Dr. Irina Stepfansky is an oncologist and internal medicine specialist at Sourasky Medical Center. She has more than 25 years of clinical experience. Since 2015, she has directed the Oncology Hospitalization department. Dr. Stepfansky earned her medical degree from Grodno University in Belarus. She completed advanced oncology training at Tel Aviv Medical Center.
Dr. Stepfansky has been licensed in Israel since 2000. She has led and participated in many phase I-III oncology clinical trials. Her work has helped improve cancer care and patient outcomes. She is recognized for her expertise in both internal medicine and oncology. Dr. Stepfansky has a strong record in research and clinical leadership.
Dr. Viola Fox is the Chief Physician at the Clinic for Haematology, Oncology, and Palliative Medicine at BKZ Solingen. This clinic is a certified interdisciplinary cancer center. Dr. Fox is a leading expert in drug therapy for tumor diseases in Germany and Europe. She has more than 15 years of experience in this field.
She is a member of the German Society of Oncology and Haemato-oncology (GDHO), the German Association of Physicians, and the American Association for Cancer Research. Dr. Fox is also active in molecular biology research. Her work supports progress in cancer treatment and molecular diagnostics.
Her main areas of expertise are chemotherapy, immunotherapy, targeted therapy, and radiation therapy. Dr. Fox is known for her innovative methods and strong commitment to patient care. Her efforts have led to high recovery rates and recognition from her peers.
Dr. Séverine Iborra is the Chief Physician of the Department of Gynecology and Obstetrics at Städtisches Klinikum Solingen. Her responsibilities include obstetrics, the delivery room, the neonatal unit, and gynecology. The department also includes the Senology/Breast Clinic at the Bergisches Breast Center Solingen, led by Dr. Manuela Seifert.
Dr. Séverine Iborra is originally from France. She began her medical studies at the University of Lyon and later transferred to Albert-Ludwigs University in Freiburg, where she received her medical license in 2007. She earned her doctorate in 2008 for experimental research in molecular oncology. From August 2008 to November 2013, Dr. Iborra worked as a resident at the University Women’s Clinic in Freiburg. After passing her specialist exams in gynecology and obstetrics, she continued her career as a specialist at the same clinic. In November 2015, she moved to RWTH University Hospital Aachen as a senior physician.
At the Clinic for Gynecology and Obstetrics, under the leadership of Prof. Dr. E. Stickeler, Dr. Iborra led the obstetrics department from 2017 to 2019. Since December 2017, she was responsible for organizing education in the department, and in October 2019, she became the Managing Senior Physician and Personnel Senior Physician of the clinic, a position she held until she moved to Solingen.
In addition to her scientific work, with numerous publications and presentations at major gynecological conferences, Dr. Iborra deepened her medical specialties. She obtained certifications in oncological diagnostics and therapy from the Gynecological Oncology Working Group, as well as additional qualifications in Cervical Pathology and Colposcopy (AGCPC), Urogynecology and Pelvic Reconstructive Surgery (AGUP), and the Professional Association of Gynecologists (BVF).
In 2019, Dr. Iborra successfully completed further specialization in “Gynecological Oncology” and “Special Obstetrics and Perinatal Medicine.” She is an active member of leading German medical societies in her field, including the German Society for Gynecology and Obstetrics, the Cervical Pathology and Colposcopy Working Group, and the German Society for Prenatal and Birth Medicine.
Treatments Offered in Our Gynecology Department
Whenever possible, we offer all procedures as minimally invasive treatments using laparoscopy or the Da Vinci robotic system.
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PROFESSIONAL EXPERIENCE
2011-2012
Erzurum Koprukoyu State Hospital
Department: General Medicine
2012-2017
Istanbul University Cerrahpaşa Medical Faculty
Department: Internal Medicine
06/2017-10/2017
Istanbul Gaziosmanpasa Taksim Training and Research Hospital
Department: Internal Medicine
10/2017-11/2018
Istanbul University Istanbul Medical Faculty
Department: Allergy and Immunology Fellowship
2018/2022
Istanbul University Oncology Institute
Department: Medical Oncology Fellowship
2022-2023
Tekirdag City Hospital
Department: Medical Oncology Specialist
2023-present
Istanbul Medipol University Medipol Bahcelievler Private Hospital
Department: Medical Oncology Assoc. Prof.
