CAR-T Therapy for Acute Lymphoblastic Leukemia (ALL) at Sheba Medical Center
What's included in this package
Medical Procedures
- CAR T-cell therapy
- Blood tests
- Biochemistry blood test
- Biopsy
- CT Scan
- Consultation with a doctor
- Consultation with an oncologist
- Consultation with a hematologist
- Consultation with an immunologist
- Consultation with a pediatric hematologist
- Complete blood count with cancer markers and a proteinogram
- CT angiography
- Electrocardiogram (ECG)
- Follow-up examination
- Post-operative care
- Preoperative tests
- PET/CT
- Сonsultation with an oncohematologist
- 24-hr nurse services
- 3 meals per day by nutritionist
Duration
- 21 days in the hospital
Accommodation
Hospitalization
Transport
Transfer airport-clinic-airport
Additional information
CAR-T Therapy for Acute Lymphoblastic Leukemia (ALL) at Sheba Medical Center
For patients diagnosed with Acute Lymphoblastic Leukemia (ALL), especially those with relapsed or treatment-resistant disease, access to advanced therapy can be life-changing.
Sheba Medical Center, one of the world’s leading hospitals, offers state-of-the-art CAR-T cell therapy, providing new hope where conventional treatments may no longer be effective.
Sheba is recognized as a global leader in CAR-T therapy for ALL, particularly in pediatric and young adult patients, combining cutting-edge science with extensive clinical experience.
A Faster Path to Life-Saving Treatment
At Sheba, the entire CAR-T process is performed on-site, ensuring speed, precision, and optimal cell quality, critical in fast-progressing diseases like ALL.
• Apheresis – collection of the patient’s T-cells
• Cell Engineering – genetic modification at Sheba’s Advanced Biotherapy Center
• Infusion – reinfusion of modified cells designed to target and eliminate leukemia cells
By keeping the entire process in-house, treatment can begin in approximately 10 days, significantly faster than many international centers.
CAR-T therapy acts as a “living drug,” continuing to work in the body and offering the potential for deep and lasting remission.
All patients are treated under the leadership of Prof. Arnon Nagler, a globally recognized expert in hemato-oncology.
Outstanding Outcomes That Offer Real Hope
Sheba is a world leader in pediatric CAR-T for ALL, with exceptional clinical results:
• Up to ~90% remission in pediatric patients
• ~80% in young adults (up to 23 years)
• ~70% in adult patients
These outcomes provide a powerful treatment option and a second chance for patients with limited alternatives.
Why Patients Choose Sheba
• Rapid access to CAR-T therapy – treatment initiation in ~10 days
• Extensive experience – leading CAR-T program in the region
• Dedicated CAR-T units – specialized care with 24/7 monitoring
• Multidisciplinary expertise – hematology, oncology, and immunotherapy teams working together
• Full international support – medical review, travel coordination, and patient assistance
Comprehensive, Personalized Care
Each patient undergoes a full diagnostic evaluation, including advanced imaging, bone marrow biopsy, genetic and molecular testing, and complete medical assessment, ensuring a precise, individualized treatment plan.
Services are available in English, Russian, and Arabic, providing a seamless experience for international patients and their families.
A Global Leader in Advanced Leukemia Care
By combining innovative CAR-T technology, in-house cell production, and world-class expertise, Sheba delivers one of the most advanced and accessible CAR-T programs for ALL worldwide, offering patients not just treatment, but a real opportunity for remission and renewed life.
24/7 Bookimed assistance
- Personal medical coordinator
- Medical travel arrangements — booking of air tickets and hotel rooms at special partner prices
- Patient advocacy during medical travel
Program price
What's NOT included in this package
Doctor
Dr. Arnon Nagler is an internationally recognized hematologist and bone marrow transplant expert. He is a Professor of Medicine at Tel Aviv University. He is Director Emeritus of Hematology & Bone Marrow Transplantation and the Cord Blood Bank at Sheba Medical Center. He earned his M.D. from the Hebrew University–Hadassah and an M.Sc. in hematopoiesis from Tel Aviv University. He completed postdoctoral training at Stanford. He is board certified in internal medicine and hematology.
He has more than 35 years of experience. He pioneered reduced‑intensity allogeneic transplant protocols for malignant and non‑malignant diseases. He founded Israel’s first public cord blood bank. He performed the country’s first cord blood transplants.
He has held international leadership roles. He served as Chair and Co‑Chair of the ALWP of the EBMT. He was a vice‑chair and long‑term member of EBMT committees. He served on the board of NetCord/EuroCord and as treasurer. He is a frequent invited speaker. He has published widely in journals such as Blood and Leukemia. He has led major clinical trials as a principal investigator and held editorial roles. He has received multiple awards for innovation and clinical excellence.
How are we doing?
About the clinic
Sheba Medical Center, Israel’s leading hospital, is consistently ranked among the world’s top institutions. Treating over 2 million patients annually, Sheba combines world-class expertise with compassionate, personalized care. Its “City of Health” campus integrates six specialized hospitals, offering advanced treatments in oncology, neurology, cardiology, orthopedics, and more. Sheba is a global leader in CAR-T and TIL immunotherapies, precision medicine, and minimally invasive surgery, making it a trusted destination for international patients seeking cutting-edge healthcare.
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