{"key":"op_141_ES","page":{"url":"https://us-uk.bookimed.com/clinics/country=spain/procedure=bone-marrow-transplantation/","procedure":{"id":141,"slug":"bone-marrow-transplantation","name":"Bone marrow transplantation","name_forms":{"plural":{"status":"missing","reason":"not_collected"},"genitive":{"status":"missing","reason":"not_collected"}},"type":"therapy","grammar_number":{"status":"missing","reason":"not_collected"},"parent_id":"oncology","family_attribute":{"status":"missing","reason":"not_collected"}},"country":{"id":34,"iso":"ES","name":"Spain"},"currency":"USD","data_date":"2026-09-24"},"pages":{"clinics_url":"https://us-uk.bookimed.com/clinics/country=spain/procedure=bone-marrow-transplantation/","cost_url":"https://us-uk.bookimed.com/clinics/country=spain/procedure=bone-marrow-transplantation/cost/","best_url":{"status":"missing","reason":"template not live"}},"price":{"from":99500,"to":125000,"avg":{"value":221894,"method":"median","source":"offers"},"us":{"from":250000,"to":400000},"uk":{"from":140000,"to":230000},"by_technique":{"status":"missing","reason":"not_collected"},"by_city":[{"city":"Barcelona","from":99500},{"city":"Madrid","from":221900},{"city":"Pamplona","from":82000},{"city":"Alicante","from":70000}],"per_unit":{"status":"missing","reason":"not_collected"},"factors":{"status":"missing","reason":"not_collected"},"tiers":{"source":"offers","items":[{"tier":"standard","min":221894,"max":221894,"median":221894,"count":1}]},"comparison":[{"country_iso":"UA","from":28000,"to":45000},{"country_iso":"FR","from":120000,"to":220000},{"country_iso":"GB","from":140000,"to":230000},{"country_iso":"US","from":250000,"to":400000},{"country_iso":"IL","from":79000,"to":190000},{"country_iso":"TR","from":25000,"to":45000},{"country_iso":"MX","from":80000,"to":100000},{"country_iso":"DE","from":120000,"to":185000},{"country_iso":"CA","from":150000,"to":280000},{"country_iso":"AE","from":55000,"to":85000},{"country_iso":"TH","from":70000,"to":85000},{"country_iso":"PL","from":45000,"to":68000},{"country_iso":"KR","from":90000,"to":130000},{"country_iso":"CZ","from":45000,"to":75000},{"country_iso":"AT","from":62000,"to":95000},{"country_iso":"IT","from":70000,"to":125000},{"country_iso":"CN","from":266000,"to":{"status":"missing","reason":"not_collected"}},{"country_iso":"AU","from":140000,"to":210000},{"country_iso":"IN","from":30000,"to":40000},{"country_iso":"MY","from":38000,"to":60000},{"country_iso":"VN","from":30000,"to":55000},{"country_iso":"BR","from":60000,"to":110000},{"country_iso":"AZ","from":29000,"to":40000},{"country_iso":"EG","from":15000,"to":35000}],"base_country":"US","base_is_fallback":false},"savings":{"pct":60,"variant":">=15%"},"package":{"included":["Individual chamber"],"excluded":["Transfer is not included"],"extra_charges":{"status":"missing","reason":"not_collected"}},"clinics":{"count":5,"items":[{"id":278,"name":"Quironsalud Madrid","city":"Madrid","rating":3.8,"reviews_count":6,"accreditations":["World's Best Hospitals 2021 by Newsweek"],"rank":1,"has_procedure":true,"why_ranked":"Performs the largest number of bone marrow transplants among private hospitals in Spain. Offers both autologous and allogenic transplants with personalized care.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":[{"id":"5d68f78759436a7a5045ee43","price":221894,"nights":0,"included":["Individual chamber"],"excluded":["Transfer is not included"],"other_services":"If a child or adolescent has leukemia, lymphoma, bone marrow failure, a congenital hematologic disorder or another condition for which hematopoietic stem cell transplantation may be considered, I recommend an expert evaluation with Prof. Luis Madero at Hospital Universitario Quirónsalud Madrid. The first objective is to confirm whether transplantation is truly indicated, which type of transplant offers the best balance of benefit and risk, and whether a suitable donor or stem-cell source is available. Why Prof. Luis Madero Prof. Luis Madero is Head of Pediatric Hemato-Oncology at Hospital Universitario Quirónsalud Madrid. • He also leads pediatric hemato-oncology and hematopoietic transplantation at Hospital Niño Jesús in Madrid. • He is Professor of Pediatrics at Universidad Autónoma de Madrid. • He has extensive experience in pediatric hematologic cancers and stem-cell transplantation. • He has authored more than 200 international publications and numerous books and chapters in pediatric hemato-oncology and transplantation. Why Quirónsalud Madrid The hospital has a dedicated Pediatric Hemato-Oncology Service led by Prof. Madero and works with pediatrics, pediatric surgery, neurosurgery, radiation oncology and other specialties when required. Within Quirónsalud Madrid, hematology services also have established expertise in hematopoietic stem-cell transplantation. The hospital’s oncology program states that its hematology service was among the pioneers in Spain in introducing hematopoietic progenitor transplantation and is accredited for allogeneic transplantation from related donors. Evaluation and treatment pathway • Specialist consultation with Prof. Luis Madero. • Review of pathology, bone marrow biopsy, cytogenetics and molecular studies. • Complete blood count, biochemistry, coagulation and infectious-disease screening. • Bone marrow aspiration/biopsy if confirmation or updated assessment is required. • HLA typing of the patient and potential family donors. • Cardiac, pulmonary and organ-function assessment before transplant. • Assessment of autologous versus allogeneic transplantation. • Conditioning chemotherapy when indicated. • Hematopoietic stem-cell infusion. • Protective inpatient monitoring during marrow recovery. • Blood-product and anti-infective support as required. • Post-transplant follow-up and immune-recovery monitoring."