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How Much Does Targeted therapy Cost in Italy?

Targeted therapy in Italy costs from $4,500 to $9,000 on average. Prices change based on the drug type, cancer stage, and city. In the US, similar procedures cost around $14,500 on average. Patients can find savings of around 53% compared to US prices. The cost usually includes the initial oncologist consultation and the medication administration.

  • Lutetium-177 therapy: $9,500 to $14,500 for advanced prostate cancer or neuroendocrine tumors.
  • Actinium-225 therapy: $18,000 to $30,000 for targeted alpha-radionuclide treatment.
  • Oncothermia: $3,600 to $6,000 as a complementary hyperthermia treatment.
  • Monoclonal antibodies: Typically cost 20-40% less in Italian private clinics than in US centers.

Bookimed Expert Insight: Milan serves as Italy's primary hub for oncology. San Raffaele Hospital acts as a major research center. It is accredited by the Italian Ministry of Health (IRCCS). They pioneered the world's first stem cell therapy for ADA-SCID. Choosing Milan-based centers provides access to clinical trials. These trials can significantly reduce out-of-pocket costs for advanced therapies.

Key Benefits

Why choose Italy for targeted therapy?

  • Accredited clinics: JCI-certified hospitals offer top-quality care and adhere to international standards.
  • Latest technologies: Italy employs cutting-edge techniques, including CAR T-cell therapy and molecular diagnostics. Leading brands like Roche and Novartis provide innovative solutions.
  • High success rates: Targeted therapies in Italy have an efficacy rate of 75-85% for various cancer types. This significantly improves patient outcomes.
  • Expert surgeons: Renowned oncologists and hematologists, certified by the European Society for Medical Oncology (ESMO), have conducted over 5,000 targeted therapy cases. This showcases their extensive experience and expertise.

Access advanced Targeted therapy solutions in trusted clinics from $4,500.

ItalyTurkeyAustria
Targeted therapy≈ $4,500from $3,000≈ $9,000
Oncothermia≈ $3,600≈ $2,400≈ $2,400
Lutetium-177 therapy≈ $9,500from $6,500≈ $35,000
Actinium-225 Therapy≈ $18,000from $23,000≈ $55,000
Data verified by Bookimed as of October 2026, based on patient requests and official quotes from 82 clinics worldwide. Median costs are based on real invoices (2025–2026) and updated monthly. Actual prices may vary.

Your Benefits and Guarantees with Bookimed

Transparent Prices & Flexible Installments

No hidden fees – just official clinic prices. Pay at the clinic for Targeted therapy upon arrival and use a flexible installment plan if needed.

Verified Clinics & Doctors Only

Bookimed is committed to your safety. We only work with medical institutions that maintain high international standards in Targeted therapy and have the necessary licenses to serve international patients worldwide.

Free 24/7 Assistance

Bookimed offers free expert assistance. A personal medical coordinator supports you before, during, and after your treatment, solving any issues. You're never alone on your Targeted therapy journey.

Why we?

Your personal Bookimed medical coordinator

  • Supports you at every stage
  • Helps choose the right clinic and doctor
  • Ensures quick and convenient access to information

Discover the Best Targeted therapy Clinics in Italy: 1 Verified Option and Prices

The Bookimed clinic ranking is based on data science algorithms, providing a trusted, transparent, and objective comparison. It takes into account patient demand, review scores (both positive and negative), the frequency of updates to treatment options and prices, response speed, and clinic certifications.

Targeted therapy Overview in Italy

Takeaways
How it works
What to expect
Benefits
Payment
patients recommend -
85%
Surgery Time - 4 hours
Stay in the country - 2 days
Rehabilitation - 1 day
Anesthesia - Local anesthesia
Requests processed - 46119
Verified patient reviews - 20
Bookimed fees - $0

Our Doctors

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verified

Fabio Ciceri

36 years of experience

Dr. Fabio Ciceri heads the Hematology and Bone Marrow Transplantation Unit at San Raffaele Research Hospital. He is a primary investigator in clinical trials for cell and gene therapies. These trials treat hematological cancers, immune deficiencies, and neuromuscular disorders. Dr. Ciceri works at San Raffaele, the hospital that achieved the world's first stem cell therapy for ADA-SCID.

  • Performs allogeneic and autologous bone marrow transplants and CAR T-cell therapy.
  • Authored over 180 scientific papers on hematology and oncology.
  • Is a member of the European Hematology Association and the International Cardio-Oncology Society.
  • Treats complex blood conditions including leukemia, lymphoma, and myeloma.

