United States of America, Phoenix
Osteoarthritis Treatment in Kentuckiana Integrative Medicine
About the clinic
Osteoarthritis care at Kentuckiana Integrative Medicine in Jeffersonville, Indiana, includes image-guided injections and regenerative therapies. A consultation may cost around $300, prolotherapy around $600, PRP around $1,500, and amniotic injections around $2,500. Dr. Rafael F. Cruz, MD, has over 30 years of experience and over 20 years treating joint and knee pain.
Assessment and image guidance
The clinic reviews movement patterns and imaging to plan treatment. Injections can use real-time fluoroscopic X-ray, ultrasound, or Orthoscan imaging. Procedures are outpatient and available on the same day.
- Regenerative medicine consultation: Includes an examination, movement-pattern review, imaging review, and personalized treatment planning.
- Image-guided assessment: Fluoroscopy, ultrasound, and Orthoscan support joint evaluation and injection guidance.
Injection and rehabilitation options
- Hyaluronic gel injections: FDA-approved for knee arthritis and available as Genvisc, Supartz, Orthovisc, Hyalgen, or Synvisc. The protocol uses five weekly injections and may be repeated every six months. Traditional Medicare and most commercial insurance cover this treatment for knee arthritis.
- Prolotherapy or Prolozone: Dextrose, or ozone mixed with nutrients, is injected into joints, ligaments, or tendons. The listed treatment price may be around $600.
- PRP injections: The patient’s concentrated platelets are injected into the joint under image guidance. Prolotherapy or Prolozone is included. The listed price may be around $1,500.
- Amniotic membrane injections: This allograft injection cushions and supports affected joints. Prolotherapy or Prolozone is included, and the listed price may be around $2,500.
- Messenger Signaling Cell therapy: Image-guided injections use cells from fat or bone marrow, or an allograft product. Knee treatment includes one to three injections; dosing uses the patient’s history, examination, and imaging. This option may cost around $7,000–$9,000.
- Osteoarthritis stem cell treatment: The listed treatment price may be around $9,000–$15,000.
- Bone marrow aspiration injections: Bone marrow aspirate is injected into the joint. Reports describe knee pain relief within 2–10 days.
- Physical therapy: Used alongside injections to support strength, joint stability, and walking mechanics.
Dr. Cruz is two-time board-certified in Emergency Medicine and a founding member and fellow of the American Academy of Ozone Therapy. Patients can request a consultation through Bookimed to discuss these options.
Highlights
2014
Year of foundation
4 doctors
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Kentuckiana Integrative Medicine
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Average answering time – 5 minutes
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Treatments prices in the clinic
Last price update – {{date}}. Prices may change depending on the medical case and the doctor's recommendations.
Orthopedics
| treatment | Price | |
|---|---|---|
| Osteoarthritis stem cell treatment | $9000 - $15000 |
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Kentuckiana Integrative Medicine: more details about the clinic
United States of America, Phoenix
Kentuckiana Integrative Medicine is a private medical center established in 2014. The clinic is located in Jeffersonville, Indiana, directly across from Louisville, Kentucky. It operates through four specialized departments focused on regenerative and functional medicine. The facility treats patients of all ages using a whole-person therapeutic approach.
Achievements and Medical Leadership
Medical Director Dr. Rafael F. Cruz leads the clinical team. He has over 30 years of expertise in integrative medicine. Dr. Cruz holds a certification in IV Chelation and Plaquex therapies. He also maintains membership in the American Academy of Alternative Medicine (ACAM).
Dr. Cruz brings over 25 years of experience in ketamine administration. He personally oversees every mental health patient receiving this therapy. The clinic was among the first in its region to offer medical ketamine. It reports zero serious adverse events for this program.
Mental Health and Ketamine Therapy
The Kentuckiana Ketamine Institute provides physician-monitored treatments for complex psychological conditions. This department focuses on treatment-resistant cases where standard therapies have failed. Specialists screen for depression, bipolar disorder, PTSD, and anxiety. The institute offers both intravenous and intramuscular ketamine in private office settings.
A standard protocol includes seven sessions for optimal results. For depression, national data shows improvement in up to 75% of patients. The clinic treats several conditions through this program:
- Treatment-resistant depression and suicidal thinking
- Bipolar affective disorder
- Post-traumatic stress disorder (PTSD)
- Obsessive-compulsive disorder (OCD)
- Neuropathic pain and fibromyalgia
- Complex regional pain syndrome (CRPS)
Best results typically require six treatments within three weeks. Some patients receive periodic booster sessions to maintain relief. The clinic also provides addiction support to help patients wean off alcohol or opiates. This recovery process can last from 60 days to 18 months.
Regenerative Injections and Stellate Ganglion Block
The clinic specializes in PRP-enhanced Stellate Ganglion Block (SGB). Standard SGB uses local anesthetics to temporarily block nerve signals. Kentuckiana Integrative Medicine instead uses autologous platelet-rich plasma around the nerve. This approach aims for natural anti-inflammatory support and long-lasting relief. Specialists perform these injections using ultrasound guidance for precise placement.
Regenerative therapies also include prolotherapy and prolozone. These injections stimulate the body's natural healing responses for musculoskeletal issues. The clinic reports that 85% to 95% of patients see improvement in low back pain. These methods offer non-surgical options for patients with chronic neuroinflammation or circulatory concerns.
