PROFESSIONAL EXPERIENCE
2011-2012
Erzurum Koprukoyu State Hospital
Department: General Medicine
2012-2017
Istanbul University Cerrahpaşa Medical Faculty
Department: Internal Medicine
06/2017-10/2017
Istanbul Gaziosmanpasa Taksim Training and Research Hospital
Department: Internal Medicine
10/2017-11/2018
Istanbul University Istanbul Medical Faculty
Department: Allergy and Immunology Fellowship
2018/2022
Istanbul University Oncology Institute
Department: Medical Oncology Fellowship
2022-2023
Tekirdag City Hospital
Department: Medical Oncology Specialist
2023-present
Istanbul Medipol University Medipol Bahcelievler Private Hospital
Department: Medical Oncology Assoc. Prof.
EDUCATION
2005-2011
Medical Education
Sivas Cumhuriyet University Medical Faculty, Sivas, Turkey
2012-2017
Internal Medicine
Istanbul University Cerrahpaşa Medical Faculty, Department of Internal Medicine, Istanbul, Turkey
2017-2018
Allergy-Immunology Fellowship
Istanbul University Istanbul Medical Faculty
Department of Internal Medicine, Division of Allergy and Immunology, Istanbul, Turkey
2018-2022
Medical Oncology Fellowship
Istanbul University Oncology Institute, Department of Medical Oncology, Istanbul, Turkey
2022
ESMO Board Certification in Medical Oncology
10th September 2022 in Paris, France.
2023
Medical Oncology Assoc. Prof.
Istanbul Medipol University Department of Medical Oncology, Istanbul, Turkey
INTERNATIONAL CLINICAL TRIALS:
1. Astefania - ROCHE
2. PFİZER
3. RECITE - AMGEN
4. NAVIGATE - BAYER
5. RUBY - Tesaro (PRA)
6. ENGOT-ov43/GOG-3036 - MSD
7. ASTRA ZENECA
8. ROSY-O - ASTRA ZENECA
INTERNATIONAL PUBLICATIONS
I. Published journal articles indexed by SCI, SSCI, and AHCI
Weekly Paclitaxel in Classic Kaposi Sarcoma
Carboplatin Desensitization in Ovarian Carcinoma
High-Dose Chemotherapy for Ewing’s Sarcoma
Multidrug Refractory TFE3(+) Renal Cell Carcinoma
Crizotinib Efficacy in NSCLC with MET Alterations
Clinicopathological Features in ALK Mutant NSCLC
PSMA-Based Tumor Burden in Prostate Cancer
Atezolizumab in Metastatic Urothelial Carcinoma
Pulmonary Sarcomatoid Carcinoma
Prognostic Factors in Atezolizumab-Treated Urothelial Carcinoma
Atezolizumab with Chemotherapy in Small Cell Lung Cancer
FOLFIRINOX vs. Gemcitabine + Nab-Paclitaxel in Pancreatic Cancer
Trastuzumab Emtansine in Older HER2-Positive Breast Cancer Patients
Real-Life Efficacy of Osimertinib in Advanced NSCLC
ALK-Positive Cells Percentage and Alectinib Efficacy
Real-World Data on Alectinib in ALK-Positive NSCLC
Prognostic Factors in Metastatic RCC with T790M Mutation
FLOT Regimen in Metastatic Gastric Cancer
Desensitization Protocol in Lenalidomide Hypersensitivity Reactions
Factors Associated with Diagnostic Skin Test Positivity in PPI Hypersensitivity
Efficacy of Capecitabine and Temozolomide in Neuroendocrine Tumors
Subsequent Treatments in Hormone-Positive Breast Cancer Progression
Termination of Trastuzumab in HER2-Positive Metastatic Breast Cancer
Long-term Outcomes and Predictors of Recurrence in Node-Negative Early Stage Breast Cancer
Prognostic Factors Influencing PFS in HER2-Positive Metastatic Breast Cancer
Treatment Efficacy of Ribociclib or Palbociclib plus Letrozole in Metastatic Breast Cancer
Efficacy and Safety of Sorafenib in Adult Metastatic Osteosarcoma Patients
Single-Agent Temozolomide as Salvage Therapy in Heavily Pretreated Metastatic Sarcoma Patients
Outcomes and Prognostic Factors in Metastatic Renal Cell Carcinoma with Brain Metastases
FLOT Regimen in First-Line Treatment of Metastatic Gastric Cancer
Prognostic Factors of Perioperative FLOT Regimen in Operable Gastric Cancer
Efficacy and Outcomes of Systemic Chemotherapy in Posttransplant Kaposi Sarcoma
Comparison of Second-Line Treatments in Metastatic Renal Cell Carcinoma
