Autologous Stem Cell Transplantation (Autologous Bone Marrow Transplantation)for Pediatric DLBCL (Diffuse Large B-Cell Lymphoma) at Sheba Medical Center- JCI accredited and Top-10 Hospitals 2026 by Newsweek
What's included in this package
Medical Procedures
- Consultation with a hematologist
- Sentinel lymph node biopsy
- Сonsultation with an oncohematologist
- Comprehensive diagnosis of lymphomas
- Lymphoma blood test
- Bone marrow puncture with cytogenetic analysis
- Bone marrow transplantation
- Autologous bone marrow transplantation
- Allogenic bone marrow transplantation from an unrelated donor
- Allogenic bone marrow transplantation from a related donor
- 3 meals per day by nutritionist
- 24-hr nurse services
- Electrocardiogram (ECG)
- Blood tests
- Chest X-ray
- Anti-HIV test
- Anti-HBC test
- Anti-HCVAb test
- Echocardiography
- Complete blood count (CBC)
- Biochemistry blood test
- PET/CT
- Consultation with an immunologist
- Consultation with a cardiologist
- Consultation with a pediatric hematologist
- Consultation with a pediatrician
- Сonsultation with an oncohematologist
- Head MRI
- Biopsy
- Complete blood count with cancer markers and a proteinogram
Duration
- 30 days in the hospital
Accommodation
Hospitalization
Transport
Transfer airport-clinic-airport
Additional information
Autologous Stem Cell Transplantation (Autologous Bone Marrow Transplantation)for Pediatric DLBCL (Diffuse Large B-Cell Lymphoma) at Sheba Medical Center – Advanced, Personalized Transplant Care for Children At Sheba Medical Center, we understand that a diagnosis of DLBCL (Diffuse Large B-Cell Lymphoma) in a child or adolescent is a deeply emotional experience for the entire family. While many children with DLBCL (Diffuse Large B-Cell Lymphoma) respond successfully to standard treatments such as chemotherapy and radiotherapy, some cases require more advanced therapy. For children with relapsed, refractory, or high-risk disease, Autologous Stem Cell Transplantation (ASCT) is a highly effective and well-established treatment approach that can help achieve long-term remission. Our pediatric transplant program combines global expertise, advanced medical technology, and compassionate, family-centered care to support children and families throughout every stage of treatment and recovery. The Role of Autologous Stem Cell Transplantation in Pediatric DLBCL (Diffuse Large B-Cell Lymphoma) Autologous Stem Cell Transplantation uses the child’s own healthy stem cells to restore bone marrow function after intensive chemotherapy. This approach plays a central role in treating: Relapsed DLBCL (Diffuse Large B-Cell Lymphoma) When DLBCL (Diffuse Large B-Cell Lymphoma) returns after initial treatment, ASCT may help achieve deeper disease control and improve long-term outcomes. Refractory Disease For children whose lymphoma does not respond adequately to standard therapy, high-dose chemotherapy followed by stem cell rescue offers a more intensive and effective treatment strategy. High-Risk Disease In selected high-risk cases, ASCT may be recommended as consolidation therapy to strengthen treatment response and reduce the risk of recurrence. How the Treatment Works Stem Cell Collection Before high-dose chemotherapy begins, healthy stem cells are collected from the child’s bloodstream and safely preserved. High-Dose Chemotherapy Children then receive intensive chemotherapy designed to eliminate remaining lymphoma cells throughout the body. Stem Cell Rescue After chemotherapy, the child’s own stem cells are reinfused to restore bone marrow function and support immune system recovery. This process allows doctors to deliver highly effective treatment while helping the body rebuild healthy blood-forming cells. Donor Options – Always a Solution Available Although most children with DLBCL (Diffuse Large B-Cell Lymphoma) undergo autologous transplantation using their own stem cells, some complex cases may require an allogeneic (donor) transplant. If a donor-based approach is needed, Sheba Medical Center provides access to multiple donor options: Matched family donors, when available Matched unrelated donors through international registries Haploidentical (half-matched) family donors Cord blood transplantation Using advanced matching technologies and global donor access, our team works to ensure that every child can receive the most suitable transplant option, even when a family match is not available. Advanced Pediatric Transplant Care Children undergoing