EDUCATION
2005-2011
Medical Education
Sivas Cumhuriyet University Medical Faculty, Sivas, Turkey
2012-2017
Internal Medicine
Istanbul University Cerrahpaşa Medical Faculty, Department of Internal Medicine, Istanbul, Turkey
2017-2018
Allergy-Immunology Fellowship
Istanbul University Istanbul Medical Faculty
Department of Internal Medicine, Division of Allergy and Immunology, Istanbul, Turkey
2018-2022
Medical Oncology Fellowship
Istanbul University Oncology Institute, Department of Medical Oncology, Istanbul, Turkey
2022
ESMO Board Certification in Medical Oncology
10th September 2022 in Paris, France.
2023
Medical Oncology Assoc. Prof.
Istanbul Medipol University Department of Medical Oncology, Istanbul, Turkey
INTERNATIONAL CLINICAL TRIALS:
1. Astefania - ROCHE
2. PFİZER
3. RECITE - AMGEN
4. NAVIGATE - BAYER
5. RUBY - Tesaro (PRA)
6. ENGOT-ov43/GOG-3036 - MSD
7. ASTRA ZENECA
8. ROSY-O - ASTRA ZENECA
INTERNATIONAL PUBLICATIONS
I. Published journal articles indexed by SCI, SSCI, and AHCI
Weekly Paclitaxel in Classic Kaposi Sarcoma
Carboplatin Desensitization in Ovarian Carcinoma
High-Dose Chemotherapy for Ewing’s Sarcoma
Multidrug Refractory TFE3(+) Renal Cell Carcinoma
Crizotinib Efficacy in NSCLC with MET Alterations
Clinicopathological Features in ALK Mutant NSCLC
PSMA-Based Tumor Burden in Prostate Cancer
Atezolizumab in Metastatic Urothelial Carcinoma
Pulmonary Sarcomatoid Carcinoma
Prognostic Factors in Atezolizumab-Treated Urothelial Carcinoma
Atezolizumab with Chemotherapy in Small Cell Lung Cancer
FOLFIRINOX vs. Gemcitabine + Nab-Paclitaxel in Pancreatic Cancer
Trastuzumab Emtansine in Older HER2-Positive Breast Cancer Patients
Real-Life Efficacy of Osimertinib in Advanced NSCLC
ALK-Positive Cells Percentage and Alectinib Efficacy
Real-World Data on Alectinib in ALK-Positive NSCLC
Prognostic Factors in Metastatic RCC with T790M Mutation
FLOT Regimen in Metastatic Gastric Cancer
Desensitization Protocol in Lenalidomide Hypersensitivity Reactions
Factors Associated with Diagnostic Skin Test Positivity in PPI Hypersensitivity
Efficacy of Capecitabine and Temozolomide in Neuroendocrine Tumors
Subsequent Treatments in Hormone-Positive Breast Cancer Progression
Termination of Trastuzumab in HER2-Positive Metastatic Breast Cancer
Long-term Outcomes and Predictors of Recurrence in Node-Negative Early Stage Breast Cancer
Prognostic Factors Influencing PFS in HER2-Positive Metastatic Breast Cancer
Treatment Efficacy of Ribociclib or Palbociclib plus Letrozole in Metastatic Breast Cancer
Efficacy and Safety of Sorafenib in Adult Metastatic Osteosarcoma Patients
Single-Agent Temozolomide as Salvage Therapy in Heavily Pretreated Metastatic Sarcoma Patients
Outcomes and Prognostic Factors in Metastatic Renal Cell Carcinoma with Brain Metastases
FLOT Regimen in First-Line Treatment of Metastatic Gastric Cancer
Prognostic Factors of Perioperative FLOT Regimen in Operable Gastric Cancer
Efficacy and Outcomes of Systemic Chemotherapy in Posttransplant Kaposi Sarcoma
Comparison of Second-Line Treatments in Metastatic Renal Cell Carcinoma
Toxicity Management and Effectiveness of Regorafenib in Advance GIST Patients: A Real-world Study - Authors: Paksoy, N., Ferhatoğlu, F., Doğan, İ., Khanmammadov, N., Bozbey, H. U., Karabulut, S., & Taştekin, D. - Journal: TURKISH JOURNAL OF ONCOLOGY, 1(1)
Demographic and Clinical Features and Factors Associated with Survival in Patients with Primary Glomerulonephritis: Single Tertiary Center Experience - Authors: Paksoy, N., Trabulus, S., Seyahi, N., & Altiparmak, M. R. - Journal: Namik Kemal Tip Dergisi, 11(1)
Efficacy of Sorafenib in Symptomatic Patients with Pretreated Progressive Desmoid Tumors - Authors: Paksoy, N., Ferhatoglu, F., Dogan, I., Ak, N., Pehlivan, M., Ekenel, M., & Basaran, M.
