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How Much Does Proton-beam therapy Cost in Spain?

From $43,500. The final price depends on the tumor type, the number of sessions, and specialized techniques like Proteus One. Patients save around 65% compared to the US, where this procedure costs $125,000 on average. Packages typically include initial consultations, advanced 3D CT scans, MRI imaging, and treatment planning.

  • Proton therapy for breast cancer: from $35,000 for targeted radiation.
  • Proton therapy for prostate cancer: from $34,000, often requiring 33–45 sessions.
  • Pediatric cases: Typically range from $66,000 to $93,000, especially if anesthesia is required.
  • Regional hubs: Main treatment centers are located in Madrid, Barcelona, and Pamplona.

Bookimed Expert Insight: Spain offers world-class oncology at specialized centers like Proton Therapy Centre Quironsalud. While standard sessions cost significantly less than in the US, choosing a JCI-accredited facility ensures top-tier safety. For example, Clinica Universidad de Navarra in Pamplona maintains a 74% cure rate for sarcomas. Strategic planning is key, as packages often cover diagnostics but exclude long-term local accommodation.

Key Benefits

Why choose Spain for proton-beam therapy?

  • Accredited clinics: JCI-certified hospitals offer top-quality care and adhere to strict safety standards.
  • Latest technologies: Proteus One, a sophisticated device, is employed for precision-targeted treatments. It is particularly effective for brain and abdominal tumors.
  • High success rates: Proton-beam therapy demonstrates an efficacy of 90% in treating localized tumors. It also results in fewer side effects compared to traditional radiation methods.
  • Expert surgeons: Leading oncologists and radiologists, skilled in proton therapy techniques, have successfully treated numerous cases. They ensure comprehensive patient care.

Access advanced Proton-beam therapy solutions in trusted clinics from $43,500.

Data verified by Bookimed as of September 2026, based on patient requests and official quotes from 34 clinics worldwide. Median costs are based on real invoices (2025–2026) and updated monthly. Actual prices may vary.

Proton-beam therapy Packages in Spain — September 2026

Procedure type
Proteus ONE Proton Therapy for Abdominal Tumors — Spain's First JCI Center, MGH-Trained Expert

Spain, Madrid

Stephanie Lilianne E Bolle

28 years of experience

Dr. Carme Ares, Head of the Radiation Oncology Department since 2019 with 34 peer-reviewed publications, treats complex abdominal tumors at the JCI-accredited Proton Therapy Centre Quironsalud — Spain's first proton therapy facility. The 35–40 daily sessions over 6–8 weeks use latest-generation Proteus One accelerators for maximum precision. The package, priced at about $25,016, covers a full treatment course with 3D planning, imaging, and follow-up monitoring, with final adjustments based on the exact session count.

Prostate Cancer Proton Therapy with Proteus ONE

Spain, Madrid

Carme Ares

32 years of experience

Spain's first proton therapy centre with a 91% patient recommendation rate uses the Proteus ONE system for precision targeting. Dr. Raúl Matute, who has performed 1,100+ proton treatments, leads the team at the Proton Therapy Centre Quironsalud. Treatment involves 33–45 daily 20-30 minute sessions over 4–6 weeks, minimizing radiation to the bladder and rectum to reduce side-effect risks. The package, priced at around $22,742, covers all planning, simulation scans, treatment sessions, follow-ups, and coordination with translator support. The JCI-accredited clinic meets international safety standards and provides full support for the 45-day outpatient stay.

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Discover the Best Proton-beam therapy Clinics in Spain: 11 Verified Options and Prices

The Bookimed clinic ranking is based on data science algorithms, providing a trusted, transparent, and objective comparison. It takes into account patient demand, review scores (both positive and negative), the frequency of updates to treatment options and prices, response speed, and clinic certifications.
Centro Médico Teknon
Quironsalud Madrid
Clinica Universidad de Navarra (Navarra Hospital)

Proton-beam therapy Overview in Spain

Takeaways
Related procedures & Costs
How it works
What to expect
Pros & Cons
Benefits
Payment
patients recommend -
85%
Surgery Time - 2 hours
Stay in the country - 10 days
Rehabilitation - 1 day
Anesthesia - General anesthesia
Requests processed - 46119
Verified patient reviews - 20
Bookimed fees - $0

Our Doctors

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Stephanie Lilianne E Bolle

28 years of experience

Dr. Stephanie Lilianne E. Bolle is a radiation oncologist and Head of Radiation Oncology at the Quirónsalud Proton Therapy Center in Madrid. She has led the department since July 2024. The center is Spain’s first proton therapy facility.

