Bone Marrow Transplant for Pediatric Ewing Sarcoma

• Biopsy
• Consultation with an oncologist
• Complete blood count
• Complex diagnostics of Ewing`s sarcoma
• Consultation of a radiologist
• Extended analysis of blood
• Lab tests
• PET/CT
• Scintigraphy
• Complex treatment of Ewing's sarcoma
• Anti-HIV test
• Anti-HBC test
• Anti-HCVAb test
• Blood tests
• Biochemistry blood test
• Biopsy
• Chest X-ray
• Complete blood count (CBC)
• Consultation with a cardiologist
• Consultation with a pediatric hematologist
• Consultation with a pediatrician
• Computerized Bone Mineralometry (CBM)
• Complete blood count with cancer markers and a proteinogram
• Electrocardiogram (ECG)
• Echocardiography
• Head MRI
• PET/CT
• Сonsultation with an oncohematologist
• 24-hr nurse services
• 3 meals per day by nutritionist

• 30 days in the hospital

• Transfer airport-clinic-airport

Bone Marrow Transplant for Pediatric Ewing Sarcoma

Sheba Medical Center – Advanced, Personalized Transplant Care for Children

At Sheba Medical Center, we understand how overwhelming it can be for families to face a diagnosis of Ewing Sarcoma. This rare and aggressive childhood cancer requires highly specialized care, precision treatment, and a deeply supportive environment for both the child and their family.

For children with high-risk, recurrent, or treatment-resistant Ewing Sarcoma, bone marrow transplantation (BMT) may be considered as part of an advanced treatment strategy, offering a powerful approach aimed at improving long-term outcomes.

Our pediatric transplant program combines world-class expertise, innovative therapies, and compassionate, family-centered care at every stage of the journey.

When is a Bone Marrow Transplant Needed?

Bone marrow transplantation is not part of standard treatment for all children with Ewing Sarcoma, but may be recommended in specific situations, including:

High-risk disease, particularly with spread beyond the primary tumor
Relapsed Ewing Sarcoma, when the disease returns after initial treatment
Refractory disease, when standard therapies are not sufficient

In these cases, BMT allows the use of high-dose chemotherapy to target cancer cells, followed by the infusion of healthy stem cells to restore the bone marrow and immune system.

Types of Transplant

Autologous Transplant (Child’s Own Cells)

This is the most commonly used transplant approach in Ewing Sarcoma when BMT is indicated.

Stem cells are collected from the child in advance
Intensive therapy is administered to eliminate cancer cells
The child’s own stem cells are reinfused to support recovery

This approach enables the safe delivery of higher-intensity treatment.

Allogeneic Transplant (Donor Cells)

In carefully selected cases, Sheba Medical Center also offers allogeneic (donor) transplantation as part of a comprehensive treatment strategy.

This option may be considered for:

Children who require an alternative stem cell source
Situations where an additional immune-based approach may be beneficial

Donor options at Sheba include:

Matched sibling donors
Matched unrelated donors through international registries
Haploidentical (half-matched) family donors

A key advantage of donor transplantation is the graft-versus-tumor effect, where the new immune system may help recognize and target remaining cancer cells.

Precision Matching and Advanced Technology

Sheba Medical Center utilizes an advanced on-site HLA laboratory to perform high-resolution genetic matching, ensuring the best possible compatibility between donor and child.

This precision supports safer transplantation and optimal outcomes.

Advanced Pediatric Sarcoma Care

Treatment for Ewing Sarcoma at Sheba is highly coordinated and personalized:

Integration of chemotherapy, surgery, and radiotherapy with transplant strategies
Access to innovative and targeted therapies when appropriate
Close collaboration between pediatric oncologists, orthopedic surgeons, and transplant specialists
Advanced supportive care throughout treatment
Specialized Pediatric Transplant Environment

Children undergoing transplantation are cared for in dedicated pediatric units designed to support healing and comfort:

Child-friendly, protected environments
Advanced infection prevention systems
Continuous monitoring by experienced pediatric teams

Every aspect of care is tailored to the needs of growing children.

Clinical Expertise

Sheba Medical Center is a leading center for pediatric oncology and transplantation, offering:

Experience in managing complex and high-risk Ewing Sarcoma cases
Expertise in high-dose therapy with stem cell support
Outcomes aligned with leading international centers
Long-term follow-up focused on recovery, growth, and quality of life
Care That Supports the Whole Family

We understand that treating a child means supporting the entire family.

At Sheba, families are guided by a multidisciplinary team including physicians, nurses, psychologists, and care coordinators ensuring clear communication, emotional support, and continuity of care throughout the journey.

Why Families Choose Sheba for Pediatric BMT

Leading pediatric transplant center
Expertise in rare and complex sarcomas
Access to a wide range of donor options
Advanced treatment technologies
Compassionate, child-centered care
Dedicated international patient services

A Message of Hope

At Sheba Medical Center, we combine advanced science with compassionate pediatric care. Even in complex conditions like Ewing Sarcoma, our goal is to provide every child with the strongest possible chance for recovery—while supporting families with confidence, care, and hope every step of the way.

• Personal medical coordinator
• Medical travel arrangements — booking of air tickets and hotel rooms at special partner prices
• Patient advocacy during medical travel