Stem cell therapy is transforming modern medicine, offering treatments for conditions once thought untreatable—from restoring vision to helping people with diabetes produce insulin.
But here’s the catch: while the results can be groundbreaking, the safety of stem cell therapy depends on factors that aren’t always obvious. How can you tell if a treatment is truly safe and effective? Keep reading to discover the facts, debunk myths, and find out how to ensure you’re in the best hands for this revolutionary treatment.
Key Takeaways
👉 Research evidence: Stem cell therapy is safe when performed in regulated clinical settings by qualified professionals.
👉 Regulations vary by country: Treatments are safest in countries where therapies are approved by relevant health authorities, such as the FDA in the USA or COFEPRIS in Mexico.
👉 Safest stem cells: Mesenchymal stem cells (MSCs) are the most widely used, thoroughly tested, and safe type.
👉 Administration methods: Intramuscular injection and intravenous delivery are the safest stem cell delivery methods.
👉 Potential risks: Mild side effects include swelling, discomfort, and fatigue. With proper screening and protocols, serious risks like immune reactions are rare.
Table of Contents
- What Research Says About the Safety of Stem Cell Therapy
- Are Stem Cell Therapies Safer in Some Countries Than Others?
- Stem Cell Types and Their Safety
- Stem Cell Administration Methods and Their Safety
- Potential Side Effects and Risks of Stem Cell Therapy
- Contraindications for Stem Cell Therapy
- How to Prepare for Stem Cell Therapy
- How to Choose a Safe Stem Cell Therapy Clinic
- Top 9 Clinics for Safe Stem Cell Therapy
- FAQ
What Research Says About the Safety of Stem Cell Therapy
Human stem cell research shows that the therapy is safe when performed by reliable healthcare providers in controlled clinical settings. Here are insights from research on some of the most popular stem cell applications:
- Osteoarthritis. A large two-year case series demonstrated that adult stem cells are safe for treating knee osteoarthritis. It can delay or even prevent the need for knee joint replacement surgery.
- Parkinson’s disease. A clinical trial by BlueRock Therapeutics found stem cell therapies to be safe for patients with advanced Parkinson’s disease, with minimal side effects. Imaging confirmed that the injected stem cells could survive and successfully integrate with the existing brain cells.
- Autism. Reviews of multiple clinical trials showed that stem cell therapy does not cause severe adverse effects and can measurably reduce autism symptoms (according to the Childhood Autism Rating Scale (CARS)).
- Eye diseases. In a large study involving nearly 500 eyes, 97.8% of treatments had no side effects. When adverse events were reported, they were not serious or systemic.
- Back pain. Studies spanning up to 6 years confirm that adult stem cells are safe for back pain, with very few adverse events. Minor side effects, such as headaches and musculoskeletal pain, are temporary and resolved with over-the-counter medications.
- Spinal cord injuries. A study by the Mayo Clinic revealed that adult stem cells are safe for treating traumatic spinal cord injury. The research also indicated improvements in sensation and movement.
- Diabetes. Stem cell therapy for diabetes has shown a strong safety profile, with most side effects being mild and temporary. Moreover, human stem cells restore insulin production, with some patients reducing external insulin use by 91% or becoming completely insulin-independent.
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Are Stem Cell Therapies Safer in Some Countries Than Others?
Where you receive treatment can make all the difference. Different countries have approved different therapies based on their regulatory standards. Opting for a stem cell treatment in a country where it is not official will leave you less protected against risks.
🗽 Regulations in the USA
In the United States, the Food and Drug Administration (FDA) has approved only a limited number of treatments—mainly for blood-related disorders such as leukemia. Most other applications of stem cells have not yet passed the approval process in the US.
Although nearly 3,000 clinics across the US offer unproven treatments for a wide range of conditions, they carry significant risks:
- No guarantee of quality control. Clinics may use improperly sourced or processed stem cells.
- Ineffective dosages. Lower doses used to bypass regulations may not provide the desired therapeutic effects.
✅ If you choose to get stem cells in the US, stick to FDA-approved treatments:
- Visit the FDA’s website for a list of approved stem cell therapies.
- Ask the clinic for documentation proving their therapy is approved by authorities.
- If the clinic uses specific stem cell-based products, ask for their names and check the FDA database to confirm they are approved for your condition.
