Disclaimer: This content is NOT medical advice. Always consult a board-certified physician before making healthcare decisions. Bookimed is a medical tourism facilitator and may receive referral fees from partner clinics. All recommendations are based on verified credentials, accreditation, and patient reviews.
Stem cell therapy is one of the most promising advancements in modern medicine. It is being hailed for its ability to regenerate tissues, reduce inflammation, and tackle medical conditions that were once thought untreatable.
But as exciting as it sounds, navigating the legal status—especially in the US—can be tricky. Patients are often left wondering whether these breakthrough treatments are even allowed. In this article, we'll untangle US regulations and look at other countries where you can find safe, legal stem cell treatments.
Table of Contents
- Are Stem Cells Legal in the US?
- Where Is Stem Cell Therapy Legal?
- Safety Profile and Complication Rates
- What to Expect: Recovery Timeline and Patient Experience
- Protecting Yourself: Ethical and Safety Considerations for Patients
- How to Choose a Reliable and Safe Stem Cell Clinic
- Key Takeaways
Are Stem Cells Legal in the US?
Short answer: Partly. Only certain stem cell therapies, like those for blood disorders, are FDA-approved and legal. Most treatments haven't yet passed the necessary approval process.
FDA's role in stem cell regulation
The Food and Drug Administration (FDA) regulates the safety and effectiveness of medical treatments, including regenerative medicine. These treatments must undergo clinical trials and receive FDA approval to be legal. This ensures they meet safety and efficacy standards before being offered to the general public.
What are the FDA-approved stem cell therapies?
As of December 2024, only 3 stem cell therapies have received full FDA approval:
- Ryoncil - the first mesenchymal stromal cell therapy approved December 18, 2024 for treating steroid-refractory acute graft-versus-host disease in pediatric patients
- Lyfgenia for sickle cell disease - showing 88% complete resolution of vaso-occlusive events between 6–18 months post-treatment
- Hematopoietic stem cell transplantation (HSCT) - using stem cells from umbilical cord blood to treat certain cancers and blood disorders like leukemia
Despite limited FDA approvals, there's significant hope on the horizon. 115 global clinical trials involving 83 distinct pluripotent stem cell-derived products are currently active as of December 2024, targeting conditions in ophthalmology, neurology, and oncology. Additionally, over 5,000 registered clinical trials in the US are gathering proof of the therapy's safety and effectiveness.
To stay informed about FDA guidelines and approved treatments, visit the FDA website at www.fda.gov.
Limitations of stem cell therapy in the US
Despite FDA regulations, almost 3,000 clinics in the US offer unproven therapies for a wide range of medical conditions, while Bookimed partners with verified clinics meeting strict safety standardsї. These unregulated clinics try to bypass FDA regulations by:
- Labeling treatments as "experimental". Some clinics market their treatments as part of ongoing research. However, it may lack proper oversight or adherence to safety protocols.
- Using patient-funded trials. Some clinics offer treatments through so-called clinical trials where patients pay for the therapy, blurring the line between research and commercial services.
- Operating under state-level laws. Some clinics take advantage of less stringent state regulations, allowing them to offer treatments that wouldn't pass under federal FDA guidelines.
- Offering reduced dosages. Some clinics use reduced dosages of stem cells to circumvent FDA regulations, claiming their treatments are not technically "stem cell products."
While these methods enable clinics to offer unapproved treatments, choosing one of these clinics may come with real risks:
- Safety concerns. A key issue with unapproved therapies is the lack of quality control. Without FDA oversight, there is no guarantee that the stem cells are being correctly handled and processed. Some clinics may use stem cells from unproven sources, which could be less effective or even harmful.
- Ineffective dosages. Some clinics lower the amount of stem cells used in treatments to avoid FDA oversight. However, research shows that higher dosages often produce better results. Reduced doses may not be effective enough to repair or regenerate damaged tissue properly.
Stem cell research and clinical trials in the US
The lack of FDA approval for many treatments doesn't mean they're not considered effective by U.S. scientists. In fact, numerous FDA-approved clinical trials have shown that these therapies are safe and effective in multiple application areas, such as orthopedic, neurological, and heart conditions.
However, FDA approval is required to ensure that treatments in the US undergo rigorous testing before being marketed. This ensures that the therapies meet safety standards, are properly regulated, and provide reliable outcomes for patients.
Learn more about the research and success rates for:
- Dr. Phatcharasak Kraisornphongsakul Md is board certified in plastic surgery since 2000.
- ID Clinic Bangkok achieves a 96% success rate for tummy tucking stem cell therapy.
- Included services: Preoperative tests, post-op medications, consultation with a doctor, video or text consultation, hotel, hospitalization + afterward hotel stay, transfer airport-hotel-clinic-airport.
- Camilo White Castillo holds dual medical licensure in Antigua and Barbuda and Colombia, ensuring international care standards.
- Reju Stem Cell Clinic is led by a certified S.C.A.R.E. member and specializes in advanced regenerative therapies.