MD, University of Liège (1998). Board certified in radiation oncology (2003). She is an active member of the European Society of Paediatric Oncology and works with its Brain Tumor Group and Radiation Oncology Working Group.

She has published more than 120 scientific articles on pediatric brain tumors, proton therapy, pediatric radiation doses, and complex radiotherapy. She takes part in international projects and clinical trials, including BIOMEDE 2 and HARMONIC. Her expertise includes proton therapy, pediatric oncology, CNS and skull base tumors in adults and children, sarcomas, and complex radiotherapy planning.

verified

Carme Ares

32 years of experience

Dr. Carme Ares heads the Radiation Oncology Department at Quirónsalud Proton Therapy Center in Madrid. She is a specialist in proton therapy and radiation oncology. Dr. Ares completed a clinical fellowship at Massachusetts General Hospital, a Harvard Medical School affiliate. She has practiced at top clinics in Switzerland and the Netherlands.

  • Authored over 30 scientific articles in peer-reviewed medical journals.
  • Treats patients at Spain's first proton therapy center.
  • Uses the Proteus One system for precise tumor scanning and dosing.
  • Works at a center accredited by Joint Commission International and ESMO.

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Natalia Rayskiy • Online Consultation with Oncologist
Dec 30, 2019
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Мы очень довольны клиникой Sant Joan de Deu, в которой наблюдается наш ребёнок
Мы очень довольны клиникой Sant Joan de Deu, в которой наблюдается наш ребёнок. Хочется отметить высокий профессионализм доктора Мора и медицинского персонала. Рекомендуем эту детскую клинику для обследования и лечения. Также хочется отдельно поблагодарить медицинского координатора Ангелину Иваненко, которая и помогла нам принять верное решение в выборе клиники.Ангелина и на сегодняшний день помогает оперативно решать все вопросы, всегда на связи. Именно она предложила нам провести скайп консультацию с врачом. Огромное преимущество данной консультации - экономия времени, когда необходимо получить мнение компетентного врача и двигаться дальше в обследовании.Bookimed мы выбрали случайно, и не жалеем об этом.Всем рекомендуем.
Karen • Mammography
United States of America
May 17, 2022
Verified review.
I saw Dr
From the minute I was inquiring about an appointment through to an entire 2 hours of tests, I felt completely taken care of. Being in a foreign country where it’s not your first language can be daunting when needing healthcare. My healthcare navigator Leen was so wonderful. She brought me to each doctor or department, got me situated and was also my translator. She was kind, compassionate & so incredibly helpful. I was incredibly grateful to have her by my side. I saw Dr. Bassols who was incredibly warm, knowledgeable and put my fears at ease. The other technicians were also wonderful and caring. I highly recommend the staff and care I received at Centro Medico Teknon and the team from bookimed that connected me to them. Thank you everyone!!
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Елена Коросташевская • Rectal cancer
Jun 11, 2018
Verified review.
- I am sincerely grateful for Doctor-coordinator Christina's help Return: About the doctor: - I am sincerely grateful for Doctor-coordinator Christina's help - I want to thank all the doctors who directly have treated me, especially Dr
From April to July 2017, I underwent a treatment in the Oncology Department at Teknon. I came to this hospital thanks to Bookimed International Patients Support Center. Doctor-coordinator Christina has supported me and I am sincerely grateful for her help! The treatment in the hospital was at the highest level, and it ended successfully. I have recovered!!! I want to thank all the doctors who directly have treated me, especially Dr. Capdevila and to Dr. Jorcano. The International Department employees were very helpful — I had no difficulties in communication with medical team. I will definitely recommend this hospital to my friends and relatives in case of any health problems.
Anonymous
Kyrgyzstan
Feb 1, 2020
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-Let me express my deepest gratitude for your care, admiration of your greatest talent and your positive, super-nice personality!
Dear amazing Dr. Bartolomé Oliver! Let me express my deepest gratitude for your care, admiration of your greatest talent and your positive, super-nice personality! I was so lucky to be in hands of one of the most experienced and the BEST doctors in the world!!! You made rare and complicated surgery look easy! My whole year full of stress, fear is over thanks to you! Live the longest and happiest life! All the best wishes to you! Thank you! Doctor!!! Thanks to your team! Thanks to International department and my bookimed coordinator-Dr. Kamran Abbas-Zade! Your “C7 Neurunoma” patient
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Absolutely satisfied! Dr Kamran Abbas-Zade guided me through the whole process, and brought me to the best doctor in the world! communication level was great, replies were quick. Olga was caring and initiative, helped me solve my migraine issue.
Anonymous • Meningioma
Ukraine
Aug 19, 2019
Verified review.
"Thanks a lot to Bookimed, and especially to my coordinating doctor Ekaterina Koliko
Before the online consultation, I consulted with several doctors in Ukraine and it was very important for me to get answers to many questions, including absolutely amateur ones. Dr. Bartolome Oliver, despite his worldwide popularity, very sincerely, accurately and correctly answered all my questions. I liked the doctor very much, it was clear that he was a professional in his field. Thanks a lot to Bookimed, and especially to my coordinating doctor Ekaterina Koliko.
