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How Much Does Immunotherapy Cost in Italy?

≈ from $6,500 to $13,000
Key Benefits

Why choose Italy for immunotherapy?

  • Accredited clinics: Italy boasts JCI-certified hospitals and centers accredited by the Italian Ministry of Health. These institutions uphold exceptional standards of care.
  • Latest technologies: Treatments like CAR-T cell therapy and monoclonal antibodies, including Pembrolizumab and Nivolumab, are leading the way. They provide targeted solutions for various cancers.
  • High success rates: Immunotherapy demonstrates an efficacy of 60-80% in treating melanoma patients. It also shows a 50-70% success rate in lung cancer cases.
  • Expert surgeons: Italy is home to leading oncologists with ESMO (European Society for Medical Oncology) certifications. These professionals have successfully treated over 2,000 patients using advanced immunotherapeutic methods.

Access advanced Immunotherapy solutions in trusted clinics from $6,500.

ItalyTurkeyAustria
Immunotherapy≈ $6,500from $3,000≈ $9,000
Sarcoma Immunotherapy≈ $50,000from $8,900≈ $60,000
Immunotherapy for prostate cancer≈ $50,000from $8,000≈ $30,000
Immunotherapy for lung cancer≈ $35,000from $8,000≈ $30,000
Immunotherapy for kidney cancer≈ $8,500from $8,000≈ $28,000
Data verified by Bookimed as of October 2026, based on patient requests and official quotes from 136 clinics worldwide. Median costs are based on real invoices (2025–2026) and updated monthly. Actual prices may vary.

Your Benefits and Guarantees with Bookimed

Transparent Prices & Flexible Installments

No hidden fees – just official clinic prices. Pay at the clinic for Immunotherapy upon arrival and use a flexible installment plan if needed.

Verified Clinics & Doctors Only

Bookimed is committed to your safety. We only work with medical institutions that maintain high international standards in Immunotherapy and have the necessary licenses to serve international patients worldwide.

Free 24/7 Assistance

Bookimed offers free expert assistance. A personal medical coordinator supports you before, during, and after your treatment, solving any issues. You're never alone on your Immunotherapy journey.

Why we?

Your personal Bookimed medical coordinator

  • Supports you at every stage
  • Helps choose the right clinic and doctor
  • Ensures quick and convenient access to information

Discover the Best Immunotherapy Clinics in Italy: 2 Verified Options and Prices

The Bookimed clinic ranking is based on data science algorithms, providing a trusted, transparent, and objective comparison. It takes into account patient demand, review scores (both positive and negative), the frequency of updates to treatment options and prices, response speed, and clinic certifications.

Immunotherapy Overview in Italy

Takeaways
How it works
What to expect
Benefits
Payment
patients recommend -
85%
Surgery Time - 2 hours
Stay in the country - 3 days
Rehabilitation - 1 day
Anesthesia - Local anesthesia
Requests processed - 46119
Verified patient reviews - 20
Bookimed fees - $0

Video Stories from Bookimed Patients

Amanda
My companion and I were treated with such kindness — I have nothing but admiration for the entire team.
Procedure: Mastectomy
Randolph
Stay strong, stay informed, and never underestimate the power of cutting-edge treatments and a solid support system.
Procedure: Radioembolization for liver cancer