}]},{"id":272,"name":"SJD Barcelona Children’s Hospital","city":"Barcelona","rating":4.7,"reviews_count":44,"accreditations":["Bookimed Award: Best pediatric hospital","World's Best Specialized Hospitals 2022 by Newsweek"],"rank":2,"has_procedure":true,"why_ranked":"Reports 90–100% survival with related-donor transplants and 70–80% with unrelated donors. Eight dedicated transplant chambers with HEPA-filtered isolation rooms for pediatric patients.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":78,"name":"Centro Médico Teknon","city":"Barcelona","rating":4.7,"reviews_count":497,"accreditations":["Joint Commission International","European Foundation for Quality Management","THE IMTJ MEDICAL TRAVEL AWARD WINNER IN 2019","Patient choice in Neurology","Patient choice in Neurosurgery","Patient choice for Epilepsy treatment","World's Best Hospitals 2021 by Newsweek"],"rank":3,"has_procedure":true,"why_ranked":"JCI accredited with leading hematologist Dr. Francesc Cobo Valien. Over 900 bone marrow transplants performed. Offers comprehensive pre- and post-transplant care plans.","bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":6225,"name":"Hospital Ruber Internacional","city":"Madrid","rating":5,"reviews_count":3,"accreditations":["Joint Commission International","International Organization for Standardization"],"rank":4,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}},{"id":339,"name":"Clinica Universidad de Navarra (Navarra Hospital)","city":"Pamplona","rating":4.7,"reviews_count":7,"accreditations":["Joint Commission International","European Society for Medical Oncology","World's Best Hospitals 2020 by Newsweek","World's Best Hospitals 2021 by Newsweek","World's Best Smart Hospitals 2021 by Newsweek","World's Best Hospitals 2022 by Newsweek","World's Best Smart Hospitals 2023 by Newsweek"],"rank":5,"has_procedure":true,"why_ranked":{"status":"missing","reason":"not_collected"},"bookimed_stats":{"status":"missing","reason":"not_published"},"procedure_description":{"status":"missing","reason":"not_collected"},"offers":{"status":"missing","reason":"no_offers"}}]},"doctors":{"count":6,"languages":{"status":"missing","reason":"not_collected"}},"cities":[{"id":98,"slug":"barcelona","name":"Barcelona","clinics_count":2,"price_from":99500,"profile":{"city_type":"Mediterranean coastal city in Spain","access":["Barcelona Airport (BCN), 15 km southwest of city center"],"sources":["https://en.wikipedia.org/wiki/Barcelona","https://en.wikipedia.org/wiki/Barcelona–El_Prat_Airport"],"checked_at":"2026-11-03","status":"ok"}},{"id":346,"slug":"madrid","name":"Madrid","clinics_count":1,"price_from":221900,"profile":{"city_type":"Capital and largest city of Spain","access":["Madrid Barajas Airport (MAD), 13 km from Puerta del Sol"],"sources":["https://en.wikipedia.org/wiki/Madrid","https://en.wikipedia.org/wiki/Madrid–Barajas_Airport"],"checked_at":"2026-11-03","status":"ok"}},{"id":366,"slug":"pamplona","name":"Pamplona","clinics_count":{"status":"missing","reason":"not_collected"},"price_from":82000,"profile":{"status":"missing","reason":"not_collected"}},{"id":441,"slug":"alicante","name":"Alicante","clinics_count":{"status":"missing","reason":"not_collected"},"price_from":70000,"profile":{"city_type":"Mediterranean port city in Spain","access":["Alicante Airport (ALC), 9 km from the city"],"sources":["https://en.wikipedia.org/wiki/Alicante","https://en.wikipedia.org/wiki/Alicante%E2%80%93Elche_Airport"],"checked_at":"2026-11-03","status":"ok"}}],"offers":{"active":1,"active_with_related":3,"hospital_nights_median":0,"days_in_country_median":{"status":"missing","reason":"fewer than 10 offers with hotel days"},"top_offers":[{"id":"5d68f78759436a7a5045ee43","clinic_id":278,"clinic_listed":true,"price":221894,"nights":0,"transfer":{"status":"missing","reason":"not_collected"},"tests":{"status":"missing","reason":"not_collected"},"meds":{"status":"missing","reason":"not_collected"},"aftercare":{"status":"missing","reason":"not_collected"},"guarantee":{"status":"missing","reason":"not_collected"},"included":["Individual chamber"],"excluded":["Transfer is not included"],"other_services":"If a child or adolescent has leukemia, lymphoma, bone marrow failure, a congenital hematologic disorder or another condition for which hematopoietic stem cell transplantation may be considered, I recommend an expert evaluation with Prof. Luis Madero at Hospital Universitario Quirónsalud Madrid. The first objective is to confirm whether transplantation is truly indicated, which type of transplant offers the best balance of benefit and risk, and whether a suitable donor or stem-cell source is available. Why Prof. Luis Madero Prof. Luis Madero is Head of Pediatric Hemato-Oncology at Hospital Universitario Quirónsalud Madrid. • He also leads pediatric hemato-oncology and hematopoietic transplantation at Hospital Niño Jesús in Madrid. • He is Professor of Pediatrics at Universidad Autónoma de Madrid. • He has extensive experience in pediatric hematologic cancers and stem-cell transplantation. • He has authored more than 200 international publications and numerous books and chapters in pediatric hemato-oncology and transplantation. Why