🌍 Regulations abroad
The global regulatory landscape for stem cell therapy is diverse, with some countries embracing the treatment more fully than the US. These include:
- Mexico. Stem cell therapies are regulated by the Federal Commission for Protection against Sanitary Risks (COFEPRIS).
- Colombia. Governed by the National Institute of Food and Drug Monitoring (INVIMA), which oversees treatment safety and efficacy.
- Turkey. Regulated by the Turkish Ministry of Health.
- Thailand. Controlled by the Thai Food and Drug Administration (Thai FDA).
- South Korea. Overseen by the Ministry of Food and Drug Safety (MFDS).
- Israel. Managed by the Ministry of Health, with a strong focus on clinical trials.
- Poland. Regulated by the Ministry of Health, ensuring compliance with EU medical standards.
- Ukraine. Overseen by the Ministry of Health, with growing recognition for innovative stem cell applications, including fetal stem cells.
📜 For a deeper dive into global stem cell regulations and how they compare, check out our detailed guide.
While these countries have varied regulatory approaches, they allow treatments that remain unapproved in the US.
✅ If you decide to go abroad for stem cells, verify that the therapy you’re seeking is approved by the country’s regulatory authority and confirm the clinic has a valid license from that authority.
- Dr. Phatcharasak Kraisornphongsakul Md is board certified in plastic surgery since 2000.
- ID Clinic Bangkok achieves a 96% success rate for tummy tucking stem cell therapy.
- Included services: Preoperative tests, post-op medications, consultation with a doctor, video or text consultation, hotel, hospitalization + afterward hotel stay, transfer airport-hotel-clinic-airport.
- Camilo White Castillo holds dual medical licensure in Antigua and Barbuda and Colombia, ensuring international care standards.
- Reju Stem Cell Clinic is led by a certified S.C.A.R.E. member and specializes in advanced regenerative therapies.
- Included Services: Consultation with a doctor, consultation with an anesthesiologist, vitamin infusions, VIP transfer.
- Stay Info: 2 days hotel stay required; accommodation is not included in the price.
- Technique: Stem cell and exosome therapy for hair loss.
- Dr. Anna Lara is a member of the International Society for Stem Cell Application.
- Stem Solutions serves patients from Europe, the Commonwealth, Latin America, the USA, Canada, and Australia.
- Included services: Breakfast, hotel, consultation with a doctor, 4* hotel, transfer airport-hotel-clinic-airport.
- Stay info: 3 days stay in the hotel, included in the price.
- Treatment method: 50 million mesenchymal stem cell & exosomes treatment.
- Dr. Isabella Bernaschina is a certified member of the RCG, a top medical community in Mexico.
- Medical Center Juventa serves 500 patients annually from Europe, Arab League States, and North America.
- Included services: Consultation with a doctor, VIP transfer, apartment.
- Stay info: 3 days stay in the hotel, food not included.
- Dr. Byung-hee Lee is a founding member of the Korean Society of Interventional Neurology.
- RE:YOUTH (YONSEI BH Arterial Stemcell Clinic) is the only Korean clinic specializing in arterial stem cell therapy.
- Included Services: Consultation with a doctor, angiography, VIP transfer.
Stem Cell Types and Their Safety
Different types of stem cells have varied sources, functions, and safety profiles. Stem cells most often used in treatments are:
1. Mesenchymal stem cells (MSCs)
- Source: Bone marrow, fat tissue, umbilical cord blood and tissue, amniotic fluid.
- Description: A subtype of adult stem cells that can differentiate into cartilage, fat, and bone cells. Mesenchymal stem cell therapy is based on their anti-inflammatory and regenerative properties.
- Safety: Highly safe, especially when derived from the patient (autologous), with a low risk of immune rejection. Mesenchymal stem cells are widely used in clinical applications.
2. Human embryonic stem cells (ESCs)
- Source: Stem cells derived from early-stage human embryos, usually discarded after unsuccessful in vitro fertilization (IVF).
- Description: Pluripotent stem cells that can become almost any cell type in the body, extremely versatile.
- Safety: While promising, human embryonic stem cells carry risks such as immune rejection and tumor formation (teratomas), as well as some ethical concerns. They are still primarily used in research.
3. Induced pluripotent stem cells (iPSCs)
- Source: Created by reprogramming adult stem cells (e.g., skin or blood) to behave like embryonic stem cells.
- Description: Pluripotent stem cells with embryonic-like properties. Since they are created from a patient’s adult stem cells, this eliminates the risk of an immune response and ethical concerns.
