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Exclusive CAR T-cell therapy Packages for June 2025
Dr. Hu Kai has performed numerous successful CAR T-cell therapies for hematologic malignancies.
Beijing GoBroad Boren Hospital is a top-tier hematology specialty hospital in Beijing, China.
Included Services: Consultation with a doctor, preoperative tests, blood tests, medications, follow-up examination, post-op medications, electrocardiogram (ECG), ultrasound, consumable materials, complete blood count (CBC), biochemistry blood test, follow-up visit, consultation with a pediatric hematologist, consultation with an oncohematologist, urine tests, biopsy, hospitalization.
Stay Info: 30 days stay in the hospital, 0 days stay in the hotel, not included in the price.
Discover the Best CAR T-cell therapy Clinics: 26 Verified Options and Prices
The Bookimed clinic ranking is based on data science algorithms, providing a trusted, transparent, and objective comparison. It takes into account patient demand, review scores (both positive and negative), the frequency of updates to treatment options and prices, response speed, and clinic certifications.
Professor Fabio Ciceri is the Head of the Hematology and Bone Marrow Transplantation Unit at San Raffaele Research Hospital and the Blood Transfusion Centre. He has over 180 papers published and has held various Medical and Teaching positions since 1989. He is a member of multiple organizations related to Hematology and was awarded a Merit Recognition Award at the University of Ferrara. He is a Principal Investigator in Cell and Gene Therapy clinical trials for haematological cancers, immune-deficiencies, and neuromuscular disorder.
Dr. Ron Ram is board-certified in Internal Medicine, Hematology, and Medical Oncology. He completed his residency at the State University of New York at Brooklyn. He also finished a fellowship in Hematology and Oncology at New York Medical College, Westchester Medical Center.
Dr. Ram has performed several hundred stem cell transplants. This shows his strong expertise in the field. He has published over 30 articles in peer-reviewed journals. He has also contributed a chapter to a medical textbook. These achievements reflect his commitment to research and education.
My request was for a specific treatment for my condition, which I believe was triggered by COVID or vaccine-related complications. The treatment itself is relatively new and not widely available; however, the doctor Faturanız Hazırdır was open to considering my request, which was a decisive factor in choosing this hospital. Her level of empathy was touching.
When I arrived, I received outstanding support from Aliser Durdiyev, who coordinated the entire process — from reception and medication procurement to scheduling the treatment.
None of this would have been possible without Hanna Karvatska, who connected all of us who has deep personal and professional connection with people here, and I’m deeply grateful to her, Alisar, and the doctor for their support and professionalism. And special thanks for the empathy from all three people, the teamwork they created to get me what we all believe could be the best treatment.
Open mind approach, willingness to solve the problem, empathy of the team
the medical staff are doing an excellent job. However, I was surprised to find that smoking is permitted on the only available open terrace for patients. It would be beneficial to have a designated smoke-free outdoor area for non-smokers.
About Bookimed service
Hanna is a remarkable individual with a big heart, dedicated to connecting patients with top-tier doctors and medical professionals across various countries. Her extensive network ensures that every partner and connection goes the extra mile to meet patient needs without hesitation.
Aliser is a young but already experienced medical advisor. I was positevley surprised with approach. One of the most critical aspects of arranging medical treatment abroad is navigating logistics in an unfamiliar country. This is where Aliser's proactive approach truly stands out. His exceptional energy, personal connections, and unwavering curiosity to find the best solutions were decisive factors in my positive experience.
Together, Hanna and Alisar helped to oerganise care and coordination, making the complex process of international medical treatment seamless and patient-focused.
Doctors of the clinic are qualified, speak English well. But the organization of treatment, that is, all these coordinators and translators already when you are in India, is a huge minus of the process. Simply huge. Expectations of everything and everywhere for hours, sometimes at times, poor awareness, a terrible accent on Russian, that one can understand a lot to the exact opposite, ignorance of medical terms, that is, only life can translate. I accompanied mamutna treatment, I speak English a little, therefore something accelerated due to this. One patient should not go, look for an accompanying person if other countries do not fit the prices for treatment. If someone is traveling alone or an accompanying person does not know English, the process will spoil your nerves. The very examination and treatment, surgery, everything is at a good level. But before the ability to organize everything painlessly for the patient, it will still come to BLK not soon. I do not know, as in other clinics in India, I think it's the same. Translators are different here, and the problems are the same. So in the whole country I think. But if there is no way out, you can entrust local doctors to the health. The patient is well fed in the hospital and the accompanying person. Chambers of any size isolate the patient with curtains around the perimeter, you see only the staff, but keep in mind that the multiple rooms are very noisy. Who prays in Arabic for the whole room, who sings the song, who plays the game with sound effects, who is screaming on the phone, because there is still no silence, people still have groans for the illnesses of people ... they do not do anybody for unconnected phones, loud talks and other inadequacy.