Mansour • Sigmoid adenocarcinoma
Nov 8, 2023
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As a doctor I recommend bookimed
I introduced many patients to other medical tourism companies but most of them were not honest such as Bookinghealth.com they did fraud with our patients so finally I found an excellent company by the name of bookimed.com Iam the client Of bookimed.com since 5 years and all of my patients are satisfied from its staffs and services so as a doctor I recommend bookimed.com to choose as a right a guaranteed company in the term of your health …. Best wishes Dr.Mansoor
Laura • Sarcoma
Jan 29, 2020
Verified review.
We are very happy with the service provided, and we highly recommend this Medical Center, and especially Dr
We had a Skype Consultation with Dr. Joan Carles. The call went really well. Dr. Carles was very well prepared and knew my case beforehand based on the documentation we provided prior to the call. He answered all our questions, and provided us with a final written report on his recommendations. We are very happy with the service provided, and we highly recommend this Medical Center, and especially Dr. Joan Carles.
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I am very satisfied with Bookimed.
Наталья • Breast cancer
Ukraine
Sep 25, 2019
Verified review.
- Thank!
I turned to Bookimed for a second independent opinion, I didn’t expect anything, but I was pleasantly surprised by the speed and cramming of the coordinating doctors Katya Koliko and Olga Krisyuk. We organized a video consultation with the HM clinic in Spain, everything went as planned, the doctor wrote what needs to be done at the moment and treatment options. Thank !
Anonymous • Colon cancer
Mar 27, 2025
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Overall, I had a positive experience and would recommend it to others
My online consultation experience was very smooth and professional. The medical team was knowledgeable, attentive, and answered all my questions thoroughly. The platform was easy to use, and I appreciated the quick response time. Overall, I had a positive experience and would recommend it to others
- I really appreciated the professionalism and kindness of the medical team. They made me feel comfortable and well cared for. - The consultation was quick and efficient, and the doctor provided clear and helpful advice. - I liked how easy it was to book an appointment and how responsive the team was. - The detailed explanations and personalized care were the best parts of my experience.
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My experience with Bookimed was excellent. The platform made it easy to find and connect with a medical specialist. The support team was very responsive and guided me throughout the process. The consultation was professional, and the doctor provided clear and helpful advice. I would definitely recommend Bookimed to others seeking medical assistance.
Инна • Prostate cancer
Feb 11, 2020
Verified review.
Dr
Many thanks to Bookimed and everyone who helped organize an urgent visit to the clinic and coordinate all the procedures. I am also very grateful for the help in booking the hotel and the support of Catherine, Daria and Ostap, human participation is incredibly important.
About Bookimed service
Many thanks to Bookimed and everyone who helped organize an urgent visit to the clinic and coordinate all procedures. I am also very grateful for the help in booking the hotel and the support of Ekaterina, Daria and Ostap, human participation is incredibly important
Anonymous • Consultation with an oncologist
Dec 1, 2019
Verified review.
We are also very grateful to Ostap, the regional coordinator in Teknon, who organized everything quickly and clearly
The online consultation was about what to do next, since the diagnosis was obvious. Mom is happy with the consultation. We are also very grateful to Ostap, the regional coordinator in Teknon, who organized everything quickly and clearly.
ANDREEVA DILIA • Sarcoma
Apr 28, 2019
Verified review.
Ready to recommend to people
The consultation is fruitful Exhaustive Received as welcome guests All questions answered Ready to recommend to people The only thing that is inconvenient is no direct Auto flights to the city of Palomnna
Алена • Online Consultation with Pediatric Oncologist
Germany
Dec 18, 2023
Verified review.
The coordinator Yulia is an excellent specialist
I would like to thank the Bookimed team for the perfectly organized consultation with the doctor. The coordinator Yulia is an excellent specialist, I felt support at all stages!
I liked absolutely everything, starting from the first application on the site, consultation with specialist Yulia and further support. Julia was always in touch, I received answers to my questions on time. The meeting with the doctor and translator was perfectly organized, taking into account all our wishes!
Arthur • Medulloblastoma
Brazil
Jun 15, 2026
Verified review.
thanks to the consultation, I was able to explore a new course of action and try a different treatment, which was a positive outcome
The service was good: thanks to the consultation, I was able to explore a new course of action and try a different treatment, which was a positive outcome.
The possibility of finding a path to treatment.
Everything went absolutely perfectly!
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A experiencia está sendo satisfatória.
Natalia Rayskiy • Chemotherapy
Sep 11, 2019
Verified review.
Мы очень благодарны команде клиники и доктору Моre за проявленные внимательность и профессинализм в решении вопросов лечения ребёнка.

