Pediatric Bone Marrow Transplant for Acute Lymphoblastic Leukemia (ALL) at Sheba Hospital- JCI accreditated and Top-10 Hospitals 2025 by Newsweek
What's included in this package
Medical Procedures
- Biochemical blood analysis
- Consultation with a hematologist
- Extended analysis of blood
- Bone marrow biopsy
- Сonsultation with an oncohematologist
- Сomprehensive diagnosis of Leukemia
- Cytogenetic study of the bone marrow
- Bone marrow puncture with cytogenetic analysis
- Bone marrow transplantation
- Autologous bone marrow transplantation
- Allogenic bone marrow transplantation from an unrelated donor
- Allogenic bone marrow transplantation from a related donor
- 3 meals per day by nutritionist
- 24-hr nurse services
- Electrocardiogram (ECG)
- Blood tests
- Chest X-ray
- Anti-HIV test
- Anti-HBC test
- Anti-HCVAb test
- Echocardiography
- Complete blood count (CBC)
- Biochemistry blood test
- PET/CT
- Consultation with an immunologist
- Consultation with a cardiologist
- Consultation with a pediatric hematologist
- Consultation with a pediatrician
- Сonsultation with an oncohematologist
- Head MRI
- Biopsy
- Complete blood count with cancer markers and a proteinogram
Duration
- 30 days in the hospital
Accommodation
Hospitalization
Transport
Transfer airport-clinic-airport
Additional information
Pediatric Bone Marrow Transplant for Acute Lymphoblastic Leukemia (ALL)
Sheba Medical Center – Advanced, Personalized Care for Children
At Sheba Medical Center, we understand how overwhelming a diagnosis of Acute Lymphoblastic Leukemia (ALL) can be for both children and their families. Our mission is to provide not only the most advanced medical care available, but also reassurance, clarity, and compassionate support throughout every stage of treatment.
As a global leader in pediatric hemato-oncology, Sheba offers cutting-edge bone marrow transplantation (BMT) for children with ALL particularly in cases where the disease is high-risk, relapsed, or resistant to standard therapies.
When is a Bone Marrow Transplant Needed in ALL?
While many children with ALL respond very well to chemotherapy, some require a more intensive approach to achieve a lasting cure.
A bone marrow transplant may be recommended when:
The leukemia has relapsed
The disease is resistant to treatment
There are high-risk genetic features
A deeper, more durable remission is needed
In these situations, BMT replaces the diseased bone marrow with healthy stem cells helping rebuild a new immune system capable of eliminating leukemia cells.
A Personalized Treatment Strategy
Every child’s condition is unique. At Sheba, treatment decisions are made by a dedicated team of pediatric leukemia and transplant specialists who carefully tailor each plan.
Whenever possible, a matched sibling donor is used.
If no sibling match is available, we actively secure the most suitable donor using advanced matching technologies and global registries, including:
Matched unrelated donors from international donor programs
Haploidentical (half-matched) family donors, such as parents
Cord blood transplantation
Our state-of-the-art HLA and molecular laboratories ensure highly accurate matching, improving safety and transplant success.
Advanced Therapies for Better Outcomes
Sheba is at the forefront of innovation in pediatric ALL treatment, combining transplantation with the latest breakthroughs:
CAR-T cell therapy, often used before transplant in relapsed or refractory ALL to achieve remission
T-cell depletion and CD34+ selection reducing complications such as graft-versus-host disease
Access to international clinical trials and novel therapies
This integrated approach allows us to treat even the most complex cases successfully.
Leading Results in Pediatric ALL
Sheba’s outcomes for pediatric ALL are among the best internationally:
~70–85% success rates in children undergoing transplant in remission
Improved outcomes in relapsed cases through CAR-T integration
Strong long-term survival and quality of life
Our continuous research and clinical expertise ensure that every child benefits from the most advanced care available today.
Care That Supports the Whole Family
At Sheba, we treat more than the disease - we care for the child and their family as a whole. Children are treated in specialized, highly protected environments with advanced infection control, while families receive ongoing support, guidance, and clear communication.
Our team stays closely involved throughout the entire journey, ensuring each child is supported medically and emotionally on the path to recovery.
Why Families Choose Sheba for ALL Treatment
Global leader in pediatric leukemia and bone marrow transplantation
Expertise in high-risk and relapsed ALL
Ability to secure optimal donors even without a family match
Integration of CAR-T therapy and advanced cellular treatments
Multidisciplinary, patient-centered approach
Dedicated services for international families
A Message of Hope
For children facing Acute Lymphoblastic Leukemia, a bone marrow transplant can offer a real chance for cure. At Sheba Medical Center, we combine advanced science with compassionate care helping children overcome leukemia and move forward toward a healthy, hopeful future.
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- Personal medical coordinator
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- Patient advocacy during medical travel
Program price
What's NOT included in this package
Doctor
Prof. Amos Toren, MD, PhD, MHA, is a pediatric hemato-oncologist and BMT specialist. He served as Director of Pediatric Hemato-Oncology and BMT at Sheba Medical Center.
He is board certified in Pediatrics, Pediatric Hemato-Oncology, and Bone Marrow Transplantation. He holds a PhD in Human Genetics. He was Head of the Hematology Division at Tel Aviv University for two terms. He is a member of ASH, COG, ESPHI, EBMT, and CIBMTR. He also serves on the Ministry of Health Cord Blood Committee.
He led one of Israel’s most advanced pediatric oncology and BMT programs. The program treated children and young adults. His focus includes leukemia and lymphoma, immunodeficiencies, and rare cancers. He specializes in BMT and CAR T-cell therapy.
His translational research covers CAR T cells, cytokine-induced killer cells, pediatric brain tumors, and targeted therapies. He has worked with St. Anna, the NIH, and St. Jude. His publications include studies on pediatric SCT prophylaxis and PARP resistance.
How are we doing?
About the clinic
Sheba Medical Center is the largest hospital in the Middle East and one of the world’s leading medical institutions, consistently ranked among the global Top 10. Recognized by Newsweek and Statista for eight consecutive years, it ranked 7th worldwide in 2026. The hospital delivers comprehensive multidisciplinary care across all major specialties, including oncology, hematology, cardiology, neurology, and advanced surgery, treating over 2 million patients annually, including international cases. With more than 200 physicians listed among Forbes' Top Doctors, Sheba is a global leader in CAR-T and TIL immunotherapies, precision medicine, and minimally invasive surgery, making it a trusted destination for complex and advanced treatment.
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