Page 5 - Best Coronary artery disease doctors: TOP 105 doctors

Prof Giuseppe Speziale specializes in minimally invasive cardiac surgery, with a focus on mitral valve repair and coronary revascularization. He holds leadership roles in major cardiac surgery associations.

• Director of Cardiac Surgery at multiple hospitals, including Santa Maria Hospital
• Co-Founder and President of the Scientific Committee of Mitral Academy
• Author of 6 books and over 90 publications in cardiology
• Recipient of the 'Top Doctors Awards' in 2021
• Expert in On and Off Pump myocardial revascularization

Cardiology Department 

Education and Specialty: 

2003 - Medical Education, School of Medicine, Çukurova University 

2009 – Specialty, School of Medicine, Uludağ University 

2015- Associate Professor, Adana Training and Research Hospital 

Experience: 

2012 - 2015 – Head of Educational and Administrative Affairs, ENT Clinic, Haseki Training and Research Hospital (3 years) 

2009 – 2011, Conscription, Şevket Yılmaz Training and Research Hospital, Bursa 

2011-2013 Bursa State Hospital 

2013-2015 Seyhan Practice Hospital, Adana Training and Research Hospital 

2015-2016 Head of Department of Cardiology, Okmeydanı Training and Research Hospital 

February 2016 – July 2019, Head of Department of Cardiology, School of Medicine, Biruni University. 

Fields of Specialties: 

Complex Coronary Interventions 

Complex Peripheral Interventions 

Pacemaker Procedures 

Electrophysiological Study and Ablation 

Heart Valve Interventions (TAVI, Mitraclip, Mitral Balloon) 

Certificates: 

Board Certificate, European Society of Cardiology 

Board Certificate, Turkish Society of Cardiology 

Professional Memberships- Number Insignificant: 

1. European Society of Cardiology 

2. Turkish Society of Cardiology 

3. Member of Istanbul Medical Chamber 

Personal motto: Your heart is entrusted to us 

Researches and Articles: 

Articles published in international peer-review journals: 

1. *Uçar H*, Gür M, Koyunsever NY, Seker T, Türkoglu C, Kaypakli O, Sahin DY, Elbasan Z, Cayli M. Mean platelet volume is independently associated with renal dysfunction in stable coronary artery disease. Platelets (ISI). 2013 Jun; 25(4):274-278. doi: 10.3109/09537104.2013.805406. Epub 2013 Jun 17 

A2. *Uçar H*, Gür M, Yildirim A, Börekçi A, Gözükara MY, Seker T, Kaypakli O, Türkoglu C, Ozaltun B, Akyol S, Harbalioglu H, Sahin DY, Elbasan Z, Cayli M. Increased Aortic Stiffness Predicts Contrast-Induced Nephropathy in Patients With Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention. Angiology (ISI). 2014 Oct;65(9):806-11. doi: 10.1177/0003319713504126. Epub 2013 Sep 26. 

A3. *Uçar H*, Gür M, Kivrak A, Koyunsever NY, Seker T, Akilli RE, Türkoglu C, Kaypakli O, Sahin DY, Elbasan Z, Tanboga HI, Cayli M. High-sensitivity cardiac troponin T levels in newly diagnosed hypertensive patients with different left ventricle geometry. Blood Pressure (ISI). 2014 Aug;23(4):240-7. doi: 10.3109/08037051.2013.840429. Epub 2013 Sep 23. 

A4. *Uçar H*, Mustafa Gür M, Gözükara MY, Kıvrak A, Kolcu Z, Akyol S, Kaypaklı O, Elbasan Z, Sahin DY, Türkoglu C, Seker T, Çaylı M. Relationship between mean platelet volume and morning blood pressure surge in newly diagnosed hypertensive patients. The Anatolian Journal of Cardiology (ISI). 2014 Apr 8. doi: 10.5152/akd.2014.5196. [Epub ahead of print]. 

