![\"car](\"https://s3.eu-central-1.amazonaws.com/bookimed/_images_without_dir/66f1f2d78f71f.jpeg\")
Samsung Medical Center's Comprehensive Cancer Center provides CAR T-cell therapy using state-of-the-art equipment, including the Da Vinci surgical system. The center holds a special status as a \"Hospital of presidential standards\" and has received numerous awards for service quality. Dr. Keun Chil Park, a hematologist-oncologist with membership in ASCO, AACR, and ESMO, specializes in treating hematologic cancers.
Samsung Medical Center is a multidisciplinary hospital in Seoul with “hospital of presidential standards” status. Its top specialties are oncology, cardiology, vascular care, stroke, and organ transplantation. The hospital holds a partnership with the Mayo Clinic and earned Newsweek’s World’s Best Hospitals recognition.
Dr. Keun Chil Park leads the Division of Hematology-Oncology at Samsung Medical Center in Seoul. He specializes in treating lung, esophageal, and head and neck cancers. Dr. Park earned his medical degree from Seoul National University College of Medicine.
Samsung Medical Center is a multidisciplinary hospital in Seoul with “hospital of presidential standards” status. Its top specialties are oncology, cardiology, vascular care, stroke, and organ transplantation. The hospital holds a partnership with the Mayo Clinic and earned Newsweek’s World’s Best Hospitals recognition.
Why consider the Republic of Korea for CAR T-cell therapy?
\nAccess advanced CAR T-cell therapy solutions in trusted clinics [from-cost].
"},"txt_price":{"text":"CAR T-cell therapy in the Republic of Korea typically costs from _op_800_price_from_ to _op_800_price_to_. The total price depends on the specific drug used, hospital stay duration, and side-effect monitoring. In the United States, patients pay _price_compare_US_average_ on average for this treatment. South Korea offers savings of approximately _price_percent_discount_%. Costs generally cover cell collection, genetic engineering, and the infusion process.
\n\nBookimed Expert Insight: Choosing a high-volume center like Samsung Medical Center provides access to presidential-standard care. This facility serves over 2,000,000 patients annually and holds KOIHA accreditation. The hospital integrates Da Vinci systems and Novalis technology within its Comprehensive Cancer Center. International patients benefit from standardized protocols that match US quality at a significantly lower price point. For those without local insurance, Seoul remains the most cost-effective hub for Kymriah therapy.
"}},"texts":{"txt_procedure_3_clinics":{"text":"CAR T-cell therapy, or chimeric antigen receptor T-cell therapy, is an immunotherapy that uses genetically altered T cells to target and destroy cancer cells. This treatment is FDA-approved to treat several types of blood cancer, including acute lymphoblastic leukemia and diffuse large B-cell lymphoma.
\n\nCAR T-cell infusion combines three types of therapy:
\n\nCell therapy;
\n\tImmunotherapy;
\n\tGene therapy.
\n\tThe leukapheresis process, where white blood cells are harvested, is a critical step in therapy preparation.
\n\nThe studies show 60% of patients with B-cell lymphoma go into remission for at least 5 years. That’s why CAR T cell therapy is a “living drug” that has a long-term effect on destroying cancer cells.
\n\n
Source - National Cancer Institute
\n\nThe process begins with the collection of the patient’s T cells, a type of white blood cell that plays a crucial role in the immune response. Once the T cells are modified, they are expanded in number and reinfused into the patient’s bloodstream.
\n\nThe CAR allows these engineered T cells to identify and attach to cancer cells, marking them for destruction. This targeted approach ensures that the immune system can effectively attack cancer cells while minimizing damage to healthy cells.
\n\nCAR T cell therapies work by:
\n\nIdentifying and targeting specific cancer cells;
\n\tActivating the immune system to attack cancer cells;
\n\tEnhancing the body’s natural ability to fight cancer;
\n\tProviding a personalized treatment approach.
\n\tCAR T-cell therapy is not a one-size-fits-all treatment. It's typically considered for patients with specific types of cancer, including:
\n\nRelapsed or refractory Acute Lymphoblastic Leukemia (ALL). The patients whose leukemia has returned after initial treatment or hasn't responded to existing therapies.
\n\tRelapsed or refractory Diffuse Large B-cell Lymphoma (DLBCL). The patients with a specific type of aggressive lymphoma that has recurred or failed to respond to other treatments.