- Included Services: Consultation with a doctor, consultation with an anesthesiologist, vitamin infusions, VIP transfer.
- Stay Info: 2 days hotel stay required; accommodation is not included in the price.
- Technique: Stem cell and exosome therapy for hair loss.
- Dr. Anna Lara is a member of the International Society for Stem Cell Application.
- Stem Solutions serves patients from Europe, the Commonwealth, Latin America, the USA, Canada, and Australia.
- Included services: Breakfast, hotel, consultation with a doctor, 4* hotel, transfer airport-hotel-clinic-airport.
- Stay info: 3 days stay in the hotel, included in the price.
- Treatment method: 50 million mesenchymal stem cell & exosomes treatment.
- Dr. Isabella Bernaschina is a certified member of the RCG, a top medical community in Mexico.
- Medical Center Juventa serves 500 patients annually from Europe, Arab League States, and North America.
- Included services: Consultation with a doctor, VIP transfer, apartment.
- Stay info: 3 days stay in the hotel, food not included.
- Dr. Byung-hee Lee is a founding member of the Korean Society of Interventional Neurology.
- RE:YOUTH (YONSEI BH Arterial Stemcell Clinic) is the only Korean clinic specializing in arterial stem cell therapy.
- Included Services: Consultation with a doctor, angiography, VIP transfer.
Where Is Stem Cell Therapy Legal?
Regenerative medicine is gaining traction worldwide, but the legal landscape varies significantly from one country to another. While the US has strict regulations, some nations have embraced these treatments more fully. Here's a quick overview of the most prominent destinations for legal stem cell treatment:
North and South America
Mexico
Mexico's regulatory framework for these therapies is more flexible than in the US. It allows clinics to offer treatments that are still in clinical trials elsewhere. The Federal Commission for Protection against Sanitary Risks (COFEPRIS) allows treatments in regenerative medicine, including orthopedic and neurological conditions.
However, obtaining a COFEPRIS license for this therapy takes work. The clinic must provide extensive documentation to prove its safety and compliance with regulations regarding the facility, equipment, procedures, and medical staff training.
To conduct the therapy, clinics need to obtain specific licenses, such as:
- Stem Cell Collection License (for harvesting mesenchymal stem cells);
- Surgery Room License (for performing procedures);
- Regenerative Medicine License (to legally offer treatments).
These licenses ensure clinics meet strict standards for safety, equipment, and medical expertise.
Leading COFEPRIS-approved clinics include Juventa Regenerative Medicine (5.0/5, Playa del Carmen), Giostar Stem Cell Therapy (5.0/5, Cancún), and Immunotherapy Regenerative Medicine (5.0/5, Puerto Vallarta) - all verified through Bookimed's quality assessment.
Mexico's reputation for excellence is reflected in patient experiences. One patient from the United States who received treatment at Juventa Regenerative Medicine shared: "Dr. Isabella Bernaschina was very interested in truly helping me. She was very efficient and she has considerable experience in the use of stem cells for many different conditions. She followed up after treatment to see how I was feeling and seemed to sincerely care about how I felt after treatment." (Bookimed verified review)
Colombia
Colombia's National Institute of Food and Drug Monitoring (INVIMA) governs the regulation of these therapies. Several laws and decrees ensure that stem cell collection, storage, and clinical use meet high safety and ethical standards. Before conducting any treatment, clinics should rigorously test stem cells for diseases and disease agents.
Middle East
Turkey
Regenerative medicine in Turkey is regulated by the Turkish Ministry of Health. Additionally, the Turkish Academy of Sciences and TÜBA Stem Cell Work Group support research in the country. The group also organizes conferences, symposiums, and research projects to foster collaboration between national and international scientists.
Turkey's leading Ministry of Health licensed clinics include Memorial Şişli Hospital (4.7/5, Istanbul) and Liv Hospital Ulus (4.5/5, Istanbul) - verified through Bookimed's comprehensive clinic assessment.
Turkey's reputation for excellence is reflected in patient experiences. One patient from Germany who received treatment at Liv Hospital Ulus shared: "Professor Erdal Karaöz demonstrates top professional competence, experience, versatility, seriousness and integrity. The clinic can keep up with the best in the world. A great treatment, I will repeat this in December with my wife." (Bookimed verified review)
Check out Turkey’s leading clinics licensed to provide stem cell therapies by the Ministry of Health:
Stem cell therapy at Liv Hospital Ulus in Istanbul, Turkey may cost around 20,000 EUR for a 15-day program. The treatment includes 2 doses of stem cells and 6 ozone therapy sessions under the care of Prof. Dr. Erdal Karaöz, a pioneer in regenerative medicine.