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Reviews about Bookimed: Discover Patients' Insights

All reviews
Larisa • Consultation with a mammologist
Italy
Apr 17, 2026
Verified review.
I am now completely confident that I can get the advice I need in my own language at any time!!!!
What I feared most was feeling lost and unheard when I decided to seek a consultation in another country. But that fear vanished as soon as I got in touch with Bookingmed, specifically with Yulia. She looked through my preliminary test results, listened to my concerns and found a suitable clinic quite quickly; then we set a date and that was it! The only inconvenience was that I live near Rome, but the appointment was in Milan – though that wasn’t a problem for me! I was met at the clinic by an interpreter, who was also the coordinator, so I didn’t have to queue or wait around (YAY!!) The doctor answered all my questions patiently and without rushing. Fortunately, my fears turned out to be overblown. The entire process, from my initial enquiry right through to the appointment itself, was well organised. Everything simply worked out. I am now completely confident that I can get the advice I need in my own language at any time!!!! Thank you so much!!!
I was very impressed by how efficient and well-organised the whole process was
As my 'case' was very small, there was nothing to improve – everything was just right!
Anonymous • Biopsy
Feb 25, 2019
Verified review.
"Just returned from there
Just returned from there. Everything was top notch, and doctors, and the organization of the stay. It took 2 days from the first call to the bookmarked to my arrival in Milan. The next morning, consult a doctor. All questions were solved almost instantly, the results of all analyzes and studies were ready the next day. And constantly in touch with the coordinator Catherine and care worker Alexander. In my trips to the clinic, I was accompanied by a super translator Yulya Sukhneva. Thanks to the clear and professional work of Julia, Kati and Alexander, my stay was very short, I saved money on the hotel. The hotel, by the way, was excellent, up to the clinic, 200 meters. Yes, and more, the prices for consultations and analyzes are quite comparable with those in Moscow. I spent much less money than I thought at first. Thank you all!
Евгения • Stomach cancer surgery
Italy
Nov 7, 2018
Verified review.
"I declare with all responsibility that the San Rafael clinic in Milan is the best
The professionalism of the doctors, the newest equipment, the care of the clinic staff are among the best in Europe. The treatment and operations in Russia and Germany have been carried out, I declare with all responsibility that the San Rafael clinic in Milan is the best. After treating my father’s stomach cancer, I visited the neurologist and gastroenterologist and myself. Thank you so much to the coordinator, the doctors from the international department of the clinic. More in the world of such doctors. THANK YOU!
Shakiha • Meningioma
Aug 27, 2021
Verified review.
بصراحة أود شكر الفريق الطبي باكمله في مستشفى سان رفائييل قسم جراحة المخ والاعصاب بقيادة الخبير البروفيسور دكتور مورتيني شكر هو من أعماق قلبي على عدة امور : مستشفى في قمة الدقة والاتقان والتنظيم وفريق طبي متميز اضافة الى ان هذا الدكتور من التواضع والخبرة والاسلوب الراقي لا اجد الكلمات المعبرة لشكره والثناء عليه هو وفريقه المساعد من الجراحين وطبيبة التخدير ووالى اصغر موظف وعامل في هذا المستشفى الانساني واتمنى لهم التوفيق والنجاح في انقاذ ارواح الناس وعلاجهم وشفائهم
About Bookimed service
راضي عن هذه المنصة والدعم تمام الرضا وان شاء الله انصح جميع الذين يعانون من اي مرض يستطيع هذا المستشفى او المنصة تقديم المساعدة لهبالتواصل معهم على الفور واشكر دكتور يونس على اسلوبه الراقي ودعمه اللامحدود
Anonymous • Consultation with an oncologist
Ukraine
Jun 29, 2022
Verified review.
- We were confirmed the same diagnosis that we received in Ukraine
We were confirmed the same diagnosis that we received in Ukraine. It was decided to continue treatment in Ukraine.
About Bookimed service
So
HALYNA NIKOLAIEVA • Melanoma
Ukraine
Jun 10, 2019
Verified review.
Thanks her
The doctor caused confidence and showed high professionalism, understood all the details and documents. She appointed the newest treatment. Satisfied with the service, Katerina Bonko was constantly in touch, showed attention and care. Thanks her.
About Bookimed service
I am satisfied with the service, Katerina Bonko was constantly in touch, showed attention and care. Thanks her.
Anonymous • Consultation with an oncologist
Italy
Jan 22, 2022
Verified review.
I would not hesitate to recommend Bookimed for enabling to have the required treatment
The Hospital handled my appointment and the paperwork promptly and efficiently. My outpatient contact with the Consultant was very professional. I would not hesitate to recommend Bookimed for enabling to have the required treatment.
About Bookimed service
Yes
Anonymous • Consultation with an oncologist
Jan 2, 2020
Verified review.
We received a remote consultation at the San Rafael Clinic, for us this format was not suitable, because the second opinion is for those who either confirm the diagnosis or ask for another alternative treatment, we were told that after the consultation, continue the same, although we were treated and there was no result, as a result, after a remote consultation, we were not assigned anything, plus all communication was extended for a couple of months, because the clinic’s response rate was very low. We could not get any concrete answer, so this consultation was useless for us.

