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"}}},"operationIndicators":{"details":{"anesthesia":"general","days_in_clinic":5,"days_in_country":10,"rehabilitation_days":30,"satisfied_percent":78,"treatment_duration_hours":4},"illness_kind_details":{"requests_processed":46119}},"responsibleDoctor":{"id":290,"alias":"yesim-yildirim","name":"Yesim Yildirim","photo":"doctor/699da18e34fa6","advisory_text":"20 years of experience\nMedical oncologist, ESMO certified","linkedin":"","specialities":[{"id":"onc.001","name":"Clinical oncologist","illness_kind_id":10}]},"direction":{"id":10,"name":"Oncology","alias":"oncology"},"illness_kind":{"id":10,"name":{"en":"Oncology"}},"parsed_details":{"procedure_type":"therapy","fields":{"anesthesia":["none"],"back_to_work_days":{"min":1,"max":3,"unit":"days","qualifier":"Depends on infusion schedule, fatigue and immune-related side effects; many resume work between cycles."},"complication_rate_pct":{"min":60,"max":85,"unit":"percent","qualifier":"Any-grade immune-related or infusion adverse events during treatment; grade 3-4 events roughly 10-20%."},"contraindications":["Active uncontrolled autoimmune disease","Organ transplant on immunosuppression","Chronic systemic steroid use","Active uncontrolled infection","Pregnancy or breastfeeding","Prior severe reaction to same agent","Severe liver, lung or heart dysfunction","Poor performance status"],"days_in_clinic":{"min":0,"max":0,"unit":"nights","qualifier":"Checkpoint inhibitor infusions are given as outpatient visits without overnight stay."},"diagnostic_duration_minutes":null,"diagnostic_preparation":null,"diagnostic_referral_needed":null,"diagnostic_result_time_hours":null,"exercise_resume_weeks":{"min":0,"max":1,"unit":"weeks","qualifier":"Light activity as tolerated; depends on fatigue and side effects."},"final_result_months":{"min":3,"max":6,"unit":"months","qualifier":"Response assessed by imaging after several cycles; responses can be delayed."},"fly_home_after_days":{"min":1,"max":3,"unit":"days","qualifier":"After first infusion once early infusion reactions are excluded; further cycles need repeat visits."},"follow_up_visits":[{"purpose":"assessment","after":{"min":14,"max":42,"unit":"days","qualifier":"Before each cycle: clinical review and blood tests for immune-related toxicity."},"requirement":"routine"},{"purpose":"result_review","after":{"min":60,"max":90,"unit":"days","qualifier":"First response imaging (CT or MRI) after several cycles."},"requirement":"routine"},{"purpose":"other","after":{"min":0,"max":365,"unit":"days","qualifier":"Urgent review whenever an immune-related adverse event is suspected."},"requirement":"conditional"}],"indications":["Advanced or relapsed sarcoma after standard options, often in trials.","Selected subtypes, such as alveolar soft part sarcoma."],"main_risks":["Immune-related colitis, pneumonitis, hepatitis, endocrine, skin reactions with checkpoint inhibitors.","Infusion reactions; cytokine release syndrome or neurotoxicity with cellular therapies."],"pain":"Infusion is painless apart from cannulation. Side effects such as fatigue, joint aches or rash may occur.","preparation":["Confirm sarcoma subtype with pathology review","Baseline blood, liver, thyroid and cortisol tests","Review autoimmune history and current medications","Imaging baseline (CT, MRI or PET-CT)","Infection screening (hepatitis, HIV, TB as indicated)","Tumor-board or trial eligibility confirmation"],"recovery_timeline":[{"phase":"Infusion day","description":"Intravenous infusion of 30-60 minutes with short observation for infusion reactions.","restrictions":["Report fever, chills or breathlessness immediately"]},{"phase":"Weeks 1-12","description":"Repeated cycles every 2-6 weeks with monitoring for immune-related side effects such as colitis, rash or hepatitis.","restrictions":["Report diarrhea, cough or jaundice promptly","Avoid unsupervised steroid use"]},{"phase":"Month 3 onward","description":"Imaging assessment of response; treatment continues, changes or stops based on result and tolerance.","restrictions":[]}],"rehabilitation_days":null,"result_longevity":"Variable; responses, when they occur, can last months to years, but most sarcoma subtypes show modest and uncertain benefit.","revision_rate_pct":null,"scars":"No scars; treatment is given by intravenous infusion or injection.","sessions_or_stages":{"sessions":{"min":4,"max":35,"unit":"visits","qualifier":"Infusions every 2-6 weeks until progression, toxicity or up to about two years."},"stages":[{"code":"baseline_assessment","label":"Baseline assessment and eligibility","after":{"min":0,"max":14,"unit":"days","qualifier":"Before first infusion."}},{"code":"infusion_cycles","label":"Infusion cycles","after":{"min":0,"max":730,"unit":"days","qualifier":"Repeated until progression, toxicity or planned completion."}},{"code":"response_imaging","label":"Response imaging","after":{"min":60,"max":90,"unit":"days","qualifier":"After several cycles."}}],"qualifier":"Schedule depends on the agent, subtype and clinical trial protocol."},"success":{"metric":"Objective response rate with checkpoint inhibitors","value":18,"unit":"percent of patients","horizon":"Within 3-6 months of treatment","population":"Adults with advanced selected sarcoma subtypes after standard therapy","evidence_status":"limited"},"techniques":[{"name":"Checkpoint inhibitors (PD-1/PD-L1, CTLA-4)","suits_whom":"Selected subtypes such as undifferentiated pleomorphic sarcoma or alveolar soft part sarcoma","recovery":"Outpatient infusions; monitor for immune-related side effects."},{"name":"Cell-based therapy (e.g., engineered T cells)","suits_whom":"Selected molecular subtypes, mainly within clinical trials","recovery":"Specialist center monitoring for cytokine release syndrome and neurotoxicity."},{"name":"Cancer vaccines","suits_whom":"Trial participants with advanced or relapsed disease","recovery":"Outpatient injections with minimal downtime."}],"treatment_conditions":["outpatient"],"treatment_duration_hours":{"min":1,"max":4,"unit":"hours","qualifier":"Per visit, including check-in, blood tests, infusion and observation."},"initial_assessment_documents":["Biopsy and pathology report with sarcoma subtype","Recent contrast MRI or CT of tumor","Chest CT report","PET-CT report (if available)","Previous chemotherapy, surgery and radiation reports","Molecular or PD-L1 testing report (if available)"],"travel_trips":{"min":1,"max":2,"one_trip_possible":true,"qualifier":"Initial visit with first infusion; later cycles and imaging can continue at home."},"clinic_checks":{"status":"ok","items":[{"id":"C1","text":"Ask whether a doctor is always present in the clinic and whether a high dependency or intensive care unit exists","scope":"treatment_abroad","source":{"url":"https://www.bapras.org.uk/public/patient-information/cosmetic-surgery/cosmetic-surgery-abroad","host":"bapras.org.uk","quote":"Is there always a doctor in the 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