Toxicity Management and Effectiveness of Regorafenib in Advance GIST Patients: A Real-world Study - Authors: Paksoy, N., Ferhatoğlu, F., Doğan, İ., Khanmammadov, N., Bozbey, H. U., Karabulut, S., & Taştekin, D. - Journal: TURKISH JOURNAL OF ONCOLOGY, 1(1)
Demographic and Clinical Features and Factors Associated with Survival in Patients with Primary Glomerulonephritis: Single Tertiary Center Experience - Authors: Paksoy, N., Trabulus, S., Seyahi, N., & Altiparmak, M. R. - Journal: Namik Kemal Tip Dergisi, 11(1)
Efficacy of Sorafenib in Symptomatic Patients with Pretreated Progressive Desmoid Tumors - Authors: Paksoy, N., Ferhatoglu, F., Dogan, I., Ak, N., Pehlivan, M., Ekenel, M., & Basaran, M.
Nodal Response to Neoadjuvant Chemotherapy is a Better Predictive Factor of Survival Than Miller-Payne Scoring in Breast Cancer - Authors: Ak, Naziye, et al. - Journal: Journal of Oncological Sciences, 7.2: 42-49
Evaluation of Prognostic and Predictive Values of Hemogram Parameters in Patients with Advanced Stage Ovarian Carcinoma - Authors: Ak, Naziye, et al. - Journal: Turkish Journal of Oncology/Türk Onkoloji Dergisi, 2021, 36.4
Identifying Risk Factors Associated with Survival and Drug-Related Toxicities in Imatinib-Resistant Gastrointestinal Stromal Tumor (GIST) Patients Treated with Sunitinib - Authors: Ferhatoglu, F., Karabulut, S., Paksoy, N., & Tastekin, D.
Real-life Outcomes of ROS1 Fusion-positive Metastatic Lung Cancer Patients who were Treated with Crizotinib - Authors: Dogan, İ., Khanmammadov, N., Paksoy, N., Ferhatoglu, F., Aydın, E., Vatansever, S., & Aydine, A. - Journal: TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY
Predictors of the acquisition of T790M mutation in EGFR-mutant metastatic lung cancer patients who were treated with EGFR inhibitors - Authors: Dogan, I., Khanmammadov, N., Paksoy, N., Vatansever, S., Saip, P., & Aydıner, A. - Journal: Eurasian Journal of Pulmonology
Laterality of Adrenal Gland Metastasis in Lung Cancer: Results of a Comparative Study - Authors: Ferhatoglu, F., Gagatay, T., Okumus, G., Aydiner, A., Paksoy, N., Ak, N., ... & Saip, P. - Journal: Eurasian Journal of Medical Investigation, 7(2)
Poor Risk Factors Affecting Cancer Patients Infected with Covid-19: A Retrospective Comparative Study from a Pandemic Hospital - Authors: Ferhatoglu, F., Kapağan, T., Paksoy, N., Ak, N., Medetalibeyoğlu, A., Şenkal, N., ... & Vatansever, S. - Journal: Turk Onkoloji Dergisi, 38(1)
Systemic Treatment Outcomes of Progressive Medullary Thyroid Carcinoma from the Registries of a Tertiary Cancer Center - Authors: Ferhatoglu, F., Paksoy, N., & Başaran, M. - Journal: Namik Kemal Tip Dergisi, 10(4)
Evaluation of clinical features and risk factors related to late recurrence (> 5 years) in patients with breast cancer - Authors: Ferhatoglu, F., Aydiner, A., & Paksoy, N. - Journal: Journal of Surgery & Medicine (JOSAM), 6(12)
Assessing the Clinical Impact of Lutetium-177 DOTATATE Peptide Receptor Radionuclide Therapy (PRRT) on Metastatic Neuroendocrine Tumors: A Multicenter Real-World Data from Türkiye
Thesis:
Istanbul University Cerrahpaşa Medical Faculty, Internal Medicine Department PAKSOY, Nail. Demographical, clinical characteristics and survival factors in patients withprimary glomerulonephritis: Cerrahpasa Medical Faculty Experience. (2016)
International Refereed Congress / Symposium Publications in Proceedings (ASCO/ESMO Abstracts)
Prognostic factors influencing progression-free survival in HER2 positive metastatic breast cancer patients who treated with lapatinib and capecitabine combination
Efficacy of regorafenib and 5-fluorouracil-based rechallenge treatment in the third-line treatment of metastatic colorectal cancer: A Turkish oncology group study
Long-term outcomes and predictors of recurrence in patients with early-stage node-negative breast cancer
Efficacy of temozolomide in pretreated patients with metastatic sarcoma
Efficacy of sorafenib in symptomatic patients with pretreated progressive desmoid tumors