- Safety: Experimental, with risks of genetic instability and tumor formation. These stem cells are not yet widely used in clinical therapies.
Stem Cell Administration Methods and Their Safety
The method used to deliver stem cells is critical for the therapy's safety and effectiveness. Here’s an overview of the most common methods:
1️⃣ Stem cell injections
- How it works: Stem cells are injected directly into the affected area.
- Safety: It is generally safe and minimally invasive. Precision is crucial to avoid complications such as infection, bleeding, or incorrect placement.
- Applications: Joint repair (e.g., arthritis), tendon injuries, and localized tissue regeneration.
2️⃣ Intravenous administration
- How it works: Stem cells are delivered into the bloodstream through an IV. They travel throughout the body and target multiple areas.
- Safety: Low risk if administered properly, though potential side effects include mild immune responses or blood clots if the cells are not adequately processed.
- Applications: Autoimmune diseases, systemic inflammation, and general regenerative therapies.
3️⃣ Intrathecal (spinal) administration
- How it works: Stem cells are injected into the cerebrospinal fluid via the spine for targeted delivery to the central nervous system.
- Safety: Requires high precision and expertise, as improper technique can cause nerve damage or infection.
- Applications: Neurological conditions like multiple sclerosis, spinal cord injury, or ALS (amyotrophic lateral sclerosis).
💉 What does regenerative medicine specialist Dr. Isabella Bernaschina have to say about spinal cord injections?
▶️ Watch Bookimed's full interview with Dr. Bernaschina here.
4️⃣ Surgical implantation
- How it works: Stem cells are implanted directly into an organ, tissue, or scaffold during surgery to promote regeneration.
- Safety: Carries higher risks due to the surgical nature of the procedure, including infection, scarring, or complications from anesthesia.
- Applications: Organ regeneration, repairing large tissue defects, and advanced treatments for spinal injuries.
Potential Side Effects and Risks of Stem Cell Therapy
As with any medical treatment, it carries certain risks. However, most side effects are mild and temporary, especially when the therapy is delivered under proper protocols.
Common side effects
1. Reactions at the injection site. Patients may experience mild redness, swelling, or discomfort at the site of injection. These usually resolve within a few days without further complications.
2. Temporary pain or stiffness. Some patients report mild joint or muscle soreness following treatment, which improves with time or over-the-counter medication.
3. Fatigue and discomfort. Common after therapy as the body adapts to the regenerative process.
Less common risks
1. Immune system response. Although this is rare, stem cells derived from a donor (allogeneic) could cause immune reactions with symptoms like fever or inflammation. This can be mitigated through proper screening or by using the patient’s adult stem cells.
2. Infection. Any procedure involving injections or surgical implantation carries a minor risk of infection, which can be minimized with proper sterilization. Using high-quality stem cells and following proper aftercare instructions will also help prevent infections.
💚 The key to minimizing risks is choosing a reputable and licensed clinic that follows strict safety protocols. If you find this challenging, Bookimed can connect you with verified clinics worldwide and help you choose the one that fits your needs.
Contraindications for Stem Cell Therapy
While stem cell therapy has proven safe and effective for many conditions, it’s not suitable for everyone. Certain health conditions or circumstances can increase the risks associated with the treatment.
1️⃣ Active infections
If you’re dealing with a bacterial or viral infection, stem cell treatment should be postponed. Treating the infection first helps prevent complications during or after the medical procedure.
2️⃣ Cancer or recent history of cancer
Stem cell therapies designed to treat cancer, such as bone marrow transplants, are well-established and effective. They are specifically designed to replace damaged blood cells and rebuild the immune system after chemotherapy or radiation.
However, other types of stem cell treatments are not suitable for individuals with active cancer or a recent history of cancer. Stem cells promote growth and repair by releasing signals that encourage cell regeneration. In people with cancer, these signals can accidentally stimulate the growth of cancer cells nearby.
3️⃣ Uncontrolled health conditions not targeted by the therapy
For stem cell treatment to be safe and effective, patients must have stable overall health. If you have uncontrolled health conditions that aren’t the focus of the therapy, the risks can outweigh the potential benefits.
For example, while stem cell therapy may target joint repair or neurological recovery, underlying issues like poorly managed chronic conditions or systemic inflammation could complicate the procedure or recovery process. Stabilizing these conditions beforehand is essential to ensure the best possible outcomes from the therapy.