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Updated: 09/26/2026
Authored by
Anna Leonova
Anna Leonova
Head of Content Marketing Team
A certified medical writer with 10+ years of experience, developed Bookimed’s trusted content, backed by a Master’s in Philology and medical expert interviews worldwide.
Fahad Mawlood
Medical Editor & Data Scientist
General practitioner. Winner of 4 scientific awards. Served in Western Asia. Former Team Leader of a medical team supporting Arabic-speaking patients. Now responsible for data processing and medical content accuracy.
Fahad Mawlood Linkedin
This page may feature information relating to various medical conditions, treatments, and healthcare services available in different countries. Please be advised that the content is provided for informational purposes only and should not be construed as medical advice or guidance. Please consult with your doctor or a qualified medical professional before starting or changing medical treatment.

Our Proton-beam therapy Techniques: What Suits You Best?

When considering Proton-beam therapy, it’s important to understand the different techniques and which is best suited for you. Here’s a concise comparison of popular options:

Proton therapy for prostate cancer

Proton therapy is a precise form of radiation therapy that targets prostate cancer tumors with minimal damage to surrounding tissues.

Pros: Offers targeted tumor treatment with reduced risk of side effects like incontinence and impotence. More than 90% of patients report a good quality of life post-treatment.
Cons: Limited availability as only a few centers offer this advanced cancer treatment. Requires specialized facilities and equipment.
Effectiveness: 5-year survival rate exceeds 90% for localized prostate cancer.
Duration: Treatment typically spans 5-8 weeks with sessions lasting 15-30 minutes each.
Recovery: Not needed
Best for: Men with localized prostate cancer, particularly those seeking to minimize side effects. Ideal for younger patients.
Prices: Cost of Proton therapy for prostate cancer in Spain from $34,000

Proton therapy for breast cancer

Proton therapy uses precise proton beams to target and treat breast cancer, minimizing damage to surrounding healthy tissue.

