Patient Consensus:</strong> Patients note it is vital not to rush home too early. Some travelers extended their stay to 3 weeks due to swelling or to ensure they received final surgeon clearance before flying.</p>"},{"q":"What advanced technologies make Israeli neurosurgery minimally invasive?","a":"<p>Israeli neurosurgery uses robotic guidance, real-time 3D imaging, and incisionless technologies to minimize physical trauma. Systems like Mazor Robotics provide sub-millimeter precision for spine implants. MRI-guided focused ultrasound (MRgFUS) treats tremors without incisions. These advanced tools ensure high accuracy and reduce recovery times.</p> <ul> <li><strong>Robotic systems:</strong> Mazor and ROSA robotics enable precise instrument placement through tiny incisions.</li> <li><strong>Incisionless ultrasound:</strong> MRgFUS uses high-intensity sound waves to treat brain tissue without anesthesia.</li> <li><strong>Digital navigation:</strong> Intraoperative MRI and 3D mapping allow surgeons to verify results in real-time.</li> <li><strong>Advanced endoscopy:</strong> Transnasal and trans-orbital approaches remove tumors without traditional skull-opening craniotomies.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Israeli clinics like Sourasky or Hadassah integrate proprietary Israeli-born technologies like Surgical Theater before they hit global markets. Our data shows these centers often use VR flight-through models for pre-surgical planning. This allows surgeons to rehearse complex cases, which is a key factor in their 90% success rates.</p> <p><strong>Patient Consensus:</strong> Patients note that technologies like the Gamma Knife allowed them to return home in days rather than weeks. Many move from traditional 10cm incisions to cuts under 2cm when using robotic-assisted systems.</p>"},{"q":"Why is Israel considered a top destination for neurosurgery?","a":"<p>Israel is a global leader in neurosurgery due to its integration of proprietary medical innovations and internationally trained specialists. High-capacity centers like Sourasky Medical Center (Ichilov) perform over 34,000 annual surgeries. Patients access advanced techniques like awake craniotomy and MR-guided focused ultrasound.</p> <ul> <li><strong>Advanced technology:</strong> Facilities use CyberKnife, Gamma Knife, and robotic systems for precision.</li> <li><strong>Expert credentials:</strong> Specialists like Dr. Zvi Ram hold leadership roles in European neurosurgical societies.</li> <li><strong>Global training:</strong> Most senior neurosurgeons completed fellowships at premier United States and European institutions.</li> <li><strong>Specialized departments:</strong> Centers feature niche units for pediatric neurosurgery, skull base, and functional disorders.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Israeli neurosurgery stands out because of the high concentration of dually certified experts. Many top surgeons, such as Dr. Zvi Lidar, are certified to practice in both Israel and the USA. This ensures that patients receive American-standard surgical care while staying in Tel Aviv or Jerusalem. Our data shows that private centers like Assuta offer significantly faster access to these specific specialists compared to the public system.</p> <p><strong>Patient Consensus:</strong> Patients note it is important to confirm a surgeon's specific volume of cases for your exact condition. They also value the ability to get expert second opinions quickly through online consultations with world-renowned professors.</p>"},{"q":"Which hospitals are ranked among the best for neurosurgery in Israel?","a":"<p>Sheba Medical Center and Sourasky Medical Center (Ichilov) are among the best neurosurgery hospitals in Israel. These JCI-accredited facilities perform thousands of operations annually. They utilize advanced technologies like CyberKnife and intraoperative MRI to treat complex brain tumors and cerebrovascular lesions.</p> <ul> <li><strong>Sheba Medical Center:</strong> Ranked among the top 10 world hospitals by Newsweek magazine.</li> <li><strong>Sourasky (Ichilov):</strong> Reports a 98% success rate and performs 2,500+ neurosurgical operations annually.</li> <li><strong>Hadassah Medical Center:</strong> Known for pioneering endoscopic techniques and integrated advanced research programs.</li> <li><strong>Assuta Medical Center:</strong> Israel largest private facility specializing in minimally invasive spine procedures.</li> <li><strong>Rambam Medical Center:</strong> Employs Nobel Prize laureates and serves as a major referral center.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Our data shows that top Israeli centers like Sourasky and Hadassah perform over 40,000 total operations yearly. This high volume allows surgeons to maintain a 90% success rate even in complex oncology cases. Patients seeking robotic spine surgery or deep brain stimulation should focus on these high-capacity municipal centers for the most experienced teams.</p> <p><strong>Patient Consensus:</strong> Patients appreciate that some hospitals quickly coordinate consultations even during regional strikes. Families of pediatric patients especially value surgeons trained at prestigious international institutions.</p>"},{"q":"Who are the leading neurosurgeons in Israel?","a":"<p>Israel's leading neurosurgeons include Professor Zvi Ram, Professor Shlomi Constantini, and Professor Itzhak Fried at Sourasky Medical Center. These experts specialize in awake craniotomy, pediatric brain tumors, and functional mapping. Most hold JCI accreditation and international fellowships from institutions like Johns Hopkins and Yale.</p> <ul> <li><strong>Brain tumors:</strong> Professor Zvi Ram specializes in image-guided microsurgery and complex brain mapping techniques.