Quirónsalud Madrid The hospital has a dedicated Pediatric Hemato-Oncology Service led by Prof. Madero and works with pediatrics, pediatric surgery, neurosurgery, radiation oncology and other specialties when required. Within Quirónsalud Madrid, hematology services also have established expertise in hematopoietic stem-cell transplantation. The hospital’s oncology program states that its hematology service was among the pioneers in Spain in introducing hematopoietic progenitor transplantation and is accredited for allogeneic transplantation from related donors. Evaluation and treatment pathway • Specialist consultation with Prof. Luis Madero. • Review of pathology, bone marrow biopsy, cytogenetics and molecular studies. • Complete blood count, biochemistry, coagulation and infectious-disease screening. • Bone marrow aspiration/biopsy if confirmation or updated assessment is required. • HLA typing of the patient and potential family donors. • Cardiac, pulmonary and organ-function assessment before transplant. • Assessment of autologous versus allogeneic transplantation. • Conditioning chemotherapy when indicated. • Hematopoietic stem-cell infusion. • Protective inpatient monitoring during marrow recovery. • Blood-product and anti-infective support as required. • Post-transplant follow-up and immune-recovery monitoring.","is_package":true}],"packages":[{"id":"5d68f78759436a7a5045ee43","clinic_id":278,"clinic_listed":true,"price":221894,"nights":0,"transfer":{"status":"missing","reason":"not_collected"},"tests":{"status":"missing","reason":"not_collected"},"meds":{"status":"missing","reason":"not_collected"},"aftercare":{"status":"missing","reason":"not_collected"},"guarantee":{"status":"missing","reason":"not_collected"},"included":["Individual chamber"],"excluded":["Transfer is not included"],"other_services":"If a child or adolescent has leukemia, lymphoma, bone marrow failure, a congenital hematologic disorder or another condition for which hematopoietic stem cell transplantation may be considered, I recommend an expert evaluation with Prof. Luis Madero at Hospital Universitario Quirónsalud Madrid. The first objective is to confirm whether transplantation is truly indicated, which type of transplant offers the best balance of benefit and risk, and whether a suitable donor or stem-cell source is available. Why Prof. Luis Madero Prof. Luis Madero is Head of Pediatric Hemato-Oncology at Hospital Universitario Quirónsalud Madrid. • He also leads pediatric hemato-oncology and hematopoietic transplantation at Hospital Niño Jesús in Madrid. • He is Professor of Pediatrics at Universidad Autónoma de Madrid. • He has extensive experience in pediatric hematologic cancers and stem-cell transplantation. • He has authored more than 200 international publications and numerous books and chapters in pediatric hemato-oncology and transplantation. Why Quirónsalud Madrid The hospital has a dedicated Pediatric Hemato-Oncology Service led by Prof. Madero and works with pediatrics, pediatric surgery, neurosurgery, radiation oncology and other specialties when required. Within Quirónsalud Madrid, hematology services also have established expertise in hematopoietic stem-cell transplantation. The hospital’s oncology program states that its hematology service was among the pioneers in Spain in introducing hematopoietic progenitor transplantation and is accredited for allogeneic transplantation from related donors. Evaluation and treatment pathway • Specialist consultation with Prof. Luis Madero. • Review of pathology, bone marrow biopsy, cytogenetics and molecular studies. • Complete blood count, biochemistry, coagulation and infectious-disease screening. • Bone marrow aspiration/biopsy if confirmation or updated assessment is required. • HLA typing of the patient and potential family donors. • Cardiac, pulmonary and organ-function assessment before transplant. • Assessment of autologous versus allogeneic transplantation. • Conditioning chemotherapy when indicated. • Hematopoietic stem-cell infusion. • Protective inpatient monitoring during marrow recovery. • Blood-product and anti-infective support as required. • Post-transplant follow-up and immune-recovery monitoring.","is_package":true}],"related_packages":[{"id":"5d6905da59436a170a091f8d","clinic_id":278,"clinic_listed":true,"price":414393,"nights":35,"transfer":{"status":"missing","reason":"not_collected"},"tests":{"status":"missing","reason":"not_collected"},"meds":{"status":"missing","reason":"not_collected"},"aftercare":{"status":"missing","reason":"not_collected"},"guarantee":{"status":"missing","reason":"not_collected"},"included":["Hospitalization"],"excluded":["Transfer is not included"],"other_services":"If a child or adolescent has leukemia, lymphoma, bone marrow failure or another serious hematological condition and no suitable family donor is available, I recommend an expert evaluation with Prof. Luis Madero at Hospital Universitario Quirónsalud Madrid. The first step is to confirm that an allogeneic transplant is medically indicated and that an unrelated donor offers the appropriate treatment strategy. The team will review previous therapy, disease status, HLA typing and organ function before beginning an international donor search. Why Prof. Luis Madero Prof. Luis Madero is Head of Pediatric Hemato-Oncology at Hospital Universitario Quirónsalud Madrid. • He also leads Pediatric Hemato-Oncology and Hematopoietic Transplantation at Hospital Infantil Universitario Niño Jesús in