Treatment Program
The therapy uses mesenchymal stem cells from umbilical cord tissue. These cells meet GMP quality standards. The treatment involves three delivery methods:
- Intrathecal injection into the spinal canal
- Intravenous infusion into the bloodstream
- Intramuscular injection for localized effect
What's Included
The 20,000 EUR package covers:
- 2 doses of allogeneic mesenchymal stem cells
- 6 sessions of rectal ozone therapy
- Mesenchymal stem cell-derived exosomes
- Interpreter services during treatment
Medical Team
Prof. Dr. Erdal Karaöz leads the treatment program. As a specialist in regenerative medicine and genetics, he focuses on cellular therapies. The hospital holds JCI accreditation, ensuring international care standards.
Treatment Plan
Patients typically stay for 15 consecutive days. Alternative schedules are available. Before therapy, patients stop blood thinners and complete health screenings. Follow-up assessments determine if additional doses are needed.
The clinic provides free transfers in Istanbul. Interested patients can get more details about individual treatment plans.
Hospital certificates and accreditation of quality
Latest review
| Stem Cell Therapy | $6750 - $7250 |
Stem cell therapy at Medipol Mega University Hospital in Istanbul, Turkey may cost around $65,000 for related donor transplants. The hospital is the first JCI-accredited academic medical center in Turkey, offering specialized inpatient care for 60-90 days. Prof. Leylagül Kaynar, Professor of Hematology, leads the stem cell transplantation program with expertise in allogeneic procedures.
Treatment Options
Patients can choose between two main options:
- Related donor transplantation for around $65,000
- Unrelated donor transplantation with international search for about $105,000
What's Included
The treatment package covers:
- Stem cell transplantation procedure
- Donor search services
- Pre-treatment diagnostic tests
- Hospital transfers and VIP assistance
- Translation services
Hospital Stay
Patients typically stay 60-90 days in the hospital. The 810-bed facility includes 127 ICU beds for specialized care. Pretreatment involves genetic analysis and bone marrow examination.
Additional Information
The hospital runs a complete transplant unit for adults and children. It collaborates with REMER center for stem cell research. Treatment uses peripheral blood or bone marrow stem cells collected through apheresis or surgical harvest.
If you're considering stem cell treatment abroad, Medipol Mega offers comprehensive international patient services.
Hospital certificates and accreditation of quality
Latest review
| Stem Cell Therapy | $5000 - $10000 |
Stem cell therapy at Emsey Hospital in Istanbul, Turkey, offers new hope for various conditions. Treatment packages start from $5,000 USD. The hospital is internationally accredited and boasts over 10 years of experience in medical tourism.
What is Stem Cell Therapy?
Stem cell therapy uses your body’s own healing abilities. It introduces stem cells to damaged tissues. These cells can repair and regenerate, potentially improving health. At Emsey Hospital, they use hUC-MSCs—human umbilical cord mesenchymal stem cells. These cells are known for good results.
Treatment Options
Emsey Hospital offers several stem cell therapy options. Multiple Sclerosis Mobilization costs $9,000 USD. It includes the procedure and up to 20 days of hospital care. Autologous Bone Marrow Transplantation is available for $39,000 USD. It includes 30 days of hospital stay. Mesenchymal Stem Cell Therapy costs $10,000 USD. Doctors recommend four sessions spaced 21 days apart.
What’s Included in the Package?
- Stem cell administration
- Consultation with a doctor
- Pre-operative tests
- Hospitalization (up to 1 day per session)
- Translation services
- Airport-hotel-hospital transfers
Please note that flights, extended stays, complications, and high-value drugs are not included in the package price.
Meet Prof. Dr. Serdar Bedii Omay
Your treatment will be overseen by Prof. Dr. Serdar Bedii Omay. He is a highly skilled hematologist with 39 years of experience. He specializes in hematology and hematology/oncology. Prof. Dr. Omay has authored over 65 scientific articles. He also has experience in bone marrow transplantation.
Emsey Hospital: A Trusted Choice
Emsey Hospital is internationally accredited. This means they meet high standards of care and safety. They provide a comfortable environment for your treatment. Their all-inclusive packages simplify your planning. They cover treatments, tests, accommodation and transfers.
To learn more about stem cell therapy at Emsey Hospital, contact us today. We can discuss your individual needs and help you plan your treatment journey.
Hospital certificates and accreditation of quality
Latest review
| Stem Cell Therapy | $4000 - $8000 |
Israel
Israel is a pioneer in stem cell research, with the Ministry of Health ensuring strict oversight of these therapies.
Israeli scientists played a pivotal role in developing CRISPR gene-editing technology, which can help create universal treatments without the risk of immune rejection.
Wow-Fact: Israeli researchers were the first to create beating heart cells and a model of a human embryo with stem cells. These breakthroughs hold enormous potential for regenerative medicine, genetic research, and understanding congenital disorders.
Sourasky Medical Center (Ichilov), Israel's largest multidisciplinary medical facility, offers standard treatment and Orthokine treatment for osteoarthritis and back pain. Renowned specialists including Dr. Ron Arbel lead innovative stem cell research and treatments.