</li> <li><strong>Pediatric expertise:</strong> Professor Shlomi Constantini leads pediatric neurosurgery, focusing on endoscopic treatments and malformations.</li> <li><strong>Functional surgery:</strong> Professor Itzhak Fried is a global authority on epilepsy and deep brain stimulation.</li> <li><strong>Spine specialists:</strong> Dr. Zvi Lidar and Dr. Eli Ashkenazi focus on minimally invasive spinal oncology.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Data shows that top-tier Israeli neurosurgeons, such as those at Sourasky Medical Center, often hold dual board certifications in Israel and the US. This unique crossover ensures patients receive American-standard protocols. These specialists typically manage over 34,000 annual operations, providing high-volume clinical experience that smaller private clinics cannot match.</p> <p><strong>Patient Consensus:</strong> Patients note that highly qualified doctors like Professor Shlomo Constantini provide satisfactory answers quickly. People emphasize that outcomes often depend on the hospital’s integrated resources rather than just a doctor's prestige.</p>"},{"q":"What neurosurgical conditions and sub-specialties are treated in Israel?","a":"<p>Israel is a global leader in neurosurgery, treating complex brain and spinal conditions using robotic-assisted and minimally invasive techniques. Highly specialized units at JCI-accredited centers like Sourasky Medical Center (Ichilov) and Hadassah Medical Center focus on neuro-oncology, pediatric neurosurgery, and functional procedures.</p> <ul> <li><strong>Neuro-oncology:</strong> Treating glioblastoma, meningioma, and skull base tumors with 90% success rates.</li> <li><strong>Functional neurosurgery:</strong> Performing deep brain stimulation (DBS) for Parkinson’s and drug-resistant epilepsy.</li> <li><strong>Pediatric specialty:</strong> Specialized care for congenital defects and childhood tumors at Schneider Children’s.</li> <li><strong>Spine surgery:</strong> Utilizing Mazor X robotic systems for scoliosis and herniated disc correction.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Israeli neurosurgical departments often function as rapid-response hubs for international patients. Data shows that large centers like Sourasky, which serves 1,800,000 patients annually, can organize expert video consultations in a very short time. This speed is critical for neuro-oncology cases where starting treatment a few days earlier significantly impacts outcomes.</p> <p><strong>Patient Consensus:</strong> Patients note that Israeli teams often accept high-risk cases that other hospitals decline. They emphasize the importance of using local coordinators to manage travel logistics or potential local disruptions during their two-week stay.</p>"},{"q":"What documentation do international patients need before traveling to Israel for neurosurgery?","a":"<p>International patients traveling to Israel for neurosurgery require a valid passport, an entry permit or medical visa, and a formal hospital invitation. You must provide recent MRI or CT scans in DICOM format and detailed medical summaries. Proof of private health insurance and financial stability are also mandatory for border entry.</p> <ul> <li><strong>Travel authorization:</strong> Most visa-exempt travelers now need an approved ETA-IL before departure.</li> <li><strong>Hospital invitation:</strong> A signed letter from facilities like Sourasky Medical Center is required.</li> <li><strong>Medical records:</strong> Provide updated summaries of diagnoses, medications, and previous neurological treatments.</li> <li><strong>Imaging files:</strong> Digital copies of scans are essential for planning complex brain surgeries.</li> <li><strong>Legal consent:</strong> Notarized power of attorney is required for patients under 18 years old.</li> </ul> <p><strong>Bookimed Expert Insight:</strong> Our data shows that top neurosurgeons at Hadassah Medical Center and Sourasky often request records 4–6 weeks before arrival. Submitting these early prevents appointment shifts. High-volume centers with over 30,000 annual operations have dedicated portals for secure DICOM file uploads. Using these ensures your surgeon reviews high-quality images before you land in Tel Aviv.</p> <p><strong>Patient Consensus:</strong> Patients emphasize bringing physical copies and digital backups of all scans on a USB drive. They also note that private insurance needs pre-authorization specifically for neurosurgery to avoid payment delays at the clinic.</p>"}],"h2":[{"text":"How Much Does Targeted therapy Cost in Israel?","kind":"content"},{"text":"Your Benefits and Guarantees with Bookimed","kind":"content"},{"text":"Your personal Bookimed medical coordinator","kind":"content"},{"text":"Discover the Best Targeted therapy Clinics in Israel: 5 Verified Options and Prices","kind":"content"},{"text":"Targeted therapy Overview in Israel","kind":"content"},{"text":"Our Trusted Doctors","kind":"ui"},{"text":"Video Stories from Bookimed Patients","kind":"ui"},{"text":"Reviews about Bookimed: Discover Patients' Insights","kind":"ui"},{"text":"Related Articles","kind":"ui"},{"text":"Share this content","kind":"ui"},{"text":"Our Targeted therapy Techniques: What Suits You Best?","kind":"content"},{"text":"FAQ about Targeted therapy in Israel","kind":"content"},{"text":"Get a free consultation","kind":"ui"}]},"placeholders":{"price_from":"{{price_from}}","clinics_count":"{{clinics_count}}","cities_count":"{{cities_count}}","savings_pct":"{{savings_pct}}","data_date":"{{data_date}}"},"legal":{"restricted_markets":{"status":"missing","reason":"not_collected"}},"conflicts":[]}