Madrid. • He is Professor of Pediatrics at Universidad Autónoma de Madrid. • He has extensive clinical and research experience in pediatric leukemia, lymphoma, bone marrow disorders and hematopoietic transplantation. • He has authored more than 200 international scientific publications and numerous specialist books and chapters. Quirónsalud Madrid also recognised Prof. Madero among its specialists included in the Forbes Spain 2025 medical selection. Evaluation and donor-search pathway • Consultation and full medical-record review. • Review or repeat bone marrow biopsy when necessary. • Cytogenetic and molecular assessment. • Complete HLA typing. • Search for a matched unrelated donor through appropriate donor registries. • Infectious-disease screening. • Cardiac, pulmonary, renal and hepatic assessment. • Assessment of disease remission/status before transplantation. • Selection of conditioning chemotherapy. • Planning of graft-versus-host disease prevention and post-transplant monitoring. Indicative pricing • Specialist evaluation with Prof. Madero • Comprehensive pre-transplant work-up: approximately • HLA typing and unrelated-donor search/confirmation • Unrelated-donor allogeneic transplantation • Donor collection, registry and international transport costs","is_package":true,"operation_id":178,"operation_name":"Allogenic bone marrow transplantation from an unrelated donor"},{"id":"5d6900aa59436a170a091f8c","clinic_id":278,"clinic_listed":true,"price":254161,"nights":35,"transfer":{"status":"missing","reason":"not_collected"},"tests":{"status":"missing","reason":"not_collected"},"meds":{"status":"missing","reason":"not_collected"},"aftercare":{"status":"missing","reason":"not_collected"},"guarantee":{"status":"missing","reason":"not_collected"},"included":["Individual chamber"],"excluded":["Transfer is not included"],"other_services":"When a related donor is available, the first priority is to confirm that allogeneic transplantation is truly indicated, assess the current disease status, and establish whether the family donor is sufficiently compatible. I recommend evaluation with Prof. Luis Madero at Hospital Universitario Quirónsalud Madrid, where the case can be reviewed within a dedicated pediatric hemato-oncology pathway. Why Prof. Luis Madero • Head of Pediatric Hemato-Oncology at Hospital Universitario Quirónsalud Madrid. • Head of Pediatric Hemato-Oncology and Hematopoietic Transplantation at Hospital Niño Jesús in Madrid. • Professor of Pediatrics at Universidad Autónoma de Madrid. • Author of more than 200 international scientific publications, with extensive experience in childhood leukemia, lymphoma, bone marrow disorders and hematopoietic transplantation. Why Quirónsalud Madrid The hospital has a dedicated Pediatric Hemato-Oncology Service and can coordinate hematology, pediatrics, intensive care, transfusion medicine, laboratory diagnostics and specialist support within the same hospital. For transplantation, the team evaluates the patient and potential related donor together, including HLA compatibility, infectious screening and organ-function testing before treatment is approved. Evaluation and treatment package • Consultation with Prof. Luis Madero • Review of bone marrow biopsy, pathology, cytogenetics and molecular studies. • Complete blood count, biochemistry and coagulation profile. • HLA typing of the patient and related donor. • Donor medical assessment and infectious-disease screening. • Cardiac, pulmonary, renal and liver assessment. • Bone marrow examination if an updated evaluation is required. • Conditioning chemotherapy. • Collection of hematopoietic stem cells from the related donor. • Allogeneic stem-cell infusion. • Protective inpatient hospitalization during marrow recovery. • Blood-product and anti-infective support. • Prevention and monitoring of graft-versus-host disease. • Early post-transplant follow-up. • Complete pre-transplant patient and donor evaluation • Related-donor allogeneic bone marrow/stem-cell transplantation","is_package":true,"operation_id":177,"operation_name":"Allogenic bone marrow transplantation from a related donor"}],"other_packages":{"status":"missing","reason":"not_classified"}},"medical":{"indications":["Hematologic malignancies such as leukemia, lymphoma and multiple myeloma","Myelodysplastic syndromes and myeloproliferative neoplasms","Bone marrow failure such as severe aplastic anemia","Thalassemia major and sickle cell disease in selected patients","Primary immunodeficiencies","Relapsed or high-risk disease needing high-dose chemotherapy rescue"],"contraindications":["Severe uncontrolled active infection","Severe organ dysfunction (heart, lung, liver, kidney) beyond acceptable thresholds","Poor performance status or limited life expectancy from other causes","Active uncontrolled or progressive disease in some settings (relative)","Pregnancy","Lack of suitable donor for allogeneic transplant"],"operation_hours":{"min":0.5,"max":4,"unit":"hours","qualifier":"Infusion itself on transplant day; conditioning and engraftment add days to weeks."},"anesthesia":["local_sedation"],"sessions_or_stages":{"sessions":{"min":1,"max":1,"unit":"visits","qualifier":"One stem cell infusion within one admission; a second transplant only for graft failure or relapse."},"stages":[{"code":"conditioning","label":"Conditioning chemotherapy with or without radiation","after":{"min":0,"max":0,"unit":"days","qualifier":"Starts about 5-10 days before infusion; counted here as admission start."