\n\tMultiple Myeloma. CAR T-cell therapy for multiple myeloma shows great results in destroying damaged bone marrow cells.
\n\tFollicular Lymphoma. The patients with affected lymph nodes develop small, round nodules called follicles.
\n\tRefractory mantle cell lymphoma. The patients with a subtype of B-cell non-Hodgkin lymphoma who suffer from lymph node enlargement and don't respond to traditional chemotherapy.
\n\tOther types of blood cancers. Research is ongoing to explore CAR T-cell therapy's effectiveness in treating other blood cancers and potentially some solid tumors.
\n\tHere's the list of standpoints that make a patient more or less suitable for undergoing CAR T-cell treatment:
\n\nAge and overall health. Younger patients with a more robust immune system are better candidates.
\n\tSpecific cancer type. T-cell therapy is most effective for certain cancer types (leukemia and lymphoma).
\n\tPrior treatments. Patients who haven't responded well to other treatments may be suitable candidates.
\n\tWhile CAR T-cell therapy offers promising results, there are potential safety concerns, including:
\n\nCytokine Release Syndrome (CRS) is a common side effect (42-100% of patients), which includes fever, chills, fatigue, and difficulty breathing. It usually occurs within a few days of receiving the CAR T-cells and can be managed with medication (antipyretics or corticosteroids for advanced cases).
\n\tImmune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) is a less common (3-64% occurrence rate) but more serious side effect affecting the nervous system. It may cause confusion, tremors, headaches, and difficulty speaking.
\n\tTumor lysis syndrome (TLS) occurs when large numbers of cancer cells are rapidly destroyed, leading to electrolyte imbalances and kidney problems.
\n\tRisk of infection. Due to the suppression of the immune system during treatment, patients are more susceptible to infections.
\n\tThere are several key differences between CAR T-cell therapy and other immunotherapy approaches (such as targeted therapy and monoclonal antibodies):
\n\n| Feature | \n\t\t\tCAR T-cell Therapy | \n\t\t\tOther Immunotherapies | \n\t\t
| \n\t\t\t Mechanism of Action \n\t\t\t | \n\t\t\t\n\t\t\t Genetically modified T-cells target specific antigens on cancer cells. \n\t\t\t | \n\t\t\t\n\t\t\t Stimulates the body's immune system to recognize and attack cancer broadly. \n\t\t\t | \n\t\t
| \n\t\t\t Specificity \n\t\t\t | \n\t\t\t\n\t\t\t Highly targeted towards particular cancer cells. \n\t\t\t | \n\t\t\t\n\t\t\t It can have a broader effect on the immune system. \n\t\t\t | \n\t\t
| \n\t\t\t Customization \n\t\t\t | \n\t\t\t\n\t\t\t Personalized treatment using the patient's T-cells. \n\t\t\t | \n\t\t\t\n\t\t\t Not personalized. \n\t\t\t | \n\t\t
| \n\t\t\t Administration \n\t\t\t | \n\t\t\t\n\t\t\t Requires complex procedures for T-cell extraction, modification, and reinfusion. \n\t\t\t | \n\t\t\t\n\t\t\t It can be administered through injections or infusions. \n\t\t\t | \n\t\t
The other table shows precise differences between CAR T-cell therapy and the most common cancer treatments.
\n\n| \n\t\t\t Feature \n\t\t\t | \n\t\t\t\n\t\t\t CAR T-cell Therapy \n\t\t\t | \n\t\t\t\n\t\t\t Chemotherapy \n\t\t\t | \n\t\t\t\n\t\t\t Stem Cell Transplant \n\t\t\t | \n\t\t
| \n\t\t\t Target cells \n\t\t\t | \n\t\t\t\n\t\t\t ONLY tumor cells. \n\t\t\t | \n\t\t\t\n\t\t\t ALL the cells that are rapidly dividing (including healthy tissues). \n\t\t\t | \n\t\t\t\n\t\t\t Not defined. \n\t\t\t | \n\t\t
| \n\t\t\t Type of cells \n\t\t\t | \n\t\t\t\n\t\t\t Patient’s OWN immune cells. \n\t\t\t | \n\t\t\t\n\t\t\t Not defined. \n\t\t\t | \n\t\t\t\n\t\t\t Donor’s cells. \n\t\t\t | \n\t\t
CAR T therapy is a one-time treatment. Once the CAR T cells are back in the body, they can fight cancer immediately.