Reviews about Bookimed: Discover Patients' Insights

All reviews
Larisa • Consultation with a mammologist
Italy
Apr 17, 2026
Verified review.
I am now completely confident that I can get the advice I need in my own language at any time!!!!
What I feared most was feeling lost and unheard when I decided to seek a consultation in another country. But that fear vanished as soon as I got in touch with Bookingmed, specifically with Yulia. She looked through my preliminary test results, listened to my concerns and found a suitable clinic quite quickly; then we set a date and that was it! The only inconvenience was that I live near Rome, but the appointment was in Milan – though that wasn’t a problem for me! I was met at the clinic by an interpreter, who was also the coordinator, so I didn’t have to queue or wait around (YAY!!) The doctor answered all my questions patiently and without rushing. Fortunately, my fears turned out to be overblown. The entire process, from my initial enquiry right through to the appointment itself, was well organised. Everything simply worked out. I am now completely confident that I can get the advice I need in my own language at any time!!!! Thank you so much!!!
I was very impressed by how efficient and well-organised the whole process was
As my 'case' was very small, there was nothing to improve – everything was just right!
Anonymous • Biopsy
Feb 25, 2019
Verified review.
"Just returned from there
Just returned from there. Everything was top notch, and doctors, and the organization of the stay. It took 2 days from the first call to the bookmarked to my arrival in Milan. The next morning, consult a doctor. All questions were solved almost instantly, the results of all analyzes and studies were ready the next day. And constantly in touch with the coordinator Catherine and care worker Alexander. In my trips to the clinic, I was accompanied by a super translator Yulya Sukhneva. Thanks to the clear and professional work of Julia, Kati and Alexander, my stay was very short, I saved money on the hotel. The hotel, by the way, was excellent, up to the clinic, 200 meters. Yes, and more, the prices for consultations and analyzes are quite comparable with those in Moscow. I spent much less money than I thought at first. Thank you all!
Евгения • Stomach cancer surgery
Italy
Nov 7, 2018
Verified review.
"I declare with all responsibility that the San Rafael clinic in Milan is the best
The professionalism of the doctors, the newest equipment, the care of the clinic staff are among the best in Europe. The treatment and operations in Russia and Germany have been carried out, I declare with all responsibility that the San Rafael clinic in Milan is the best. After treating my father’s stomach cancer, I visited the neurologist and gastroenterologist and myself. Thank you so much to the coordinator, the doctors from the international department of the clinic. More in the world of such doctors. THANK YOU!
Shakiha • Meningioma
Aug 27, 2021
Verified review.
بصراحة أود شكر الفريق الطبي باكمله في مستشفى سان رفائييل قسم جراحة المخ والاعصاب بقيادة الخبير البروفيسور دكتور مورتيني شكر هو من أعماق قلبي على عدة امور : مستشفى في قمة الدقة والاتقان والتنظيم وفريق طبي متميز اضافة الى ان هذا الدكتور من التواضع والخبرة والاسلوب الراقي لا اجد الكلمات المعبرة لشكره والثناء عليه هو وفريقه المساعد من الجراحين وطبيبة التخدير ووالى اصغر موظف وعامل في هذا المستشفى الانساني واتمنى لهم التوفيق والنجاح في انقاذ ارواح الناس وعلاجهم وشفائهم
About Bookimed service
راضي عن هذه المنصة والدعم تمام الرضا وان شاء الله انصح جميع الذين يعانون من اي مرض يستطيع هذا المستشفى او المنصة تقديم المساعدة لهبالتواصل معهم على الفور واشكر دكتور يونس على اسلوبه الراقي ودعمه اللامحدود
Anonymous • Consultation with an oncologist
Ukraine
Jun 29, 2022
Verified review.
- We were confirmed the same diagnosis that we received in Ukraine
We were confirmed the same diagnosis that we received in Ukraine. It was decided to continue treatment in Ukraine.
About Bookimed service
So
HALYNA NIKOLAIEVA • Melanoma
Ukraine
Jun 10, 2019
Verified review.
Thanks her
The doctor caused confidence and showed high professionalism, understood all the details and documents. She appointed the newest treatment. Satisfied with the service, Katerina Bonko was constantly in touch, showed attention and care. Thanks her.
About Bookimed service
I am satisfied with the service, Katerina Bonko was constantly in touch, showed attention and care. Thanks her.
Anonymous • Consultation with an oncologist
Italy
Jan 22, 2022
Verified review.
I would not hesitate to recommend Bookimed for enabling to have the required treatment
The Hospital handled my appointment and the paperwork promptly and efficiently. My outpatient contact with the Consultant was very professional. I would not hesitate to recommend Bookimed for enabling to have the required treatment.
About Bookimed service
Yes
Anonymous • Consultation with an oncologist
Jan 2, 2020
Verified review.
We received a remote consultation at the San Rafael Clinic, for us this format was not suitable, because the second opinion is for those who either confirm the diagnosis or ask for another alternative treatment, we were told that after the consultation, continue the same, although we were treated and there was no result, as a result, after a remote consultation, we were not assigned anything, plus all communication was extended for a couple of months, because the clinic’s response rate was very low. We could not get any concrete answer, so this consultation was useless for us.

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Updated: 10/02/2026
Authored by
Anna Leonova
Anna Leonova
Head of Content Marketing Team
A certified medical writer with 10+ years of experience, developed Bookimed’s trusted content, backed by a Master’s in Philology and medical expert interviews worldwide.
Fahad Mawlood
Medical Editor & Data Scientist
General practitioner. Winner of 4 scientific awards. Served in Western Asia. Former Team Leader of a medical team supporting Arabic-speaking patients. Now responsible for data processing and medical content accuracy.
Fahad Mawlood Linkedin
This page may feature information relating to various medical conditions, treatments, and healthcare services available in different countries. Please be advised that the content is provided for informational purposes only and should not be construed as medical advice or guidance. Please consult with your doctor or a qualified medical professional before starting or changing medical treatment.

Our Immunotherapy Techniques: What Suits You Best?

When considering Immunotherapy, it’s important to understand the different techniques and which is best suited for you. Here’s a concise comparison of popular options:

Immunotherapy with Keytruda (Pembolizumab)

Keytruda, a form of immune-based therapy, leverages the body's immune system to target and destroy cancer cells using monoclonal antibodies.

Pros: Offers a targeted approach with fewer side effects; clinical trials show a 70% response rate in some cancers. Suitable for varied cancer types due to its immune modulation properties.
Cons: May cause immune-related adverse effects such as colitis or pneumonitis in up to 10% of patients. Limited effectiveness in tumors with low PD-L1 expression.
Effectiveness: 70% response rate in some cancer types.
Duration: Each session lasts about 30 minutes.
Recovery: Not needed.
Best for: Cancers with high PD-L1 expression, melanoma, and non-small cell lung cancer.