Dyakoy for the Bookimed project, so this wasn’t so bad
Those who I almost wanted - pochula, claims mute. Briefly, zrozumіlo, distinctly.
So, I’m lіkar, in my menu I’ve got a list of food, I have reproved them for selling and selling them for the price of money. At the moment, the situation is checked.
I myself would not have been able to organize a conference call, too, I’m setting an estimate. Dyakoy for the Bookimed project, so this wasn’t so bad. Agony to you - you will master the good
"I can only say thanks to your company and Katerina
Good evening. I can only say thanks to your company and Katerina. Thank you so much for your help and support. The impression about the clinic itself was not very, often made nervous, dragged time, I can’t say anything about the professor either. Five minutes talk for $ 120 a bit too much. The clinic itself is not bad, in my opinion, a lot of clients have simply gathered and cannot cope with such volume, and here we are not talking about the desire to help, just money. How to undertake, I can say that robots need to take as much as possible so that they can cope with it, otherwise it negatively affects their reputation. Thank you again
Believe miracles happen, do not miss your chance, contact Bookimed and they will do their best that you are healthy
I want to thank from the bottom of my heart your company, and in particular a very competent and qualified coordinator-Soyak Alionu for help and advice provided in the process of selecting and treating liver melanoma. Having chosen the country of India and the Global Hospital, we received a consultation and made a diagnosis, thanks to which the oncologist, our doctor, picked up an innovative drug that gave us hope for recovery. We have a diagnosis of grade 4 melanoma of the liver and lung. After returning from India, we undergo further treatment in Ukraine. Believe miracles happen, do not miss your chance, contact Bookimed and they will do their best that you are healthy. RS We are very grateful to Alyona, for helping us in everything from uploading documents to the site and ending with the purchase of tickets for the plane. She worked with us 24 hours a day and if not for her help with our medicine in Ukraine there would be no hope.
Big thanks for bookimed. And special thanks for doctor Ahmed Khaled for helping us to choose Anadulo medical centre. Thanks a lot for everything.I'm really grateful.
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Big thanks for bookimed. And special thanks for doctor Ahmed Khaled for helping us to choose Anadulo medical centre. Thanks a lot for everything.I'm really grateful
I am so impressed by the dedication and professionalism of the medical team of Anadolu!!Their fast acting, applying right procedures, the care and attention they give to pacients and family truly bring honor to this profession!!We felt that people and their lives are valued for real, before verything else,unlike in other places!!A big thank you to all!!
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I am extremely sattisfied with the support.I really need to mention the consultant Teodora, an amazing ptofessional and person, who gave us the best support through a vry hard situation!Our thanks from the heart!!!
A certified medical writer with 10+ years of experience, developed Bookimed’s trusted content, backed by a Master’s in Philology and medical expert interviews worldwide.
General practitioner. Winner of 4 scientific awards. Served in Western Asia. Former Team Leader of a medical team supporting Arabic-speaking patients. Now responsible for data processing and medical content accuracy.
This page may feature information relating to various medical conditions, treatments, and healthcare services available in different countries. Please be advised that the content is provided for informational purposes only and should not be construed as medical advice or guidance. Please consult with your doctor or a qualified medical professional before starting or changing medical treatment.
Fast Facts about CAR T-cell therapy
CAR T-cell therapy
CAR T-cell therapy is a personalized immune system therapy that modifies a patient's T-cells to target and destroy cancer cells.
Pros: This immune-based therapy offers a high remission rate of up to 90% in certain blood cancers. It provides long-lasting effects by boosting the immune system's ability to combat cancer.
Cons: It can cause severe side effects like cytokine release syndrome in up to 50% of patients. This biotherapy is complex and not suitable for solid tumors.
Effectiveness: 80% remission rate in certain leukemia and lymphoma cases.
Duration: 2-3 weeks.
Recovery: 1-2 months.
Best for: Blood cancers like acute lymphoblastic leukemia and diffuse large B-cell lymphoma.
CAR T-cell therapy, or chimeric antigen receptor T-cell therapy, is an immunotherapy that uses genetically altered T cells to target and destroy cancer cells. This treatment is FDA-approved to treat several types of blood cancer, including acute lymphoblastic leukemia and diffuse large B-cell lymphoma.
CAR T-cell infusion combines three types of therapy:
Cell therapy;
Immunotherapy;
Gene therapy.
The leukapheresis process, where white blood cells are harvested, is a critical step in therapy preparation.
The studies show 60% of patients with B-cell lymphoma go into remission for at least 5 years. That’s why CAR T cell therapy is a “living drug” that has a long-term effect on destroying cancer cells.