A5. *Uçar H*, Gür M, Seker T, Kaypaklı O, Elbasan Z, Koyunsever NY, Türkoglu C, Özaltun B, Kuloglu O, Kalkan GY, Sahin DY, Çaylı M. High-Sensitivity Cardiac Troponin T is Associated with SYNTAX Score and Diabetes Mellitus in Patients with Stable Coronary Artery Disease. Journal of Clinical & Experimental Cardiology , 2013 Jun; 4(9):1-5. doi: 10.4172/2155-9880.1000263 

A6. *Uçar H*, Gür M, Gözükara MY, Kalkan GY, Baykan AO, Türkoğlu C, Kaypakl O, Seker T, Sen O, Selek S, Cayl M. Gamma glutamyl transferase activity is Independently associated with oxidative stress rather than SYNTAX score. Scand J Clin Lab Invest (ISI). 2014 Sep 2:1-6. [Epub ahead of print] 

A7. *Uçar H*, Gür M, Börrekçi A, Yıldırım A, Baykan AO, Kalkan GY,Koç M, Şeker T, Coşkun M, Şen Ö, Çaylı M. Relationship between extent and complexity of coronary artery disease and different left ventricular geometric patterns in patients with coronary artery disease and hypertension. The Anatolian Journal of Cardiology (ISI). DOI:10.5152/akd.2014.5747 

A8. Çaylı M, Elbasan Z, Gür M, Şeker T, *Uçar H*, Kuloğlu O, Şen O, Şahin DY, Yüksel Kalkan G. Modified flower petal technique in the treatment of isolated ostial left main and non-left main bifurcation lesions. Eurointervention. Accepted 2014 Oct. 20140324-02-R2 

A9. Baykan AO, Yüksel Kalkan G, Gür M, *Uçar H*, Acele A, Seker T, Sen O, Kaypakli O, Harbalioğlu H, Cayli M. Coronary Flow Velocity Reserve in Patients with Ascending Aorta Aneurysm. Echocardiography (ISI). 2014 Oct 7. doi: 10.1111/echo.12782. [Epub ahead of print] 

A10. Şeker T, Gür M, *Uçar H*, Türkoğlu C, Baykan AO, Özaltun B, Harbalıoğlu H, Kalkan GY, Kaypaklı O, Kuloğlu O, Şen Ö, Koç M, Çaylı M. Lower serum 25-hydroxyvitamin D level is associated with impaired myocardial performance and left ventricle hypertrophy in newly diagnosed hypertensive patients. The Anatolian Journal of Cardiology (ISI). DOI:10.5152/akd.2014.5637 

A11. Gözükara MY, Börekçi A, Gür M, Aksoy N, Seker T, Kaypaklı O, *Uçar H*, Türkoğlu C, Koç M, Makca I, Akyol S, Selek S, Caylı M. Gamma Glutamyl Transferase Activity is Associated With Both Paraoxonase Activity and Aortic Stiffness in Hypertensive Patients. J Clin Lab Anal (ISI). 2014 Aug 17. doi: 10.1002/jcla.21785. [Epub ahead of print] 

A12. Kalkan GY, Gür M, Baykan AO, *Uçar H*, Elbasan Z, Şahin DY, Koç M, Börekçi A, Çaylı M. Mean platelet volume is associated with aortic intima-media thickness in patients without clinical manifestation of atherosclerotic cardiovascular disease. The Anatolian Journal of Cardiology (ISI). DOI:10.5152/akd.2014.5576 

A13. Gür M, Türkoglu C, Taskın A, *Uçar H*, Börekçi A, Seker T, Gözükara MY, Kaypaklı O, Akyol S, Selek S, Sahin DY, Elbasan Z, Çayli M. Paraoxonase 1 activity and oxidative stress in patients with anterior ST elevation myocardial infarction undergoing primary percutaneous coronary intervention with and without no-reflow. Atherosclerosis (ISI). 2014 Jun;234(2):415-20. doi: 10.1016/j.atherosclerosis.2014.03.005. Epub 2014 Apr 3. 

A14. Sahin DY, Gür M, Elbasan Z, Kırım S, *Uçar H*, Seker T, Kaypaklı O, Uysal OK, Kıvrak A, Koyunsever NY, Akıllı RE, Caylı M. NT-proBNP predicts impaired myocardial function in newly diagnosed hypertensive patients with preserved ejection fraction. Clinical and Experimental Hypertension (ISI). 2014;36(5):289-94. doi: 10.3109/10641963.2013.810234. Epub 2013 Jul 18. 

