Advanced Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Stomach/ Colon/ Ovarian/Appendix Cancer at Sheba Hospital- JCI accredited and Top-10 Hospitals 2026 by Newsweek
What's included in this package
Medical Procedures
- Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
- Medical Examination for pre-operation
- General anesthesia
- Preoperative tests
- Blood tests
- Echocardiography
- Complete blood count (CBC)
- Biochemistry blood test
- MRI of one area
- PET/CT
- Consultation with an oncologist
- Consultation with a surgeon
- Histopathology revision
- Complete blood count with cancer markers and a proteinogram
Duration
- 8 days in the hospital
- 14 days in the hotel
Accommodation
Hospitalization + afterward hotel stay
Transport
Transfer is not included
Additional information
Advanced HIPEC Program for Abdominal Cancers
Sheba Medical Center – A Global Leader in Precision Cancer Surgery
For many patients diagnosed with advanced abdominal cancers, being told that surgery is no longer possible can feel devastating. At Sheba Medical Center, we believe that every patient deserves access to the most advanced treatment options available and for carefully selected patients, HIPEC may offer a new path forward.
Sheba is internationally recognized for its expertise in Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and is home to the International Center for the Study of HIPEC & PIPAC, treating hundreds of patients from Israel and around the world each year.
By combining highly specialized cancer surgery with heated chemotherapy delivered directly into the abdomen, our team is helping patients achieve outcomes that were once considered impossible.
What Is HIPEC?
HIPEC (Hyperthermic Intraperitoneal Chemotherapy) is an advanced treatment designed for cancers that have spread within the abdominal cavity.
The procedure combines two powerful treatment strategies:
Cytoreductive Surgery (CRS) to remove all visible tumor deposits
Heated chemotherapy delivered directly into the abdomen to destroy microscopic cancer cells that may remain after surgery
The chemotherapy is gently heated to approximately 42°C (107.6°F) and circulated throughout the abdominal cavity, allowing it to penetrate tissues more effectively while targeting cancer cells directly.
Why HIPEC Is Different
Traditional intravenous chemotherapy often has difficulty reaching cancer cells spread across the lining of the abdomen.
HIPEC allows our specialists to:
Deliver significantly higher concentrations of chemotherapy directly to the affected area
Improve penetration of cancer-fighting drugs through the use of heat
Target microscopic disease that cannot be seen during surgery
Minimize exposure of the rest of the body to chemotherapy
This innovative approach may provide improved disease control and, in selected patients, the possibility of long-term survival.
Conditions Commonly Treated with HIPEC
HIPEC may be considered for carefully selected patients with:
Peritoneal metastases from colorectal cancer
Advanced ovarian cancer
Gastric (stomach) cancer with peritoneal spread
Appendix cancer and pseudomyxoma peritonei
Peritoneal mesothelioma
Selected rare abdominal malignancies
Every case is individually reviewed by our multidisciplinary team to determine whether HIPEC is the most appropriate treatment option.
Why Patients Choose Sheba
World-Class Surgical Expertise
Sheba's surgical oncologists are among the most experienced specialists performing cytoreductive surgery and HIPEC procedures in the region.
Comprehensive Multidisciplinary Care
Each patient benefits from a coordinated team that includes:
Surgical oncologists
Medical oncologists
Radiologists
Pathologists
Anesthesiologists
Intensive care specialists
Rehabilitation experts
Advanced Safety Standards
Our dedicated teams utilize sophisticated surgical planning, advanced intraoperative monitoring, and specialized postoperative care protocols designed to maximize safety and recovery.
Personalized Treatment Planning
Every patient undergoes a comprehensive evaluation and multidisciplinary tumor board review to ensure the most effective and individualized treatment strategy.
What the Program Includes
Comprehensive oncology and surgical consultation
Advanced diagnostic review and treatment planning
Multidisciplinary tumor board assessment
Cytoreductive surgery when indicated
HIPEC treatment performed by specialized experts
Intensive postoperative monitoring and recovery support
Ongoing follow-up and long-term care planning
A Message of Hope
At Sheba Medical Center, we are committed to transforming possibilities for patients facing advanced abdominal cancers. Through innovative treatments such as HIPEC, world-class surgical expertise, and personalized multidisciplinary care, we strive to provide every patient with the best opportunity for longer survival, improved quality of life, and renewed hope for the future. This program is designed for patients requiring highly specialized surgical treatment with maximum safety and effectiveness.
Key advantages:
Extensive experience in performing HIPEC procedures for complex oncological cases
High success rates due to precise patient selection and expert surgical techniques
Multidisciplinary approach involving oncologists, surgeons, anesthesiologists, and intensive care specialists
Focus on minimizing postoperative complications and risks
Advanced infrastructure ensuring maximum safety during and after surgery
What’s included:
Preoperative evaluation by leading oncology and surgical experts
Multidisciplinary tumor board review
Cytoreductive surgery (if required) combined with HIPEC
Advanced intraoperative monitoring
Postoperative intensive care and recovery management
Ongoing follow-up and treatment planning
⚡ Comprehensive care in one place- from evaluation to surgery and recovery under the supervision of top-tier specialists.