Efficacy of sorafenib in heavily pretreated adult patients with metastatic osteosarcoma
Outcomes and prognostic factors in metastatic renal cell carcinoma patients with brain metastases
Association of response to first-line chemotherapy with the efficacy of atezolizumab in patients with metastatic urothelial carcinoma
Safety and survival in adult women with platinum-sensitive relapsed BRCA mutant ovarian cancer: A study of patients in Olaparib Turkey Early Access Program—LynTurk study
Atezolizumab in patients with metastatic urothelial carcinoma who have progressed after first-line chemotherapy: Results of real-life experiences
Professor Bosch is a highly reputed leader in Chronic Lymphocytic Leukemia (CLL) and conducts clinical and basic research on CLL and other lymphoproliferative disorders, focusing on the molecular pathogenesis of CLL and new therapeutic approaches. He has published over 100 articles in prestigious journals and is a professor of haematology at the Vall d'Hebron University Hospital of Barcelona.
Doctor is a Medical Oncologist with expertise in angiogenesis, DNA repair mechanisms, and immunology. She has a degree in medicine from Complutense University of Madrid, a medical oncology MD from the same university, and a PhD from Univesidad Autonoma de Barcelona. She is a Co-Chair of the GEICO Group, Faculty member for the Gyn-Track in the European Society of Medical Oncology, Spanish Representative of GOG, Spanish representative in the Cervical Committee and Phase II Committee of the GCIG Group, and an active member of the American Society of Clinical Oncology, European Society of Medical Oncology, and the Spanish Association of Medical Oncology. She has authored over 100 publications and presentations.
Dr. Prat is a clinical scientist with expertise in breast cancer research, clinical trials, and gene expression. He has a MD degree from the University of Barcelona and completed a medical oncology fellowship at the Vall d'Hebron Institute of Oncology. He is Head of the Translational Genomics and Targeted Therapeutics in Solid Tumors Group at August Pi i Sunyer Biomedical Research Institute, President of the Board of Directors of SOLTI, and member of the Executive Committee of The Breast International Group. He has published 160 publications with 13.479 citations and is a Tenure-Track Professor of Barcelona University and Director of the Breast Pathology – Senology Master´s degree.
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Licensed Radiation Oncologist with 8 years of medical training, including undergraduate studies at Marmara University Faculty of Medicine (2004-2011) and Radiation Oncology specialization training at Marmara University Faculty of Medicine (2012-2016). Previous education from Sixteen Numbered Shirvan School (Azerbaijan) High School (1998-2004).
Dr. Raj is a highly experienced Surgical Oncologist with 19 years of experience and over 50,000 cancer surgeries performed. He is involved in numerous clinical trials and has many international and national publications to his credit. He specializes in Breast and Thoracic Surgical Oncology and serves as a professor for DNB Superspecialty Surgical Oncology and Breast Surgery at the Maharashtra University of Health Sciences. His belief is in "adding life to years" and improving the quality of life, not just adding years to life.
1.Bachelor’s degree
- Doctor of medicine, Rangsit university.
2.Master’s degree
>Medical and health science degree
- Professional master’s degree in clinical nutrition in medicine.
- Professional master’s degree in integrative medicine.
>Management degree
- Professional master’s degree in hospital and health services management.
3.Doctorate degree
- Doctorate in psychology (candidate).
4.Diploma
- American Bord of nutritional wellness.
- American naturopathic certification board.