\n\nDespite the safety concerns mentioned earlier, CAR T-cell therapy can cause other side effects, including:
\n\nFatigue;
\n\tNausea and vomiting;
\n\tLow blood counts;
\n\tFever;
\n\tHair loss;
\n\tMouth sores.
\n\tThese side effects are usually temporary and manageable.
\n\nBefore receiving CAR T-cell therapy, patients may undergo a conditioning regimen of lymphodepleting chemotherapy (which reduces the number of damaged lymphocytes). This preparatory step aims to reduce the presence of existing immune cells, thereby minimizing the risk of the body rejecting the infused CAR T cells.
\n\nThe administration of CAR T cells involves a relatively straightforward procedure. The engineered cells are infused intravenously, similar to receiving blood, and the process typically takes between 5 and 30 minutes.
\n\nFollowing CAR T-cell therapy, patients often require hospitalization for 7 to 10 days to allow for close monitoring and management.
\n\nAllogenic stem cell transplant (allo-HCT) is a standard treatment for B-cell lymphomas, but it often doesn't work for long. Patients may have relapses even after the transplant. As a type of immune cell therapy, CAR T-cell treatment for cancer can be combined with allo-HCT to speed up the remission.
\n\nThe studies show that patients with CAR T-cell therapy alone lived for an average of 10.5 months. On the contrary, those who had transplantation after the T-cell treatment had an average survival of 70.2 months. This is an excellent example of how combining cancer treatments improves patient outcomes.
\n\nStem cell transplantation is also an option for the following cases:
\n\nWhen lymphoma/multiple myeloma doesn't respond to CAR T-cell therapy;
\n\tWhen the initial disease relapses multiple times;
\n\tAfter the previous stem cell transplantation.
\n\tBookimed has selected the top CAR T-cell centers using our Smart Ranking System. This system considers various factors, such as:
\n\nDoctor's experience;
\n\tSuccess rates;
\n\tTechnological advancements;
\n\tPatient satisfaction.
\n\tBy leveraging this data-driven approach, we ensure our patients can access the most effective and cutting-edge treatments available. The choice is always yours, and we highly recommend consulting with our medical coordinators before signing up for the treatment.
\n\nHere's the list of the best hospitals where is car t-cell therapy available:
\n\nThe Hematology Institute is a leading CAR T-cell therapy clinic in Israel. Their experts have much experience treating patients with CAR T-cells and managing any side effects. The center has a 90% success rate in oncology clinical trials and treatments.
\n\nDr. Ron Ram is one of the best hematology/oncology department specialists. He has performed numerous stem cell transplants and contributed to chimeric cancer treatment.
\n\nThe Ichilov was also the first CAR T hospital in Israel to get government approval.
\n\nSheba Medical Center is an example of how large academic hospitals are developing CAR T-cell therapy through integrated clinical and laboratory programs. The hospital has performed 450+ CAR-T procedures for patients with leukemia, lymphoma, multiple myeloma, and other relapsed or refractory blood cancers.
\n\nA key feature of Sheba’s program is in-house CAR-T manufacturing. The hospital produces CAR-T cells onsite through its GMP-certified Advanced Biotherapy Center (ABC), rather than relying only on external commercial production. This model can shorten the “vein-to-vein” timeline — from T-cell collection to reinfusion — to approximately 10 days.
\n\nSheba’s cellular therapy program is also connected with bone marrow transplantation, pediatric hemato-oncology, precision oncology, bispecific antibody therapy, and TIL therapy for metastatic melanoma. The center is also involved in research on CAR-T approaches for severe autoimmune diseases, including lupus, rheumatoid arthritis, Sjögren’s syndrome, vasculitis, and scleroderma.
\n\n![\"Sheba](\"https://s3.eu-central-1.amazonaws.com/bookimed/_images_without_dir/6a024108cf819.jpeg\")
The head of the oncology department, Dr. Guo Li Gai, has studied thousands of CAR T-cell therapy for non-Hodgkin lymphoma cases to administer effective CAR T-cell therapy for his patients.
\n\nThe hospital's oncology department works closely with the Mayo Clinic. The doctors use a system called MICM to make accurate cancer diagnoses. Here's what they evaluate:
\n\nShape of cells (morphology);
\n\tSpecific substances (immunology);
\n\tChromosomes (cytogenetics);
\n\tDNA of cells (molecular science).