4️⃣ Pregnancy and breastfeeding
There’s simply not enough research to say stem cell therapy is safe during pregnancy or breastfeeding, so it’s best to wait until after.
5️⃣ Allergies to medications or anesthesia
If you have known allergies to medications used during the procedure, your doctor must assess and adjust the approach to minimize risks.
Other considerations
Stem cell treatment may not be recommended for:
- Elderly patients with significant frailty. Advanced age alone isn’t necessarily a contraindication, but weakness and poor health can make the procedure unsafe or less effective.
- Obese patients, as obesity can increase complications during the procedure.
- Smokers, due to impaired tissue regeneration and healing.
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How to Prepare for Stem Cell Therapy
Although stem cell treatment doesn’t require extensive preparation, it doesn’t come down to just about showing up for the procedure. By preparing correctly, you can get the most out of the therapy and lower potential risks. Here’s how to get ready:
1️⃣ Undergo a full check-up
Your doctor will need to understand your overall health before recommending stem cell treatment. Be honest about your medical history and undergo any necessary tests.
🔬 Dr. Isabella Bernaschina explains what medical tests are required before undergoing stem cell therapy:
2️⃣ Adjust lifestyle habits
- Quit smoking. Smoking reduces your body’s ability to heal and can compromise the effectiveness of stem cells. Aim to quit at least several weeks before the procedure.
- Improve nutrition. Focus on a diet rich in fruits, vegetables, lean proteins, and healthy fats to boost your body’s natural regenerative abilities.
- Exercise regularly. If your condition allows, light to moderate exercise can improve circulation and help your body prepare for recovery. Even a daily walk can make a difference but always check with your doctor first.
3️⃣ Keep your health conditions in check
If you have conditions like diabetes or high blood pressure, make sure they’re under control. Follow your doctor’s recommendations to keep these conditions under control.
4️⃣ Double-check your meds
Some medications, like anti-inflammatory drugs or blood thinners, might interfere with the treatment. Your doctor will let you know if you need to stop or adjust anything beforehand.
5️⃣ Stay hydrated
Drink plenty of water in the days leading up to your treatment. Staying hydrated helps your cells function better and sets you up for a smoother recovery.
6️⃣ Plan for recovery
Arrange for transportation and prepare your home for a comfortable recovery. Stock up on things you might need, such as ice packs or over-the-counter pain relievers.
7️⃣ Follow your doctor’s instructions
Every stem cell treatment is different, and your clinic will give you specific guidelines for your case. These instructions will optimize the therapy’s effectiveness and ensure your safety, so make sure to follow them closely.
How to Choose a Safe Stem Cell Therapy Clinic
Finding the right stem cell clinic is arguably the most important factor determining the safety and success of therapy. With so many options out there, it’s easy to feel overwhelmed. Here are some tips to help you make an informed choice:
1️⃣ Verify licensing and accreditation
Check that the clinic is licensed and accredited by the relevant health authorities in its country. Clinics operating under regulatory oversight offer properly processed stem cells and follow strict safety protocols.
2️⃣ Research the clinic’s track record
Look for reviews and testimonials from patients who have undergone similar medical treatments. Use reputable platforms like Google Reviews or check the Bookimed website. Be cautious of clinics that lack verifiable patient feedback.
3️⃣ Confirm the type of stem cells
Ask the clinic to specify the source (autologous or allogeneic) and type of stem cells they use (e.g., mesenchymal stem cells, embryonic stem cells, etc.). Ensure these stem cells are appropriate for your condition. Verify that the clinic sources and handles them according to regulatory standards.
4️⃣ Look into the medical team’s credentials
A reputable clinic will have experienced and qualified doctors specializing in regenerative medicine. Don’t hesitate to ask about the team’s training and expertise in stem cell-based procedures.
5️⃣ Ask about the treatment protocol
A trustworthy clinic will clearly explain its step-by-step treatment process. Be wary of clinics that avoid providing details or seem vague about the procedure.
6️⃣ Check if the clinic conducts a medical evaluation
Reputable clinics will perform a thorough medical evaluation to assess your suitability for the therapy. If a clinic offers immediate approval without reviewing your health history, it’s a red flag.
7️⃣ Ask about post-treatment support
Good clinics provide comprehensive follow-up care to monitor your progress and address any complications. This shows they are invested in your long-term results.
8️⃣ Pay attention to communication
Doctors who take the time to answer your questions are more likely to prioritize your safety and satisfaction. Poor or rushed communication can be a sign of disorganization or lack of professionalism.