- Certified integrative oncology physician, American institute of integrative oncology.
- Certified fertility wellness physician.
- Certified CBT-I physician.
- Advanced nutritional wellness, IFNW.
-Biochemical and clinical analysis diploma.
- Functional gastroenterology and pediatric food allergies diploma.
- IV nutrition diploma, IFNW.
-Medicinal herbology diploma, IFNW.
Professor Santoro is heavily involved in research, with interest in many topics, such as the development of new cancer drugs and new biological therapies, interests for solid and haematological tumours, and not only he treats cancer survivors but also patients with comorbidities.
He has worked in Humanitas Research Hospital for 22 years. Professor Santoro’s post-graduate research was carried out at the Unité de Development Therapeutique (Institut de Cancerologie et d’Immunogenetique, Villejuif of Paris) from 1974 to 1975, and in the Division of Medical Oncology of the National Cancer Institute of Milan from 1976 to 1977.
In 1977, he specialized in Clinical and Laboratory Haematology at University of Rome. In 1979, he completed his fellowship post-graduate work in the Memorial Sloan Kettering Cancer Center of New York and later, at Stanford University. In 1980, he specialized in oncology at the University of Genoa.
Current Teaching Activity: Professor Santoro worked as Contract Professor at the Specialization School in Clinical Pathology ad Pavia University from 1992 to 1997. Also, from 1993 to 2002 he has been President of the Rare Tumour Group. Now he is full professor at Humanitas University.
Current Positions:
In addition, Professor Santoro’s unique expertise was recognized through numerous awards, such as the Managing Doctor of the Year award (2013), the City of Siena S. Caterina d’Oro Award (2013, Serra Association Award for scientific research) and social and healthcare commitment (Salerno, 2009).
Publications: santoro%a - Search Results - PubMed (nih.gov)
Professional experience:
04.2009 – 04.2013: Resident in the Department for Radiation Oncology, Klinikum Offenbach
05.2013 – 12. 2015: Senior physician in the Department for Radiation Oncology, Klinikum Offenbach
Education
09 / 2004 – 07 / 2006 Movie Director School, ANT1 Movie School Athens, Greece, Degree “Television Director”, grade point average: B
09 / 2006 – 08 / 2008 Medical School, Semmelweis University Budapest, Hungary, Medical preliminary examination (Physikum), grade point average: A
10 / 2008 – 05 / 2013 Medical School, Albert-Ludwigs-Universität Freiburg, Germany, State examination in medicine, grade point average: A
02/ 2009 – 02/2012 Institute of Pharamcology and Toxicology I, Albert-Ludwigs-Universität Freiburg, Germany, Doctoral thesis, grade: summa cum laude
05 / 2018 Basic and advanced course in German drug law and GCP, Clinical Trials Unit, Medical Center - University of Freiburg
01 / 2019 Board certification: Radiotherapy and Radiation Oncology
03 / 2020 Medical Center University of Freiburg, Department of Radiation Oncology, Germany, Habilitation (Postdoctoral lecture qualification)
09 / 21 – 08 / 23 MHBA, Friedrich Alexander University, Nuernberg, Germany
07 / 2022 Completion of ISO 9001:2015 training, Nicosia, Cyprus
Professional Career
09 / 2013 – 01 / 2019 Medical Center University of Freiburg, Department of Radiation Oncology, Germany, Residency
07 / 2017 – 07 / 2020 Bertha-Ottenstein programme, Medical Center, University of Freiburg, Germany, Clinician Scientist
Since 06 / 2019 Medical Center University of Freiburg, Department of Radiation Oncology, Germany, Consultant
01 / 2021 – 12 / 2022 Bertha-Ottenstein programme, Medical Center, University of Freiburg, Germany, Advanced Clinician Scientist
01 / 2021 – 12 / 2021 Head of the section “Interventional Radiation Oncology”, Medical Center University of Freiburg, Department of Radiation Oncology, Germany
Since 01 / 2022 Medical Center University of Freiburg, Department of Radiation Oncology, Germany, Prostate cancer research group leader
Since 01 / 2022 German Medical Institute, Limassol, Cyprus, Vice Medical Director
Professional Memberships and Distinctions
2010 Sanofi-Aventis poster prize, Annual meeting of the German Society of Pharmacology and Toxicology 2010, Mainz, Germany
2017 Poster prize, Annual meeting of the German Society of Radiation Oncology (DEGRO) 2017, Berlin, Germany
2019 Poster prize, Uro-Oncological Symposium 2019, Magdeburg, Germany
2020 Invited member of the German expert panel for prostate cancer of the German Society of Radiation Oncology (DEGRO)
2020 Herman-Holthusen Award, German Society of Radiation Oncology (DEGRO)
2021 Invited member of the ESTRO-ACROP guideline committee for prostate cancer
2021 Best Abstract, EMUC congress 2021, Athens, Greece
2023 Annual ARO study price for the HypoFocal-SBRT study from the German Cancer Foundation
2023 Invited member of the ESTRO focus group “Urology”
Experience
2002-present | Attached to the Department of Gamma Radiosurgery and Functional Neurosurgery of Ruber International Hospital.