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Updated: 10/03/2026
Authored by
Anna Leonova
Anna Leonova
Head of Content Marketing Team
A certified medical writer with 10+ years of experience, developed Bookimed’s trusted content, backed by a Master’s in Philology and medical expert interviews worldwide.
Fahad Mawlood
Medical Editor & Data Scientist
General practitioner. Winner of 4 scientific awards. Served in Western Asia. Former Team Leader of a medical team supporting Arabic-speaking patients. Now responsible for data processing and medical content accuracy.
Fahad Mawlood Linkedin
This page may feature information relating to various medical conditions, treatments, and healthcare services available in different countries. Please be advised that the content is provided for informational purposes only and should not be construed as medical advice or guidance. Please consult with your doctor or a qualified medical professional before starting or changing medical treatment.

Our Targeted therapy Techniques: What Suits You Best?

When considering Targeted therapy, it’s important to understand the different techniques and which is best suited for you. Here’s a concise comparison of popular options:

Lutetium-177 therapy

Lutetium-177 therapy is a targeted radiotherapy utilizing the Lutetium-177 radioisotope to treat certain cancers effectively.

Pros: Offers a high degree of precision, minimizing damage to healthy tissues. Demonstrates a favorable response rate in 60% of patients with neuroendocrine tumors.
Cons: Not suitable for all cancer types. Requires rigorous patient selection and monitoring due to potential kidney toxicity.
Effectiveness: Achieves 30-40% reduction in tumor size for responsive patients.
Duration: 1-2 hours per session.
Recovery: Initial recovery period of 1-2 days, with full recovery taking a few weeks.
Best for: Neuroendocrine tumors and prostate cancer with specific receptor expression.

FAQ about Targeted therapy in Italy

These FAQs come from real patients seeking medical assistance through Bookimed. Answers are given by experienced medical coordinators and trusted clinic representatives.

What is the process for genetic or molecular profiling before starting targeted therapy in Italy?

Genetic profiling in Italy involves a structured pathway where oncologists use next-generation sequencing (NGS) to identify actionable mutations. Pathologists obtain tumor tissue or liquid biopsies for analysis in accredited labs. A multidisciplinary molecular tumor board then reviews the results to match patients with personalized therapies or clinical trials.

  • Biopsy sampling: Pathologists collect tumor tissue or use liquid biopsies for blood-based DNA testing.
  • Genomic testing: Labs use next-generation sequencing (NGS) to identify specific mutations, translocations, or alterations.
  • Tumor board review: Specialists including geneticists and bioinformaticians interpret results to recommend personalized treatments.
  • Therapy matching: Doctors prescribe drugs aligned with Italian Medicines Agency (AIFA) standards or trial protocols.

Bookimed Expert Insight: Research centers like San Raffaele in Milan combine clinical care with active research. This allows patients to access advanced diagnostic tools like PET-MRI alongside standard molecular profiling. Facilities treating 12,000 cancer patients annually often provide faster access to broad biomarker panels than smaller regional hospitals.

Patient Consensus: Patients emphasize the importance of confirming turnaround times for molecular results before starting treatment. Most advise clarifying whether a test covers all driver mutations to avoid delays in finding the right drug.

How is targeted cancer therapy regulated and approved in Italy?

Targeted cancer therapy in Italy requires European Medicines Agency (EMA) authorization followed by Italian Medicines Agency (AIFA) reimbursement approval. Italy uses digital registries and Health Technology Assessment (HTA) to monitor drug efficacy. Public access depends on biomarker testing and inclusion in the Servizio Sanitario Nazionale (SSN) system.

  • EMA authorization: Grants legal marketing rights across all European Union member states including Italy.
  • AIFA assessment: Negotiates drug pricing and therapeutic value for public healthcare system reimbursement.
  • Digital registries: Tracks real-world effectiveness and genetic diagnostic data for every treated patient.
  • Early access: Law 648/1996 allows reimbursement for innovative drugs before formal national marketing.

