Bone Marrow Transplant for Pediatric Non-Hodgkin Lymphoma (DLBCL, FL, MCL)
What's included in this package
Medical Procedures
- Bone marrow puncture with cytogenetic analysis
- Consultation with a hematologist
- Comprehensive diagnosis of lymphomas
- Lymphoma blood test
- Sentinel lymph node biopsy
- Сonsultation with an oncohematologist
- Autologous bone marrow transplantation
- Allogenic bone marrow transplantation from an unrelated donor
- Allogenic bone marrow transplantation from a related donor
- Bone marrow transplantation
- Anti-HIV test
- Anti-HBC test
- Anti-HCVAb test
- Blood tests
- Biochemistry blood test
- Biopsy
- Chest X-ray
- Complete blood count (CBC)
- Consultation with an immunologist
- Consultation with a cardiologist
- Consultation with a pediatric hematologist
- Consultation with a pediatrician
- Complete blood count with cancer markers and a proteinogram
- Electrocardiogram (ECG)
- Echocardiography
- Head MRI
- PET/CT
- Сonsultation with an oncohematologist
- 24-hr nurse services
- 3 meals per day by nutritionist
Duration
- 30 days in the hospital
Accommodation
Hospitalization
Transport
Transfer airport-clinic-airport
Additional information
Bone Marrow Transplant for Pediatric Non-Hodgkin Lymphoma
(DLBCL, FL, MCL)
Sheba Medical Center – Advanced, Personalized Transplant Care for Children
At Sheba Medical Center, we understand that a diagnosis of Non-Hodgkin Lymphoma (NHL) in a child, including Diffuse Large B-Cell Lymphoma (DLBCL), Follicular Lymphoma (FL), and Mantle Cell Lymphoma (MCL) is life-changing for the entire family.
When standard treatments are not enough, bone marrow transplantation (BMT) may offer a powerful and potentially curative option for children and adolescents.
Our pediatric transplant program combines world-class medical expertise, advanced technology, and a family-centered approach designed to support both the child and their loved ones throughout the entire journey.
When is a Bone Marrow Transplant Needed?
In pediatric NHL, a bone marrow transplant may be recommended when:
The lymphoma returns after initial treatment (relapsed disease)
The disease does not respond fully to standard therapies (refractory disease)
A more intensive treatment is needed to achieve long-term remission
The goal of BMT is to replace the affected bone marrow with healthy stem cells, allowing the child’s body to rebuild a new, healthy immune system capable of fighting the disease.
Types of Transplant
At Sheba, each child receives a personalized treatment plan based on their condition and medical needs:
Autologous Transplant (Child’s Own Cells)
Most commonly used in pediatric relapsed lymphoma, this approach uses the child’s own stem cells. They are collected, safely stored, and returned after high-dose therapy.
Allogeneic Transplant (Donor Cells)
Used in selected high-risk cases, this approach uses stem cells from a donor to build a new immune system that can also help fight lymphoma.
Finding the Right Donor
A suitable donor is a key part of successful treatment.
Whenever possible, a matched family donor (such as a sibling) is preferred. If this is not available, Sheba Medical Center works to identify the best possible alternative:
Matched unrelated donors from international registries
Haploidentical (half-matched) family donors
Cord blood units
Advanced laboratory testing ensures precise matching to improve safety and outcomes for children.
Specialized Pediatric Transplant Care
Children undergoing BMT at Sheba are treated in dedicated pediatric transplant units designed specifically for young patients. Care includes:
Child-friendly, highly protected environments
Advanced infection prevention systems
Individualized treatment protocols for pediatric lymphoma
Continuous monitoring by pediatric transplant specialists
Our approach is carefully adapted to the needs of growing children.
Clinical Expertise in Children
Sheba is one of the leading centers for pediatric bone marrow transplantation, offering:
Extensive experience in treating childhood NHL, including complex and high-risk cases
High success rates in autologous and selected allogeneic transplants
Long-term follow-up focused on healthy growth, development, and quality of life
Care That Supports the Whole Family
A pediatric bone marrow transplant is not only a medical procedure - it is a journey for the entire family.
At Sheba Medical Center, children are supported by a multidisciplinary team including pediatric oncologists, transplant specialists, nurses, psychologists, and social workers.
Families are guided through every stage, from diagnosis and preparation to transplant, recovery, and long-term follow-up.
Why Families Choose Sheba for Pediatric BMT
One of the leading pediatric transplant centers in the region
Expertise in pediatric DLBCL, FL, and MCL
Ability to identify optimal donors, even without a sibling match
Advanced transplant techniques tailored for children
Strong focus on safety, comfort, and emotional support
Dedicated international pediatric care coordination
A Message of Hope
At Sheba Medical Center, we combine advanced medical science with compassionate pediatric care. Our goal is to give every child the best possible chance for recovery, while supporting families with strength, clarity, and hope throughout the entire journey.
24/7 Bookimed assistance
- Personal medical coordinator
- Medical travel arrangements — booking of air tickets and hotel rooms at special partner prices
- Patient advocacy during medical travel
Program price
What's NOT included in this package
Doctor
Prof. Amos Toren, MD, PhD, MHA, is a pediatric hemato-oncologist and BMT specialist. He served as Director of Pediatric Hemato-Oncology and BMT at Sheba Medical Center.
He is board certified in Pediatrics, Pediatric Hemato-Oncology, and Bone Marrow Transplantation. He holds a PhD in Human Genetics. He was Head of the Hematology Division at Tel Aviv University for two terms. He is a member of ASH, COG, ESPHI, EBMT, and CIBMTR. He also serves on the Ministry of Health Cord Blood Committee.
He led one of Israel’s most advanced pediatric oncology and BMT programs. The program treated children and young adults. His focus includes leukemia and lymphoma, immunodeficiencies, and rare cancers. He specializes in BMT and CAR T-cell therapy.
His translational research covers CAR T cells, cytokine-induced killer cells, pediatric brain tumors, and targeted therapies. He has worked with St. Anna, the NIH, and St. Jude. His publications include studies on pediatric SCT prophylaxis and PARP resistance.
How are we doing?
About the clinic
Sheba Medical Center, Israel’s leading hospital, is consistently ranked among the world’s top institutions. Treating over 2 million patients annually, Sheba combines world-class expertise with compassionate, personalized care. Its “City of Health” campus integrates six specialized hospitals, offering advanced treatments in oncology, neurology, cardiology, orthopedics, and more. Sheba is a global leader in CAR-T and TIL immunotherapies, precision medicine, and minimally invasive surgery, making it a trusted destination for international patients seeking cutting-edge healthcare.
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