9️⃣ Beware of false promises
Be skeptical of stem cell clinics that guarantee miraculous results or claim their therapy is a “cure-all.” Legitimate institutions will set realistic expectations based on your condition. Research their claims and look for evidence from peer-reviewed studies or reputable medical sources.
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Top 9 Clinics for Safe Stem Cell Therapy
Bookimed has compiled its top 9 verified clinics for stem cell therapy to help you make a safe decision. Guided by our Ranking Policy, we considered clinics’ accreditations, availability of comprehensive treatment programs, patient reviews, and efficiency.
1. Cellular Hope Institute — Cancún, Mexico
🌟 Why this clinic:
- Accredited by the Mexican General Health Council and the Canadian Accreditation Council.
- Over 12 years of experience in regenerative medicine.
- Equipped with a state-of-the-art cell culture lab and cryopreservation unit.
- Trusted by high-profile patients like Mike Tyson and Cristiano Ronaldo.
- Uses different types of stem cells, including allogeneic and autologous mesenchymal stem cells and umbilical cord blood stem cells.
💵 Cost: $7,000-$30,000.
🎯 Best for: Autoimmune diseases, orthopedic conditions, neurodegenerative disorders.
📝 Check out the reviews about Cellular Hope Institute from Bookimed patients:
2. ID Clinic Bangkok — Bangkok, Thailand
Stem Cell Therapy at ID Clinic Bangkok in Thailand offers umbilical cord MSC therapy with IV infusion. The main treatment with 80 million cells may cost around $9,000 USD. It involves a senior plastic surgeon with over 20,000 stem cell procedures performed.
Treatment Details
The clinic provides umbilical cord-derived mesenchymal stem cell therapy. Cells come from ethically screened donors. The procedure uses an ISO-certified clean room facility for safety. Patients receive IV infusion over 60-90 minutes. Most people return to daily activities immediately with no downtime.
Treatment Options
- Anti-aging IV therapy with 50 million cells (about $5,800)
- CKD treatment with 50 million cells (around $6,500)
- Facial rejuvenation using 5 million cells (approximately $1,800)
What's Included
The package contains medical tests before treatment. It covers doctor fees and medications. Patients get three days hotel stay and local transfers. The clinic handles all laboratory work with their certified facility.
Doctor Expertise
Dr Phatcharasak Kraisornphongsakul leads the treatments. He has performed 20,000+ stem cell procedures. His plastic surgery background brings precision to cell therapies. The Royal College of Surgeons Thailand accredits the clinic.
Patients can receive a customized treatment plan after evaluation. The clinic welcomes international patients with English-speaking staff.
Hospital certificates and accreditation of quality
Latest review
| Stem Cell Therapy | $5200 - $6800 |
🌟 Why this clinic:
- Accredited by the Royal College of Surgeons Thailand.
- Uses mesenchymal stem cells from rigorously screened umbilical cord donors.
- Led by experienced specialists, including Dr. Wuttiphan (>20 years in stem cell treatments) and Dr. Kraisornphongsakul (>30 years in aesthetic medicine).
- Treats over 4,000 international patients annually.
💵 Cost: $1,200-$7,500.
🎯 Best for: Autoimmune diseases, joint pain, hair loss, rejuvenation.
3. Liv Hospital Ulus — Istanbul, Turkey
Stem cell therapy at Liv Hospital Ulus in Istanbul, Turkey may cost around 20,000 EUR for a 15-day program. The treatment includes 2 doses of stem cells and 6 ozone therapy sessions under the care of Prof. Dr. Erdal Karaöz, a pioneer in regenerative medicine.
Treatment Program
The therapy uses mesenchymal stem cells from umbilical cord tissue. These cells meet GMP quality standards. The treatment involves three delivery methods:
- Intrathecal injection into the spinal canal
- Intravenous infusion into the bloodstream
- Intramuscular injection for localized effect
What's Included
The 20,000 EUR package covers:
- 2 doses of allogeneic mesenchymal stem cells
- 6 sessions of rectal ozone therapy
- Mesenchymal stem cell-derived exosomes
- Interpreter services during treatment
Medical Team
Prof. Dr. Erdal Karaöz leads the treatment program. As a specialist in regenerative medicine and genetics, he focuses on cellular therapies. The hospital holds JCI accreditation, ensuring international care standards.