Vascular Support and IV Therapies
Physicians provide IV Chelation Therapy for circulatory and vascular support. This intravenous treatment uses EDTA to address heavy metal toxicity. The clinic offers it as a supportive strategy for cardiovascular-related health concerns. Patients can also access IV Vitamin therapies, such as the Meyer's Cocktail. These infusions support patients dealing with recurrent infections or severe fatigue.
Services for International Patients
Kentuckiana Integrative Medicine provides telehealth appointments for initial consultations. Virtual visits let patients speak with a physician before traveling to Indiana. The clinic treats individuals from across the region who travel specifically for regenerative care. Mental health screenings are available online to help determine the appropriate course of action.
Additional services
Transfer
Clinic to airport
$25 -
$45
Airport to clinic
$25 -
$45
Language assistance
Available
free
Accommodation
Hotel (apartments) near the clinic, billed daily
Requirements for admission
Payment methods
Cash
Credit cards
Age
14 -
0
Patient reviews
5 Google
reviews
Ronald Barnes
Oct 7, 2026
I am grateful to be able to have the advice and care by Dr. Cruz. The staff are excellent, Kitty in particular.
I would encourage anyone interested in being proactive about their health care to meet with Dr. Cruz and learn about options that exist to improve their wellbeing.
Amy Nelson
May 7, 2026
Dr Cruz and his staff are friendly, relatable, knowledgeable and very patient centered. Dr Cruz is patient, kind, and really wants you to make an informed decision about your care. He is not pushy or arrogant. He is very supportive and celebrate your victories with you. My husband had three injections in his shoulder: his range of motion has Improved tremendously, He has had no pain In his shoulder (used to hurt daily) or his knees (His knees reap the benefit of the treatment). I believe in his treatments whole heartedly and want my parents, kids, and friends to experience the amazing results of this treatment!
Tonya Knebel
Apr 2, 2026
I love the staff here. Todd keeps everything running smoothly and is very knowledgeable. He takes the time to make sure you know about all the treatments. Kitty is right there with him helping people. My appointment with Dr. Cruse was lengthy and very informative. If he doesn't think the treatment will work for you then he won't do it. He takes the time to talk with you without rushing. He's there if you have any more questions. He wants to go home and think about it before you decide. There's no pressure to make a quick decision.
Jim Gilpin
Mar 12, 2026
I live in Boston and have been a patient at Kentuckiana Integrative Medicine for 13 months. Dr Cruz helped me eliminate a 60% blockage in my verebral artery in 9 months with no surgery.
I first contacted Dr Cruz's team after being hospitalized in a foreign country with Transient Global Amnesia (TGA). A MRI brain scan showed I had 60% blockage in my left vertebral artery (neck). This event, three years after open heart surgury, was THE huge wake up call for me.
Neurologists in Boston MA had no solution other than "Your Lucky", so I started a nationwide search for the best functional/integrative medical team.
I interviewed teams in New York, Miami, Denver and Jeffersonville, IN. My discussions with Dr Cruz and the relevant reference materials he provided for addressing my issues made Kentuckianna Integrative Medicine the clear choice.
He suggested I begin with a healthy diet. I had been thinking of converting to a plant based diet and he encouraged me to get started. Next he suggested supplements to help improve the function of the endothelium lining of my arteries. I followed these recommendations. Finally, six months later I travelled to Indiana where I lived for 6 weeks to complete the recomended IV Chelation and IV PlaqueX therapy.
As soon as this therapy was complete, Dr Cruz suggested I do the exact MRI Brain scan from 9 months earlier. The result was 0% blockage in my left vertebral artery. Dr Cruz had me follow the MRI with additional Ultrasounds of my heart and Corodid arteries. All testing showed 0% blockage.
Some advise from my journey...My primary care and other traditional medicine doctors did not encourage this path. I had to ignore my doctors advice and do my own research to be confident I was doing what was right for me.
Dr Cruz and his team provided and explained the research materials, encouraged me and answered questions along the way. They continue to provided expertise as I now continue my journey following a quarterly maintenance schedule.
I highly recommend Kentuckiana Integrative Medicine.
Jane Salko
May 16, 2024
I AM HAPPY! Dr Cruz has built an incredible team and facility to be able to provide service that went above and beyond all expectations, over and over again. These people were a huge part of my transformation from an unhappy, depressed and fed up woman: into a happy, go-with-the-flow, open and fearless, confident in my skin, person!! The MUCH needed integration both before and after the treatments were what I believe made my experience with this medicine the best that it could be! I lived with depression my whole life until ketamine. The healing actually began as I opened my mind while listening to the book How to Stop Worrying and Start Living by Dale Carnegie. That book saves lives and that’s only one of the ways they prepare you for the best experience possible. Dr Cruz and his team have been helping people with PTSD, depression, anxiety and a whole realm of other long standing conditions, for many, many years. They are not new to this type of treatment, they are experts. I have suggested that every one of my loved ones treats themselves to ketamine with Dr Cruz. They deserve what I now have! Happiness and peace of mind. ❤️
405 E Court Ave #102, Jeffersonville, IN 47130, United States
updated 11/6/2026
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Kentuckiana Integrative Medicine
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