Nodal Response to Neoadjuvant Chemotherapy is a Better Predictive Factor of Survival Than Miller-Payne Scoring in Breast Cancer - Authors: Ak, Naziye, et al. - Journal: Journal of Oncological Sciences, 7.2: 42-49
Evaluation of Prognostic and Predictive Values of Hemogram Parameters in Patients with Advanced Stage Ovarian Carcinoma - Authors: Ak, Naziye, et al. - Journal: Turkish Journal of Oncology/Türk Onkoloji Dergisi, 2021, 36.4
Identifying Risk Factors Associated with Survival and Drug-Related Toxicities in Imatinib-Resistant Gastrointestinal Stromal Tumor (GIST) Patients Treated with Sunitinib - Authors: Ferhatoglu, F., Karabulut, S., Paksoy, N., & Tastekin, D.
Real-life Outcomes of ROS1 Fusion-positive Metastatic Lung Cancer Patients who were Treated with Crizotinib - Authors: Dogan, İ., Khanmammadov, N., Paksoy, N., Ferhatoglu, F., Aydın, E., Vatansever, S., & Aydine, A. - Journal: TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY
Predictors of the acquisition of T790M mutation in EGFR-mutant metastatic lung cancer patients who were treated with EGFR inhibitors - Authors: Dogan, I., Khanmammadov, N., Paksoy, N., Vatansever, S., Saip, P., & Aydıner, A. - Journal: Eurasian Journal of Pulmonology
Laterality of Adrenal Gland Metastasis in Lung Cancer: Results of a Comparative Study - Authors: Ferhatoglu, F., Gagatay, T., Okumus, G., Aydiner, A., Paksoy, N., Ak, N., ... & Saip, P. - Journal: Eurasian Journal of Medical Investigation, 7(2)
Poor Risk Factors Affecting Cancer Patients Infected with Covid-19: A Retrospective Comparative Study from a Pandemic Hospital - Authors: Ferhatoglu, F., Kapağan, T., Paksoy, N., Ak, N., Medetalibeyoğlu, A., Şenkal, N., ... & Vatansever, S. - Journal: Turk Onkoloji Dergisi, 38(1)
Systemic Treatment Outcomes of Progressive Medullary Thyroid Carcinoma from the Registries of a Tertiary Cancer Center - Authors: Ferhatoglu, F., Paksoy, N., & Başaran, M. - Journal: Namik Kemal Tip Dergisi, 10(4)
Evaluation of clinical features and risk factors related to late recurrence (> 5 years) in patients with breast cancer - Authors: Ferhatoglu, F., Aydiner, A., & Paksoy, N. - Journal: Journal of Surgery & Medicine (JOSAM), 6(12)
Assessing the Clinical Impact of Lutetium-177 DOTATATE Peptide Receptor Radionuclide Therapy (PRRT) on Metastatic Neuroendocrine Tumors: A Multicenter Real-World Data from Türkiye
Thesis:
Istanbul University Cerrahpaşa Medical Faculty, Internal Medicine Department PAKSOY, Nail. Demographical, clinical characteristics and survival factors in patients withprimary glomerulonephritis: Cerrahpasa Medical Faculty Experience. (2016)
International Refereed Congress / Symposium Publications in Proceedings (ASCO/ESMO Abstracts)
Prognostic factors influencing progression-free survival in HER2 positive metastatic breast cancer patients who treated with lapatinib and capecitabine combination
Efficacy of regorafenib and 5-fluorouracil-based rechallenge treatment in the third-line treatment of metastatic colorectal cancer: A Turkish oncology group study
Long-term outcomes and predictors of recurrence in patients with early-stage node-negative breast cancer
Efficacy of temozolomide in pretreated patients with metastatic sarcoma
Efficacy of sorafenib in symptomatic patients with pretreated progressive desmoid tumors
Efficacy of sorafenib in heavily pretreated adult patients with metastatic osteosarcoma
Outcomes and prognostic factors in metastatic renal cell carcinoma patients with brain metastases
Association of response to first-line chemotherapy with the efficacy of atezolizumab in patients with metastatic urothelial carcinoma
Safety and survival in adult women with platinum-sensitive relapsed BRCA mutant ovarian cancer: A study of patients in Olaparib Turkey Early Access Program—LynTurk study
Atezolizumab in patients with metastatic urothelial carcinoma who have progressed after first-line chemotherapy: Results of real-life experiences
Education
Career
1998–2000 — Conducted research on the genesis of cancer at The Royal Marsden Hospital (England).