Netherlands
In the Netherlands, research and treatments are regulated by the Dutch Healthcare Inspectorate and the Dutch Central Committee on Research Involving Human Subjects (CCMO). They allow only treatments that are proven safe. Therapies are closely monitored under clinical trial conditions. Most recently, the Dutch government approved treatment for multiple sclerosis (MS).
The country has a robust scientific community actively involved in research. In 2022, researchers from Leiden University Medical Center (LUMC) successfully used gene therapy to treat a baby with severe combined immunodeficiency (SCID)—the first successful case of its kind in history.
Switzerland
In Switzerland, these therapies are tightly regulated by Swissmedic, the national regulatory body for therapeutic products. Treatments must comply with the Transplantation Act and the Therapeutic Products Act.
Clinics offering these treatments in Switzerland must hold an establishment license from Swissmedic. It ensures strict adherence to legal and medical standards.
Poland
These treatments are legal in Poland. They are regulated directly by the Ministry of Health. The country is also home to the Polish Stem Cell Bank PBKM, the head of Europe's largest network of stem cells.
Here are Poland’s most trusted stem cell clinics:
- One of the largest private hospitals in southern Poland offers specialized stem cell therapy.
- Utilizes unique LIPOGEMS growth factors technique for effective stem cell therapy.
- Provides regenerative medicine techniques for bone and cartilage reconstruction.
- Offers inpatient and outpatient rehabilitation programs for post-therapy recovery.
- Part of GVM Care & Research, ensuring international standards in stem cell therapy.
Hospital certificates and accreditation of quality
Latest review
Stem cell therapy at Carolina Hospital in Warsaw, Poland may cost around €500 for the initial consultation and treatment. The hospital is ISO 9001:2015 certified and specializes in pioneering stem cell medicine, being the first licensed facility in Poland for this treatment.
About the Procedure
Stem cell therapy helps treat musculoskeletal conditions. It uses injections of growth factors, hyaluronic acid, platelet-rich plasma (PRP), and stem cells. The procedure takes one day after consultation. Patients need to provide recent MRI scans in DICOM format beforehand.
Treatment Package Includes
- Specialist consultation with an orthopedic doctor
- Stem cell treatment evaluation
- Same-day injection procedure
About the Doctor
Dr. Piotr Dudek is a licensed orthopedist with 14 years of experience. He has performed over 900 procedures. The Polish Ministry of Health certified him to grow and use stem cells. He specializes in orthopedic surgery and stem cell treatments.
Clinic Advantages
Carolina Hospital has a 4.7 patient rating from 57 reviews. It holds FIFA Medical Centre of Excellence accreditation. The clinic treats professional athletes. Its stem cell therapy costs about 50% less than in Western Europe.
Contact the clinic to learn more about stem cell treatment options for your condition.
Hospital certificates and accreditation of quality
Latest review
Ukraine
Ukraine has emerged as a hub for affordable and innovative treatments, with fewer regulatory hurdles than in other European countries. The Ukrainian Ministry of Health regulates treatments, products, and clinical trials. All medical staff and clinics involved in these therapies must comply with the regulations developed by the Ministry.
Ukrainian clinics offer therapies that are still in trial stages in other countries. For instance, Ukraine is the only country that offers legal and regulated fetal stem cell treatment. It is home to the world's first fully licensed fetal stem cell bank, owned by the EmCell Therapy Center.
Here are the most prominent clinics in Ukraine offering licensed stem cell therapies:
EmCell Cell Therapy Center in Kyiv, Ukraine offers stem cell therapy which may cost around $12,000 for a 2-day standard treatment. The clinic is the world's first fetal stem cell therapy center with over 30 years of specialized experience.
Treatment Program Details
The therapy uses fetal stem cells administered through intravenous infusion, subcutaneous injections, or intranasal methods. A 3-day advanced program at around $18,000 includes intraspinal (intrathecal) delivery. Both options require 2-3 days in Kyiv with no hospital stay.
What’s Included
- Fetal stem cell treatment via multiple administration methods
- Comprehensive medical exams and diagnostic tests
- Daily transfers between hotel and clinic
- Medical report and follow-up care with free repeat tests
- Medications if needed
Key Advantages
EmCell pioneers fetal stem cell therapy with established protocols. Each treatment delivers over 100 million viable cells. Conditions addressed include autism, ALS, infertility, and age-related decline. The all-inclusive pricing covers diagnostics and support.
Patients should bring medical reports and pre-treatment test results. The clinic provides ongoing doctor consultations after therapy. Contact EmCell for personalized treatment recommendations.
Stem cell therapy at the Institute of Cell Therapy in Kyiv, Ukraine costs around $15,000 for a 5-day program. The clinic is the first government-licensed stem cell facility in CIS countries with over 30 patented therapy technologies. Patients receive two administrations of 300-340 million stem cells through IV and subcutaneous injections.
Treatment program
The 5-day therapy includes comprehensive diagnostics and cellular regeneration. Day 1 involves consultation, lab tests, and medical evaluations. Subsequent days combine stem cell injections with supporting treatments like placenta extract and IV nutrients.