\n\tBesides collecting stem cells, the local laboratory also separates and cryopreserves their components for later use. This can benefit urgent cases for patients in the last stages of cancer.
\n\nSant Joan de Déu is known for its technological advances and discoveries. The specialists here were the first in Spain to develop a vaccine against tumors of the brain and medulla, as well as a nanofiber tissue for local cancer treatment.
\n\nThe cell therapy center accepts children and young adults up to 21 years old. It has the best conditions for both bone marrow transplantation and CAR T-cell therapy. The cancer center has 4 boxes with HEPA filters and positive pressure for transplant-eligible patients.
\n\nWhile CAR T-cell therapies have shown significant success in treating blood cancers, their application in solid tumors (such as sarcomas, carcinomas, and lymphomas) presents unique challenges.
\n\nSolid tumors have a complex microenvironment that can hinder CAR T cells from effectively reaching and attacking the tumor site. This has made it difficult to achieve the same level of success seen in blood cancers.
\n\nHowever, researchers are actively exploring new strategies to overcome these obstacles, including:
\n\nDeveloping CAR T cells that can target specific proteins on solid tumor cells;
\n\tUsing CAR T-cell therapies in combination with other treatment methods to enhance their effectiveness;
\n\tInvestigating the use of CAR T cells in combination with other treatments, such as checkpoint inhibitors or chemotherapy.
\n\tCAR T-cell therapy has the potential to help many patients with solid tumors. More research is needed to learn how it works and find new ways to use it.
\n\nFinding the right center for CAR T-cell therapy can be challenging. Bookimed coordinators will be happy to assist you with:
\n\nApplying to reputable hospitals. Our medical partners have well-trained staff and expertise in CAR T-cell therapy programs.
\n\tTransparent cost estimates. We will calculate all the potential costs associated with treatment abroad.
\n\tTravel arrangements. We will arrange flights, accommodation, and local transportation.
\n\tLanguage assistance. Our coordinators will provide translation services to ease your treatment journey.
\n\tCAR-T after Stem Cell Transplantation in B-Cell Lymphoproliferative Disorders: Are They Really Autologous or Allogenic Cell Therapies?. PubMed Central (PMC). URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470158/ (date of access: 23.09.2024).
\n\nCAR T-cell Therapy and Its Side Effects. Information and Resources about Cancer: Breast, Colon, Lung, Prostate, Skin | American Cancer Society. URL: https://www.cancer.org/cancer/managing-cancer/treatment-types/immunotherapy/car-t-cell1.html (date of access: 23.09.2024).
\n\nCART Cell Therapy Toxicity - StatPearls - NCBI Bookshelf. National Center for Biotechnology Information. URL: https://www.ncbi.nlm.nih.gov/books/NBK592426/ (date of access: 23.09.2024).
\n\nLong-term outcomes following CAR T cell therapy: what we know so far - Nature Reviews Clinical Oncology. Nature. URL: https://www.nature.com/articles/s41571-023-00754-1 (date of access: 23.09.2024).
"},"guide_mc":{"text":"Day 1
\nDay 2 - Day 3
\nDay 4
\nDay 5 - Day 12
\nDay 13
\nDay 14 - Day 20
\nWeek 3 - Week 4
\nWeek 5 onwards
\nPlease note that each case is individual. This timeline may vary based on your personal health condition and the specifics of your treatment plan.
"},"overview":{"text":"CAR T-cell therapy is a personalized immune system therapy that modifies a patient's T-cells to target and destroy cancer cells.
Qualified centers in South Korea must receive Ministry of Food and Drug Safety approval to administer CAR T-cell therapy. Primary authorized facilities include Samsung Medical Center, Seoul National University Hospital, and Seoul St. Mary Hospital. These institutions manage commercial products like Kymriah for lymphoma and leukemia patients.
Bookimed Expert Insight: Samsung Medical Center serves over 2,000,000 patients annually and maintains a presidential-tier infrastructure. This high volume translates to significant experience in complex oncology. Their early adoption of a dedicated center makes them a leader in managing cytokine release syndrome. This specialized care is vital for patient safety during the aggressive CAR T-cell infusion phase.
Patient Consensus: Patients emphasize the need for official verification. They recommend contacting oncology departments directly to confirm current KFDA approval status for specific therapies. Many suggest budgeting over $300,000 and planning for a 6-week stay.
