Follicular lymphoma Treatment in Private Koru Ankara Hospital

Follicular lymphoma care at Private Koru Ankara Hospital in Ankara, Turkey, includes staging, drug therapy, radiation, and stem cell transplantation. The JCI-accredited hospital has an on-site Bone Marrow Transplantation Centre and PET-CT and Gallium PET imaging for lymphoma staging. Medical oncologist Prof. Dr. Mehmet Metin Şeker administers chemotherapy and immunotherapy at the hospital.

Follicular lymphoma diagnostic options

Testing can help stage the lymphoma and assess tumor features. Available options include:

• PET-CT and Gallium PET: Imaging for hematological cancer staging.
• Liquid biopsy: Tumor DNA analysis using a blood sample.
• Next-generation sequencing (NGS): Genomic profiling to guide treatment planning.
• Molecular pathology: Immunohistochemistry, FISH, and PCR testing.
• Biomarker testing: Tumor mutational burden (TMB) and microsatellite instability (MSI) tests.
• Flow cytometry: Analysis of cells in a sample.
• Clinical laboratory testing: Hematology, biochemistry, and pathology tests.

Treatment options, including stem cell transplantation

The hospital offers drug therapy, radiation, and transplant options for lymphoma. The transplant unit uses HEPA-filtered, positive-pressure rooms and laminar airflow during immunosuppression.

• Autologous stem cell transplantation: A salvage option after relapse in Hodgkin and non-Hodgkin lymphoma, including follicular lymphoma. Peripheral blood stem cells are collected by apheresis and stored in liquid nitrogen at -196°C. After high-dose chemotherapy, the cells are reinfused. Conditioning may be myeloablative, reduced-intensity, or non-myeloablative. Using the patient’s own cells avoids tissue incompatibility and graft-versus-host disease.
• Allogeneic stem cell transplantation: Donor stem cell treatment for hematological cancers, using international protocols. Donor cells rebuild blood-forming cells.
• Chemotherapy: Systemic treatment given intravenously, orally, or intrathecally. It may be used before or after other treatment, or for symptom relief.
• Immunotherapy: Immune checkpoint inhibitors targeting PD-1, PD-L1, or CTLA-4.
• Targeted therapy: Molecularly targeted drugs, including tyrosine kinase inhibitors, monoclonal antibodies, antibody-drug conjugates, and anti-angiogenic agents. NGS profiling can guide drug selection.
• Radiation therapy: Image-guided IMRT or IGRT using the Elekta Versa HD system to target tumors while sparing healthy tissue.
• CAR-T cell therapy and bispecific antibodies: Research options for lymphoma that resists standard treatment, available through national and international clinical trials.

Patients can request a consultation through Bookimed to discuss the available diagnostic and treatment options.