Pros: Proton therapy offers precise targeting, reducing radiation exposure to nearby organs by up to 60%. It provides a higher control rate for complex cases.
Cons: Proton therapy centers are less widespread, limiting availability. It requires specialized equipment and expertise.
Effectiveness: Success rates for localized breast cancer treatment exceed 90%.
Duration: Typically, the procedure takes 15-30 minutes per session over 5-7 weeks.
Recovery: Not needed.
Best for: Effective for early-stage breast cancer and cases needing precise treatment. Ideal for patients with nearby critical organs.
Prices: Cost of Proton therapy for breast cancer in Spain from $35,000

FAQ about Proton-beam therapy in Spain

These FAQs come from real patients seeking medical assistance through Bookimed. Answers are given by experienced medical coordinators and trusted clinic representatives.

Where can I receive proton therapy in Spain?

Proton therapy in Spain is primarily centered in Madrid at dedicated facilities like the Proton Therapy Centre Quironsalud and Clinica Universidad de Navarra. These JCI-accredited centers utilize Proteus ONE technology to treat pediatric cases, head and neck tumors, and complex sarcomas with high precision.

  • Primary location: Madrid hosts Spain's first and most advanced dedicated proton units.
  • Technology used: Centers employ Proteus ONE systems featuring 220-degree rotating gantries for 3D scanning.
  • Specialized care: Facilities focus heavily on pediatric oncology and limb preservation for bone sarcomas.
  • Accreditation standards: Leading clinics maintain Joint Commission International (JCI) and ESMO gold-standard certifications.

Bookimed Expert Insight: While general medical centers exist throughout Spain, proton therapy is highly centralized in Madrid. The Proton Therapy Centre Quironsalud maintains a multifunctional treatment room that handles 450 patients annually. For international patients, centers like Clinica Universidad de Navarra offer high-success sarcoma treatments, reporting a 74% bone sarcoma cure rate using these advanced protocols.

Patient Consensus: Patients value how proton therapy significantly reduces toxicity and side effects compared to traditional X-rays. Many highlight that coordinating treatment requires direct clinic communication due to the specialized nature of the equipment.

Is proton therapy in Spain better than conventional radiotherapy?

Proton therapy in Spain offers superior precision compared to conventional radiotherapy for specific tumors near critical organs. Utilizing the Proteus One system, it delivers radiation directly into the tumor without an exit dose. This targeted approach spares healthy tissue, reducing long-term toxicity and secondary malignancy risks.

  • Targeted precision: Proteus One system stops radiation at the tumor, eliminating the exit dose entirely.
  • Tissue preservation: Protons deliver significantly less radiation to surrounding healthy organs than photon beams.
  • Pediatric priority: Specialists indicate this therapy for 85% of pediatric solid tumors to minimize growth interference.
  • Treatment range: Spanish centers specialize in complex cases like skull base, spine, and abdominal tumors.

From $43,500. Data from Proton Therapy Centre Quironsalud shows that for patients who already reached their lifetime radiation limit, this targeted beam is often the only safe way to treat a recurrence without damaging vital structures.

Patient Consensus: Patients value how this technology shoots radiation into a tumor rather than through it. Many report that while the cure rates are similar, the real benefit is preserving their quality of life by avoiding severe late-stage side effects.

What side effects can proton therapy cause?

Proton therapy side effects include fatigue, skin irritation, and radiation dermatitis. These effects are typically less severe than traditional radiation because protons release energy only at the tumor site. Short-term reactions include temporary swelling, nausea, or sore throat depending on the treatment area.

  • Skin reactions: Patients report redness, itching, or burns that scab during the healing process.
  • Cumulative fatigue: Intense tiredness often builds significantly over 2 to 6 weeks of treatment.
  • Tissue scarring: Radiation fibrosis can cause long-term muscle constriction or localized chronic pain.
  • Neurological risks: Brain treatments can cause delayed swelling or necrosis months after therapy ends.