","is_active":true,"category":{"id":"68f5f2ea1567cb687e0a7542","name":"faq_content","title":"faq_content"}},{"id":"6a05ea1b34774719ea0d7522","question":"What CAR T-cell products are commercially approved in the Republic of Korea?","answer":"South Korea's Ministry of Food and Drug Safety has approved four major CAR T-cell therapies: Kymriah (tisagenlecleucel), Yescarta (axicabtagene ciloleucel), Carvykti (ciltacabtagene autoleucel), and Rimqarto (anbalcabtagene autoleucel). These products treat specific lymphomas and multiple myeloma. Administration occurs at specialized centers like Samsung Medical Center.
Bookimed Expert Insight: While approvals are increasing, manufacturing logistics remain a significant bottleneck. Data shows patients often wait over 6 months for imported products. Top centers like Samsung Medical Center manage these timelines better due to high patient volumes. They serve over 2,000,000 patients annually and have established apheresis protocols.
Patient Consensus: Patients emphasize the need to verify hospital capabilities early. They often report that insurance coverage lags behind regulatory approval, making out-of-pocket costs a major concern.
","is_active":true,"category":{"id":"68f5f2ea1567cb687e0a7542","name":"faq_content","title":"faq_content"}},{"id":"6a05ea6b8df1dc3a3e04f5e2","question":"Which hematologic malignancies are reimbursed for CAR T-cell therapy under Korea’s National Health Insurance?","answer":"South Korea National Health Insurance covers CAR T-cell therapy primarily for relapsed or refractory diffuse large B-cell lymphoma and pediatric B-cell acute lymphoblastic leukemia. Coverage usually applies starting from third-line treatment under strict National Health Insurance Service guidelines at accredited medical centers.
Bookimed Expert Insight: Samsung Medical Center serves over 2,000,000 patients annually and holds KOIHA accreditation for safety. Their high volume suggests they manage the complex National Health Insurance reimbursement and hospital-level approvals efficiently. Patients should verify their specific malignancy against the latest risk-sharing agreements at such high-capacity centers.
Patient Consensus: Patients report that while pediatric leukemia coverage is reliable, many adults with multiple myeloma face private costs. Most advise preparing for a 10% to 20% copay even when insurance approves the treatment.
","is_active":true,"category":{"id":"68f5f2ea1567cb687e0a7542","name":"faq_content","title":"faq_content"}},{"id":"6a05eab9630167b87c0ff4b2","question":"What ongoing CAR T-cell clinical trials are recruiting in South Korea?","answer":"South Korea actively recruits for CAR T-cell clinical trials targeting lymphoma, leukemia, and liver cancer. Prominent studies include the ALPHA3 trial for B-cell lymphoma and the EU307 phase 1 trial for hepatocellular carcinoma. Enrollment centers include Samsung Medical Center and Seoul National University Hospital.
Bookimed Expert Insight: While many global trials use ClinicalTrials.gov, South Korean centers often prioritize the local CRIS registry. Samsung Medical Center, which serves over 2,000,000 patients annually, frequently operates internal trial pipelines. Checking their specific Cancer Center listings usually reveals more active slots than international databases.
Patient Consensus: Many find that trial information is mainly available in Korean. Direct contact with tier-1 hospital international departments is more effective than searching public online listings.
","is_active":true,"category":{"id":"68f5f2ea1567cb687e0a7542","name":"faq_content","title":"faq_content"}}],"faqInSchema":true,"articles":[{"id":"en:car-t-cell-therapy-cost","name":"CAR T-Cell Therapy Cost Effectiveness","image":{"main":"https://bookimed.s3.eu-central-1.amazonaws.com/articles/ae85_b.jpeg","preview":"https://bookimed.s3.eu-central-1.amazonaws.com/articles/ae85_s.jpeg"},"author":{"first_name":"Anna","last_name":"Leonova","avatar":"https://s3.eu-central-1.amazonaws.com/bookimed/admin/5d24698525ec3_b.jpeg"}}],"relations":{"countries":[{"name":"Austria","alias":"austria","iso_code":"AT"},{"name":"China","alias":"china","iso_code":"CN"},{"name":"Germany","alias":"germany","iso_code":"DE"},{"name":"Israel","alias":"israel","iso_code":"IL"},{"name":"Italy","alias":"italy","iso_code":"IT"},{"name":"Lithuania","alias":"lithuania","iso_code":"LT"},{"name":"Republic of 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