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What's the Cost of Multiple sclerosis Diagnosis and Treatment in Italy?

Multiple sclerosis treatment cost in Italy typically includes brain MRI with contrast ranging from $400 to $600 and medication treatment for multiple sclerosis running from $5,500 to $10,000. Expenses depend on the Expanded Disability Status Scale (EDSS) score, specific drug protocols, and rehabilitation needs. Patients often find 20-40% savings compared to the US. Top cities for MS care include Milan, Rome, and Bari.

Typical Multiple Sclerosis Treatment Costs in Italy

  • Brain MRI with contrast: $400 – $600
  • Consultation with a neurologist: $200 – $300
  • Complex diagnostics of multiple sclerosis: $500 – $1,400
  • Visual Evoked Potentials (VEP-test): $200 – $300
  • OCT (Optical coherence tomography): $100 – $200
  • Medication treatment for multiple sclerosis: $5,500 – $10,000
  • Ocrevus (ocrelizumab): $35,000 – $50,000
  • Plasmapheresis: $2,200 – $4,000
  • Multiple sclerosis rehabilitation: $4,500 – $9,500
  • Natural Killer Cell Therapy (NK Cell Therapy): Price on request

Bookimed Expert Insight: Patients requiring advanced neurological monitoring should consider IRCCS-accredited research hospitals like San Raffaele in Milan. This center is a leader in neurosurgery and neurology, managing over 300,000 patients annually. For specialized MS rehabilitation, Clinic Villa Stuart in Rome provides FIFA-accredited facilities. This is ideal for patients focusing on mobility recovery. Milan-based centers offer the highest concentration of MS specialists in Italy.

ItalyTurkeyAustria
Plasmapheresisfrom $2,200from $1,200from $2,000
Ocrevus (ocrelizumab)from $35,000from $10,000from $35,000
Multiple sclerosis rehabilitationfrom $4,500from $3,000from $10,000
Medication treatment for multiple sclerosisfrom $5,500from $2,500from $2,000
Therapeutic Apheresisfrom $2,200from $1,350-
Data verified by Bookimed as of May 2026, based on patient requests and official quotes from 161 clinics worldwide. Median costs are based on real invoices (2025–2026) and updated monthly. Actual prices may vary.

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Best Multiple sclerosis Treatment Centers in Italy: 5 Verified Options and Prices

The Bookimed clinic ranking is based on data science algorithms, providing a trusted, transparent, and objective comparison. It takes into account patient demand, review scores (both positive and negative), the frequency of updates to treatment options and prices, response speed, and clinic certifications.
San Donato Hospital
San Raffaele
Ospedale Santa Maria

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Updated: 02/06/2024
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Anna Leonova
Anna Leonova
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A certified medical writer with 10+ years of experience, developed Bookimed’s trusted content, backed by a Master’s in Philology and medical expert interviews worldwide.
Fahad Mawlood
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This page may feature information relating to various medical conditions, treatments, and healthcare services available in different countries. Please be advised that the content is provided for informational purposes only and should not be construed as medical advice or guidance. Please consult with your doctor or a qualified medical professional before starting or changing medical treatment.

Expert Overview about Multiple sclerosis Treatment in Italy

These FAQs come from real patients seeking medical assistance through Bookimed. Answers are given by experienced medical coordinators and trusted clinic representatives.

Which are the top-rated MS treatment centers in Italy?

Italy hosts leading neurology centers recognized globally for multiple sclerosis (MS) care. Top-rated facilities include San Raffaele Hospital and San Donato Hospital in Milan. These institutions hold IRCCS accreditation for combining clinical excellence with advanced research. They rank among the best specialized hospitals globally.

  • San Raffaele Hospital: Ranked 43rd globally for neurology with elite MS research programs.
  • San Donato Hospital: Holds a 4.9 rating and specializes in advanced neurorehabilitation.
  • Carlo Besta Institute: Ranked as the top neurology hospital in Italy for complex disorders.
  • Gemelli University Policlinic: A premier Rome-based center ranked 29th globally for neurology.