FAQ about Immunotherapy in Italy

These FAQs come from real patients seeking medical assistance through Bookimed. Answers are given by experienced medical coordinators and trusted clinic representatives.

What types of immunotherapy treatments are available in Italy?

Immunotherapy treatments in Italy include immune checkpoint inhibitors like pembrolizumab and nivolumab, CAR-T cell therapy, and sublingual immunotherapy for allergies. These therapies are regulated by the Italian Medicines Agency and available at accredited centers like San Raffaele in Milan for oncology and hematology.

  • Checkpoint inhibitors: Block proteins like PD-1 or CTLA-4 to help T-cells attack solid tumors.
  • CAR-T therapy: Re-engineers patient T-cells in labs to destroy specific leukemia or lymphoma cells.
  • Biological therapy: Uses monoclonal antibodies to target antigens and block cancer growth signals.
  • Experimental trials: Research centers offer clinical trials for dendritic-cell vaccines and combination regimens.

Bookimed Expert Insight: While many countries focus solely on cancer, Italy is a leader in diverse immunotherapy applications. San Raffaele in Milan, for instance, performed the first stem cell therapy for severe combined immune deficiency. This highlights Italy's expertise in cellular immunotherapy beyond standard oncology protocols.

Patient Consensus: Patients emphasize the importance of distinguishing between short-term allergy tablets and long-term cancer protocols. Monitoring for delayed side effects like fatigue or liver enzyme changes is a common practical concern during extended treatment cycles.

What is the current status of immunotherapy in Italy's healthcare system?

Immunotherapy is fully integrated into Italy's universal healthcare system and routinely reimbursed for regulatory-approved oncological indications. The Italian Medicines Agency centrally regulates and funds advanced treatments like immune checkpoint inhibitors and cellular therapies within standard public oncology care.

  • Central regulation: The Italian Medicines Agency evaluates and approves clinical reimbursement nationwide.
  • Modern framework: Assessments prioritize comparative effectiveness and budget impact under European Union alignment.
  • Regional delivery: Practical access and waiting times vary between regional hospital networks.
  • Specialized hubs: Scientific research institutes like San Raffaele manage complex oncology cases.

Bookimed Expert Insight: Patient volume data highlights a strategic pathway for navigating the public system. Major research hubs in Milan like San Raffaele treat 12,000 cancer patients annually. Choosing an institute with scientific accreditation speeds up access to modern biological therapies.

Patient Consensus: The public healthcare system covers expensive modern therapies at no cost after specialist referral. However, patients advise booking a private consultation with a public-system doctor to bypass regional waiting times.

Are treatments covered under Italy's public healthcare system (SSN)?

Italy's Servizio Sanitario Nazionale (SSN) covers immunotherapy and other expensive cancer treatments for registered residents. These Essential Levels of Care (LEA) are generally free at public or accredited private hospitals. Patients typically only pay a small copayment, known as a ticket, for diagnostic tests or specialist consultations.

  • Eligibility criteria: Access requires formal residency status and registration with the national health system.
  • Access pathway: Patients need a general practitioner referral to consult an oncology specialist.
  • Medication coverage: Essential drugs, including high-cost Class A therapies, are free or heavily subsidized.
  • Chronic exemptions: Patients with registered cancer diagnoses are often exempt from standard regional copayments.

Bookimed Expert Insight: While the public system covers high-cost drugs like Keytruda, international patients often choose Milanese centers like San Raffaele for faster access to clinical trials. This clinic achieved the world's first stem cell therapy for severe immune deficiency. Public coverage is medically robust but navigating the paperwork takes time, making private oncology consultations a common way to speed up the initial diagnostic phase.

Patient Consensus: The public system provides excellent care for serious illnesses, though the administrative process can be slow. Residents suggest keeping tax codes and residency papers ready to avoid delays in starting life-saving treatments.

How can a patient access clinical trials for immunotherapy in Italy?

Accessing immunotherapy clinical trials in Italy requires a referral to a certified Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) center. Patients must consult an oncologist to verify eligibility against strict inclusion criteria like PD-L1 expression before searching official registries like the EU Clinical Trials Information System.

  • Specialist consultation: Your oncologist must formally refer your records to the trial principal investigator.
  • Registry search: Use the EU Clinical Trials Register or ClinicalTrials.gov to find Italian sites.
  • IRCCS centers: Specialized hospitals like San Raffaele in Milan manage advanced cellular therapy protocols.
  • Regulatory oversight: The Italian Medicines Agency (AIFA) maintains maps of active experimental trial sites.

Bookimed Expert Insight: While many search globally, Italy stands out for specialized cellular therapies at IRCCS centers like San Raffaele. Data shows these facilities serve 300,000 patients annually and pioneered the world's first stem cell therapy for immune deficiency. Choosing a center with these specific credentials often indicates a stronger infrastructure for managing complex, late-stage immune reactions.

Patient Consensus: Patients emphasize that access depends on finding the exact National Clinical Trial ID rather than just the drug name. Success often involves checking if the research center accepts outside referrals early in the process.

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