Bone Marrow Transplant for Pediatric Neuroblastoma

• Bone marrow biopsy
• Consultation with a pediatrician
• Complex diagnostics of neuroblastoma
• Consultation with an oncologist
• Consultation of a radiologist
• Complex treatment of neuroblastoma
• Anti-HIV test
• Anti-HBC test
• Anti-HCVAb test
• Blood tests
• Biochemistry blood test
• Biopsy
• Chest X-ray
• Complete blood count (CBC)
• Consultation with an oncologist
• Consultation with an immunologist
• Consultation with a cardiologist
• Consultation with a pediatric hematologist
• Consultation with a pediatrician
• Computerized Bone Mineralometry (CBM)
• Complete blood count with cancer markers and a proteinogram
• Electrocardiogram (ECG)
• Echocardiography
• Head MRI
• PET/CT
• Сonsultation with an oncohematologist
• 24-hr nurse services
• 3 meals per day by nutritionist

• 30 days in the hospital

• Transfer airport-clinic-airport

Bone Marrow Transplant for Pediatric Neuroblastoma

Sheba Medical Center – Advanced, Personalized Transplant Care for Children

At Sheba Medical Center, we understand how challenging it is for families to face a diagnosis of neuroblastoma. This complex childhood cancer requires not only advanced medical expertise, but also compassionate, family-centered care.

For children with high-risk or relapsed neuroblastoma, bone marrow transplantation (BMT) plays a vital role in treatment offering a powerful approach aimed at improving long-term outcomes and giving children the best possible chance for recovery.

Our pediatric transplant program combines world-leading expertise, innovative therapies, and a supportive environment designed specifically for children and their families.

When is a Bone Marrow Transplant Needed?

In neuroblastoma, bone marrow transplantation is typically part of an intensive treatment strategy and may be recommended when:

The disease is high-risk at diagnosis
Neuroblastoma has spread beyond the original tumor site
The disease returns after initial treatment

BMT allows doctors to use high-dose therapy to eliminate cancer cells, followed by the infusion of healthy stem cells to restore the bone marrow and immune system.

Types of Transplant
Autologous Transplant (Child’s Own Cells)

For most children with neuroblastoma, this is the standard approach.

Stem cells are collected from the child in advance
High-dose therapy is delivered to target remaining cancer cells
The child’s own cells are reinfused to rebuild healthy bone marrow

In selected cases, tandem (double) transplants may be recommended to further strengthen treatment outcomes.

Allogeneic Transplant (Donor Cells)

While autologous transplantation is the most common approach, Sheba Medical Center also offers advanced allogeneic (donor) transplantation for carefully selected cases.

This option may be considered for:

Children who need an alternative stem cell source
Children who require an additional therapeutic strategy after prior treatment

Donor Options at Sheba include:

Matched sibling donors, when available
Matched unrelated donors through international registries
Haploidentical (half-matched) family donors, often a parent

Sheba’s expertise allows access to the most suitable donor for every child, ensuring that no patient is left without options.

A unique advantage of donor transplantation is the graft-versus-tumor effect, where the new immune system can help recognize and fight any remaining neuroblastoma cells.

Precision Matching and Advanced Technology

Successful transplantation begins with the best possible donor match.

Sheba Medical Center operates an advanced on-site HLA laboratory, performing high-resolution genetic testing to ensure optimal compatibility between donor and child, enhancing safety and treatment effectiveness.

Advanced Pediatric Neuroblastoma Care

Sheba offers highly specialized treatment tailored to each child:

Personalized transplant protocols
Integration with immunotherapy and targeted treatments
Advanced supportive care to promote recovery
Close collaboration between pediatric oncology and transplant teams
Specialized Pediatric Transplant Environment

Children are treated in dedicated pediatric transplant units designed for safety, comfort, and healing:

Child-friendly, highly protected environments
Advanced infection prevention systems
Continuous care by experienced pediatric specialists

Every aspect of care is adapted to support children physically and emotionally.

Clinical Expertise

Sheba Medical Center is a leading center for pediatric cancer care, offering:

Extensive experience in high-risk neuroblastoma
Expertise in autologous and donor transplantation approaches
Strong outcomes aligned with leading international centers
Long-term follow-up focused on growth, development, and quality of life
Care That Supports the Whole Family

We understand that this journey involves the entire family.

At Sheba, children and their families are supported by a multidisciplinary team including physicians, nurses, psychologists, and care coordinators ensuring guidance, reassurance, and continuous support at every stage.

Why Families Choose Sheba for Pediatric BMT

Leading pediatric transplant center
Expertise in complex neuroblastoma cases
Access to a wide range of donor options
Advanced technologies and treatment approaches
Child-focused, compassionate care
Dedicated international patient services

A Message of Hope

At Sheba Medical Center, we combine innovation, expertise, and compassionate pediatric care to give every child the strongest possible chance for recovery, while supporting families with confidence, clarity, and hope every step of the way.

• Personal medical coordinator
• Medical travel arrangements — booking of air tickets and hotel rooms at special partner prices
• Patient advocacy during medical travel