Omotesando HELENE Clinic
About the clinic
Omotesando HELENE Clinic is a regenerative medicine center in Tokyo, Japan. It specializes in autologous mesenchymal stem cell (MSC) and exosome-based therapies. The clinic opened in 2014 and treats adults across 19 departments. Its in-house Cell Processing Center meets ISO Class 5 cleanroom standards. The lab uses AI image analytics and barcode management for cell traceability.
In 2017, it became the world's first stem cell clinic to receive GCR certification. The clinic also holds ISO 9001 certification for quality management. It won the Quality Choice Prize in the Diamond category from the ESQR. Its 24 doctors take part in international research on MSC safety. Medical interpreters support patients in 13 languages, including English, Chinese, and French.
Highlights
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Omotesando HELENE Clinic: more details about the clinic
Omotesando HELENE Clinic is a private regenerative medicine facility in Tokyo's Omotesando district. Established in 2014, it operates from a single building dedicated to advanced cellular therapies. The clinic specializes in autologous adipose-derived mesenchymal stem cells (MSCs) and exosome-based treatments.
Accreditations and International Recognition
The clinic holds several quality credentials that validate its clinical and laboratory standards. It maintains ISO 9001 certification for quality management. In June 2017, the facility became the first stem cell clinic worldwide to receive GCR (Global Clinic Rating) certification.
The European Society for Quality Research has recognized the clinic with multiple awards:
- Quality Choice Prize 2025 in the Diamond category
- Quality Achievements Award 2024
The clinic has published peer-reviewed research on the safety of high-dose intravenous MSC administration. MEDTECH Outlook APAC named it a Top Regenerative Medicine Solution Provider in 2025.
Specialized Stem Cell Therapies
The medical team focuses on autologous therapies, which use a patient's own cells to support healing. Physicians conduct detailed evaluations using medical history and in-house blood tests before starting any protocol. Each patient receives a dossier with certified laboratory reports for every procedure.
Specialists offer targeted treatments for several indications:
- MSC therapy for osteoarthritis and cartilage repair
- MSC-derived exosome treatments (cell-free therapy)
- Intravenous MSC administration for diabetic nephropathy
- NK cell therapy for immune support
- Subcutaneous MSC administration for facial treatments
The rehabilitation department supports stroke recovery. Protocols address motor impairments, cognitive issues, and autonomic nervous system disorders. The team provides guidance for both the acute phase and long-term recovery after hospital discharge.
In-House Cell Processing Center
The clinic operates the Omotesando Cell Culture Lab, a dedicated Cell Processing Center (CPC). This facility manages the entire cellular workflow – from collection and storage to cultivation and testing. The lab meets standards equivalent to Good Manufacturing Practice (GMP).
Safety protocols include several technical safeguards:
- ISO Class 5 clean-bench operations for sterile conditions
- HEPA filtration and UV sterilization to prevent contamination
- Barcode management for full sample traceability
- Virus testing performed immediately upon cell receipt
Stem cell quantification follows a multi-stage verification workflow. Staff confirm cell count and viability at least twice using ZEISS Axio Vert.A1 microscopy. Proprietary AI image analytics then assess cell activity before preparation.
Services for International Patients
Omotesando HELENE Clinic treats international patients through a specialized multilingual team. Medical interpreters help with consultations and coordination. The team supports over 10 languages, including English, Chinese, French, Korean, and Vietnamese.
Patients can access online pre-consultations before traveling to Japan. These sessions let physicians review medical records and discuss treatment options remotely. After treatment, patients rest in a dedicated recovery area. Staff provide home-care instructions and emergency guidance before discharge.
Additional services
Ao Bld., 3-11-7 Kita-Aoyama, Minato City, Tokyo 107-0061, Japan
Get a free consultation
The clinic is not accepting new requests
Average answering time – 5 minutes
How it works:
- We find a medical coordinator familiar with the matter
- You get a personal offer with a step-by-step guide and the cost estimate
- We arrange your travel including appointment scheduling and flights booking
- You arrive at the hospital, we support you 24/7