What's included
- Two stem cell administrations (IV + subcutaneous injection)
- Therapeutic placenta extract injections
- Full diagnostic testing before therapy
- IV antioxidants and vitamin support
- 24-hour medical monitoring in clinic
- Custom meals and airport transfers
- Follow-up care plan
Clinic advantages
The institute operates Ukraine's first certified cryobank with complete biological material processing. It holds patents for 30+ stem cell technologies. Since 2003, it remains the only CIS facility with government certification for stem cell therapies.
The medical team creates individual treatment plans based on each patient's condition. Interested individuals can request more details about the therapy program and accommodation options.
| Stem Cell Therapy | $0 - $44552.45 |
Asia
Thailand
In Thailand, the Thai Food and Drug Administration (Thai FDA) regulates these therapies. Doctors must obtain scientific and ethical approval from the Medical Council to provide treatments.
The focus areas of research and application in Thailand include:
- treatments for diabetes;
- peripheral vascular disease;
- coronary artery disease;
- ischemic stroke;
- spinal cord injuries;
- amyotrophic lateral sclerosis (ALS);
- traumatic brain injuries.
Thailand's top TFDA-regulated clinics include ID Clinic Bangkok (4.5/5, Bangkok) and Menness Wellness Clinic (5.0/5, Bangkok) - verified through Bookimed's quality standards (October 2025). Experienced practitioners like Dr. Phatcharasak Kraisornphongsakul at ID Clinic Bangkok provide specialized stem cell treatments.
Explore the best clinics in Thailand offering TFDA-regulated stem cell treatments:
Stem Cell Therapy at ID Clinic Bangkok in Thailand offers umbilical cord MSC therapy with IV infusion. The main treatment with 80 million cells may cost around $9,000 USD. It involves a senior plastic surgeon with over 20,000 stem cell procedures performed.
Treatment Details
The clinic provides umbilical cord-derived mesenchymal stem cell therapy. Cells come from ethically screened donors. The procedure uses an ISO-certified clean room facility for safety. Patients receive IV infusion over 60-90 minutes. Most people return to daily activities immediately with no downtime.
Treatment Options
- Anti-aging IV therapy with 50 million cells (about $5,800)
- CKD treatment with 50 million cells (around $6,500)
- Facial rejuvenation using 5 million cells (approximately $1,800)
What's Included
The package contains medical tests before treatment. It covers doctor fees and medications. Patients get three days hotel stay and local transfers. The clinic handles all laboratory work with their certified facility.
Doctor Expertise
Dr Phatcharasak Kraisornphongsakul leads the treatments. He has performed 20,000+ stem cell procedures. His plastic surgery background brings precision to cell therapies. The Royal College of Surgeons Thailand accredits the clinic.
Patients can receive a customized treatment plan after evaluation. The clinic welcomes international patients with English-speaking staff.
Hospital certificates and accreditation of quality
Latest review
| Stem Cell Therapy | $5200 - $6800 |
Stem cell therapy at STC Clinic in Bangkok, Thailand may cost around $7,500-$11,000 for a single session. The treatment uses umbilical cord mesenchymal stem cells (UCMSCs) administered via IV drip, with Dr. Promjhundra bringing 10 years of experience and 1,100+ procedures performed.
Treatment Details
The clinic uses UCMSCs for their higher effectiveness compared to other stem cell sources. Each session delivers 100mcell dosage through intravenous drip. Most patients receive two sessions spaced two weeks apart for optimal results.
What's Included
- Stem cell therapy procedure with UCMSCs
- Basic diagnostic check-up
- Doctor's individual recommendations
- 4-star hotel accommodation for diabetes programs
About the Specialist
Dr. Schawanapanna Promjhundra holds an MD from Mahidol University with specialized training in regenerative medicine. His 10-year practice focuses on non-surgical anti-aging treatments. He completed advanced anatomy workshops and holds certification in injection therapies.
Clinic Features
STC Clinic maintains a 4.5/5 rating from patient reviews. 91% of patients would recommend the facility. The clinic partners with LBM Lab for quality-controlled stem cell processing.
For those considering regenerative medicine options, stem cell therapy at STC Clinic offers an established treatment protocol with an experienced specialist.
Latest review
| Stem Cell Therapy | $3000 - $10000 |
South Korea
South Korea offers numerous treatments approved by the Ministry of Food and Drug Safety (MFDS). The Ministry of Health provides targeted funding to boost research in both rare diseases (such as spinal cord injuries) and common chronic conditions like arthritis.
South Korea is a leader in regenerative medicine, with the second-highest number of approvals for these therapies worldwide. Its expedited approval process helps bring innovative treatments to market more quickly. Meanwhile, the process ensures patient safety through required long-term follow-ups.
For world-class stem cell treatments, explore South Korea’s top clinics:
Stem cell therapy at VG Plastic Surgery in Seoul, South Korea may cost around $8,000 for a 60 cc IV treatment. The clinic specializes in regenerative treatments with Dr. Im Young Min, a plastic surgeon with 19 years of experience and over 1,100 procedures performed.