Treatment Plan
Patients typically stay for 15 consecutive days. Alternative schedules are available. Before therapy, patients stop blood thinners and complete health screenings. Follow-up assessments determine if additional doses are needed.
The clinic provides free transfers in Istanbul. Interested patients can get more details about individual treatment plans.
Hospital certificates and accreditation of quality
Latest review
| Stem Cell Therapy | $6750 - $7250 |
🌟 Why this clinic:
- Licensed by the Turkish Ministry of Health to cultivate and use stem cells.
- Offers innovative therapies, including stem cell-based facial fillers and post-cancer breast reconstruction.
- Holds GMP certification and complies with global quality standards.
💵 Cost: $8,000-$15,500.
🎯 Best for: Orthopedic conditions, skin treatments, breast reconstruction.
4. Immunotherapy Regenerative Medicine — Puerto Vallarta, Mexico
Stem cell therapy at Immunotherapy Regenerative Medicine in Puerto Vallarta, Mexico may cost around $3,000 for shoulder injections. The clinic specializes in regenerative medicine with 20+ years of experience, led by Dr. Ernesto Romero who has performed over 1,100 stem cell treatments.
About the Treatment
Mesenchymal stem cell therapy uses 50 million to 1 billion cells depending on the condition. The cells are delivered through local injections, IV infusions, or spinal fluid applications. Treatment duration ranges from 1 to 10 days.
What's Included
- Stem cell injections (50-100 million cells per site)
- Medical assessment and consultation
- Airport transfers
- Personalized treatment plan
- Interventional injections (joints or spine)
Doctor's Expertise
Dr. Ernesto Romero has 22 years of experience in regenerative medicine. He founded the biotechnology institute Bioplenum and researches stem cell protocols for ALS, diabetes, and arthritis. His clinic developed the MISID activation technique to enhance stem cell effectiveness.
Conditions Treated
The therapy helps with neurological diseases like Parkinson's and Alzheimer's, plus joint degeneration and dental bone loss. Most patients resume normal activities within 24 hours after this outpatient procedure.
For those seeking alternative regenerative treatments, the clinic offers various programs starting from $3,000. Contact them to discuss personalized options.
Hospital certificates and accreditation of quality
Latest review
🌟 Why this clinic:
- Over 20 years of experience in regenerative medicine.
- Uses fresh, non-frozen adult stem cells for enhanced treatment effectiveness.
- A multidisciplinary team of internationally recognized biologists, biochemists, and nutritionists.
💵 Cost: $4,000-$28,000.
🎯 Best for: Immunology, chronic diseases, anti-aging, sports injuries.
5. Medical Center Juventa — Playa del Carmen, Mexico
Stem cell therapy at Juventa Regenerative Medicine in Playa del Carmen, Mexico may cost around $6,000. The clinic specializes in regenerative treatments using mesenchymal stem cells and exosomes, with Dr. Isabella Bernaschina leading the procedures as an RCG-certified specialist.
Treatment Options
The clinic offers customized stem cell packages:
- 100 million MSC + 20 billion exosomes ($6,000) for polyneuropathy/psoriasis
- 200 million MSC + 10 billion exosomes ($8,500) for cardiovascular regeneration
- 150 million MSC + 20 billion exosomes + 70 million NK ($7,900) for HIV support
What's Included
Each package contains:
- Stem cell IV therapy (100-200 million MSC)
- Exosome IV therapy (10-20 billion)
- Placenta implant
- NAD+ IV drip
- 3-4 nights accommodation
- VIP airport transfers
Procedure Details
The intravenous therapy takes 3-4 nights with physician consultation included. Patients typically stay 4-5 days in Mexico. The treatment aims to improve energy levels within days post-procedure.
Dr. Bernaschina holds certifications in stem cell therapies and belongs to AMPTI. The clinic treats over 500 international patients yearly with VIP services throughout their stay.
Interested patients can inquire about current package availability and payment options.
Latest review
| Stem Cell Therapy | $5000 - $6500 |
🌟 Why this clinic:
- Led by Dr. Isabella Bernaschina, an expert certified by RCG, Mexico’s leading regenerative medicine association.
- Its patient-centric approach and focus on individualized care set it apart.
💵 Cost: $3,200-$11,000.
🎯 Best for: Orthopedics, diabetes, Parkinson’s disease, HIV treatment, alopecia, rejuvenation.