The process begins with the collection of the patient’s T cells, a type of white blood cell that plays a crucial role in the immune response. Once the T cells are modified, they are expanded in number and reinfused into the patient’s bloodstream.
The CAR allows these engineered T cells to identify and attach to cancer cells, marking them for destruction. This targeted approach ensures that the immune system can effectively attack cancer cells while minimizing damage to healthy cells.
CAR T cell therapies work by:
Identifying and targeting specific cancer cells;
Activating the immune system to attack cancer cells;
Enhancing the body’s natural ability to fight cancer;
Providing a personalized treatment approach.
Who Is a Candidate for CAR T-cell Therapy?
CAR T-cell therapy is not a one-size-fits-all treatment. It's typically considered for patients with specific types of cancer, including:
Relapsed or refractory Acute Lymphoblastic Leukemia (ALL). The patients whose leukemia has returned after initial treatment or hasn't responded to existing therapies.
Relapsed or refractory Diffuse Large B-cell Lymphoma (DLBCL). The patients with a specific type of aggressive lymphoma that has recurred or failed to respond to other treatments.
Multiple Myeloma. CAR T-cell therapy for multiple myeloma shows great results in destroying damaged bone marrow cells.
Follicular Lymphoma. The patients with affected lymph nodes develop small, round nodules called follicles.
Refractory mantle cell lymphoma. The patients with a subtype of B-cell non-Hodgkin lymphoma who suffer from lymph node enlargement and don't respond to traditional chemotherapy.
Other types of blood cancers. Research is ongoing to explore CAR T-cell therapy's effectiveness in treating other blood cancers and potentially some solid tumors.
What Factors Have an Impact on Patient's Potential?
Here's the list of standpoints that make a patient more or less suitable for undergoing CAR T-cell treatment:
Age and overall health. Younger patients with a more robust immune system are better candidates.
Specific cancer type. T-cell therapy is most effective for certain cancer types (leukemia and lymphoma).
Prior treatments. Patients who haven't responded well to other treatments may be suitable candidates.
What Are the Safety Concerns Associated with CAR T-cell Treatment?
While CAR T-cell therapy offers promising results, there are potential safety concerns, including:
Cytokine Release Syndrome (CRS) is a common side effect (42-100% of patients), which includes fever, chills, fatigue, and difficulty breathing. It usually occurs within a few days of receiving the CAR T-cells and can be managed with medication (antipyretics or corticosteroids for advanced cases).
Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) is a less common (3-64% occurrence rate) but more serious side effect affecting the nervous system. It may cause confusion, tremors, headaches, and difficulty speaking.
Tumor lysis syndrome (TLS) occurs when large numbers of cancer cells are rapidly destroyed, leading to electrolyte imbalances and kidney problems.
Risk of infection. Due to the suppression of the immune system during treatment, patients are more susceptible to infections.
What Are the Differences Between CAR-T Cell Therapies and Other Immunotherapy Treatments?
There are several key differences between CAR T-cell therapy and other immunotherapy approaches (such as targeted therapy and monoclonal antibodies):
Feature
CAR T-cell Therapy
Other Immunotherapies
Mechanism of Action
Genetically modified T-cells target specific antigens on cancer cells.
Stimulates the body's immune system to recognize and attack cancer broadly.
Specificity
Highly targeted towards particular cancer cells.
It can have a broader effect on the immune system.
Customization
Personalized treatment using the patient's T-cells.
Not personalized.
Administration
Requires complex procedures for T-cell extraction, modification, and reinfusion.
It can be administered through injections or infusions.
The other table shows precise differences between CAR T-cell therapy and the most common cancer treatments.
Feature
CAR T-cell Therapy
Chemotherapy
Stem Cell Transplant
Target cells
ONLY tumor cells.
ALL the cells that are rapidly dividing (including healthy tissues).
Not defined.
Type of cells
Patient’s OWN immune cells.
Not defined.
Donor’s cells.
What Are the CAR T-Cell Therapy Side Effects?
CAR T therapy is a one-time treatment. Once the CAR T cells are back in the body, they can fight cancer immediately.
Despite the safety concerns mentioned earlier, CAR T-cell therapy can cause other side effects, including:
Fatigue;
Nausea and vomiting;
Low blood counts;
Fever;
Hair loss;
Mouth sores.
These side effects are usually temporary and manageable.
What to Expect Before, During, and After Treatment?
Before receiving CAR T-cell therapy, patients may undergo a conditioning regimen of lymphodepleting chemotherapy (which reduces the number of damaged lymphocytes). This preparatory step aims to reduce the presence of existing immune cells, thereby minimizing the risk of the body rejecting the infused CAR T cells.
The administration of CAR T cells involves a relatively straightforward procedure. The engineered cells are infused intravenously, similar to receiving blood, and the process typically takes between 5 and 30 minutes.