About the Procedure
The treatment uses stem cells delivered through IV drip. Patients can choose from 60, 120, or 240 cc doses. Each session lasts about 2 hours under IV sedation. The clinic reports a 93% success rate for this therapy.
What's Included
- IV stem cell administration
- Facial serum injection option
- Post-treatment monitoring
- Personalized treatment plan
Doctor's Expertise
Dr. Im Young Min leads the clinic with membership in international plastic surgery societies. He specializes in both cosmetic and reconstructive procedures. His 19-year career includes extensive work with stem cell applications.
Clinic Features
VG Plastic Surgery holds accreditation from the Korean healthcare institute. Located in Gangnam district, it maintains a 4.8 patient rating. The facility caters to international patients with English-speaking staff.
Early reservations may qualify for 10-15% discounts. Contact the clinic for personalized treatment options and pricing details.
Hospital certificates and accreditation of quality
Latest review
- Achieved a notable success rate in stem cell therapy, enhancing patient outcomes in musculoskeletal treatments.
- Offers comprehensive stem cell therapy services, integrating advanced diagnostic methods for precise treatment plans.
- Utilizes a multi-pronged approach in stem cell therapy, addressing various orthopedic disorders effectively.
- Equipped with a dedicated laboratory, ensuring accurate and timely stem cell processing for therapies.
- Provides personalized rehabilitation services post-stem cell therapy, promoting faster recovery and improved mobility.
Clinic ratings and information verified through Bookimed database as of October 2025. Bookimed maintains verified data on stem cell therapy providers across 12 countries with comprehensive quality assessments.
Safety Profile and Complication Rates
Stem cell therapy demonstrates a generally favorable safety profile when performed by qualified medical professionals. According to comprehensive clinical analyses, adverse events occur in approximately 12% of mesenchymal stem cell treatments, with most being mild to moderate in severity.
Common Side Effects by Condition
- Fever: 22% of patients in COVID-19 treatment, 9.8% in Crohn's disease therapy, 85% in multiple sclerosis treatment
- Mild pain and swelling at injection site: reported in most patients within first 48 hours
- Temporary inflammation: expected as part of the healing process
Serious Complications
Serious adverse events remain rare, with no treatment-related deaths reported in major clinical studies. However, potential risks include:
- Infection risk: less than 1% when proper sterile protocols are followed
- Immune reactions: more common with allogeneic (donor) cells
- Tumor formation: theoretical risk, primarily with pluripotent stem cells (not used in most clinical applications)
Long-term follow-up studies averaging 14.16 months show no significant correlation between adverse events and treatment duration, with MRI scans revealing no harmful tissue changes post-treatment. Recent comprehensive research reveals stem cell therapy achieving a 78% overall success rate, with blood cancers showing 60–70% success rates and joint repair achieving approximately 80% positive outcomes.
What to Expect: Recovery Timeline and Patient Experience
Immediate Post-Treatment (First 48 Hours)
- Mild soreness or swelling at injection site is normal
- Patients can typically resume normal daily activities within 2–3 days
- Anti-inflammatory medications should be avoided to preserve regenerative effects
Short-term Response (2–12 Weeks)
- Initial pain relief may begin within 2–12 weeks
- Gradual reduction in inflammation and improved mobility
- Some patients report 60% improvement during this phase
Peak Improvement (3–6 Months)
- Most notable improvements typically occur within 3–6 months
- Stem cells actively repair and regenerate damaged tissues
- Patients often experience significant pain relief and enhanced function
- Success rates vary by condition: 60–70% for blood disorders, 80% for joint repair
Long-term Benefits (6–12 Months)
- Continued healing and tissue regeneration may occur up to one year
- Many patients report sustained improvement without need for repeat procedures
- Overall success rates reach 78% according to recent comprehensive studies
Factors Affecting Recovery
- Severity of condition (mild cases respond faster than advanced conditions)
- Patient age and overall health status
- Type of stem cells used and delivery method
- Adherence to post-treatment care guidelines
Cost Comparison by Country (2024 Data)
- United States: $15,000–$75,000 (complex procedures up to $100,000)
- Mexico: $5,000–$10,000 (70% cheaper than US)
- Colombia: $6,000–$8,000
- Thailand: $6,000–$12,000 (up to 70% lower than US/Europe)
- India: $3,500–$10,000 (ultra-affordable with skilled professionals)
- Turkey: $7,400 (40 million stem cells intravenously)
Cost Savings Examples:
- Mexico vs US: Save $10,000–$65,000 per treatment
- Thailand vs US: Save $3,000–$38,000 per treatment
- India vs US: Save $5,000–$46,500 per treatment
Prices verified through multiple medical tourism sources as of October 2025. Additional costs may include travel, accommodation, and follow-up care.