▶️ Hear Dr. Bernaschina explain what stem cell types she uses in her practice and how they are screened for safety:
6. Medipol Mega University Hospital — Istanbul, Turkey
Stem cell therapy at Medipol Mega University Hospital in Istanbul, Turkey may cost around $65,000 for related donor transplants. The hospital is the first JCI-accredited academic medical center in Turkey, offering specialized inpatient care for 60-90 days. Prof. Leylagül Kaynar, Professor of Hematology, leads the stem cell transplantation program with expertise in allogeneic procedures.
Treatment Options
Patients can choose between two main options:
- Related donor transplantation for around $65,000
- Unrelated donor transplantation with international search for about $105,000
What's Included
The treatment package covers:
- Stem cell transplantation procedure
- Donor search services
- Pre-treatment diagnostic tests
- Hospital transfers and VIP assistance
- Translation services
Hospital Stay
Patients typically stay 60-90 days in the hospital. The 810-bed facility includes 127 ICU beds for specialized care. Pretreatment involves genetic analysis and bone marrow examination.
Additional Information
The hospital runs a complete transplant unit for adults and children. It collaborates with REMER center for stem cell research. Treatment uses peripheral blood or bone marrow stem cells collected through apheresis or surgical harvest.
If you're considering stem cell treatment abroad, Medipol Mega offers comprehensive international patient services.
Hospital certificates and accreditation of quality
Latest review
| Stem Cell Therapy | $5000 - $10000 |
🌟 Why this clinic:
- One of Turkey’s largest and most advanced hospitals with a JCI accreditation.
- Treats over 1,200 patients daily and 1 million patients yearly.
- A leader in joint disorder treatments.
💵 Cost: $5,000-$10,000.
🎯 Best for: Joint diseases, bone marrow transplants.
7. Giostar — Cancún, Mexico
Stem cell therapy at Giostar Stem Cell Therapy | Cancun Clinic in Cancún, Mexico may cost around $6,900 to $18,968 USD depending on the protocol. The clinic specializes in regenerative treatments using umbilical cord-derived stem cells, with 98% patient satisfaction and personalized treatment plans under Dr. Evelyn García's guidance.
About the Treatment
The clinic uses umbilical cord-derived mesenchymal stem cells (UC-MSCs) for various conditions. Procedures typically take 1-2 sessions. Patients receive between 70 million to 105 million stem cells based on their needs.
Treatment Protocols
- Facial rejuvenation: 70 million cells + 2 billion exosomes (~$6,900)
- Orthopedic shoulder repair: 105 million cells + 7 billion exosomes (~$9,879)
- ALS neurodegenerative care: 4 vials UC-MSCs + 8 billion exosomes (~$15,968)
Doctor Profile
Dr. Evelyn García leads the clinic with 5 years of specialized experience. She has performed over 900 stem cell treatments. Her training includes a Master's in Regenerative Medicine from Spain's Complutense University of Madrid.
What's Included
Treatment packages typically cover airport transfers, 4-star hotel stays, medical consultations, and follow-up care. Patients usually stay 2-7 days depending on their protocol.
The clinic welcomes international patients with multilingual staff. For exact pricing, patients receive personalized quotes after consultation.
Latest review
🌟 Why this clinic:
- An international leader in stem cell research, headquartered in San Diego, California, and certified by COFEPRIS.
- Founded by leading U.S. researchers and connected to prestigious institutions, including the University of California.
💵 Cost: $8,000-$9,000.
🎯 Best for: Anti-aging, muscular injuries, degenerative diseases, arthritis, sports injuries.
8. Reju Medical Clinic — Medellín, Colombia
🌟 Why this clinic:
- Uses mesenchymal stem cells sourced from a COFEPRIS-licensed lab.
- Employs a highly experienced medical team with over 15 years in regenerative medicine.
💵 Cost: From $5,000.
🎯 Best for: Orthopedics, chronic diseases, diabetes, autism, autoimmune diseases, neurodegenerative disorders.
9. R3 Life Wellness Center — Bangkok, Thailand
Stem cell therapy at R3 Life Wellness Center in Bangkok, Thailand may cost around 657,600 THB for a complete rejuvenation package. The clinic uses umbilical tissue-derived mesenchymal stem cells, the youngest available source with universal compatibility. American Board-certified specialists oversee the treatment, ensuring high standards of care.
Treatment Details
The intravenous stem cell therapy delivers 60 million cells per session. Each treatment takes 45 minutes to 1.5 hours. Patients receive pre-treatment blood compatibility testing and post-treatment vitamins for optimal recovery.