Following CAR T-cell therapy, patients often require hospitalization for 7 to 10 days to allow for close monitoring and management.
Do Patients Still Need Stem Cell Transplants After CAR T-Cell Therapy?
Allogenic stem cell transplant (allo-HCT) is a standard treatment for B-cell lymphomas, but it often doesn't work for long. Patients may have relapses even after the transplant. As a type of immune cell therapy, CAR T-cell treatment for cancer can be combined with allo-HCT to speed up the remission.
The studies show that patients with CAR T-cell therapy alone lived for an average of 10.5 months. On the contrary, those who had transplantation after the T-cell treatment had an average survival of 70.2 months. This is an excellent example of how combining cancer treatments improves patient outcomes.
Stem cell transplantation is also an option for the following cases:
When lymphoma/multiple myeloma doesn't respond to CAR T-cell therapy;
When the initial disease relapses multiple times;
After the previous stem cell transplantation.
What Are the Top Hospitals Offering CAR T-Cell Therapy?
Bookimed has selected the top CAR T-cell centers using our Smart Ranking System. This system considers various factors, such as:
Doctor's experience;
Success rates;
Technological advancements;
Patient satisfaction.
By leveraging this data-driven approach, we ensure our patients can access the most effective and cutting-edge treatments available. The choice is always yours, and we highly recommend consulting with our medical coordinators before signing up for the treatment.
Here's the list of the best hospitals where is car t-cell therapy available:
The Hematology Institute is a leading CAR T-cell therapy clinic in Israel. Their experts have much experience treating patients with CAR T-cells and managing any side effects. The center has a 90% success rate in oncology clinical trials and treatments.
Dr. Ron Ram is one of the best hematology/oncology department specialists. He has performed numerous stem cell transplants and contributed to chimeric cancer treatment.
The Ichilov was also the first CAR T hospital in Israel to get government approval.
The head of the oncology department, Dr. Guo Li Gai, has studied thousands of CAR T-cell therapy for non-Hodgkin lymphoma cases to administer effective CAR T-cell therapy for his patients.
The hospital's oncology department works closely with the Mayo Clinic. The doctors use a system called MICM to make accurate cancer diagnoses. Here's what they evaluate:
Shape of cells (morphology);
Specific substances (immunology);
Chromosomes (cytogenetics);
DNA of cells (molecular science).
Besides collecting stem cells, the local laboratory also separates and cryopreserves their components for later use. This can benefit urgent cases for patients in the last stages of cancer.
Sant Joan de Déu is known for its technological advances and discoveries. The specialists here were the first in Spain to develop a vaccine against tumors of the brain and medulla, as well as a nanofiber tissue for local cancer treatment.
The cell therapy center accepts children and young adults up to 21 years old. It has the best conditions for both bone marrow transplantation and CAR T-cell therapy. The cancer center has 4 boxes with HEPA filters and positive pressure for transplant-eligible patients.
Is CAR T-Cell Therapy Suitable for Solid Tumors?
While CAR T-cell therapies have shown significant success in treating blood cancers, their application in solid tumors (such as sarcomas, carcinomas, and lymphomas) presents unique challenges.
Solid tumors have a complex microenvironment that can hinder CAR T cells from effectively reaching and attacking the tumor site. This has made it difficult to achieve the same level of success seen in blood cancers.
However, researchers are actively exploring new strategies to overcome these obstacles, including:
Developing CAR T cells that can target specific proteins on solid tumor cells;
Using CAR T-cell therapies in combination with other treatment methods to enhance their effectiveness;
Investigating the use of CAR T cells in combination with other treatments, such as checkpoint inhibitors or chemotherapy.
CAR T-cell therapy has the potential to help many patients with solid tumors. More research is needed to learn how it works and find new ways to use it.
How Can Bookimed Help You Find the Best Hospital for CAR T-Cell Therapy?
Finding the right center for CAR T-cell therapy can be challenging. Bookimed coordinators will be happy to assist you with:
Applying to reputable hospitals. Our medical partners have well-trained staff and expertise in CAR T-cell therapy programs.
Transparent cost estimates. We will calculate all the potential costs associated with treatment abroad.
Travel arrangements. We will arrange flights, accommodation, and local transportation.
Language assistance. Our coordinators will provide translation services to ease your treatment journey.
References
CAR-T after Stem Cell Transplantation in B-Cell Lymphoproliferative Disorders: Are They Really Autologous or Allogenic Cell Therapies?. PubMed Central (PMC). URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8470158/ (date of access: 23.09.2024).
CART Cell Therapy Toxicity - StatPearls - NCBI Bookshelf. National Center for Biotechnology Information. URL: https://www.ncbi.nlm.nih.gov/books/NBK592426/ (date of access: 23.09.2024).