}},{"code":"stem_cell_infusion","label":"Stem cell infusion","after":{"min":5,"max":10,"unit":"days","qualifier":"Approximate interval after conditioning starts."}}],"qualifier":"One transplant episode: single infusion after conditioning."},"hospital_nights":{"value":0,"source":"offers","parsed_details":{"min":14,"max":35,"unit":"nights","qualifier":"Autologous: about 2–3 weeks. Allogeneic: about 3–5 weeks until engraftment. Complications extend stay."}},"treatment_conditions":["inpatient"],"rehabilitation_days":{"min":60,"max":180,"unit":"days","qualifier":"Daily activities resume in about 1–3 months (autologous) or 3–6 months (allogeneic). Full stamina can take a year."},"fly_home_after_days":{"min":30,"max":100,"unit":"days","qualifier":"Autologous: about 4 weeks after infusion, once counts recover. Allogeneic: usually stay near the center until about day +100."},"back_to_work_days":{"min":90,"max":365,"unit":"days","qualifier":"Autologous: desk work in about 3–6 months. Allogeneic: 6–12 months, longer with GVHD. Often part-time at first."},"exercise_resume_weeks":{"min":13,"max":52,"unit":"weeks","qualifier":"Light activity early. Strenuous exercise after about 3-6 months (autologous) or 6-12 months (allogeneic), if counts and GVHD allow."},"final_result_months":{"min":6,"max":24,"unit":"months","qualifier":"Engraftment takes about 2–4 weeks. Immune recovery and confirmed remission or disease correction take about 6–24 months."},"result_longevity":"Benefit is often lifelong in patients who stay in remission: most relapses occur within 2 years, and disease-free beyond 2–5 years means high cure chance. In non-malignant disorders, engraftment can be permanent.","main_risks":["Serious infections due to prolonged immunosuppression","Graft-versus-host disease (allogeneic)","Graft failure requiring a second transplant","Mucositis, nausea and organ toxicity from conditioning","Bleeding and need for transfusions","Veno-occlusive disease of the liver","Infusion reactions","Infertility and late effects including secondary cancers","Transplant-related mortality"],"complication_rate_pct":{"min":50,"max":80,"unit":"percent","qualifier":"Any significant complication in first year; higher with allogeneic transplant."},"revision_rate_pct":{"min":1,"max":5,"unit":"percent","qualifier":"Second transplant for graft failure, mainly after allogeneic transplant."},"success":{"metric":"Overall survival after transplant","value":50,"horizon":"5 years","source":{"status":"missing","reason":"not_collected"},"evidence_status":"limited"},"scars":"No surgical scar; only a small mark remains at the central venous catheter site.","pain":"The infusion itself is usually painless, similar to a blood transfusion; discomfort mainly comes from conditioning, mouth sores, nausea and other side effects, managed with supportive care.","preparation":["Comprehensive evaluation of disease status, organ function and infection screening","Stem cell collection by apheresis after mobilization (autologous)","Donor HLA matching and donor clearance (allogeneic)","Central venous catheter placement","Conditioning chemotherapy with or without radiation before infusion","Dental and fertility counseling, and arrangement of caregiver support"],"recovery_timeline":[{"phase":"Conditioning and infusion (day -10 to 0)","description":"Conditioning therapy followed by infusion of stem cells over about 30 minutes to a few hours in hospital.","restrictions":["Inpatient protective isolation"]},{"phase":"Aplasia and engraftment (about days 0-30)","description":"Low blood counts until engraftment, with transfusions, infection prophylaxis and supportive care.","restrictions":["Strict infection precautions","Hospital monitoring"]},{"phase":"Early recovery (about 1-3 months)","description":"Frequent outpatient visits, monitoring for infection and graft-versus-host disease, and gradual strength recovery.","restrictions":["Avoid crowds and sick contacts","Food safety precautions","Stay near transplant center"]},{"phase":"Extended recovery (about 3-12 months)","description":"Gradual immune reconstitution; immunosuppression tapered in allogeneic cases; vaccinations restarted per team schedule; slow return to normal activities.","restrictions":["Ongoing infection precautions","Limited sun exposure"]}],"follow_up_visits":[{"purpose":"assessment","requirement":"routine","after":{"min":30,"max":45,"unit":"days","qualifier":"Blood count and complication review after discharge; frequent outpatient visits in the first weeks."}},{"purpose":"assessment","requirement":"routine","after":{"min":90,"max":100,"unit":"days","qualifier":"Day +100 review of GVHD, infections and immunosuppression taper, mainly after allogeneic transplant."}},{"purpose":"result_review","requirement":"routine","after":{"min":180,"max":365,"unit":"days","qualifier":"Disease restaging and chimerism or marrow assessment to confirm remission and immune recovery."}},{"purpose":"other","requirement":"conditional","after":{"min":30,"max":180,"unit":"days","qualifier":"Unscheduled review if fever, infection, GVHD signs or graft problems arise."}}],"sources":{"status":"missing","reason":"not_collected"},"clinic_checks":{"status":"ok","items":[{"id":"C1","text":"Check that you can ask the clinician questions about your treatment during the consultation","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Have you been able to ask them questions about your treatment?","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C2","text":"Check how your aftercare will be coordinated once you return home","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Ensure you're clear about how your aftercare will be coordinated.