Authored numerous peer-reviewed articles in scientific journals. Selected topics include:
Oncotype Dx Recurrence Score in BRCA1/2 germline mutation carriers with hormone receptor-positive breast cancer.
TP53 missense mutation recurrence in cancer patients of Arab descent.
Adjuvant autologous vaccine for stage III microscopic melanoma: biomarker survival and enhanced response to CTLA-4 blockade.
Prognostic significance of (R)CA15-3 assay in primary breast cancer.
Diagnostic and prognostic value of comparative thymidine kinase 1 (TK1) activity assays in breast cancer patient serum.
Complete remission in a BRCA2 mutation carrier with metastatic pancreatic adenocarcinoma treated with cisplatin.
Autologous vaccine-induced antitumor and self-reactive immune responses in melanoma: impact on patient survival and dependence on MHC class II expression.
Israeli Society of Clinical Oncology
Israel Medical Association
Cancer Genetics Research Foundation Award
Landau Prize
Judith Segal Memorial Award
Prof. Peled is a leading specialist in lung cancer immunotherapy, with expertise in Internal Medicine, Pulmonology and Medical Oncology. He has received the ASCO Merit Award, and is the head of the Thoracic Cancer Unit at Davidoff Cancer Center and Head of the Research and Detection Unit for Thoracic malignancies at Sheba Medical Center. He is a member of the Thoracic Oncology Assembly of the European Respiratory Society and Chair of the Early Detection and Prevention Committee of the International Association for the Study of Lung Cancer.
Dr. Beatrice Uziely is an experienced cancer specialist, specializing in breast cancer, metastasis treatment, application of hormone and chemotherapy. She has been the Head of Oncology Department at Hadassah Medical Center since 2001. She holds a degree in biology and a degree in medicine from the Hebrew University of Jerusalem, as well as a specialty in oncology and radiation oncology. She is an author of 59 publications devoted to cancer research, has 11 grants, and is a member of multiple professional associations.
Dr. Tamar Jablonski-Perec is an oncologist at Hadassah Medical Center in Jerusalem. She holds a Doctor of Medical Sciences from the Hebrew University and has experience from the renowned Sloan-Kettering Cancer Center in New York. She is the Head of Institute of Oncology, Head of Breast Cancer Treatment Center, and Professor of the Department of Oncology at the Hebrew University. She is a member of several international cancer communities and was awarded a scholarship from the Hadassah Medical School.
Chief Physician of the Oncology Center, Oncologist
Prof. Moshe Inbar is an Israeli oncologist and the Head of Department of Oncology at Sourasky (Ichilov) Medical Center, specializing in breast cancer, cancer of the uterus and ovaries, urogenital cancer in female and male, and gastro-intestinal cancer. He is a Clinical Associate Professor in Tel Aviv University, holds numerous awards and is a member of various research organizations.
Oncohematologist
Oncologist, Radiologist
Children's Oncologist
Head of the Department of Pediatric Hematology and Oncology.
Radiotherapy specialist, Oncologist
Dr. Aleix Prat is a clinical scientist with expertise in breast cancer research, gene expression, and clinical trials. He earned his MD from the University of Barcelona. He completed his oncology fellowship at Vall d’Hebron Institute of Oncology. Dr. Prat leads the Translational Genomics and Targeted Therapeutics in Solid Tumors Group at IDIBAPS. He is also President of SOLTI and serves on the Executive Committee of The Breast International Group.
Dr. Prat has published over 160 scientific papers. His work has received 13,479 citations, and he has an H-Index of 51. He is a Tenure-Track Professor at the University of Barcelona. He also directs the Breast Pathology–Senology Master’s degree. His roles highlight his strong academic and clinical contributions to oncology.