Excision of skull base tumor in Sheba Medical Center

Sheba Medical Center is the largest and most advanced medical center in Israel and one of the world’s leading hospitals for oncology, immunotherapy, precision medicine, and complex multidisciplinary care. Located in Ramat Gan near Tel Aviv, Sheba serves as Israel’s national referral center for highly specialized treatments and innovative therapies unavailable in many countries.

In 2026, Newsweek ranked Sheba #7 among the world’s best hospitals, marking eight consecutive years in the global Top 10. The medical center treats more than 2 million patients annually and employs over 11,000 healthcare professionals, including internationally recognized physicians, surgeons, researchers, and scientists. More than 200 Sheba doctors are listed among Forbes’ Top Doctors.

Sheba’s “City of Health” campus integrates six major hospitals and dozens of specialized institutes and research centers within one advanced medical ecosystem, allowing patients to receive seamless multidisciplinary care across all stages of diagnosis, treatment, surgery, rehabilitation, and recovery.

The campus includes:

• Acute Care Hospital — comprehensive advanced treatment across all major medical specialties
• Rehabilitation Hospital — one of the world’s leading rehabilitation centers for neurological, orthopedic, and trauma recovery
• Jusidman Cancer Center — internationally recognized center for oncology, hemato-oncology, cellular therapies, and cancer research
• Josef Buchmann Gynecology & Maternity Center — advanced women’s health, gynecology, fertility, and maternity care
• Leviev Heart Center — one of Israel’s leading cardiovascular centers for minimally invasive and robotic heart procedures
• Edmond and Lily Safra Children’s Hospital — multidisciplinary pediatric center for complex and rare diseases

Sheba is internationally recognized as one of the leading centers for advanced oncology and hemato-oncology. The hospital provides comprehensive treatment for leukemia, lymphoma, multiple myeloma, solid tumors, metastatic cancers, and rare oncological diseases using the most advanced technologies in modern medicine.

One of Sheba’s key areas of expertise is cellular immunotherapy. The medical center is a global leader in CAR-T cell therapy for refractory and relapsed hematologic malignancies, including acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma, follicular lymphoma, multiple myeloma, and other aggressive blood cancers.

Unlike many hospitals worldwide, Sheba performs in-house CAR-T manufacturing through its Advanced Biotherapy Center (ABC), one of the largest GMP-certified cell and gene therapy production facilities in Israel. This unique infrastructure allows significantly faster treatment timelines, higher cell viability, and greater treatment personalization by eliminating the need to send patient cells abroad for commercial manufacturing.

The Advanced Biotherapy Center specializes in CAR-T cell production, TIL (Tumor-Infiltrating Lymphocyte) therapy manufacturing, personalized cell therapy production, viral vector manufacturing, cell and gene therapy development, translational medicine and clinical research, regenerative medicine, and tissue engineering.

Sheba is also one of the few medical centers worldwide actively developing CAR-T therapies for severe autoimmune diseases. The hospital’s pioneering autoimmune CAR-T program focuses on treatment-resistant conditions such as systemic lupus erythematosus (lupus), rheumatoid arthritis, Sjögren’s syndrome, scleroderma, vasculitis, dermatomyositis, and idiopathic inflammatory myositis.

Another major area of expertise is TIL therapy for metastatic melanoma. Through the Ella Lemelbaum Institute of Immuno-Oncology, Sheba provides one of the world’s most advanced TIL immunotherapy programs for patients with progressive or treatment-resistant melanoma. The therapy uses tumor-infiltrating lymphocytes extracted directly from the patient’s tumor, expanded in a GMP laboratory, and reinfused to enhance the immune response against cancer.

Sheba also provides comprehensive bone marrow and stem cell transplantation programs for adults and children, including autologous stem cell transplantation, allogeneic bone marrow transplantation, haploidentical transplantation, unrelated donor transplantation, and transplantation for leukemia, lymphoma, and multiple myeloma.

The medical center is a recognized leader in pediatric hemato-oncology and pediatric bone marrow transplantation, treating children with complex oncological and hematological disorders using advanced immunotherapies and precision medicine approaches.

In solid tumor oncology, Sheba offers highly specialized treatments and technologies including HIPEC (Hyperthermic Intraperitoneal Chemotherapy), PRRT (Peptide Receptor Radionuclide Therapy), precision oncology, genomic tumor profiling, targeted therapy, immunotherapy, radiosurgery, minimally invasive oncologic surgery, and robotic cancer surgery.

The hospital is also a leader in neurology and neurosurgery, offering focused ultrasound, deep brain stimulation (DBS), Novalis radiosurgery, minimally invasive brain and spine procedures, epilepsy surgery, and neuro-oncology treatment.

The Leviev Heart Center performs advanced cardiovascular interventions including robotic cardiac surgery, minimally invasive heart surgery, TAVR (Transcatheter Aortic Valve Replacement), catheter ablation for arrhythmias, heart failure management, and structural heart procedures.

Sheba is internationally recognized for complex surgery and transplantation programs, including robotic surgery, minimally invasive abdominal surgery, liver transplantation, kidney transplantation, thoracic surgery, pancreatic surgery, orthopedic and spine surgery with robotic navigation and 3D imaging.

The medical center also maintains one of Israel’s most advanced regenerative medicine programs. Through the Advanced Biotherapy Center and affiliated surgical departments, Sheba develops and applies cultured epidermal autografts (Epicel), 3D bioengineered skin grafts, regenerative tissue therapies for severe burns, and reconstructive cellular therapies.

Research and innovation are central to Sheba’s medical model. The hospital collaborates with leading international universities, biotech companies, and pharmaceutical organizations while conducting hundreds of clinical trials in oncology, immunotherapy, neurology, cardiology, genetics, and regenerative medicine.

Beyond clinical care and scientific research, Sheba Medical Center plays an active role in international medical education, physician training, and healthcare collaboration programs worldwide. Sheba specialists regularly participate in global conferences, clinical workshops, and multidisciplinary training initiatives focused on oncology, hemato-oncology, transplantation, immunotherapy, precision medicine, and advanced surgical techniques.

As part of its international outreach and medical collaboration efforts, Sheba physicians have conducted professional training programs and educational initiatives in multiple countries, including Ethiopia, where specialists provided lectures, hands-on workshops, and clinical knowledge exchange programs for local physicians, residents, and medical students.

These initiatives focus on advancing modern approaches to leukemia treatment, bone marrow transplantation, cellular immunotherapy, CAR-T therapies, precision oncology, and complex hematological care. Through ongoing international partnerships and medical education programs, Sheba contributes to strengthening healthcare systems and expanding access to advanced medical expertise worldwide.

By combining large-scale clinical experience, cutting-edge technology, translational research, and patient-centered medicine, Sheba Medical Center has established itself as one of the world’s leading destinations for advanced and personalized medical care.

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