A15. Caylı M, Gür M, Kalkan GY, Elbasan Z, Sahin DY, Koyunsever NY, Türkoglu C, Seker T, Kaypaklı O, Harbalıoglu H, Uçar. Gamma glutamyl transferase activity: Relationship with thoracic aortic intima media thickness and inflammation. Herz (ISI). 2014 Sep;39(6):761-766. Epub 2013 Aug 11. 

A16. Çaylı M, Gür M, Elbasan Z, Seker T, Türkoglu C, Kaypaklı O, Sahin DY, *Uçar H*, Kıvrak A, Koyunsever NY, Sen Ö. High-sensitivity cardiac troponin T predicts nondipper hypertension in newly diagnosed hypertensive patients. J Clin Hypertens (Greenwich) (ISI). 2013 Oct;15(10):731- 6. doi: 10.1111/jch.12176. Epub 2013 Aug 7. 

A17. Kalkan GY, Gür M, Baykan AO, Koyunsever NY, Kaypakli O, Sen O, Kuloglu O, Seker T, *Uçar H*, Akyol S, Elbasan Z, Sahin DY, Çayli M. Serum bilirubin level and aortic intima-media thickness in patients without clinical manifestation of atherosclerotic cardiovascular disease. Angiology (ISI). 2014 Apr;65(4):308-12. doi: 10.1177/0003319713507627. Epub 2013 Oct 24. 

A18. Gür M, *Uçar H*, Kuloglu O, Kıvrak A, Seker T, Türkoglu C, Ozaltun B, Kaypaklı O, Sahin DY, Elbasan Z, Tanboga HI, Caylı M. Estimated glomerular filtration rate is associated with both arterial stiffness and N-terminal pro-brain natriuretic peptide in newly diagnosed hypertensive patients. Clinical and Experimental Hypertension (ISI). 2014;36(6):374-9. doi: 10.3109/10641963.2013.827703. Epub 2014 Jan 16. 

A19. Gür M, Caylı M, *Uçar H*, Elbasan Z, Sahin DY, Gözükara MY, Selek S, Koyunsever NY, Seker T, Türkoglu C, Kaypaklı O, Aksoy N. Paraoxonase (PON1) activity in patients with subclinical thoracic aortic atherosclerosis. Int J Cardiovasc Imaging (ISI). 2014 Jun;30(5):889-95. doi: 10.1007/s10554-014-0407-y. Epub 2014 Apr 4. 

A20. Budak YU, Huysal K, Polat M, Tarakçi G, *Uçar H*. Evaluation of the Steelex M600H coagulometer prothrombin time-international normalized ratio assay with Steelex test reagents. Biochem Med (Zagreb) (ISI). 2012 Jan; 22: 121-126 pp. 

A21. Seker T, Türkoglu C, *Uçar H*, Gür M, Sahin DY, Caylı M. Treatment of totally occluded aortic coarctation using a covered stent. Herz (ISI). 2014 Mar; DOI: 10.1007/s00059-013-3984-y [Epub ahead of print] 

A22. Börekçi A, Gür M, Türkoğlu C, Çaylı M, Selek S, Kaypaklı O, *Uçar H*, Coskun M, Seker T, Koç M, Gökdeniz T, Gözükara MY. Oxidative Stress and Paraoxonase 1 Activity Predict ContrastInduced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Angiology (ISI). 2014 May; DOI: 10.1177/0003319714533588 [Epub ahead of print] 

A23. Kalkan GY, Gür M, Haydardedeoglu FE , Sinan Kırım S, Baykan AO, Kuloglu O, *Uçar H*, Sahin DY, Elbasan Z, Seker T, Turkoglu C, Yildirim A, Cayli M. The Association between Aortic Distensibility and Coronary Flow Reserve in Newly Diagnosed Diabetic Patients. Echocardiography (ISI). 2014 May; DOI: 10.1111/echo.12631 [Epub ahead of print] 

A24. Kalkan GY, Gür M, Koyunsever NY, Seker T, Gözükara MY, *Uçar H*, Kaypaklı O, Baykan AO, Akyol S, Türkoglu C, Elbasan Z, Sahin DY, Çaylı M. Serum 25-hydroxyvitamin D level and aortic intima-media thickness in patients without clinical manifestation of atherosclerotic cardiovascular disease. Journal of Clinical Laboratory Analysis (ISI). 2014 Aug 17. doi: 10.1002/jcla.21770. [Epub ahead of print]. 