What's Included
- 60 million umbilical tissue-derived mesenchymal stem cells
- Pre-treatment blood compatibility testing
- Medical consultation and personalized plan
- Post-treatment vitamins and detox support
About the Specialist
Dr. Tanaporn Eiamprapai is a regenerative medicine specialist certified by the American Board of Anti-Aging and Regenerative Medicine. She holds a Master's in Clinical Dermatology from Cardiff University.
Clinic Accreditation
R3 Life Wellness Center follows standards set by the Thai Cell Therapy Association. Their specialists maintain certifications in anti-aging and regenerative medicine.
The clinic offers flexible day treatments for international patients. Maintenance sessions are recommended every six months for lasting results. Contact the clinic to discuss your personalized treatment options.
🌟 Why this clinic:
- Accredited by the Thai Cell Therapy Association and the American Board of Anti-Aging and Regenerative Medicine (ABAARM).
- Collaborates with global stem cell banks for high-quality stem cell sourcing.
💵 Cost: $3,500 - $16,500 (for a package).
🎯 Best for: Facial and body rejuvenation, inflammation, hair growth, erectile dysfunction.
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FAQ
Why are stem cells so powerful?
Stem cells can become almost any type of cell in the body, repair damage, and regenerate diseased tissues—essentially acting as the body’s natural repair system.
🧪 Learn more from Dr. Isabella Bernaschina:
What are the main effects of stem cells?
- Immunomodulation. Stem cells help balance and regulate the immune system, reducing overactive responses in autoimmune diseases.
- Anti-inflammatory action. They decrease inflammation, promoting healing in chronic and acute conditions.
- Tissue regeneration. Stem cells repair injured tissue and generate new cells to restore function.
What are the benefits of stem cell therapy over traditional treatments?
- Regenerative capability. Stem cell-based therapies heal by repairing and regenerating damaged tissues rather than just managing symptoms.
- Minimally invasive. Carries fewer risks and requires minimal downtime compared to surgeries.
- Therapeutic potential for chronic conditions. Offers hope for conditions that traditional treatments struggle to address, like neurodegenerative diseases or autoimmune disorders.
- Reduced dependency on medications. May lower the need for long-term medication and its associated side effects.
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All medical content on this page is prepared by authors with specialized medical education and reviewed by certified physicians in the relevant field. Medical review by Fahad Mawlood, Medical Editor & Data Scientist.
Last updated: June 20, 2025.
- Statistics: Figures are based on Bookimed’s internal database January 2026, which includes analysis of 12,450 patient requests across 7 accredited clinics in Thailand.
- Pricing: Cost information is provided directly by Bookimed’s partner clinics and updated regularly to reflect current 2026 market conditions. Actual expenses may differ depending on case complexity, surgeon expertise, and clinic location.
- Clinical Data: Treatment outcomes and patient satisfaction figures are collected from Bookimed’s verified clinic database and supported by data from peer-reviewed medical sources such as PubMed, The Lancet, JAMA, and NEJM (2023–2026).
All data is provided for general informational purposes and may not represent individual results or experiences.
- Nature. (2024). World-first stem-cell treatment restores vision in people. https://www.nature.com/articles/d41586-024-03656-z
- Nature. (2024). Stem cells reverse woman’s diabetes — a world first. https://www.nature.com/articles/d41586-024-03129-3
- Mayo Clinic. (2024). Study documents safety, improvements from stem cell therapy after spinal cord injury. https://newsnetwork.mayoclinic.org/discussion/study-documents-safety-improvements-from-stem-cell-therapy-after-spinal-cord-injury/
- Regenerative Medicine. (2022). Real-world Evidence of Mesenchymal Stem Cell Therapy in Knee Osteoarthritis: A Large Prospective Two-Year Case Series. https://www.tandfonline.com/doi/full/10.2217/rme-2022-0002
- UCI Health. (2024). Can dopamine be restored in Parkinson's patients? https://www.ucihealth.org/blog/2024/01/restoring-dopamine-in-parkinsons-patients
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- Journal of Translational Medicine. (2017). Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy. https://pmc.ncbi.nlm.nih.gov/articles/PMC5610473/
- World Journal of Stem Cells. (2022). Stem cell therapy for insulin-dependent diabetes: Are we still on the road? https://pmc.ncbi.nlm.nih.gov/articles/PMC9350623/