This program is especially recommended for patients with:
peritoneal metastases from colorectal or gastric cancer
advanced ovarian cancer
cases requiring aggressive yet controlled surgical approach
24/7 Bookimed assistance
- Personal medical coordinator
- Medical travel arrangements — booking of air tickets and hotel rooms at special partner prices
- Patient advocacy during medical travel
Program price
What's NOT included in this package
Doctor
Dr. Almog Ben-Yaacov is an Attending Surgeon in the Department of General and Oncological Surgery (Surgery C) at Sheba Medical Center. He specializes in cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). His clinical focus includes gastric cancer, sarcoma, and complex colorectal malignancies. Since 2018, he has performed more than 200 HIPEC procedures.
MD, Semmelweis University, 2006, with honors. Training in cardiothoracic surgery at Sheba Medical Center. Residency in general surgery at Montefiore (Albert Einstein) and at Rabin (Beilinson). Board-certified in General Surgery and in Surgical Oncology.
Advanced training includes ESSO-certified HIPEC in Hamburg. Microwave liver ablation in Reims. NanoKnife at King’s College London. Advanced surgical oncology at Memorial Sloan Kettering (2019). His publications cover CRS+HIPEC outcomes and Hartmann’s reversal.
How are we doing?
About the clinic
Sheba Medical Center is the largest hospital in the Middle East and one of the world’s leading medical institutions, consistently ranked among the global Top 10. Recognized by Newsweek and Statista for eight consecutive years, it ranked 7th worldwide in 2026. The hospital delivers comprehensive multidisciplinary care across all major specialties, including oncology, hematology, cardiology, neurology, and advanced surgery, treating over 2 million patients annually, including international cases. With more than 200 physicians listed among Forbes' Top Doctors, Sheba is a global leader in CAR-T and TIL immunotherapies, precision medicine, and minimally invasive surgery, making it a trusted destination for complex and advanced treatment.
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FAQ
What does HIPEC treatment cost depend on?
- Surgery cost. “Heated chemo” is performed 1 time during the surgery. That means surgery price affects HIPEC cost.
- Doctor’s experience. If a doctor has huge experience, academic degrees, his services can be more expensive.
- Country's price policy. Some countries provide low cost for HIPEC according to their price policy. For example, in India HIPEC surgery cost starts from $17,000 and in the USA – from $20,000 to $100,000. The quality of the chemo is at the same high level in both countries. Low costs in India are explained by general country's price policy.
- Hospital brand recognition. Several hospitals have their specific price lists and HIPEC cost varies depending on a hospital’s popularity and medical services it provides.
- Extra charges. Some German medical centers ask for prepayment but if a treatment occurs cheaper, a patient gets the rest of the money back. Additional services as transfer, language assistance, meals are paid separately.
What does HIPEC cost include?
- Surgery prices
- doctors’ fees
- medicines
- hospital stay.
What are the benefits of HIPEC?
- Hyperthermic intraperitoneal chemotherapy affects damaged tissues locally. It does not penetrate the common bloodstream and does not influence the whole body.
- Such a therapy kills cancer cells with high temperature. The heating damages the membrane and internal structure of malignant cells. It enforces the delivery of chemo to the necessary areas in the abdominal cavity.
- HIPEC drug can penetrate tumor tissue to 3 mm that helps effectively destroy cancer cells.
- A patient gets a dose of HIPEC once during the surgery.
- The combination of surgery and HIPEC therapy is more effective than these both treatments separately.
- This treatment improves the patient’s quality of life. Side effects after HIPEC are mild and not long-term compared to traditional chemotherapy.
When is hyperthermic intraperitoneal chemo indicated?
- tumor removals (helps to reduce the risk of relapses)
- recurrent cancer
- large tumors in the abdomen.
HIPEC has almost no contraindications. Such a method is applied when other options have been ineffective.
What is the cheapest HIPEC treatment cost?
The cheapest HIPEC cost is in India – from $17,000 according to local medical centers’ data. Such a low cost is explained by the price policy of the country, where the population’s income is low as well. Concerning healthcare quality in India, it is at the highest level as in the USA or Germany.
HIPEC for colorectal cancer
After colorectal cancer surgery, specialists use HIPEC for stages 3-4. That helps to increase the survival rate and to make patients live longer. Such a method gave positive results in treatment of colon and rectal cancers.
How to get personalized HIPEC cost?
- Check and compare costs of HIPEC in the clinics listed below.
- Pick the most appropriate place for you.
- Submit a request on our website.
- Bookimed manager will contact you and help to book a medical center for HIPEC.
- Then you will receive a personal price from a chosen clinic.
- Bookimed will arrange your medical trip.
Bookimed services are FREE for patients.