Leukemia treatment at Sheba Medical Center

Leukemia treatment at Sheba Medical Center in Ramat Gan, Israel, covers a full range of services from precision diagnostics to advanced cellular therapies. A CT scan may cost around $200–$400, while specialized CAR-T cell collection is around $6,600 and allogeneic donor bone marrow transplants typically run $154,000. As a JCI-accredited facility and MD Anderson Cancer Center partner, the hospital features an in-house GMP-certified lab that produces CAR-T cells in just 10–11 days.

Advanced leukemia diagnostics

The diagnostic process begins with a detailed assessment to identify the specific subtype of leukemia and genetic mutations. Patients receive a personalized evaluation led by Prof. Arnon Nagler, who serves as the President of the Hemato-Oncology Center. A standard pre-treatment ambulatory assessment typically runs $5,000–$10,000 and includes the following:

• Hemato-oncologist consultation. A meeting with Prof. Arnon Nagler to review history and plan therapy.
• Bone marrow biopsy. The collection of tissue to confirm the presence and type of cancer cells.
• Malignancy genotyping. Analysis of DNA changes to help select targeted drugs.
• Imaging and blood tests. Scans such as a brain MRI, which may cost around $1,000, to check for disease spread.

Specialized treatment and immunotherapy

Sheba Medical Center is known for its ability to manufacture CAR-T cells on-site, which allows for the use of fresh, non-cryopreserved cells. This process shortens the wait time for patients with relapsed or refractory disease. The clinic also provides traditional chemotherapy and targeted therapies that focus on specific mutations, such as midostaurin for AML.

• CAR T-cell therapy. This immunotherapy uses modified T-cells to attack cancer. The collection phase is around $6,600, and the procedure involves up to 21 days of hospitalization.
• Allogeneic donor bone marrow transplant. This procedure uses stem cells from a matched or haploidentical donor. The package, which typically runs $154,000, includes up to 30 days in the transplant unit and two months of follow-up care.
• Autologous stem cell transplant. This method uses the patient's own cells after they receive high-dose chemotherapy.
• HLA confirmatory typing. Essential testing to match donors, which may cost around $1,700.

Expertise of Prof. Arnon Nagler

Prof. Arnon Nagler leads the leukemia program with decades of experience in hemato-oncology and bone marrow transplantation. Prof. Arnon Nagler pioneered non-myeloablative and reduced-intensity allogeneic transplants, making these life-saving procedures safer for more patients. Besides directing the cord blood bank, Prof. Arnon Nagler holds a MSc and is a Professor of Medicine at Tel Aviv University. Under the leadership of Prof. Arnon Nagler, the center operates one of the most active transplant and cellular therapy programs in the Middle East.

To learn more about leukemia treatment options or to book an evaluation, you may request a consultation on Bookimed.