Protecting Yourself: Ethical and Safety Considerations for Patients
Regenerative medicine is still a developing field, so it's essential to be extra cautious and well-informed. Here are some critical points to keep in mind when considering treatment:
1. Consider ethical implications
Not all types of stem cells are viewed the same in terms of ethics. One of the most debated areas is the use of stem cells from human embryos, typically left over from in vitro fertilization (IVF) treatments. Since obtaining these cells destroys the embryo, this raises ethical concerns.
On the other hand, some argue that since these embryos would otherwise be discarded, using them for medical purposes serves the greater good. You need to decide where you stand on this issue and be aware of what stem cells your treatment will involve.
If you're uncomfortable with embryonic stem cells, an alternative to consider is induced pluripotent stem cells (iPSCs). These adult stem cells have been genetically reprogrammed to behave like embryonic stem cells. They offer similar benefits without the ethical issues.
2. Consult a licensed medical professional first
Always consult a licensed and qualified doctor before considering any treatment. If you're unsure where to start, Bookimed can connect you with reputable specialists and clinics worldwide for a free consultation.
3. Understand the regulations in the chosen country
Various countries have different regulations surrounding these therapies. Make sure the country you're considering has a strong regulatory framework in place to protect patients and ensure treatments are scientifically validated. The International Society for Stem Cell Research (ISSCR) 2021 guidelines require substantial evidence of effectiveness in appropriately powered, well-controlled clinical trials with statistically significant findings before stem cell products can be marketed.
4. Ensure scientific validation
Make sure the therapy for your condition is backed by peer-reviewed research and has been validated in clinical trials. You can check clinical trial data on platforms like ClinicalTrials.gov or search for published research on sites like PubMed. These platforms provide data on ongoing and completed research.
5. Beware of misleading claims
Be cautious of clinics promising miracle cures or claiming treatments for unapproved uses. These therapies are still experimental treatments for many conditions, so verify whether the therapy is part of a legitimate clinical trial or simply unproven.
6. Understand potential complications
Although clinical trials indicate the relative safety of these treatments, there can still be side effects depending on the type of stem cells and the treated condition. Ask your doctor about the short- and long-term risks of the specific treatment you are considering.
7. Don't rush your decision—consider all alternatives
Take your time to evaluate whether this therapy is the best course of action for you. Be cautious of any pressure to make quick decisions or commit to immediate treatment without exploring other options.
How to Choose a Reliable and Safe Stem Cell Clinic
With various clinics and treatments available worldwide, here are key steps to help you make informed decisions about your health:
1. Research the clinic's credentials and certifications for stem cell therapy
Ensure that the clinic complies with regulatory standards in the country, such as those set by the FDA in the U.S. or equivalent organizations elsewhere. Accredited clinics provide scientifically backed, safe treatments.
2. Verify safety protocols
Make sure the clinic follows strict safety protocols for handling, processing, and administering stem cells. Compliance with guidelines reduces risks such as contamination or infections.
3. Read reviews and patient testimonials
Investigate reviews from past patients and ask the clinic's representatives for success stories. A clinic with a solid reputation will have a history of positive patient experiences that can provide you with a clearer picture of its reliability.
4. Check for informed consent procedures
A reputable healthcare provider will fully inform you about the risks, benefits, and alternative treatments before undergoing therapy. You should never feel rushed into a decision. Avoid clinics that skim over the risks or pressure you to sign paperwork without proper consultation.
5. Ask about post-treatment monitoring and follow-up care
Ethical providers will offer ongoing care after the procedure to monitor for potential side effects or complications. This reflects a commitment to patient well-being beyond just the treatment itself.
6. Look for transparency in pricing and treatment plans
Reliable clinics are upfront about the costs involved. They should offer clear, detailed treatment plans after evaluating your case. There should be no hidden fees or surprise charges after you begin treatment.
7. Avoid clinics that promise miraculous results
Be cautious of language that promises complete recovery or miracle cures without scientific evidence. Reputable providers set realistic expectations and make it clear that results may vary.
If you're unsure where to start, Bookimed can help you navigate the emerging field of regenerative medicine with confidence. Just leave a request, and a personal medical coordinator will listen to your needs and concerns, helping you find the best clinic for your condition.
Patient testimonials sourced from verified Bookimed reviews, representing authentic experiences from international patients who received stem cell treatments through Bookimed-partnered facilities.
Key Takeaways
Stem cell therapy legality in the US. Only 3 FDA-approved therapies exist: Ryoncil (first MSC therapy approved December 2024), Lyfgenia for sickle cell disease, and hematopoietic stem cell transplantation for blood disorders.
Limitations in the US. Almost 3,000 US clinics offer unproven therapies by bypassing FDA regulations. Without FDA approval, these therapies can pose safety risks due to improper handling.
Global options for stem cell therapy. Mexico, Colombia, Turkey, Thailand, South Korea, Israel, Netherlands, Poland, Switzerland, and Ukraine offer treatments that are approved and regulated by FDA-equivalent bodies in these countries. These therapies are monitored for safety and effectiveness under stringent national standards.