Bookimed Expert Insight: Speed of access depends on facility volume rather than just regulation. Large centers like San Raffaele in Milan treat 12,000 cancer patients annually. These institutions often provide faster access to second opinions and complex molecular testing. This infrastructure helps patients bypass administrative delays found in smaller regional clinics.

Patient Consensus: Access to treatment relies heavily on public health system enrollment and residency status. Verifying if a specific drug is already AIFA-reimbursed is essential before starting the clinical evaluation process.

Are targeted therapies covered by the Italian National Health Service (SSN)?

Targeted therapies are fully covered by the Italian National Health Service (SSN) for eligible patients. The Italian Medicines Agency (AIFA) evaluates these drugs for safety and efficacy. Approved medicines fall under reimbursement categories Fascia A or Fascia H, meaning the public system covers 100% of the drug cost.

  • Approval body: The Italian Medicines Agency (AIFA) regulates all reimbursed molecular-targeted agents.
  • Reimbursement status: Eligible patients receive medications at no cost through hospital or local pharmacies.
  • Diagnostic testing: Biomarker and genomic profiling are increasingly integrated into the public healthcare framework.
  • Access pathway: Coverage requires validation from a public specialist within the regional health system.

Bookimed Expert Insight: While public coverage is extensive, patients at centers like San Raffaele often use private consultations to speed up initial diagnosis. This clinic treats 12,000 cancer patients annually and uses advanced PET-MRI for precise molecular staging. Starting privately allows faster access to the public reimbursement pathway once the diagnosis is confirmed.

Patient Consensus: Patients note that the public system is financially generous but involves slow bureaucratic hurdles. To avoid delays, individuals often pay for private assessments before transitioning to public coverage for long-term drug administration.

Where are the main centers of excellence for targeted therapy and oncology in Italy?

Italy hosts globally recognized IRCCS Scientific Institutes for oncology, centering on precision medicine and molecular profiling. Key hubs include Milan's San Raffaele and Istituto Europeo di Oncologia, Rome's Regina Elena, and Naples' Fondazione Pascale. These centers lead in radioligand and molecular targeted therapies within JCI and Newsweek-ranked facilities.

  • Milan cluster: San Raffaele treats 12,000 cancer patients annually using PET-MRI and molecular diagnostics.
  • Southern flagship: Fondazione Pascale in Naples provides major access to immunotherapy and targeted protocols.
  • Northern hubs: Istituto Oncologico Veneto in Padua excels in matching genetic alterations with therapy.
  • Advanced diagnostics: San Raffaele utilizes Gamma Knife and Cyber Knife for precise tumor targeting.

Bookimed Expert Insight: Milan serves as the primary gateway for international oncology patients. San Raffaele alone handles 300,000 patients yearly and has completed over 1,000 bone marrow transplants. For complex cases, choosing a Milan-based IRCCS facility ensures access to the highest concentration of subspecialists and robotic technologies like the da Vinci system.

Patient Consensus: Patients recommend matching the facility to your specific tumor type rather than just general hospital reputation. Those seeking care in Milan or Rome emphasize asking clinics directly about molecular profiling availability before traveling.

Can international or non-resident patients receive targeted therapy in Italy?

International and non-resident patients can receive targeted therapy in Italy through the private healthcare sector or specialized international departments at major oncology centers. Access typically requires molecular profiling, previous pathology records, and an oncological evaluation at an IRCCS (Institutes for Scientific Research, Hospitalization and Health Care) facility.

  • System access: Private clinics offer the fastest path for non-residents and international medical tourists.
  • EU patients: European citizens can use the EHIC for urgent care or S2 forms.
  • Diagnostic testing: Next-generation sequencing is required to match medications to specific tumor genetic mutations.
  • Required documents: Patients must provide translated medical histories, pathology reports, and tissue blocks or slides.

Bookimed Expert Insight: Milan serves as a primary hub for complex oncology due to high-capacity centers like San Raffaele. This facility alone treats 12,000 cancer patients annually and holds IRCCS accreditation. For patients seeking radio-ligand subtypes, Lutetium-177 therapy costs significantly less than Actinium-225 treatments in Italian clinics.

Patient Consensus: Short-term visitors often face delays in the public system and should choose private routes for faster specialist access. Successful treatment depends on having all diagnostic records translated and confirming that the clinic provides English-speaking staff.

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