Liu Shi Xin

New
40 years of experience
Location: China, Xiamen
Clinic:Xiamen Humanity Hospital
Professor Shixin Liu, MD, PhD, is the Discipline Leader of the Oncology Center. He is the former President of Jilin Provincial Cancer Hospital and former Director of the Cancer Prevention and Treatment Research Institute. He is a second-level professor and doctoral supervisor. He has received the State Council Special Government Allowance, the 4th National Famous Doctor (Outstanding Contribution) award, and the Model of Medical Ethics honor.

He specializes in the comprehensive diagnosis and treatment of malignant tumors. His focus is precision radiotherapy for thoracic and abdominal cancers. He is skilled in IMRT, VMAT, and SBRT for lung, esophageal, breast, and rectal cancers.

His leadership roles include Vice Chair of CMA Radiation Oncology, CACA Radiotherapy, and CACA Particle Therapy. He serves on the CSCO Standing Committee and as Vice Chair of the CSCO Radiation Oncology Expert Committee. He is Vice Chair of CPAM Radiation Oncology and a Standing Committee member of CSMEA. He chairs the Jilin Medical Association Radiation Oncology branch. He is on the editorial boards of the Chinese Journal of Radiation Oncology and the Practical Journal of Cancer.
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Bookimed Insights: Top Melanoma Specialists in China (2026)

Bookimed has coordinated 4 requests for Melanoma treatment in China, collaborating with 1 top-rated specialists. The doctors in this table are selected based on their international credentials, clinical expertise, and patient outcomes. The 2026 ranking is formed using verified data from actual patient cases and current programs from our partner clinics.

Rank	Doctor	experience	Good Fit For	What Sets Them Apart	Clinic & Location	Consultation

FAQ

These FAQs come from real patients seeking medical assistance through Bookimed. Answers are given by experienced medical coordinators and trusted clinic representatives.

What are the primary treatment options for melanoma in China?

China treats melanoma using surgery, immunotherapy, and targeted therapies. Specialized centers focus on aggressive acral and mucosal subtypes. JCI-accredited facilities like Fuda Cancer Hospital offer over 10 minimally invasive options. These include cryosurgery and NanoKnife technology for advanced cases.

Surgical standards: Wide local excision removes primary tumors with 0.5 to 2 cm margins.
Advanced immunotherapy: Toripalimab is a Chinese-developed anti-PD-1 antibody for advanced or metastatic cases.
Minimally invasive: Microwave ablation (MWA) and radiofrequency ablation (RFA) treat localized lesions or metastases.
Targeted therapy: Clinicians use Tunlametinib for NRAS mutations and combination therapies for BRAF-mutant cancers.

Bookimed Expert Insight: Analysis of clinical availability suggests Guangzhou is a hub for specialized melanoma interventional oncology. Dr. Liuying at Jinshazhou Hospital specifically integrates microwave ablation with traditional oncology. This focus on thermal ablation offers an alternative for patients who cannot undergo standard surgical resection.

Patient Consensus: Patients note that seeking treatment at major tertiary hospitals ensures access to critical staging tools like sentinel lymph node biopsies. Many emphasize confirming genetic mutation status through reliable labs before starting targeted drug regimens.

Are modern immunotherapies like PD-1 inhibitors available and effective in China?

Modern immunotherapy using PD-1 and PD-L1 inhibitors is widely available and clinically effective in China. Patients can access over 20 approved medications. These include global brands like Keytruda and domestic alternatives like Toripalimab. Studies show success rates comparable to international protocols.

Drug availability: Over 20 PD-1 inhibitors are marketed, including domestic and global options.
Survival rates: Domestic inhibitors show a 0.87 hazard ratio for overall survival.
Regional expertise: Guangzhou centers like Fuda Cancer Hospital serve over 30,000 international patients.
Subtype efficacy: Chinese therapies like Camrelizumab show high effectiveness for mucosal melanoma.

Bookimed Expert Insight: China has specialized protocols for acral and mucosal melanoma, which are more common in Asian populations. JCI-accredited facilities often combine PD-1 inhibitors weight-based dosing with minimally invasive therapies like cryosurgery. This multidisciplinary approach can improve local tumor control where standard surgery alone might be insufficient.

Patient Consensus: Patients find that accessing domestic PD-1 inhibitors in major cities like Guangzhou is straightforward and significantly more affordable. Many emphasize the importance of upfront biomarker testing to ensure the chosen drug matches their specific cancer profile.

How does melanoma in China differ from that seen in Western countries?

Melanoma in China primarily affects the palms, soles, and mucous membranes. This contrasts with Western populations where sun-exposure patterns dominate. Chinese patients often present at advanced stages. Genetic mutations like KIT and NRAS are more frequent than the BRAF mutations seen in Caucasians.

Dominant subtypes: Acral lentiginous melanoma accounts for 42–50% of Chinese cases.
Mucosal prevalence: Internal cases (nose, mouth) represent 20–30% of diagnoses in China.
Genetic markers: KIT and NRAS mutations are common, while BRAF prevalence is lower.
Diagnosis stage: Patients frequently start treatment at Stage III or IV in China.

Bookimed Expert Insight: Data from Fuda Cancer Hospital highlights a push for specialized minimally invasive therapies. They offer NanoKnife and microwave hyperthermia for late-stage cases. Dr. Liuying at Jinshazhou Hospital manages complex melanoma liver metastases using interventional ablation. This specialized focus on advanced-stage intervention mirrors the clinical reality of China’s later diagnosis patterns.

Patient Consensus: Patients note that acral melanoma on the hands or feet often goes ignored for years before confirmation. Experts recommend seeking evaluation at tertiary centers in major cities like Guangzhou to access advanced interventional oncology.