A25. *Uçar H*, Karaagaç K, Serdar OA, Yetkin ZA, Aktürk Y, Karaagaç EU, Sarıcaoglu H, Arterial Elasticity Measurement in Patients with Behçet Disease. HealthMED (2012’ de ISI) 2012 May; 6: 3255-3261 pp. 

A26. Karaagaç K, *Uçar H*, Karaagaç E, Yetkin ZA, Aktürk Y. The Relation Betwen Aspirin Resistance and Mean Platelet Volume in Patients with Significant Coronary Artery Stenosis. HealthMED (2012’ de ISI) 2012 May ;6: 3701-3705 pp. 

A27. Cander S, Coban S Altuner S, Gül ÖÖ, Yetgin ZA, Akkurt A, *Uçar H*, Tuncel E. Prevalence and Correlates of Erectile Dysfunction in Type 2 Diabetes Mellitus: A Cross-Sectional SingleCenter Study Among Turkish Patients. Metabolic Syndrome and Related Disorders (ISI). 2014 Aug;12(6):324-9. doi: 10.1089/met.2013.0150. Epub 2014 Mar 25. 

A28. Abalı G, *Uçar H*, Elbasan Z , Gür M ,Seker T, Koyunsever NY, Çaylı M, Akpınar O. Effect of Statin on Neutrophil to Lymphocyte Ratio in Patients with Coronary Artery Disease. Experimental & Clinical Cardiology (ISI). 2014 May 

A29. Effect of fasting on 24-h blood pressure values of individuals with no previous history of hypertension. Seker A, Demirci H, Ocakoglu G, Aydin U, Ucar H, Yildiz G, Yaman O. Blood Press Monit. 2017 Oct;22(5):247-252. doi: 10.1097/MBP.0000000000000244 

A30. The importance of the neutrophil-to-lymphocyte ratio in patients with hypertrophic cardiomyopathy. Ozyilmaz S, Akgul O, Uyarel H, Pusuroglu H, Gul M, Satilmisoglu MH, Bolat I, Ozyilmaz I, *Uçar H*, Yildirim A, Bakir I. Rev Port Cardiol. 2017 Apr;36(4):239-246. doi: 10.1016/j.repc.2016.09.014. Epub 2017 Mar 18. English, Portuguese 

A31. A case of stent thrombosis presenting as acute myocardial infarction related to right coronary artery originating from the left coronary system. Ermis E, Kahraman S, Ucar H, Allahverdiyev S. Intractable Rare Dis Res. 2018 Feb;7(1):58-60. doi: 10.5582/irdr.2018.01001. 

A32. Triple Coronary Artery Thrombosis Presenting as Acute Anterior ST-Segment Elevation Myocardial Infarction. Ermis E, Kahraman S, Ucar H, Ozyılmaz SO, Allahverdiyev S. Int J Angiol. 2018 Dec;27(4):223-226. doi: 10.1055/s-0037-1608959. Epub 2017 Dec 12 

A33. Relationship between blood pressure variability and cognitive function in geriatric hypertensive patients with well-controlled blood pressure. Yıldırım E, Ermis E, Allahverdiyev S, Ucar H, Yavuzer S, Yavuzer H, Cengiz M. Aging Clin Exp Res. 2019 Feb 1. doi: 10.1007/s40520- 019-01141-6. 

C2. Book chapters written in other languages: 

C2.1. Hung JS, Lau KW, *Uçar H*, Çaylı M, Çaylı M, Practical Handbook: Practical Handbook of Advanced Interventional Cardiology (Inoue balloon mitral valvuloplasty),437-473 pp, Adana / Turkey, Çukurova Nobel Medical Bookstore, 2014 

C2.2. Feldman T, Nguyen TN, *Uçar H*, Çaylı M, Çaylı M, Practical Handbook: Practical Handbook of Advanced Interventional Cardiology (retrograde percutaneous aortic valvuloplasty), 475-486 pp, Çukurova, Adana / Turkey, Çukurova Nobel Medical Bookstore, 2014 

