Sheba Pediatric CAR-T Program for Primary CNS Lymphoma
What's included in this package
Medical Procedures
- Consultation with a hematologist
- Extended analysis of blood
- Сomplex oncology diagnostic
- Sentinel lymph node biopsy
- Сonsultation with an oncohematologist
- Comprehensive diagnosis of lymphomas
- PET/CT in lymphoma
- Lymphoma blood test
- CAR T-cell therapy
- 3 meals per day by nutritionist
- 24-hr nurse services
- Electrocardiogram (ECG)
- Blood tests
- Chest X-ray
- Anti-HIV test
- Anti-HBC test
- Anti-HCVAb test
- Echocardiography
- Complete blood count (CBC)
- Biochemistry blood test
- PET/CT
- Consultation with an oncologist
- Consultation with a hematologist
- Consultation with an immunologist
- Consultation with a cardiologist
- Consultation with a pediatric hematologist
- Consultation with a pediatrician
- Сonsultation with an oncohematologist
- Head MRI
- Biopsy
- Complete blood count with cancer markers and a proteinogram
Duration
- 21 days in the hospital
Accommodation
Hospitalization
Transport
Transfer airport-clinic-airport
Additional information
Sheba Pediatric CAR-T Program for Primary CNS Lymphoma
At Sheba Medical Center, children and young patients with primary central nervous system (CNS) lymphoma have access to one of the most advanced and specialized CAR-T therapy programs in the world. This rare and complex lymphoma, affecting the brain and spinal cord, requires highly precise and coordinated care, especially in relapsed or treatment-resistant cases.
A Personalized Treatment Designed for Each Patient
CAR-T therapy uses the patient’s own immune system to recognize and destroy cancer cells. For CNS lymphoma, this innovative approach offers a targeted option when conventional therapies are no longer sufficient.
At Sheba, the entire CAR-T process is performed on-site, ensuring speed, precision, and optimal cell quality:
Apheresis – collection of the patient’s T-cells
Cell Engineering – genetic modification at Sheba’s Advanced Biotherapy Center
Infusion – reintroduction of modified cells to target lymphoma cells
Because no steps are outsourced, treatment can begin quickly and is typically completed within ~10 days. CAR-T acts as a “living therapy,” continuing to work in the body and offering the potential for long-term disease control.
Expert Pediatric Leadership and Multidisciplinary Care
The program is led by Prof. Amos Toren, a globally recognized expert in pediatric hemato-oncology and cellular therapies, with decades of experience and over 1,500 bone marrow transplants performed.
Given the complexity of CNS lymphoma, care is delivered through a multidisciplinary team, including pediatric hemato-oncologists, neurologists, neurosurgeons, and radiology experts.
The program includes:
Specialized pediatric CAR-T units with 24/7 monitoring
Advanced neuro-imaging and precision diagnostics
A supportive, family-centered environment
Full international patient services, including travel and care coordination
Proven Expertise in Complex and High-Risk Cases
Sheba is a global leader in CAR-T therapy, with strong outcomes across hematologic cancers:
~90% remission in pediatric patients
~80% in young adults (up to 23 years)
~70% in adults
The team has extensive experience in treating rare and high-risk conditions, including CNS involvement, offering advanced options when other treatments are limited.
Comprehensive Evaluation and Ongoing Support
Each patient undergoes a full diagnostic work-up, including:
advanced brain and spinal imaging (MRI/CT), bone marrow evaluation, genetic and molecular testing, and cardiac and pulmonary assessment.
Care is provided in English, Russian, and Arabic, ensuring families feel supported and informed throughout the entire journey.
A Trusted Place for Advanced Pediatric Neuro-Oncology Care
By combining cutting-edge immunotherapy, neurological expertise, and compassionate care, Sheba provides one of the most advanced environments for treating primary CNS lymphoma with CAR-T focused on achieving the best possible outcomes and quality of life for every patient.
24/7 Bookimed assistance
- Personal medical coordinator
- Medical travel arrangements — booking of air tickets and hotel rooms at special partner prices
- Patient advocacy during medical travel
Program price
What's NOT included in this package
Doctor
Dr. Amos Toren is a pediatric hemato-oncologist at Sheba Medical Center. He served as Director of the Pediatric Hemato-Oncology and Bone Marrow Transplant Division. Dr. Toren holds a PhD in Human Genetics. He specializes in CAR T-cell therapy and bone marrow transplantation for children. Forbes Israel has recognized his expertise in hematology.
- Served as the Head of the Hematology Division at Tel Aviv University.
- Treats complex cases of leukemia, lymphoma, and rare pediatric cancers.
- Member of the American Society of Hematology and European Group for Blood and Marrow Transplantation.
- Collaborates on research with the NIH and St. Jude Children’s Research Hospital.
How are we doing?
About the clinic
Sheba Medical Center is the largest hospital in the Middle East and ranked 7th worldwide by Newsweek in 2026. It treats over 2 million patients annually and is a global leader in CAR-T and TIL immunotherapies. Core specialties include oncology, immunotherapy, precision medicine, and cardiology.
- JCI and ISO accredited with eight consecutive years in the Newsweek global Top 10.
- In-house CAR-T manufacturing through its GMP-certified Advanced Biotherapy Center (ABC).
- Over 200 Sheba doctors are listed among Forbes' Top Doctors.
- One of the few centers worldwide developing CAR-T therapies for severe autoimmune diseases.
- Campus includes six major hospitals, among them the Leviev Heart Center and Edmond and Lily Safra Children's Hospital.
Payment & Rewards
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