Bookimed Expert Insight: Data shows Milan is the primary hub for MS care. Hospitals like San Raffaele and San Donato serve over 300,000 patients annually. This high volume ensures specialists manage diverse MS cases regularly. Choosing these larger IRCCS centers often provides faster access to the latest disease-modifying therapies. These treatments may reach smaller regional hospitals much later.

Patient Consensus: Patients note that university hospitals in Milan and Rome offer the best specialist access. Many recommend using private consultations to skip long public wait times for initial diagnosis. Traveling from southern regions to northern centers is common to access newer monoclonal antibody treatments.

Are the latest Disease-Modifying Therapies (DMTs) available in Italy?

The latest Disease-Modifying Therapies (DMTs) for multiple sclerosis are available in Italy. The Italian Pharmaceutical Agency (AIFA) authorizes and reimburses high-efficacy treatments. Patients access these therapies through specialized MS centers. Availability includes S1P receptor modulators and monoclonal antibodies like ocrelizumab.

  • Available medications: Ocrelizumab, ozanimod, siponimod, and ponesimod are approved for clinical use.
  • High-efficacy options: Cladribine tablets and ofatumumab are refundable for highly active relapsing MS.
  • Specialized care: Neurologists at IRCCS-accredited centers like San Raffaele manage advanced treatment protocols.
  • Research integration: Leading hospitals combine clinical assistance with active research into emerging MS therapies.

Bookimed Expert Insight: Data shows a clear advantage in seeking treatment at IRCCS-accredited facilities in Milan. San Raffaele and San Donato Hospital both maintain this research designation. These institutions often provide faster access to newer protocols. They serve over 300,000 patients annually and integrate the latest research directly into clinical practice.

Patient Consensus: Patients note it is important to document all disease activity to speed up drug approvals. Those in Northern Italy often report shorter waiting times for receiving their first infusions.

Can I get a second opinion from an Italian MS specialist remotely?

International patients can obtain remote second opinions from leading Italian neurological centers specializing in Multiple Sclerosis. Institutions like San Raffaele Research Hospital in Milan provide virtual consultations via secure platforms. Specialists review clinical history, laboratory reports, and MRI scans to confirm diagnoses or suggest treatment adjustments.

  • Expert access: Professor Massimo Filippi at San Raffaele provides expert reviews via video sessions.
  • Digital platforms: Consultations typically occur through secure channels like Microsoft Teams or Zoom.
  • Required records: Patients must upload MRI scans in DICOM format and neurological reports first.
  • Written reports: Specialists provide formal documentation outlining findings and recommended next steps.

Bookimed Expert Insight: San Raffaele and San Donato share the same Italian Ministry of Health accreditation. Both facilities manage over 300,000 patients annually using high-volume research protocols. This shared infrastructure ensures that even remote consultations benefit from Europe's largest clinical data pools. Choosing either facility provides access to identical quality standards for complex neuro-immunological reviews.

Patient Consensus: Patients note that uploading high-quality MRI scans in advance is the most critical step. They suggest using translation tools for initial outreach to ensure clinical records are understood correctly.

How does the Italian National Health Service support MS patients?

Italy's National Health Service (SSN) provides free or highly subsidized care for Multiple Sclerosis. Patients access specialized centers for diagnosis and monitoring. Disease-modifying therapies (DMTs) are fully covered. The system includes exemptions for specialist visits and diagnostic tests like MRI scans.

  • Specialized network: Over 240 neurology centers manage prescriptions and follow-ups.
  • Subsidized medication: First-line and advanced therapies require no out-of-pocket costs.
  • Financial support: Patients receive exemptions from co-payments for all MS-related care.
  • Disability benefits: Approved patients access free walking aids and monthly allowances.

Bookimed Expert Insight: Quality of care often correlates with research hospital status. Facilities like San Raffaele and San Donato in Milan hold IRCCS accreditation. This status combines clinical care with advanced research activities. Data shows these northern centers often provide faster access to innovative treatments. This includes protocols like hematopoietic stem cell transplantation (HSCT) for aggressive cases.

Patient Consensus: Patients value the zero-cost access to expensive medications compared to other countries. Many note it is important to prepare for bureaucratic delays when applying for disability pensions.

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