D. Articles published in local peer-review journals: 

D1. *Uçar H*, Gür M, Seker T, Sahin DY, Kalkan GY, Türkoglu C, Yıldırım A, Kaypaklı O, Elbasan Z, Çaylı M. Impaired kidney function is associated with syntax scorein patients with stable coronary artery disease. Archive of Turkish Society of Cardiology, 2014; DOI: 10.5543/tkda.2014.67790 

D2. Kalkan GY, Gür M, Elbasan Z, Baykan AO, Kuloğlu O, Sahin DY, Seker T, Haydardedeoglu FE, Şen Ö, *Uçar H*, Kırım S, Çayli M. Left Ventricle Geometry Affects Coronary Flow Reserve in Diabetic Patients. Archive of Turkish Society of Cardiology, Doi: 10.5543/tkda.2015.59432 

D3. *Uçar H*, Karaagaç K, Tiryakioglu S. Woven Left Coronary Artery: A Case Report. Turkish Clinics Journal of Medical Research-Case Reports 2014 (22), 5-6 pp. 

D4. Albayrak S, Kemal Karaagaç K, Baran I, Yetgin ZA, *Uçar H*, Aydınlar A, "Carvedilol and Metoprolol in Acute Myocardial Infarction Early Effect of Oxidized LDL and Paraoxonase-1 Activity Abant Medical Journal 2013; DOI: 10.5505/abantmedj.2013.30592 

D5. Gür AK, Eker E, Akyol A, Akdag S, Kolcu Z, Odabası D, *Uçar H*. Useage of Intra-aortic Baloon Pump in the Open Heart Surgeries. Medical Journal of School of Medicine, Harran University 2014 (11), 10-14 pp. 

D6. Aktürk Y, Dilek Yesilbursa D, *Uçar H*, Yücel E, Özdabakoglu O, Eryılmaz S, Sensoy B, Serdar OA, Aydınlar A. The Effect of Diurnal Blood Pressure Change on Heart Rate Recovery After Cardiac Stress Testing in Hypertensive Patients Receiving Treatment. Uludağ University, School of Medicine Journal 2008 (34), 9-13 pp. 

D7. Yesilbursa D, Aydinlar A, Karaagaç K, *Uçar H*, Aktürk Y, Yetgin ZA. Comparison of Depression and Anxiety Levels in Patients With Acute Coronary Syndrome. Journal of Clinical and Analytical Medicine 2014; DOI: 10.4328/JCAM.1443 

D8. Emül A, Karaagaç K, Yetgin ZA, *Uçar H*, Baran I, Aydınlar A. The Effects of Metabolic Syndrome on Aortic Distensibility in Patients with Angiographically Normal Coronary Arteries. Sakarya Medical Journal 2013; DOI: 10.5505/sakaryamj.2013.69672 

D9. Assessment of side branch patency using a jailed semi-inflated balloon technique with coronary bifurcation lesions. Ermiş E, *Uçar H*, Demirelli S, İpek E, Gür M, Çaylı M. Archive of Turkish Society of Cardiology 2018 Jul;46(5):340-348. doi: 10.5543/tkda.2018.47347.

Specializes in spine surgery and orthopedic conditions, with training at prestigious institutions like Chicago Loyola University.

• Trained in spine surgery at Sisli Hamidiye Etfal Training and Research Hospital
• Certified in advanced trauma and fracture management techniques
• Member of Turkish Orthopedics and Traumatology Association
• Completed specialized courses in microsurgery and arthroscopic surgery

Board-certified internist with extensive hospital leadership experience, ensuring thorough care coordination for complex cases at YeahSmile.

• Specializes in preoperative evaluations for high-risk dental patients
• Over a decade of experience in intensive care units
• Current General Director of Hospital Medica Cancun
• Diploma in Hospital Administration from Instituto Politecnico Nacional

100+ scientific publications and 23 book chapters – Dr. Alzueta Rodriguez is a leading expert in cardiac arrhythmia and electrophysiology at Quirónsalud Marbella.

• Over 40 years of experience in cardiology
• Former Head of the Arrhythmia Unit at Clínica Puerta de Hierro
• Senior Lecturer at Malaga University, teaching future cardiologists
• Member of the European Society of Cardiology and Heart Rhythm Association
• Coordinated the Implantable Defibrillator team for Spanish Cardiology Society

Eslie Perez leads teaching at Puerto Vallarta Regional Hospital, bringing expertise from diverse medical roles.