Can international patients join clinical trials for melanoma in China?

International patients can join melanoma clinical trials in China if they meet specific medical criteria. Chinese centers specialize in cellular therapies like Tumor-Infiltrating Lymphocyte (TIL) treatment. Global eligibility encompasses patients from over 100 countries. Participation requires detailed biopsy reports and scans showing measurable lesions.

Specialized facilities: JCI-accredited centers like Fuda Cancer Hospital offer minimally invasive alternatives.
Treatment technologies: Patients access cryosurgery, NanoKnife, and vascular interventional therapy alongside immunotherapy.
Regulatory speed: Independent researcher-initiated trials often proceed faster than standard FDA-regulated protocols.
Survival criteria: Eligibility generally requires an expected survival of at least 3 months.

Bookimed Expert Insight: Focus on Guangzhou academic centers where specialists like Dr. Liuying manage melanoma liver metastasis. These hospitals treat 30,000+ international patients annually and often combine standard immunotherapy with local interventions. Seeking trials directly through directors of oncology wards often bypasses the lack of centralized English-language recruitment databases.

Patient Consensus: Patients note it is essential to ask about English protocols since documents are often only in Chinese. Clarifying long-term visa options early is vital because clinical trials require extended hospital stays.

Which hospitals in China offer specialized melanoma care?

Specialized melanoma care in China centers on JCI-accredited facilities in Guangzhou and Beijing. Hospitals like Fuda Cancer Hospital and Jinshazhou Hospital offer advanced minimally invasive treatments. These include NanoKnife and cryosurgery. Chinese oncology hubs integrate surgical resection with multidisciplinary immunotherapy and cell-based therapies.

Specialized facilities: Fuda Cancer Hospital provides cryosurgery and NanoKnife therapies.
Expert pathology: Jinshazhou Hospital specializes in melanoma and liver metastasis cases.
Advanced procedures: Centers offer Actinium-225 therapy and Natural Killer cell immunotherapy.
Case management: Multidisciplinary teams manage complex late-stage oncology and vascular interventions.

Bookimed Expert Insight: Focus on Guangzhou clinics if you require non-surgical alternatives to chemotherapy. Fuda Cancer Hospital uses over 10 types of minimally invasive therapies. This is ideal for late-stage cases where traditional surgery is not possible. Dr. Liuying at Jinshazhou Hospital integrates microwave ablation specifically for metastatic melanoma spread. These specialized protocols are often more accessible in Guangzhou than in packed Beijing centers.

Patient Consensus: Patients emphasize the need for a bilingual concierge or translator when visiting public oncology centers. Many note that surgeon experience with specific mutations like BRAF+ is more important than hospital prestige.

Do treatment protocols for acral and mucosal melanoma differ from cutaneous disease?

Treatment protocols for acral and mucosal melanoma differ significantly from cutaneous disease in surgical margins and systemic response. While cutaneous types often respond to immunotherapy, acral and mucosal variants frequently require KIT-targeted therapies and specialized surgeries to preserve function in palms, soles, or mucosal membranes.

Molecular targeting: Acral and mucosal types often harbor KIT mutations instead of BRAF.
Surgical complexity: Mucosal cases require aggressive excision in deep anatomic sites like sinonasal tracts.
Functional preservation: Acral surgery balances oncologic margins with motor function in hands and feet.
Adaptive therapies: China-based centers utilize microwave ablation and cryoablation for locally advanced mucosal lesions.
Systemic resistance: These subtypes generally show lower response rates to standard immune checkpoint inhibitors.

Bookimed Expert Insight: While Western protocols focus heavily on PD-1 inhibitors, Chinese JCI-accredited centers like Fuda Cancer Hospital utilize a multi-modal approach. Data shows they prioritize combining minimally invasive techniques like NanoKnife or cryosurgery with systemic treatments. This is particularly effective for mucosal melanomas in difficult-to-reach areas where traditional wide-margin surgery is physically impossible.

Patient Consensus: Patients with acral melanoma emphasize that finding a surgeon who prioritizes limb function is just as vital as clearing the cancer. Those treated for rare subtypes note that specialized molecular testing was the turning point in their treatment plan.

What modern therapies are available for advanced melanoma in China besides surgery?

Advanced melanoma treatment in China utilizes immunotherapy, targeted drugs for specific genetic mutations, and advanced ablation techniques. Beyond surgery, patients access checkpoint inhibitors like Toripalimab and Pembrolizumab. Specialized centers integrate cryosurgery and NanoKnife technology. These options aim to manage metastatic cases and mucosal subtypes effectively.

Immunotherapy: Domestic PD-1 inhibitors like Toripalimab show improved survival in advanced cases.
Targeted therapy: Tunlametinib targets NRAS mutations specifically found in Chinese patient profiles.
Ablation techniques: Fuda Cancer Hospital offers cryosurgery and NanoKnife for minimally invasive tumor destruction.
Cellular therapy: Specialized clinical protocols include Tumor-Infiltrating Lymphocytes (TIL) and Natural Killer cells.

Bookimed Expert Insight: China is a unique hub for combining traditional immunotherapy with advanced ablation. Fuda Cancer Hospital has treated over 30,000 patients using `3C` therapy (Cryosurgery, Cancer Microvascular Intervention, and Combined Immunotherapy). This approach often yields results for late-stage patients who have exhausted standard chemotherapy options elsewhere.

Patient Consensus: Patients emphasize getting genetic testing early to check for BRAF status. Some note that domestic immunotherapy options like Toripalimab can lead to long-term remission for Stage 4 cases.

Best Melanoma doctors in Xiamen: TOP 1 doctor

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