Memorial Göztepe Hospital
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Dr. Ibrahim Ziyal is a neurosurgeon at Memorial Göztepe Hospital in Istanbul (2025–present). He was Professor and Head of Neurosurgery at Marmara University (2012–2025). Earlier, he held faculty roles at Hacettepe University (2001–2012). He was the Founding Head of Neurosurgery at Abant İzzet Baysal University, Düzce (1999–2001). He also worked as a clinical researcher in brain tumors at George Washington University (1996–1998). He then focused on cerebrovascular diseases at the São Paulo Institute of Neurological Sciences (1998–1999).
Expertise: skull base tumors, pituitary surgery, and aneurysm/AVM/cavernoma surgery. Neurosurgery training: Şişli Etfal Hospital. MD: Trakya University. Memberships: Turkish Neurosurgical Society, Neuro-Oncology Association, AANS, CNS, WFNS, EANS.
Leqembi is not currently approved for general use by Turkey's regulatory body, TITCK. While the drug has received approvals in the US and EU, it remains unavailable in the Turkish standard healthcare system. Access is typically restricted to specific clinical research settings at major academic hospitals.
Bookimed Expert Insight: Turkish neurology centers are rapidly scaling infrastructure like AI-supported 3 Tesla MRI and digital PET/CT. These technologies are vital for the strict eligibility screening required for lecanemab. Hospitals with established clinical research units offer the most reliable path for tracking future availability.
Patient Consensus: Patients often find that general approval does not mean immediate local access. Many note the importance of finding a specialist center that handles complex infusion protocols and monitoring.
Leqembi treatment is eligible for adults with mild cognitive impairment or mild dementia due to Alzheimer's disease. Patients must have confirmed amyloid beta pathology. This therapy targets early-stage cognitive decline. It is not suitable for advanced Alzheimer's. Screening requires advanced imaging like PET scans.
Bookimed Expert Insight: Turkish neurology centers like Memorial Göztepe Hospital utilize 3 Tesla MRI and digital PET/CT for eligibility screening. This equipment is vital because doctors must precisely rule out microbleeds before starting infusions. Our data shows clinics with dedicated clinical research units provide more robust ARIA monitoring protocols. Always verify if the facility has 512-slice CT scanners for rapid emergency assessment if needed.
Patient Consensus: Patients note that eligibility depends heavily on genetic testing for the APOE4 gene. They often suggest having recent MRI scans ready to check for pre-existing brain swelling risks.
Safety monitoring for LEQEMBI focuses on detecting Amyloid-Related Imaging Abnormalities (ARIA). These include brain swelling or microbleeds identified via repeated MRI scans. High-volume Turkish centers like Memorial Goztepe Hospital utilize AI-supported 3 Tesla MRI and 512-slice CT imaging to monitor these neurologic changes effectively.
Bookimed Expert Insight: Safety protocols in Turkey often leverage advanced diagnostic suites like the AI-supported 3 Tesla MRI at Memorial Goztepe Hospital. This technology provides the high-resolution imaging needed to detect subtle ARIA findings early. Centers with multidisciplinary tumor boards and clinical research units typically have more experience managing complex medication side effects.
Patient Consensus: Patients emphasize the need for genetic testing and regular MRI scans to stay safe. They note that tracking new headaches or confusion is vital for finding issues early.
The goal of Leqembi therapy is to slow cognitive and functional decline in early-stage Alzheimer's. This monoclonal antibody targets and removes beta-amyloid plaques from the brain. It aims to preserve independence and memory. It does not cure or reverse existing damage.
Bookimed Expert Insight: Turkish hospitals like Memorial Göztepe integrate advanced diagnostics into these protocols. This clinic uses AI-supported 3 Tesla MRI and digital PET/CT. These tools are vital for confirming amyloid presence before treatment begins. High-resolution imaging also allows doctors to monitor safety during the infusion cycles. Clinical research units in Istanbul provide access to these evolving global standards.
Patient Consensus: Many families focus on the therapy as a way to buy more time. They prioritize the ability to delay intensive care or memory loss. Caregivers often emphasize that success means a slower decline, not a full recovery.
Leqembi is administered via intravenous infusion every 2 weeks. Medical staff deliver the medication into a vein over approximately 1 hour. Patients receive these infusions in specialized hospitals or infusion centers. Professional monitoring is required during each session to ensure safety and manage reactions.
Bookimed Expert Insight: Turkish facilities like Memorial Göztepe Hospital are designed for high-volume specialized care. This hospital features 127 outpatient clinics and can treat over 40 patients simultaneously. This infrastructure helps patients secure consistent infusion slots every 14 days without delays. High-capacity centers often provide better logistics for long-term chronic treatments.
Patient Consensus: Patients find the twice-monthly clinic visits time-consuming but appreciate having professional staff nearby. Many focus on the importance of safety monitoring during the hour-long sessions.
Diagnostic steps for Leqembi in Turkey include confirming amyloid plaque through PET scans or CSF analysis. Patients must have mild cognitive impairment or early-stage Alzheimer's dementia. A baseline 3 Tesla MRI is required to check for pre-existing brain conditions. ApoE genetic testing assesses safety risks.
Bookimed Expert Insight: Turkish facilities like Memorial Göztepe Hospital utilize 3 Tesla MRI and digital PET/CT for high-precision screening. These advanced technologies are essential because Leqembi eligibility depends entirely on accurate amyloid detection. Using high-resolution imaging reduces the chance of misdiagnosis before committing to long-term therapy.
Patient Consensus: Patients emphasize that amyloid testing is the main gatekeeper for treatment. Many note that doctors carefully review bleeding history and current medications before clearing them for infusions.