2002-2007 | Assistant, Department of Radiation Oncology, Ruber International Hospital.
2002| Medical Affairs Manager Medical Department Janssen-Cilag, SA Madrid
Qualification
2012|Doctor of Medicine and Surgery Madrid. Department of Surgery, Autonomous University of Madrid. Spain
2001 | Specialist in Radiation Oncology at the Gregorio Marañón University Hospital in Madrid. Training completed at the Gustave-Roussy Institute in Paris in 2000.
1995 | Graduate of the Faculty of Medicine and Surgery, Complutense University of Madrid. Spain.
2016-present | Member of the Ruber International Hospital Gamma Knife Radiosurgery Team, International Gamma Knife Consortium: Led by the Pittsburgh Hospital.
1999-2000| Project Manager: "Protocol for Pamidronate Treatment of Breast Cancer Patients with Predominantly Lytic Bone Metastases"
1999 | GICOR Study: "Incidence of Anemia in Patients Receiving Radiation Therapy"
1999 | GICOR study: "Androgen deprivation protocol associated with radiation therapy for localized high-risk prostate cancer"
1997-2001|Participant (collaborator) in the research project (FIS FELLOWSHIP): "Multimodal fusion of medical images in oncology" at HGU Gregorio Marañon. Project leader: Dr. Desco Menéndez.
Teaching :
2018-present|Professor of the International Master of Radiosurgery of the Central Nervous System at the Complutense University of Madrid.
2020-present|Professor at the School of Radiosurgery of the Spanish Society of Neurosurgeons.
2017-2019|Professor of the Master of Radiosurgery and Clinical Stereotactic Radiotherapy of the Spanish Society of Radiation Oncology.
2017 - 2022| Member of the Dissertation Committee in Radiosurgery three times at the Autonomous University of Madrid and the Complutense University of Madrid.
2011-2012|Professor, International Master's Program in Advanced Technological Applications in Radiation Oncology, 3rd ed.
2001-2002|Associate Professor of Dentistry at the Alfonso X El Sabio University.
1998 - 2001|Professor of the secondary school I.E. Technical and vocational school of health K.A.M. (Radiation oncology technicians and archival technicians).
Publications
2022|Stereotactic radiosurgery of obsessive-compulsive disorders. Chapter. 25. Book: Intracranial stereotactic radiosurgery. ed. 2022. Pages: 251-256.
2022|Active monitoring and stereotactic radiosurgery provide a low risk of symptoms associated with incident frontobasal meningioma, but stereotactic radiosurgery provides better radiological control – a subanalysis of the IMPASSE trial. Cancers 2022; 14(5).1300. https://doi.org/10.3390/cancers14164047
2022|Stereotactic radiosurgery for Kuss grade IV vestibular schwannoma: a multi-institutional study. Journal of Neurosurgery. 2022 Jun 3; DOI: 10.3171/2022.4.JNS22203.
2022|Stereotactic radiosurgery for Rathke's cleft cyst: an international multicenter study. J Neurosurg 137: 1041–1046, 2022. DOI: 10.3171/2021.12.JNS212108.
2021|Surgery and radiosurgery in autism: a retrospective study on 10 patients. Stereotactic Function Neurosurgery. 2021;99(6):474–483. 15.
Presentations
2019| "Other indications in malignant tumor pathology" Cranial Radiosurgery Conference. Valencia 2019.