• Head of Teaching at Puerto Vallarta Regional Hospital
• General practitioner in private medical office for 7 years
• Specialized in weight control clinic management
• Certified in biomagnetism by Higher Institute of Biomagnetism
• Skilled in various cosmetic and dermatological procedures

Dr. Yilmaz specializes in coronary bypass surgery and TAVI procedures at Istanbul Florence Nightingale Hospital.

• Over 20 years of experience in cardiovascular surgery
• Professorship at Istanbul Arel University
• Trained at Florence Nightingale Hospital/Kadir Has University
• Specializes in complex heart valve diseases and aortic aneurysms

Dr. Castriota specializes in coronary interventions, with extensive experience in endovascular techniques and brain protection during TAVI procedures.

• Graduated from the University of Milan and specialized in Cardiology and Radiology
• Fellow at the Arizona Heart Institute under Professor Diethrich
• Principal investigator of the Protected TAVR study
• Author of 150+ full-length publications and 20+ book chapters
• Member of multiple prestigious scientific societies including EAPCI and FESC

Prof. Savini specializes in minimally invasive surgery for coronary artery disease – trained at top European cardiac centers like Vall d'Hebron and St. Antonius hospitals.

• Over 25 years of experience in cardiac surgery
• Associate Professor at University of Bologna – trains next-generation surgeons
• Published research on aortic valve repair and coronary disease
• Member of EACTS and ISMICS – leading cardiac surgery societies

Senior Medical Director at American Clinic, Demarest, with extensive leadership in healthcare management and innovation.

• CEO of Imperium Bio@Capital with 3+ years in healthcare strategy
• General Director of R&D Company focusing on endovascular technologies
• Chief Physician at Hadassah Medical Moscow, Skolkovo

Dr. Altin trained at Cleveland Clinic, a global leader in interventional cardiology. He specializes in advanced treatments for coronary artery disease at Medicalpoint International Hospital.

• Expert in balloon stent and stent applications for aortic aneurysms
• Performs Mitraclip and Triclip procedures for valve diseases
• Member of European Society of Cardiology and European Association of Cardiovascular Imaging

Dr. Topaloglu specializes in invasive cardiology with a focus on coronary artery interventions at Medicalpoint International Hospital.

• Performs balloon angioplasty and stent implantation
• Skilled in permanent cardiac pacemaker implantation
• Member of the European Society of Cardiology
• Treats heart attack, heart failure, and rhythm disorders

Dr. Koç trained at Cleveland Clinic, a leading heart center in the US, focusing on invasive cardiology.

• Specialized at Selçuk University Meram Faculty of Medicine
• Worked at Akdeniz University's Cardiology Department
• Experienced in complex coronary interventions

Professor Riza Turkoz brings over 30 years of cardiology expertise, specializing in coronary artery disease at Acibadem Bakirkoy Hospital.

• Professor at Acibadem Bakirkoy Hospital – a leading cardiac center
• Extensive experience in interventional cardiology procedures
• Former faculty member at multiple prestigious Turkish universities
• Specialized training from Ege University and Izmir Ataturk Hospital

Over 20 years of cardiology expertise – Dr. Bandrina specializes in emergency and diagnostic cardiology at Dobrobut Clinic.

• Skilled in Doppler ultrasound and echocardiography
• Advanced certification in cardiology with highest qualification
• Extensive background in ICU and emergency care
• Trained at Strazhesko and Amosov Institutes

Prof. Dr. Deniz Suha Kucukaksu pioneered mechanical circulatory support and artificial heart programs in Turkey, with 35+ years in cardiovascular surgery.

• Director of Heart Transplantation and Artificial Heart Center at Başkent University Istanbul Hospital
• Specializes in coronary bypass (off-pump), valve replacements, and aortic repair
• Trained in LVAD systems and heart failure surgery in Germany, France, and the US
• Established heart transplant centers at multiple institutions
• Active contributor to total artificial heart surgery development

Professor Ertas specializes in coronary artery disease at Liv Hospital Ulus, bringing extensive expertise in complex cardiac interventions.

• Over 14 years of experience in cardiology
• Expert in percutaneous valve interventions like TAVI and MitraClip
• Trained at Thorax Center, Erasmus MC in Rotterdam
• Board-certified cardiologist with a focus on ischemic heart disease