Pediatric Bone Marrow Transplantation (BMT) at Sheba Medical Center

• Bone marrow transplantation
• Autologous bone marrow transplantation
• Allogenic bone marrow transplantation from an unrelated donor
• Allogenic bone marrow transplantation from a related donor
• Anti-HIV test
• Anti-HBC test
• Anti-HCVAb test
• Blood tests
• Biochemistry blood test
• Biopsy
• Chest X-ray
• Complete blood count (CBC)
• Consultation with a pediatric hematologist
• Consultation with a pediatrician
• Consultation with a cardiologist
• Complete blood count with cancer markers and a proteinogram
• Electrocardiogram (ECG)
• Echocardiography
• Head MRI
• PET/CT
• Сonsultation with an oncohematologist
• 24-hr nurse services
• 3 meals per day by nutritionist

• 30 days in the hospital

• Transfer airport-clinic-airport

Pediatric Bone Marrow Transplantation (BMT) at Sheba Medical Center
Advanced, Life-Saving Care for Children with Complex Blood Disorders and Cancers

At Sheba Medical Center, pediatric bone marrow transplantation is more than a procedure, it is a comprehensive, highly specialized journey of care, designed to give children the best possible chance at recovery, long-term health, and a full life ahead.

As one of the leading pediatric transplant centers worldwide, Sheba combines cutting-edge science, extensive clinical experience, and a deeply compassionate approach tailored to each child and family.

A Dedicated Pediatric Transplant Unit Designed for Safety and Comfort

The Pediatric Hemato-Oncology and BMT Unit at Sheba is specifically designed to support children during the most delicate phases of treatment.

Private, advanced isolation rooms with HEPA air filtration to minimize infection risk
Highly trained multidisciplinary teams available 24/7
A child-friendly environment focused on both medical excellence and emotional well-being

Each detail is carefully planned to ensure maximum safety, comfort, and continuous monitoring throughout the transplant process.

When is Bone Marrow Transplant Needed?

BMT is a potentially curative treatment for a wide range of serious conditions.

Malignant Diseases (Cancers)
Leukemias (ALL, AML, CML)
Hodgkin and Non-Hodgkin lymphomas
Solid tumors (e.g., neuroblastoma, sarcomas, brain tumors)
Non-Malignant Conditions
Blood disorders (thalassemia, sickle cell disease, aplastic anemia, Fanconi anemia)
Immune deficiencies (SCID, HLH, Wiskott-Aldrich syndrome)
Metabolic diseases (e.g., Hurler syndrome, adrenoleukodystrophy)

For many of these conditions, BMT offers the only curative option.

Types of Pediatric Transplants at Sheba
Autologous Transplant (Using the Child’s Own Cells)

Used mainly for solid tumors. Stem cells are collected, preserved, and re-infused after intensive therapy without the need for a donor.

Allogeneic Transplant (Using Donor Cells)

Used for leukemias, genetic diseases, and immune disorders. Donors may include:

Fully matched siblings
Haploidentical (half-matched) family donors, such as parents
Unrelated donors from international registries
Cord Blood Transplant

Stem cells collected from umbilical cord blood provide an additional option, especially when no matched donor is available.

Advanced Donor Matching & Laboratory Precision

Finding the right donor is critical. Sheba’s on-site HLA and molecular laboratories use high-resolution DNA testing to ensure the closest possible match.

As a full member of international donor programs, Sheba provides access to global donor registries, significantly increasing the chances of finding a suitable donor for every child.

Cutting-Edge Transplant Techniques

When a perfect donor match is not available, Sheba applies advanced technologies to improve safety and outcomes:

T-cell depletion to reduce complications
CD34+ cell selection for precise stem cell transplantation
Integration with CAR-T therapy for high-risk or relapsed cancers

These innovations allow physicians to safely perform transplants even in complex or previously untreatable cases.

The Transplant Journey: What to Expect
1. Preparation & Conditioning

Children undergo carefully tailored treatment (chemotherapy ± radiation) to prepare the body for new stem cells.

2. Stem Cell Infusion

The transplant itself is a simple intravenous infusion, similar to a blood transfusion.

3. Engraftment & Recovery

New cells begin forming a healthy immune system—this critical phase is closely monitored in a protected environment.

Expert Monitoring & Post-Transplant Care
Inpatient Phase (3–6 weeks)
Continuous monitoring of blood counts and immune recovery
Preventive treatments against infections
Nutritional and supportive care
Outpatient Phase (Day 30–100+)
Monitoring for graft-versus-host disease (GvHD)
Advanced testing to confirm successful engraftment
Gradual immune system recovery and rehabilitation
Long-Term Follow-Up

Sheba’s dedicated survivorship clinic supports children as they grow, focusing on:

Development and hormonal health
Fertility preservation
Long-term quality of life
Clinical Outcomes & Success Rates

Sheba is recognized internationally for its strong clinical outcomes:

Leukemia (ALL/AML): ~70–85% success in early remission stages
Non-malignant diseases: Often over 90% cure rates with matched donors
Primary immunodeficiencies: ~80–90% survival when treated early

For high-risk cases, combining CAR-T therapy with BMT has further improved outcomes, offering new hope where options were previously limited.

Experience You Can Trust
45–55 pediatric transplants performed annually
Extensive experience in high-risk and complex cases
Active participation in global registries such as EBMT and IBMTR
Collaboration with leading international centers
A Patient-First Approach

At Sheba, every child is treated as an individual with a personalized plan, a dedicated medical team, and continuous support for the entire family.

From diagnosis through recovery, the focus remains on:

Safety and clinical excellence
Emotional support for children and parents
Access to the most advanced therapies available worldwide
Hope Through Innovation

By combining advanced transplantation techniques, world-class expertise, and compassionate care, Sheba Medical Center stands at the forefront of pediatric bone marrow transplantation helping children overcome life-threatening diseases and move forward to healthy, fulfilling lives.

• Personal medical coordinator
• Medical travel arrangements — booking of air tickets and hotel rooms at special partner prices
• Patient advocacy during medical travel