2018| Gamma Knife Radiosurgery: Concept, Equipment and Treatment Description I Scientific Conference on Gamma Knife Radiosurgery, Madrid, 2018
2018|Radiotherapy and protons in children. XX meeting of the SENEC Working Group on Neuro-Oncology:. Madrid.
2015| "Visualization monitoring of response and complications of brain treatment". XVIII National Congress of S.E.O.R. Valencia
2015 | Gamma Knife Radiosurgery in the Treatment of Refractory Epilepsy Associated with Nodular Heterotopia: Long-Term Safety and Efficacy. Congress of the Spanish Society of Neurology.
Communities it belongs to:
-SER, Spanish Society of Radiosurgery (she currently serves on the Board of Directors as Treasurer)
-SEOR, Spanish Society of Oncological Radiotherapy: Working Groups "Brain Tumors (NEUROONCOR)" and "Radiation Oncology Activities in the Private Sector"
-SSRI, International Society for Stereotactic Radiosurgery
- Member of the Oncology Group of the Spanish Society of Neurosurgery (SENEC).
Dr. Nuria Martínez Moreno , working in tandem with Dr. Roberto Martínez Álvarez, combines expert oncology knowledge and high-precision radiosurgery technology , providing patients with the most advanced and effective treatment in Spain.
Dr Ozates was born in 1966 in Birecik district of Sanliurfa in Turkey. He completed his primary and secondary education in my hometown, Birecik. He got into Istanbul University Istanbul Faculty of Medicine in 1983. After 6 years of successful education, he started Radiology education at Dicle University Faculty of Medicine by passing the Medical Specialization Examination (TUS) in the same year I graduated in 1989.
Between 1993 and 1995, he worked as a Radiology Specialist in various hospitals in Gaziantep. He passed the Assistant Professorship exam and started to work as a faculty member at Dicle University in 1995.
Post-Specialization Trainings:
2003, Gazi University Faculty of Medicine, MRI Department, Ankara
2003, Marmara University Faculty of Medicine, MRI Department, Istanbul
2001-2004, ESNR European Course of Neuroradiology (3 Semesters)
1997, Johns Hopkins University, Neuroradiology, Baltimore, USA
1997, Cornell University, Neuroradiology, New York, USA
1996, Istanbul University Faculty of Medicine, MRI Department, Istanbul
1994, Dokuz Eylül University Faculty of Medicine, MRI Department, İzmir
1993, Uludağ University Faculty of Medicine, MRI Department, Bursa
1993, UCLA Medical Center (as visitor), Los Angles, USA
1992-1993, Maçka EMAR, Dr. Murat Dinçer, Istanbul
His Academic Studies:
International Publications: 23
International Papers: 27
National Publications: 45
National Papers: 48
Conferences: 11
Citations: 210 Scientific Publications (Average Citations per Item: 10.50, h-index: 9), USA edition 1 Book, Various Conferences
Scientific Organizations he is a member of:
European Society of Radiology (ESR)
Turkish Radiology Association (TRD)
Magnetic Resonance Association
Istanbul Medical Chamber (ITO)
Turkish Neuroradiology Association
In 2003, he was awarded the title of Associate Professor with the examination held at Marmara University Faculty of Medicine. In 2005-2013, Dr. Lütfi Kırdar Kartal Training and Research Hospital Radiology Clinic Chief, Training and Administrative Officer.
In 2013, he started to work as a professor at Nişantaşı University. On March 15, 2013, he was appointed as the Inter-University Board Representative for 1 year. He is a Member of the Board of Trustees of Ayvansaray University. He is a sub – specialist in “Pediatric Radiology”
His articles have been published in many magazines in Turkey and abroad. He presented written and oral presentations and gave conferences at congresses in various cities and countries.
As the Radiology Clinic Chief of Bağcılar Training and Research Hospital, he is the first professor who performed Coronary CT Angiography in a state hospital in Istanbul.
He is one of Turkey’s first Children’s Radiology Specialist Minor. He did his military service between March and April 2000 at the 200-bed Malatya Military Hospital.
Dr. X is a Medical Oncologist with over 30 years of experience. He has a Medical Education from Istanbul University, specialization in Internal Medicine, and a Medical Oncology Specialization from Istanbul University's Oncology Institute. He is a member of the Medical Oncology Association, Lung Cancers Association, ESMO, ASCO and Istanbul Medical Chamber.