transplantation at Sheba are treated in dedicated pediatric transplant units designed specifically for young patients and their families. Care includes: Highly protected, child-friendly environments Advanced infection prevention systems Pediatric-specific chemotherapy and transplant protocols Continuous monitoring by experienced pediatric oncology and transplant teams Every aspect of care is adapted to the physical and emotional needs of children. Precision, Safety, and Support Sheba Medical Center utilizes advanced laboratory technology and highly specialized transplant protocols to optimize safety and treatment effectiveness. Our multidisciplinary teams provide comprehensive supportive care throughout every stage of transplantation and recovery. Clinical Expertise in Pediatric Hodgkin Lymphoma Sheba Medical Center is a leading center for pediatric hematologic malignancies, offering: Extensive experience in relapsed and refractory DLBCL (Diffuse Large B-Cell Lymphoma) Expertise in Autologous Stem Cell Transplantation High success rates with advanced transplant protocols Long-term follow-up focused on growth, development, and quality of life Our treatment strategies are continuously refined according to the latest international research and clinical advances. Care That Supports the Whole Family We recognize that treating a child means supporting the entire family. At Sheba, families are cared for by a multidisciplinary pediatric team including oncologists, transplant specialists, nurses, psychologists, social workers, and care coordinators. From diagnosis through recovery, families receive clear communication, emotional support, and continuous guidance every step of the way. Why Families Choose Sheba for Pediatric ASCT Leading center for pediatric transplantation in lymphoma Strong expertise in relapsed and refractory DLBCL (Diffuse Large B-Cell Lymphoma) Advanced autologous transplant protocols Ability to secure suitable donors when needed Safe, supportive, child-centered care environment Dedicated international patient coordination services A Message of Hope At Sheba Medical Center, we combine advanced medical science with compassionate pediatric care. Through innovative approaches like Autologous Stem Cell Transplantation, we strive to provide children with DLBCL (Diffuse Large B-Cell Lymphoma) the strongest possible chance for recovery, while supporting families with confidence, care, and hope throughout the entire journey.
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- Patient advocacy during medical travel
Program price
What's NOT included in this package
Doctor
Prof. Amos Toren, MD, PhD, MHA, is a pediatric hemato-oncologist and BMT specialist. He served as Director of Pediatric Hemato-Oncology and BMT at Sheba Medical Center.
He is board certified in Pediatrics, Pediatric Hemato-Oncology, and Bone Marrow Transplantation. He holds a PhD in Human Genetics. He was Head of the Hematology Division at Tel Aviv University for two terms. He is a member of ASH, COG, ESPHI, EBMT, and CIBMTR. He also serves on the Ministry of Health Cord Blood Committee.
He led one of Israel’s most advanced pediatric oncology and BMT programs. The program treated children and young adults. His focus includes leukemia and lymphoma, immunodeficiencies, and rare cancers. He specializes in BMT and CAR T-cell therapy.
His translational research covers CAR T cells, cytokine-induced killer cells, pediatric brain tumors, and targeted therapies. He has worked with St. Anna, the NIH, and St. Jude. His publications include studies on pediatric SCT prophylaxis and PARP resistance.
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About the clinic
Sheba Medical Center is the largest hospital in the Middle East and one of the world’s leading medical institutions, consistently ranked among the global Top 10. Recognized by Newsweek and Statista for eight consecutive years, it ranked 7th worldwide in 2026. The hospital delivers comprehensive multidisciplinary care across all major specialties, including oncology, hematology, cardiology, neurology, and advanced surgery, treating over 2 million patients annually, including international cases. With more than 200 physicians listed among Forbes' Top Doctors, Sheba is a global leader in CAR-T and TIL immunotherapies, precision medicine, and minimally invasive surgery, making it a trusted destination for complex and advanced treatment.
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