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C3","text":"Check the qualifications of the medical team treating you","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Have you checked the qualifications of the medical team treating you?","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C4","text":"Check that the clinic provides regular post-transplant check-ups after discharge","scope":"procedure","source":{"url":"https://www.nhs.uk/tests-and-treatments/stem-cell-or-bone-marrow-transplants/recovery/","host":"nhs.uk","quote":"After you leave hospital, you'll have regular check-ups with your care team.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C5","text":"Check that medicines protecting against infection and immune-system complications are provided when needed","scope":"procedure","source":{"url":"https://www.nhs.uk/tests-and-treatments/stem-cell-or-bone-marrow-transplants/recovery/","host":"nhs.uk","quote":"give you medicines to protect from infections; give you medicine to stop your immune system attacking the new stem cells (if they came from a donor)","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"C6","text":"Check that the clinic can arrange blood or platelet transfusions when required after transplantation","scope":"procedure","source":{"url":"https://www.nhs.uk/tests-and-treatments/stem-cell-or-bone-marrow-transplants/recovery/","host":"nhs.uk","quote":"arrange for you to have blood or platelet transfusions, if your body has not started to make enough healthy blood cells yet","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-11","next_check_at":"2027-11-11","version":1},"red_flags":{"status":"ok","items":[{"id":"F1","text":"Treatment advice coming from sales staff or agents rather than the treating clinician is a warning sign","scope":"treatment_abroad","source":{"url":"https://travelhealthpro.org.uk/news/699/travelling-abroad-for-treatment","host":"travelhealthpro.org.uk","quote":"Do not accept advice from a travel agent, sales representatives or administrators.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"F2","text":"An advert or information that guarantees complete success should raise concerns","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Any advert or information that guarantees complete success should raise concerns.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"F3","text":"Forceful persuasion or cheap, time-limited offers pushing you into a quick decision","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Don’t be pressured into quick decisions either through forceful persuasion or cheap, time limited offers.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-11","next_check_at":"2027-11-11","version":1},"warning_signs":{"status":"ok","items":[{"id":"W1","text":"Shortness of breath or changes in breathing","urgency":"contact_clinic","general":false,"source":{"url":"https://www.cancer.org/cancer/treatment-types/stem-cell-transplant/transplant-side-effects.html","host":"cancer.org","quote":"Report any shortness of breath or changes in your breathing to your transplant team right away.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"W2","text":"Rash or redness on palms and soles","urgency":"contact_clinic","general":false,"source":{"url":"https://www.cancer.org/cancer/treatment-types/stem-cell-transplant/transplant-side-effects.html","host":"cancer.org","quote":"A rash, burning, and redness of the skin on the upper chest, palms and soles is often the earliest sign of GVHD.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"W3","text":"Easy bruising and bleeding, such as nosebleeds","urgency":"contact_clinic","general":false,"source":{"url":"https://www.cancer.org/cancer/treatment-types/stem-cell-transplant/transplant-side-effects.html","host":"cancer.org","quote":"During this time, you might notice easy bruising and bleeding, such as nosebleeds and bleeding gums.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"W4","text":"Severe diarrhea","urgency":"contact_clinic","general":false,"source":{"url":"https://www.cancerresearchuk.org/about-cancer/treatment/bone-marrow-stem-cell-transplants/side-effects","host":"cancerresearchuk.org","quote":"Tell your team if your diarrhoea is severe.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"W5","text":"Fever","urgency":"contact_clinic","general":true,"source":{"url":"https://www.cancer.org/cancer/treatment-types/stem-cell-transplant/transplant-side-effects.html","host":"cancer.org","quote":"It's very important to contact your transplant team if you have a fever or any other signs of infection.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-11","next_check_at":"2027-11-11","version":1},"take_home":{"status":"ok","items":[{"id":"T1","text":"Home doctor needs the clinic's follow-up recommendations in a written discharge summary","document":"discharge summary","source":{"url":"https://sbuhb.nhs.wales/about-us/individual-patient-commissioning/ipc-folder/advice-on-accessing-treatment-abroad","host":"sbuhb.nhs.wales","quote":"When you have treatment abroad, you must ask the treatment provider for their follow-up recommendations documented within a written discharge summary in English.