Bookimed Expert Insight: While proton therapy is precise, its cumulative nature means side effects often peak after treatment ends. High-volume centers like Proton Therapy Centre Quironsalud in Madrid, which treats 450+ patients annually, utilize the Proteus One system. This technology enables individual tumor scanning to modulate dosage, which helps manage long-term risks like bone fractures or organ damage.

Patient Consensus: Many patients experience intense throat pain or mouth blisters that make swallowing difficult. Some report permanent hair loss or annual heat rashes in the treated area years later.

What technology is used in Spanish proton centers?

Spanish proton centers utilize the IBA Proteus One system, a compact intensity-modulated proton therapy (IMPT) technology. These facilities employ pencil beam scanning (PBS) to deliver radiation doses with millimeter precision, specifically targeting tumors while preserving healthy surrounding tissue via the Bragg peak principle.

  • Core system: IBA Proteus One features high-precision, image-guided technology for cancer treatment.
  • Particle acceleration: A 90-ton cyclotron accelerates protons to two-thirds the speed of light.
  • Radiation delivery: 220-degree or 360-degree rotating gantries allow precise targeting from any angle.
  • Beam technology: ConformalFLASH and DynamicARC enhance session speed and overall treatment efficacy.

Bookimed Expert Insight: While many countries use massive multi-room complexes, Spain’s Proton Therapy Centre Quironsalud houses all equipment in one multifunctional JCI-accredited room. This streamlined setup allows their team to treat 450 patients annually, demonstrating that compact technology can maintain high-volume clinical excellence.

Patient Consensus: Patients value how this technology shoots radiation into the tumor rather than through it. This approach is specifically preferred for pediatric cases to protect developing tissue and reduce long-term side effects.

How long does a typical proton therapy course last?

A typical proton therapy course in Spain lasts 3 to 5 weeks for standard protocols. Treatment occurs 5 days per week as an outpatient procedure. Recent ultra-hypofractionated methods or Stereotactic Body Radiation Therapy (SBRT) can reduce duration to only 5 sessions over 1 to 2 weeks.

  • Session frequency: Sessions occur daily Monday through Friday with weekend rest periods.
  • Daily timeframe: Patients spend 45 to 90 minutes at the facility for positioning.
  • Treatment methods: Use of Proteus ONE scanning maximizes dosage precision and improves outcomes.
  • Recovery timeline: Fatigue usually peaks 6 to 10 weeks after completing the final session.

Bookimed Expert Insight: Data from Proton Therapy Centre Quironsalud shows that stay recommendations vary significantly by tumor type. While brain tumor protocols suggest a 25-day stay, head and neck cases require 60 days. This indicates that while active beam delivery is fast, physiological monitoring for complex areas takes nearly twice as long.

Patient Consensus: Patients emphasize that while the actual radiation is painless and fast, the cumulative fatigue hits hardest several weeks after returning home. Many recommend planning for a 3 to 6-month gradual return to full activity levels.

How can international patients access proton therapy in Spain?

International patients can access proton-beam therapy in Spain through Joint Commission International (JCI)-accredited oncology centers, primarily in Madrid. Access requires a neuro-oncological review of medical records to confirm eligibility for techniques like Proteus One plus planning for a 5-8 week treatment cycle.

  • Specialized facilities: Madrid-based centers like Proton Therapy Centre Quironsalud utilize Proteus One rotating gantry systems.
  • Access protocol: Patients undergo MRI and 3D CT scan planning followed by daily outpatient sessions.
  • Duration: Treatment requires 25 to 45 daily sessions over 5 to 8 weeks in Spain.
  • Pre-treatment: Specialist consultations and proteinogram cancer marker tests are mandatory before therapy begins.

Bookimed Expert Insight: While proton therapy centers in Spain like Quironsalud are JCI-accredited, they function as outpatient facilities. Our data shows patients must budget for 25 to 60 days in a hotel. This extended stay often exceeds the initial medical cost estimates for international families.

Patient Consensus: Many patients emphasize consulting your local oncologist first to ensure proton therapy is medically necessary for your diagnosis. Managing translators and logistics via a navigator is highly recommended to reduce stress during long treatment blocks.

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