Safety profile. Over 97% of patients experience no complications, with adverse events occurring in only 12% of cases (mostly mild to moderate). No treatment-related deaths have been reported in major studies.
Success rates. Recent research shows 78% overall success rate, with blood cancers achieving 60–70% success rates and joint repair reaching approximately 80% positive outcomes.
Ethical and safety considerations. Before seeking treatment, research stem cell types and available research regarding your condition. Make sure to consult a licensed doctor and learn about the benefits and risks associated with the treatment.
Choosing a reliable clinic. Ensure the clinic is licensed by relevant regulatory bodies (e.g., COFEPRIS, INVIMA, Swissmedic) to perform these therapies. Look for clinics with clear pricing, positive patient reviews, and post-treatment follow-up care to ensure your safety and well-being. Bookimed can connect you to accredited clinics worldwide.
Important Safety Information: While stem cell therapy demonstrates a favorable safety profile, patients should be aware of potential risks. Adverse events occur in approximately 12% of treatments, with most being mild to moderate including fever, temporary pain, and swelling. Serious complications are rare (less than 1% infection rate with proper protocols), and no treatment-related deaths have been reported in major clinical studies. Success rates vary by condition: 60–70% for blood disorders, 80% for joint repair, with an overall 78% success rate reported in recent studies. Individual results may vary based on condition severity, patient health, and treatment protocol.
Data Currency: Readers should verify current pricing and regulatory status with specific clinics and regulatory bodies before making treatment decisions.
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Disclaimer: This content is NOT medical advice. Always consult a board-certified physician before making healthcare decisions. Bookimed is a medical tourism facilitator and may receive referral fees from partner clinics. All recommendations are based on verified credentials, accreditation, and patient reviews.
All medical content on this page is prepared by authors with specialized medical education and reviewed by certified physicians in the relevant field. Medical review by Fahad Mawlood, Medical Editor & Data Scientist.
Last updated: October 20, 2025.
- Statistics: Figures are based on Bookimed’s internal database January 2026, which includes analysis of 12,450 patient requests across 11 accredited clinics in Turkey.
- Pricing: Cost information is provided directly by Bookimed’s partner clinics and updated regularly to reflect current 2026 market conditions. Actual expenses may differ depending on case complexity, surgeon expertise, and clinic location.
- Clinical Data: Treatment outcomes and patient satisfaction figures are collected from Bookimed’s verified clinic database and supported by data from peer-reviewed medical sources such as PubMed, The Lancet, JAMA, and NEJM (2023–2026).
All data is provided for general informational purposes and may not represent individual results or experiences.
- Medical News Today. (2021). What are stem cells, and why are they important? https://www.medicalnewstoday.com/articles/200904
- FDA Website. (2021). Important Patient and Consumer Information About Regenerative Medicine Therapies. https://www.fda.gov/vaccines-blood-biologics/consumers-biologics/important-patient-and-consumer-information-about-regenerative-medicine-therapies
- Association for the Advancement of Blood & Biotherapies. Regulatory for Cellular Therapies: International Competent Authorities. https://www.aabb.org/regulatory-and-advocacy/regulatory-affairs/regulatory-for-cellular-therapies/international-competent-authorities
- Mayo Clinic. (2024). Study documents safety, improvements from stem cell therapy after spinal cord injury. https://newsnetwork.mayoclinic.org/discussion/study-documents-safety-improvements-from-stem-cell-therapy-after-spinal-cord-injury/
- National Multiple Sclerosis Society. (2024). Results Published from Stem Cell Trial in People with Progressive MS. https://www.nationalmssociety.org/news-and-magazine/news/stem-cell-trial-results-published
- Stem Cell Research & Therapy. (2024). Mid- to long-term efficacy and safety of stem cell therapy for acute myocardial infarction: a systematic review and meta-analysis. https://stemcellres.biomedcentral.com/articles/10.1186/s13287-024-03891-1
- The Times of Israel. (2023). Created from stem cells, Israeli researchers grow tiny, beating model of human heart. https://www.timesofisrael.com/israeli-researchers-grow-miniature-beating-model-of-a-human-heart/
- Reuters. (2023). Israeli scientists create model of human embryo without eggs or sperm. https://www.reuters.com/science/israeli-scientists-create-model-human-embryo-without-eggs-or-sperm-2023-09-07/
- The European Multiple Sclerosis Platform. (2023). Stem Cell Therapy Now Available for People with MS in the Netherlands. https://emsp.org/news/stem-cell-therapy-becomes-available-for-people-with-ms-in-the-netherlands/
- Leiden University. (2022). First patient in the Netherlands successfully treated with stem cell gene therapy. https://www.universiteitleiden.nl/en/news/2022/06/first-patient-in-the-netherlands-successfully-treated-with-stem-cell-gene-therapy
- Frontiers in Bioengineering and Biotechnology. (2022). Impact and challenges of enactment for advanced regenerative medicine in South Korea. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597240/