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"T2","text":"Ask for copies of all prescriptions before you leave","document":"prescription copies","source":{"url":"https://travelhealthpro.org.uk/news/699/travelling-abroad-for-treatment","host":"travelhealthpro.org.uk","quote":"Remember to ask for copies of all your treatment records, including prescriptions, scans and x-rays before you leave.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"T3","text":"The home doctor needs it to continue re-vaccinations after the transplant","document":"re-vaccination schedule","source":{"url":"https://www.worcsacute.nhs.uk/leaflets/going-home-after-an-autologous-stem-cell-transplant/","host":"worcsacute.nhs.uk","quote":"Your GP will also be sent a copy of the discharge summary and re-vaccination schedule.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}}],"checked_at":"2026-11-11","next_check_at":"2027-11-11","version":1}},"parsed_details":{"procedure_type":"therapy","fields":{"anesthesia":["local_sedation"],"back_to_work_days":{"min":90,"max":365,"unit":"days","qualifier":"Autologous: desk work in about 3–6 months. Allogeneic: 6–12 months, longer with GVHD. Often part-time at first."},"complication_rate_pct":{"min":50,"max":80,"unit":"percent","qualifier":"Any significant complication in first year; higher with allogeneic transplant."},"contraindications":["Severe uncontrolled active infection","Severe organ dysfunction (heart, lung, liver, kidney) beyond acceptable thresholds","Poor performance status or limited life expectancy from other causes","Active uncontrolled or progressive disease in some settings (relative)","Pregnancy","Lack of suitable donor for allogeneic transplant"],"days_in_clinic":{"min":14,"max":35,"unit":"nights","qualifier":"Autologous: about 2–3 weeks. Allogeneic: about 3–5 weeks until engraftment. Complications extend stay."},"diagnostic_duration_minutes":null,"diagnostic_preparation":null,"diagnostic_referral_needed":null,"diagnostic_result_time_hours":null,"exercise_resume_weeks":{"min":13,"max":52,"unit":"weeks","qualifier":"Light activity early. Strenuous exercise after about 3-6 months (autologous) or 6-12 months (allogeneic), if counts and GVHD allow."},"final_result_months":{"min":6,"max":24,"unit":"months","qualifier":"Engraftment takes about 2–4 weeks. Immune recovery and confirmed remission or disease correction take about 6–24 months."},"fly_home_after_days":{"min":30,"max":100,"unit":"days","qualifier":"Autologous: about 4 weeks after infusion, once counts recover. Allogeneic: usually stay near the center until about day +100."},"follow_up_visits":[{"purpose":"assessment","after":{"min":30,"max":45,"unit":"days","qualifier":"Blood count and complication review after discharge; frequent outpatient visits in the first weeks."},"requirement":"routine"},{"purpose":"assessment","after":{"min":90,"max":100,"unit":"days","qualifier":"Day +100 review of GVHD, infections and immunosuppression taper, mainly after allogeneic transplant."},"requirement":"routine"},{"purpose":"result_review","after":{"min":180,"max":365,"unit":"days","qualifier":"Disease restaging and chimerism or marrow assessment to confirm remission and immune recovery."},"requirement":"routine"},{"purpose":"other","after":{"min":30,"max":180,"unit":"days","qualifier":"Unscheduled review if fever, infection, GVHD signs or graft problems arise."},"requirement":"conditional"}],"indications":["Hematologic malignancies such as leukemia, lymphoma and multiple myeloma","Myelodysplastic syndromes and myeloproliferative neoplasms","Bone marrow failure such as severe aplastic anemia","Thalassemia major and sickle cell disease in selected patients","Primary immunodeficiencies","Relapsed or high-risk disease needing high-dose chemotherapy rescue"],"main_risks":["Serious infections due to prolonged immunosuppression","Graft-versus-host disease (allogeneic)","Graft failure requiring a second transplant","Mucositis, nausea and organ toxicity from conditioning","Bleeding and need for transfusions","Veno-occlusive disease of the liver","Infusion reactions","Infertility and late effects including secondary cancers","Transplant-related mortality"],"pain":"The infusion itself is usually painless, similar to a blood transfusion; discomfort mainly comes from conditioning, mouth sores, nausea and other side effects, managed with supportive care.","preparation":["Comprehensive evaluation of disease status, organ function and infection screening","Stem cell collection by apheresis after mobilization (autologous)","Donor HLA matching and donor clearance (allogeneic)","Central venous catheter placement","Conditioning chemotherapy with or without radiation before infusion","Dental and fertility counseling, and arrangement of caregiver support"],"recovery_timeline":[{"phase":"Conditioning and infusion (day -10 to 0)","description":"Conditioning therapy followed by infusion of stem cells over about 30 minutes to a few hours in hospital.","restrictions":["Inpatient protective isolation"]},{"phase":"Aplasia and engraftment (about days 0-30)","description":"Low blood counts until engraftment, with transfusions, infection prophylaxis and supportive care.","restrictions":["Strict infection precautions","Hospital monitoring"]},{"phase":"Early recovery (about 1-3 months)","description":"Frequent outpatient visits, monitoring for infection and graft-versus-host disease, and gradual strength recovery.","restrictions":["Avoid crowds and sick contacts","Food safety precautions","Stay near transplant center"]},{"phase":"Extended recovery (about 3-12 months)","description":"Gradual immune reconstitution; immunosuppression tapered in allogeneic cases; vaccinations restarted per team schedule; slow return to normal activities.","restrictions":["Ongoing infection precautions","Limited sun exposure"]}],"rehabilitation_days":{"min":60,"max":180,"unit":"days","qualifier":"Daily activities resume in about 1–3 months (autologous) or 3–6 months (allogeneic). Full stamina can take a year."