CAR-T Therapy for Chronic Lymphocytic Leukemia / Richter’s Transformation at Sheba Medical Center
What's included in this package
Medical Procedures
- CAR T-cell therapy
- Blood tests
- Biochemistry blood test
- Biopsy
- CT Scan
- Consultation with a doctor
- Consultation with an oncologist
- Consultation with a hematologist
- Consultation with an immunologist
- Consultation with a pediatric hematologist
- Complete blood count with cancer markers and a proteinogram
- CT angiography
- Electrocardiogram (ECG)
- Follow-up examination
- PET/CT
- Ultrasound biomicroscopy (UBM)
- Ultrasonography (USG)
- Сonsultation with an oncohematologist
- 24-hr nurse services
- 3 meals per day by nutritionist
Duration
- 21 days in the hospital
Accommodation
Hospitalization
Transport
Transfer airport-clinic-airport
Additional information
CAR-T Therapy for CLL / Richter’s Transformation at Sheba Medical Center
For patients diagnosed with Chronic Lymphocytic Leukemia (CLL) or Richter’s Transformation, a more aggressive progression of the disease, finding an effective treatment option can be especially challenging.
Sheba Medical Center, one of the world’s leading hospitals, offers advanced CAR-T cell therapy, providing new hope for patients with relapsed or treatment-resistant disease.
Sheba combines cutting-edge immunotherapy with deep expertise in complex hematologic cancers, delivering personalized solutions even in the most aggressive cases.
A Faster Path to Advanced Treatment
At Sheba, the entire CAR-T process is performed on-site, ensuring speed, precision, and optimal cell quality, a critical advantage for patients with rapidly progressing disease.
• Apheresis – collection of the patient’s T-cells
• Cell Engineering – genetic modification at Sheba’s Advanced Biotherapy Center
• Infusion – reinfusion of modified cells designed to identify and destroy cancer cells
By eliminating the need for external laboratories, treatment can begin in approximately 10 days, significantly reducing delays compared to many international centers.
CAR-T therapy acts as a “living therapy,” continuing to work in the body and offering the potential for deep and durable remission, even in aggressive disease forms like Richter’s transformation.
All patients are treated under the leadership of Prof. Arnon Nagler, a globally recognized expert in hemato-oncology.
Advanced Treatment for Complex Cases
CLL and Richter’s transformation often require highly specialized care. At Sheba, hematologists, oncologists, and immunotherapy experts work together to design the most effective, individualized treatment strategy.
CAR-T therapy provides a promising option for patients who have exhausted conventional therapies, offering meaningful clinical responses and improved outcomes in difficult-to-treat cases.
Why Patients Choose Sheba
• Rapid access to CAR-T therapy – treatment initiation in ~10 days
• Extensive experience – one of the leading CAR-T programs in the region
• Dedicated CAR-T units – with 24/7 expert monitoring
• Multidisciplinary expertise – integrated care across specialties
• Full international support – medical review, travel coordination, and patient assistance
Comprehensive, Personalized Care
Each patient undergoes a complete diagnostic evaluation, including advanced imaging, bone marrow biopsy, genetic and molecular testing, and full medical assessment, ensuring a precise, personalized treatment plan.
Services are provided in English, Russian, and Arabic, ensuring a smooth and supportive experience for international patients.
A Leading Center for Advanced Hemato-Oncology Care
By combining innovative CAR-T technology, in-house cell production, and world-class expertise, Sheba delivers one of the most advanced and accessible CAR-T programs for CLL and Richter’s transformation worldwide offering patients a real opportunity for disease control and improved quality of life.
24/7 Bookimed assistance
- Personal medical coordinator
- Medical travel arrangements — booking of air tickets and hotel rooms at special partner prices
- Patient advocacy during medical travel
Program price
What's NOT included in this package
Doctor
Dr. Arnon Nagler is an internationally recognized hematologist and bone marrow transplant expert. He is a Professor of Medicine at Tel Aviv University. He is Director Emeritus of Hematology & Bone Marrow Transplantation and the Cord Blood Bank at Sheba Medical Center. He earned his M.D. from the Hebrew University–Hadassah and an M.Sc. in hematopoiesis from Tel Aviv University. He completed postdoctoral training at Stanford. He is board certified in internal medicine and hematology.
He has more than 35 years of experience. He pioneered reduced‑intensity allogeneic transplant protocols for malignant and non‑malignant diseases. He founded Israel’s first public cord blood bank. He performed the country’s first cord blood transplants.
He has held international leadership roles. He served as Chair and Co‑Chair of the ALWP of the EBMT. He was a vice‑chair and long‑term member of EBMT committees. He served on the board of NetCord/EuroCord and as treasurer. He is a frequent invited speaker. He has published widely in journals such as Blood and Leukemia. He has led major clinical trials as a principal investigator and held editorial roles. He has received multiple awards for innovation and clinical excellence.
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About the clinic
Sheba Medical Center, Israel’s leading hospital, is consistently ranked among the world’s top institutions. Treating over 2 million patients annually, Sheba combines world-class expertise with compassionate, personalized care. Its “City of Health” campus integrates six specialized hospitals, offering advanced treatments in oncology, neurology, cardiology, orthopedics, and more. Sheba is a global leader in CAR-T and TIL immunotherapies, precision medicine, and minimally invasive surgery, making it a trusted destination for international patients seeking cutting-edge healthcare.
Payment & Rewards
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