},"result_longevity":"Benefit is often lifelong in patients who stay in remission: most relapses occur within 2 years, and disease-free beyond 2–5 years means high cure chance. In non-malignant disorders, engraftment can be permanent.","revision_rate_pct":{"min":1,"max":5,"unit":"percent","qualifier":"Second transplant for graft failure, mainly after allogeneic transplant."},"scars":"No surgical scar; only a small mark remains at the central venous catheter site.","sessions_or_stages":{"sessions":{"min":1,"max":1,"unit":"visits","qualifier":"One stem cell infusion within one admission; a second transplant only for graft failure or relapse."},"stages":[{"code":"conditioning","label":"Conditioning chemotherapy with or without radiation","after":{"min":0,"max":0,"unit":"days","qualifier":"Starts about 5-10 days before infusion; counted here as admission start."}},{"code":"stem_cell_infusion","label":"Stem cell infusion","after":{"min":5,"max":10,"unit":"days","qualifier":"Approximate interval after conditioning starts."}}],"qualifier":"One transplant episode: single infusion after conditioning."},"success":{"metric":"Overall survival after 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healthy blood cells yet","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-11","next_check_at":"2027-11-11","version":1},"red_flags":{"status":"ok","items":[{"id":"F1","text":"Treatment advice coming from sales staff or agents rather than the treating clinician is a warning sign","scope":"treatment_abroad","source":{"url":"https://travelhealthpro.org.uk/news/699/travelling-abroad-for-treatment","host":"travelhealthpro.org.uk","quote":"Do not accept advice from a travel agent, sales representatives or administrators.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}},{"id":"F2","text":"An advert or information that guarantees complete success should raise concerns","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Any advert or information that guarantees complete success should raise 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Bone marrow transplantation in Spain typically costs from _op_141_price_from_ to _op_141_price_to_. The final price depends on the transplant type, donor matching complexity, and patient age. In the US, similar procedures cost around _price_compare_US_average_ on average. Spain offers savings of around _price_percent_discount_%. Standard packages often include donor search, conditioning chemotherapy, and extended hospitalization in specialized isolation rooms.

\n\n\n\n

Bookimed Expert Insight: Choosing JCI-accredited centers like Centro Médico Teknon or Clinica Universidad de Navarra ensures top-tier safety. These hubs manage massive patient volumes from over 70 countries. For pediatric cases, SJD Barcelona Children’s Hospital is a global leader. It houses a dedicated molecular medicine lab for advanced diagnostics. This infrastructure helps justify the higher costs of complex pediatric protocols.

","faq":[{"q":"Is a bone marrow transplant considered surgery?","a":"

A bone marrow transplant is not surgery. It is a non-surgical medical procedure similar to a blood transfusion. Healthy stem cells are infused into the bloodstream through a central intravenous line. These cells naturally travel to the bone marrow to begin producing new blood cells through engraftment.

Bookimed Expert Insight: While the transplant itself is quick, Spanish protocols emphasize a rigorous 10-day hospital stay. Centers like Quironsalud Madrid focus heavily on the conditioning phase before infusion. This intensive preparation ensures the body is ready for new cells, which is the most critical recovery step.

Patient Consensus: Patients are often surprised that the transplant feels like a simple IV drip. The real challenge is the strength needed for chemotherapy before the actual procedure begins.

"},{"q":"What conditions are treated with bone marrow transplants in Spain?","a":"

Bone marrow transplants in Spain effectively treat hematologic cancers including leukemia, lymphoma, and multiple myeloma. Specialist centers also use stem cell transplantation for severe genetic conditions, immunodeficiencies, and autoimmune disorders like multiple sclerosis. JCI-accredited facilities offer autologous, allogeneic, and haploidentical techniques for adult and pediatric patients.

Bookimed Expert Insight: Spain is a global leader in transplant volume, with Quironsalud Madrid performing the highest annual number of procedures in Europe. While many patients focus on large general hospitals, some top-tier Spanish clinics like Navarra Hospital achieve a 74% cure rate for bone sarcomas. This specific focus on onco-hematology outcomes makes Spain a primary destination for complex pediatric and adult cases.

Patient Consensus: Dealing with HLA matching is a primary concern for international patients, as it determines transplant success. Families often highlight the importance of choosing centers with molecular medicine laboratories to ensure precision in donor selection.

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